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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cervical cancer
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Accession:DOID:4362 term browser browse the term
Definition:A female reproductive organ cancer that is located_in the cervix. (DO)
Synonyms:exact_synonym: cancer of cervix;   cancer of the cervix;   cancer of the uterine cervix;   cervix cancer;   cervix cancers;   cervix uteri cancer;   uterine cervical cancer;   uterine cervical cancers
 xref: ICD10CM:C53;   ICD9CM:180;   MONDO:0002974;   NCI:C2940;   NCI:C9311
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
cervical cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANG angiogenin IEP protein:increased expression:serum RGD PMID:11299848 RGD:2325708 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971 		JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 IEP
IAGP		 DNA:polymorphism: :p.D148E (human) RGD PMID:19292061 PMID:18503157 RGD:2315657, RGD:2315662 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772 		JBrowse link
G API5 apoptosis inhibitor 5 disease_progression IEP mRNA:increased expression RGD PMID:10780674 RGD:1643340 NCBI chr11:43,311,996...43,344,529
Ensembl chr11:43,311,963...43,344,529 		JBrowse link
G BCL2L1 BCL2 like 1 IEP protein:increased expression:uterine cervix RGD PMID:17311011 RGD:1643476 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 IEP mRNA:decreased expression:uterine cervix RGD PMID:16504151 RGD:1643527 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BRCA1 BRCA1 DNA repair associated disease_progression IDA DNA:hypermethylation:promoter RGD PMID:12773202 RGD:2298941 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G BRIP1 BRCA1 interacting helicase 1 IAGP ClinVar Annotator: match by term: Cervical cancer ClinVar PMID:18483852 PMID:25741868 PMID:26467025 PMID:26790966 PMID:28492532 More... NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559 		JBrowse link
G BSG basigin (Ok blood group) disease_progression IEP RGD PMID:18223224 RGD:2296028 NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494 		JBrowse link
G CASP3 caspase 3 IEP RGD PMID:18177927 RGD:2298948 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCNB1 cyclin B1 IEP mRNA, protein:increased expression:uterine cervix RGD PMID:16614707 RGD:2315938 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CD55 CD55 molecule (Cromer blood group) IEP RGD PMID:9358772 RGD:2293549 NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804 		JBrowse link
G CDC25A cell division cycle 25A IDA RGD PMID:18299147 RGD:2296067 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417 		JBrowse link
G CDC25C cell division cycle 25C IEP RGD PMID:15289842 RGD:4105450 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355 		JBrowse link
G CDH13 cadherin 13 IDA DNA:hypermethylation:promoter RGD PMID:17548682 RGD:2293543 NCBI chr16:82,626,969...83,800,640
Ensembl chr16:82,626,965...83,800,640 		JBrowse link
G CDK1 cyclin dependent kinase 1 IDA RGD PMID:18299147 RGD:2296067 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G EBAG9 estrogen receptor binding site associated antigen 9 disease_progression IEP protein:increased expression:uterine cervix RGD PMID:16112176 RGD:2289851 NCBI chr 8:109,539,702...109,565,996
Ensembl chr 8:109,539,711...109,570,072 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 IEP protein:increased expression: uterine cervix, cytoplasm RGD PMID:28042953 RGD:126790468 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841 		JBrowse link
G FANCA FA complementation group A no_association IAGP DNA:SNPs, haplotypes: :[rs2239359, rs7190823, rs7195066 (human)
DNA:SNP: :rs11649196 (human)		 RGD PMID:19012493 PMID:21543111 RGD:11344886, RGD:11344901 NCBI chr16:89,737,549...89,816,647
Ensembl chr16:89,726,683...89,816,977 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 IAGP ClinVar Annotator: match by term: Cervical cancer
ClinVar Annotator: match by term: Cancer of cervix
ClinVar Annotator: match by term: Cervix cancer		 ClinVar PMID:1908846 PMID:7647778 PMID:7649548 PMID:7670477 PMID:7702086 More... NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility IAGP RGD PMID:18177825 RGD:2293825 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 susceptibility IAGP RGD PMID:18177825 RGD:2293825
