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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Wnt signaling, canonical pathway
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Accession:PW:0000201 term browser browse the term
Definition:The Wnt signaling pathway is involved in many developmental processes. In the conventional or canonical Wnt pathway, beta-catenin is a central component required for the transcriptional control of Wnt signaling target genes.
Synonyms:related_synonym: beta-catenin dependent Wnt signaling pathway;   canonical Wnt signaling pathway
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Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO PID
RGD		 PMID:18432252 PID:200077, RGD:2293188 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Axin1 axin 1 ISO PID
RGD		 PMID:18432252 PID:200077, RGD:2293188 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:18432252 RGD:2293188 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200077 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:16793760 RGD:2302032 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Csnk1g1 casein kinase 1, gamma 1 ISO PID
RGD		 PMID:18432252 PID:200077, RGD:2293188 NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826 		JBrowse link
G Ctnnb1 catenin beta 1 IDA
ISO		 PID
RGD		 PMID:16478782 PMID:20042609 PMID:18432252 PID:200077, RGD:1581696, RGD:7242068, RGD:2293188 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cul3 cullin 3 ISO PID PID:200077 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO RGD PMID:18432252 PMID:17143291 RGD:2293188, RGD:2301921 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 ISO RGD PMID:17143291 RGD:2301921 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225 		JBrowse link
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 ISO RGD PMID:17143291 RGD:2301921 NCBI chr16:69,403,215...69,406,580
Ensembl chr16:69,402,989...69,406,580 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 IDA
ISO		 PID
RGD		 PMID:16478782 PID:200077, RGD:1581696 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 ISO PID PID:200077 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 ISO PID PID:200077 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G Frzb frizzled-related protein ISO RGD PMID:23085770 RGD:7365107 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Fzd1 frizzled class receptor 1 ISO RGD PMID:15923619 RGD:2293491 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Fzd10 frizzled class receptor 10 ISO RGD PMID:15923619 RGD:2293491 NCBI chr12:28,098,371...28,101,566
Ensembl chr12:28,098,371...28,101,566 		JBrowse link
G Fzd5 frizzled class receptor 5 ISO PID PID:200077 NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO PID PID:200077 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IDA
ISO		 PID
RGD		 PMID:16478782 PMID:20042609 PMID:18432252 PID:200077, RGD:1581696, RGD:7242068, RGD:2293188 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Klhl12 kelch-like family member 12 ISO PID PID:200077 NCBI chr13:45,899,913...45,933,648
Ensembl chr13:45,899,928...45,933,643 		JBrowse link
G Kremen1 kringle containing transmembrane protein 1 ISO RGD PMID:17143291 RGD:2301921 NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516 		JBrowse link
G Kremen2 kringle containing transmembrane protein 2 ISO RGD PMID:17143291 RGD:2301921 NCBI chr10:12,763,345...12,767,622
Ensembl chr10:12,763,397...12,767,854 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 ISO RGD PMID:18432252 PMID:10528152 RGD:2293188, RGD:2301908 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 ISO RGD PMID:23085770 RGD:7365107 NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899 		JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 ISO RGD PMID:23085770 RGD:7365107 NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446 		JBrowse link
G Lrp5 LDL receptor related protein 5 ISO RGD PMID:18432252 PMID:15923619 RGD:2293188, RGD:2293491 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp6 LDL receptor related protein 6 ISO PID
RGD		 PMID:18432252 PID:200077, RGD:2293188 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Ndp norrin cystine knot growth factor NDP ISO RGD PMID:23085770 RGD:7365107 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 ISO PID PID:200077 NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821 		JBrowse link
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha ISO PID PID:200077 NCBI chr 1:240,902,804...240,929,234
Ensembl chr 1:240,902,855...240,929,337 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta ISO PID PID:200077 NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672 		JBrowse link
G Porcn porcupine O-acyltransferase ISO RGD PMID:23439944 RGD:7365109 NCBI chr  X:14,285,864...14,298,481
Ensembl chr  X:14,285,871...14,298,481 		JBrowse link
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha ISO PID PID:200077 NCBI chr13:102,931,264...102,975,661
Ensembl chr13:102,931,264...102,975,661 		JBrowse link
G Ranbp3 RAN binding protein 3 ISO PID PID:200077 NCBI chr 9:1,507,233...1,544,460
Ensembl chr 9:1,507,361...1,544,460 		JBrowse link
G Rnf43 ring finger protein 43 ISO RGD PMID:23151663 RGD:7365105 NCBI chr10:72,461,508...72,537,301
Ensembl chr10:72,464,348...72,536,977 		JBrowse link
G Rspo1 R-spondin 1 ISO RGD PMID:23151663 RGD:7365105 NCBI chr 5:137,251,629...137,273,273
Ensembl chr 5:137,251,659...137,272,933 		JBrowse link
G Rspo2 R-spondin 2 ISO RGD PMID:23151663 RGD:7365105 NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933 		JBrowse link
G Rspo3 R-spondin 3 ISO RGD PMID:23151663 RGD:7365105 NCBI chr 1:28,283,914...28,368,661
Ensembl chr 1:28,283,914...28,367,061 		JBrowse link
