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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | RGD:1314176 | 6480464 | Estradiol promotes the reaction [CARM1 protein binds to TFF1 promoter] | CTD | PMID:20360387 | 17beta-estradiol | decreases expression | ISO | RGD:1314176 | 6480464 | Estradiol results in decreased expression of CARM1 mRNA | CTD | PMID:19167446 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CARM1 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of CARM1 mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | ISO | | 6480464 | n-butoxyethanol results in increased expression of CARM1 mRNA | CTD | PMID:19812364 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:1314176 | 6480464 | CARM1 protein promotes the reaction [Cyclic AMP results in increased activity of ESR1 protein]; more ... | CTD | PMID:20360387 | 3',5'-cyclic AMP | increases phosphorylation | ISO | RGD:1314176 | 6480464 | Cyclic AMP results in increased phosphorylation of CARM1 protein | CTD | PMID:20360387 | benzo[a]pyrene | multiple interactions | ISO | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CARM1 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | | 6480464 | Benzo(a)pyrene results in decreased expression of CARM1 mRNA | CTD | PMID:22228805 | cobalt dichloride | decreases expression | ISO | RGD:1314176 | 6480464 | cobaltous chloride results in decreased expression of CARM1 mRNA | CTD | PMID:19320972 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of CARM1 mRNA | CTD | PMID:20187946 | doxorubicin | multiple interactions | ISO | RGD:1314176 | 6480464 | Doxorubicin promotes the reaction [CARM1 protein binds to ESR1 promoter]; more ... | CTD | PMID:19351845 | paracetamol | decreases expression | ISO | RGD:1314176 | 6480464 | Acetaminophen results in decreased expression of CARM1 mRNA | CTD | PMID:22230336 | tamoxifen | multiple interactions | ISO | RGD:1314176 | 6480464 | [CARM1 protein binds to ESR1 protein] which affects the susceptibility to Tamoxifen; more ... | CTD | PMID:20360387 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Coregulation of Androgen receptor activity (PID:200049) |
| Direct p53 effectors (PID:200120) | |
| Regulation of Androgen receptor activity (PID:200121) | |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| Pathway Interaction Database | Coregulation of Androgen receptor activity (PID:200049) |
| Direct p53 effectors (PID:200120) | |
| Regulation of Androgen receptor activity (PID:200121) | |
References - curated| 1. |
Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72. |
| 2. |
Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33. |
| 3. |
Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11. |
| 4. |
Fujiwara T, etal., Mol Cell Biol. 2006 Mar;26(6):2273-85. |
| 5. |
Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57. |
| 6. |
Hong H, etal., Cancer. 2004 Jul 1;101(1):83-9. |
| 7. |
Krones-Herzig A, etal., J Biol Chem. 2006 Feb 10;281(6):3025-9. Epub 2005 Dec 5. |
| 8. |
MGD data from the GO Consortium |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
Teyssier C, etal., J Biol Chem 2002 Nov 29;277(48):46066-72. Epub 2002 Sep 25. |
References - uncurated
RGD Disease Portals| Carm1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Carm1 (Rattus norvegicus) |
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| CARM1 (Homo sapiens) |
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| Carm1 (Mus musculus) |
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Position Markers| RH132083 |
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| RH135268 |
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| RH133576 |
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| RH141547 |
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| Carm1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001030041 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001034088 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06053685 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01053600 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB201114 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB201115 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB201116 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB201117 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473993 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001030041 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001025212 | ||||||||||||||||||||
| Peptide Label: | isoform a | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001034088 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001029260 | ||||||||||||||||||||
| Peptide Label: | isoform d | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001025212 | (Get FASTA) |
| NP_001029260 | (Get FASTA) | |
| GenBank Protein | BAE16333 | (Get FASTA) |
| BAE16334 | (Get FASTA) | |
| BAE16335 | (Get FASTA) | |
| BAE16336 | (Get FASTA) | |
| EDL78286 | (Get FASTA) | |
| Q4AE70 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000031129 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000042739 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000049428 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000041577 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000048245 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Entrez Gene | 363026 | ENTREZGENE |
| Germonline | ENSRNOG00000031129 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 10990 | ENTREZGENE |
| InterPro | Arg_MeTrfase | UniProtKB/Swiss-Prot |
| Arg_MeTrfase_CARM1 | UniProtKB/Swiss-Prot | |
| Histone-Arg_MeTrfase_N | UniProtKB/Swiss-Prot | |
| IPI | IPI00366497 | UniProtKB/Swiss-Prot |
| IPI00568674 | UniProtKB/Swiss-Prot | |
| IPI00650083 | UniProtKB/Swiss-Prot | |
| IPI00655258 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:363026 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR11006 | UniProtKB/Swiss-Prot |
| Pfam | CARM1 | UniProtKB/Swiss-Prot |
| PRMT5 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.94869 | ENTREZGENE |
| UniProt | CARM1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-05-21 | Carm1 | coactivator-associated arginine methyltransferase 1 | Prmt4 | protein arginine N-methyltransferase 4 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Prmt4 | protein arginine N-methyltransferase 4 | Carm1 | coactivator-associated arginine methyltransferase 1 | Symbol and Name updated | 10779 | APPROVED |
| 2005-12-06 | Carm1 | coactivator-associated arginine methyltransferase 1 | Carm1_predicted | coactivator-associated arginine methyltransferase 1 (predicted) | Symbol and Name updated | 14393 | APPROVED |
| 2005-01-12 | Carm1_predicted | coactivator-associated arginine methyltransferase 1 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Carm1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1305879 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




