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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:estrogen signaling pathway
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Accession:PW:0000507 term browser browse the term
Definition:Estrogens are C18 steroid hormones that constitute the females sex hormones. Estrogens signal via the estrogen receptor which, once activated, drives the expression of target genes.
Synonyms:related_synonym: ESR-mediated signaling;   intracellular estrogen receptor signaling pathway
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estrogen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascc1 activating signal cointegrator 1 complex subunit 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr20:27,941,053...28,031,272
Ensembl chr20:27,941,283...28,031,272 		JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ddx5 DEAD-box helicase 5 ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 ISO RGD PMID:18451092 RGD:4892102 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901 		JBrowse link
G Ep300 E1A binding protein p300 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Esr1 estrogen receptor 1 ISO
IDA		 RGD PMID:16651458 PMID:19274700 PMID:17928626 RGD:1580338, RGD:4892064, RGD:5128669 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 IDA
ISO		 RGD PMID:15564578 PMID:19274700 PMID:17928626 RGD:1582269, RGD:4892064, RGD:5128669 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO
IDA
IMP		 RGD PMID:19274700 PMID:20445128 PMID:19767412 PMID:20445128 RGD:4892064, RGD:4892084, RGD:5128698, RGD:4892084 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO RGD PMID:18451092 RGD:4892102 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Med1 mediator complex subunit 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Ncoa6 nuclear receptor coactivator 6 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 3:143,890,896...143,961,916
Ensembl chr 3:143,890,896...143,952,268 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Phb2 prohibitin 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Ppid peptidylprolyl isomerase D ISO RGD PMID:18451092 RGD:4892102 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 ISO RGD PMID:16394250 RGD:5128512 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Sra1 steroid receptor RNA activator 1 ISO RGD PMID:16394250 RGD:5128512 NCBI chr18:28,269,192...28,273,023
Ensembl chr18:28,269,311...28,272,538 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IMP RGD PMID:17928626 PMID:20445128 RGD:5128669, RGD:4892084 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 ISO RGD PMID:18451092 RGD:4892102 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      transcription factor mediated signaling pathway 460
        estrogen signaling pathway 30
          altered estrogen signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      hormone signaling pathway 624
        lipid hormone signaling pathway 224
          steroid hormone signaling pathway 92
            sex steroids signaling pathway 34
              estrogen signaling pathway 30
                altered estrogen signaling pathway 0
paths to the root