G Rspo4 R-spondin 4 ISO RGD PMID:23151663 RGD:7365105 NCBI chr 3:140,357,256...140,391,780
Ensembl chr 3:140,357,424...140,388,254 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 ISO RGD PMID:23085770 RGD:7365107 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO RGD PMID:23085770 RGD:7365107 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 ISO RGD PMID:23085770 RGD:7365107 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 ISO RGD PMID:23085770 RGD:7365107 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224 		JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO RGD PMID:16793760 RGD:2302032 NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975 		JBrowse link
G Sost sclerostin ISO RGD PMID:23085770 RGD:7365107 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561 		JBrowse link
G Sostdc1 sclerostin domain containing 1 ISO RGD PMID:23085770 RGD:7365107 NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579 		JBrowse link
G Tcf7 transcription factor 7 ISO RGD PMID:10528152 RGD:2301908 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
G Tcf7l1 transcription factor 7 like 1 ISO RGD PMID:10528152 RGD:2301908 NCBI chr 4:104,680,734...104,846,086
Ensembl chr 4:104,680,739...104,845,287 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO RGD PMID:10528152 RGD:2301908 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tsc2 TSC complex subunit 2 IDA RGD PMID:12511557 RGD:1304267 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Wif1 Wnt inhibitory factor 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360 		JBrowse link
G Wls Wnt ligand secretion mediator ISO RGD PMID:23439944 RGD:7365109 NCBI chr 2:248,931,885...249,047,248
Ensembl chr 2:248,931,903...249,048,298 		JBrowse link
G Wnt1 Wnt family member 1 ISO RGD PMID:18765832 PMID:20848229 RGD:2313743, RGD:13209023 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wnt10a Wnt family member 10A ISO RGD PMID:15789446 PMID:18765832 RGD:2300202, RGD:2313743 NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400 		JBrowse link
G Wnt10b Wnt family member 10B ISO RGD PMID:16477437 PMID:18765832 RGD:2300029, RGD:2313743 NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892 		JBrowse link
G Wnt11 Wnt family member 11 ISO RGD PMID:18765832 RGD:2313743 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Wnt16 Wnt family member 16 ISO RGD PMID:18765832 RGD:2313743 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380 		JBrowse link
G Wnt2 Wnt family member 2 ISO RGD PMID:18765832 RGD:2313743 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402 		JBrowse link
G Wnt2b Wnt family member 2B ISO RGD PMID:18765832 RGD:2313743 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308 		JBrowse link
G Wnt3 Wnt family member 3 ISO RGD PMID:18765832 RGD:2313743 NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099 		JBrowse link
G Wnt3a Wnt family member 3A ISO PID
RGD		 PMID:15789446 PMID:18765832 PID:200077, RGD:2300202, RGD:2313743 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Wnt4 Wnt family member 4 ISO RGD PMID:18765832 RGD:2313743 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
G Wnt5a Wnt family member 5A ISO RGD PMID:18765832 RGD:2313743 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Wnt5b Wnt family member 5B ISO RGD PMID:18765832 RGD:2313743 NCBI chr 4:152,609,566...152,733,790
Ensembl chr 4:152,609,569...152,733,407 		JBrowse link
G Wnt6 Wnt family member 6 ISO RGD PMID:18765832 RGD:2313743 NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523 		JBrowse link
G Wnt7a Wnt family member 7A IGI
ISO		 RGD PMID:16164600 PMID:18765832 RGD:1601222, RGD:2313743 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
G Wnt7b Wnt family member 7B IGI
ISO		 RGD PMID:16164600 PMID:18765832 PMID:15923619 RGD:1601222, RGD:2313743, RGD:2293491 NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581 		JBrowse link
G Wnt8a Wnt family member 8A ISO RGD PMID:18765832 RGD:2313743 NCBI chr18:26,137,690...26,143,283
Ensembl chr18:26,137,690...26,143,283 		JBrowse link
G Wnt8b Wnt family member 8B ISO RGD PMID:18765832 RGD:2313743 NCBI chr 1:243,354,145...243,376,000
Ensembl chr 1:243,354,086...243,374,286 		JBrowse link
G Wnt9a Wnt family member 9A ISO RGD PMID:16818445 PMID:18765832 RGD:2300156, RGD:2313743 NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133 		JBrowse link
G Wnt9b Wnt family member 9B ISO RGD PMID:18765832 RGD:2313743 NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035 		JBrowse link
G Znrf3 zinc and ring finger 3 ISO RGD PMID:23151663 RGD:7365105 NCBI chr14:80,157,854...80,313,456
Ensembl chr14:80,160,278...80,313,485 		JBrowse link
altered Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:18432252 RGD:2293188 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Axin1 axin 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Ctnnb1 catenin beta 1 ISO RGD PMID:18432252 PMID:19078924 RGD:2293188, RGD:4143515 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Lrp5 LDL receptor related protein 5 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IMP RGD PMID:20128690 RGD:150573713 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Wnt9a Wnt family member 9A ISO RGD PMID:18772397 RGD:5490966 NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to development 536
        Wnt signaling pathway 192
          Wnt signaling, canonical pathway 76
            altered Wnt signaling, canonical pathway 8
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      glycoconjugated protein signaling pathway 416
        glycoprotein signaling pathway 300
          Wnt signaling pathway 192
            Wnt signaling, canonical pathway 76
              altered Wnt signaling, canonical pathway 8
paths to the root