G HLA-B major histocompatibility complex, class I, B susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphism: :HLA-B7 RGD PMID:12543794 RGD:2314696 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067 		JBrowse link
G HLA-DPB1 major histocompatibility complex, class II, DP beta 1 susceptibility IAGP DNA:polymorphism: :HLA-DPB1*1301 (human) RGD PMID:17349874 RGD:150429811 NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,990...33,089,696 		JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphism: :HLA-DQB1 G > A (rs6457617)(human)
DNA:polymorphisms::HLA-DQB1*050201, DQB1*060101, DQB1*0602(human)		 RGD PMID:25893807 PMID:16425277 RGD:36174015, RGD:36174023 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383 		JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C IEP protein:increased expression:cervical epithelium (human) RGD PMID:19319956 RGD:10054394 NCBI chr14:21,209,147...21,269,442
Ensembl chr14:21,209,136...21,269,494 		JBrowse link
G HOXB13 homeobox B13 IEP mRNA:increased expression:uterine cervix RGD PMID:16803519 RGD:2314728 NCBI chr17:48,724,763...48,728,750
Ensembl chr17:48,724,763...48,728,750 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 IEP Protein: increased expression RGD PMID:21137014 RGD:6218976 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G IL10 interleukin 10 disease_progression IEP protein:increased expression:serum RGD PMID:9541628 RGD:2317658 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta susceptibility IAGP associated with Papillomavirus Infections;DNA:SNP:promoter: -511 C>T (rs16944)(human) RGD PMID:25893807 RGD:36174015 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G KDM3A lysine demethylase 3A severity IMP human gene in a mouse model RGD PMID:23492365 RGD:9590219 NCBI chr 2:86,437,044...86,492,716
Ensembl chr 2:86,440,647...86,492,716 		JBrowse link
G KMT2A lysine methyltransferase 2A IMP human gene in a mouse model RGD PMID:22926525 RGD:9588221 NCBI chr11:118,436,492...118,526,832
Ensembl chr11:118,436,456...118,526,832 		JBrowse link
G KMT2E lysine methyltransferase 2E (inactive) IMP human gene in a mouse model RGD PMID:25172963 RGD:9588553 NCBI chr 7:105,014,205...105,115,019
Ensembl chr 7:104,940,943...105,115,019 		JBrowse link
G LINC00885 long intergenic non-protein coding RNA 885 IEP
IMP		 mRNA:increased expression:cervical region (human)
human cells in mouse model		 RGD PMID:33603486 PMID:33603486 RGD:152999025, RGD:152999025 NCBI chr 3:196,142,636...196,160,890
Ensembl chr 3:196,142,516...196,160,893 		JBrowse link
G MACC1 MET transcriptional regulator MACC1 IEP mRNA:increased expression:cervical region (human) RGD PMID:33603486 RGD:152999025 NCBI chr 7:20,134,655...20,217,384
Ensembl chr 7:20,134,655...20,217,404 		JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 treatment IMP RGD PMID:20980434 RGD:7495806 NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 IMP RGD PMID:20980434 RGD:7495806 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865 		JBrowse link
G MDC1 mediator of DNA damage checkpoint 1 IEP mRNA, protein:increased expression:uterine cervix (human) RGD PMID:21853275 RGD:9589052 NCBI chr 6:30,699,807...30,717,281
Ensembl chr 6:30,699,807...30,717,447 		JBrowse link
G MED4 mediator complex subunit 4 severity IEP mRNA:decreased expression:uterine cervix (human) RGD PMID:19911042 RGD:12880436 NCBI chr13:48,075,724...48,095,104
Ensembl chr13:48,053,323...48,095,131 		JBrowse link
G MIR152 microRNA 152 IEP miRNA:decreased expression:uterine cervix RGD PMID:30131089 RGD:19165142 NCBI chr17:48,037,161...48,037,247
Ensembl chr17:48,037,161...48,037,247 		JBrowse link
G MIR21 microRNA 21 severity IEP RGD PMID:32256824 RGD:40925949 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR432 microRNA 432 IEP mRNA:decreased expression:cervical region (human) RGD PMID:33603486 RGD:152999025 NCBI chr14:100,884,483...100,884,576
Ensembl chr14:100,884,483...100,884,576 		JBrowse link
G MMP1 matrix metallopeptidase 1 disease_progression IAGP DNA:insertion:promoter:g.-1607insG (human) RGD PMID:14550952 RGD:7207024 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP13 matrix metallopeptidase 13 IEP mRNA:increased expression:uterine cervix RGD PMID:17243165 RGD:2306082 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility IAGP DNA:missense mutation:cds:g.1298A>C (human) RGD PMID:27771518 RGD:38501051 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G NDUFS6 NADH:ubiquinone oxidoreductase subunit S6 disease_progression IAGP DNA, mRNA:amplification, increased expression:uterine cervix RGD PMID:18559093 RGD:2302384 NCBI chr 5:1,801,407...1,816,048
