Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nuclear factor, erythroid 2 like 2 signaling pathway
go back to main search page
Accession:PW:0000369 term browser browse the term
Definition:Nuclear factor, 2 like 2 (Nfe2l2, also known as Nrf2) signaling pathway is one of the most important regulator of antioxidant and/or electrophilic stress responses. Upon activation, Nfe2l2 induces the expression of antioxidant, xenobiotic metabolism, and cytoprotective genes, among others. Deregulation of the pathway has been associated with various conditions, including neurodegeneration and cancer.
Synonyms:exact_synonym: Nrf2 signaling pathway
 related_synonym: Nfe2l2 signaling pathway
View Interactive Diagram


show annotations for term's descendants           Sort by:
nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:24647116 PMID:25937177 RGD:11535066, RGD:11535070 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO RGD PMID:24647116 RGD:11535066 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:149,596,509...149,757,765
Ensembl chr 3:149,596,509...149,757,755 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cul1 cullin 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Cul3 cullin 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO RGD PMID:25937177 RGD:11535070 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:25937177 RGD:11535070 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD PMID:24647116 RGD:11535066 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 IMP
IDA
ISO		 RGD PMID:11439354 PMID:20026152 PMID:26419687 PMID:24647116 RGD:727319, RGD:6902900, RGD:11530066, RGD:11535066 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Maff MAF bZIP transcription factor F ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mafg MAF bZIP transcription factor G ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mafk MAF bZIP transcription factor K ISO RGD PMID:24647116 RGD:11535066 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO RGD PMID:26419687 PMID:24647116 PMID:25937177 RGD:11530066, RGD:11535066, RGD:11535070 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP RGD PMID:31889292 PMID:31432116 RGD:21201308, RGD:25823187 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase ISO RGD PMID:24647116 RGD:11535066 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:25937177 RGD:11535070 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rnf4 ring finger protein 4 ISO RGD PMID:24647116 RGD:11535066 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Sqstm1 sequestosome 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cellular detoxification pathway 156
        nuclear factor, erythroid 2 like 2 signaling pathway 27
          altered nuclear factor, erythroid 2 like 2 signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1752
        transcription pathway 1074
          transcription pathway via transcription factor mediated signaling 460
            nuclear factor, erythroid 2 like 2 signaling pathway 27
              altered nuclear factor, erythroid 2 like 2 signaling pathway 0
paths to the root