Ensembl chr 5:1,801,407...1,816,048 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase IEP mRNA:increased expression:uterine cervix RGD PMID:14984964 RGD:2314838 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771 		JBrowse link
G PGM3 phosphoglucomutase 3 IEP RGD PMID:508567 RGD:2299870 NCBI chr 6:83,148,705...83,193,900
Ensembl chr 6:83,147,324...83,193,936 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase disease_progression IEP protein:decreased expression:uterine cervix (human) RGD PMID:28631565 RGD:13432557 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G PTK2 protein tyrosine kinase 2 disease_progression IEP RGD PMID:16638855 RGD:2292556 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 IEP protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IEP protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316 		JBrowse link
G RASSF1 Ras association domain family member 1 IDA associated with Papillomavirus Infections;DNA:hypermethylation:promoter RGD PMID:18608185 RGD:2299861 NCBI chr 3:50,329,788...50,340,836
Ensembl chr 3:50,329,782...50,340,980 		JBrowse link
G SF3B4 splicing factor 3b subunit 4 severity IEP
IMP		 mRNA, protein:increased expression:cervix (human)
human cells in mouse model		 RGD PMID:35853859 PMID:35853859 RGD:155882439, RGD:155882439 NCBI chr 1:149,923,317...149,927,803
Ensembl chr 1:149,923,317...149,927,803 		JBrowse link
G SMAD2 SMAD family member 2 IAGP DNA, mRNA:insertion, deletion, decreased expression:uterine cervix RGD PMID:12894231 RGD:2299968 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD4 SMAD family member 4 IEP mRNA:decreased expression:uterine cervix RGD PMID:12894231 RGD:2299968 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP mRNA:increased expression:cervix epithelium (human) RGD PMID:27581326 RGD:13441596 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345 		JBrowse link
G SPAG5 sperm associated antigen 5 severity IEP mRNA, protein:increased expression:cervix (human) RGD PMID:35853859 RGD:155882439 NCBI chr17:28,577,574...28,599,025
Ensembl chr17:28,577,565...28,599,025 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member susceptibility IAGP DNA:SNPs: : RGD PMID:18248301 PMID:12648582 RGD:6482260, RGD:6482272 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member susceptibility IAGP DNA:SNPs: : RGD PMID:18248301 PMID:12648582 RGD:6482260, RGD:6482272 NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,739 		JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 disease_progression IEP mRNA:increased expression:uterine cervix RGD PMID:15816637 RGD:2290434 NCBI chr 3:12,153,068...12,158,912
Ensembl chr 3:12,153,068...12,158,912 		JBrowse link
G TNF tumor necrosis factor susceptibility IAGP DNA:polymorphism:promoter:-308G>A (human) RGD PMID:19823053 RGD:2315116 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a IMP RGD PMID:16271751 RGD:2290493 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102 		JBrowse link
G TP53 tumor protein p53 IAGP ClinVar Annotator: match by term: Cancer of cervix ClinVar PMID:1349102 PMID:1849234 PMID:8001119 PMID:8843196 PMID:9407971 More... NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TP73 tumor protein p73 susceptibility IAGP DNA:SNPs:exon 2:4G>A, 14C>T (rs2273953, rs1801173) (human) RGD PMID:30420492 RGD:151347580 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 IAGP DNA:polymorphism: :p.R194W RGD PMID:18851872 RGD:2302567 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473 		JBrowse link
G ZFHX3 zinc finger homeobox 3 IEP mRNA:increased expression:uterine cervix RGD PMID:11812077 RGD:2315697 NCBI chr16:72,782,885...73,891,930
Ensembl chr16:72,782,885...73,891,871 		JBrowse link
cervical adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPINK1 serine peptidase inhibitor Kazal type 1 IEP RGD PMID:2258083 RGD:2300391 NCBI chr 5:147,824,582...147,839,196
Ensembl chr 5:147,824,572...147,831,671 		JBrowse link
G TFF1 trefoil factor 1 IEP mRNA, protein:increased expression:uterine cervix RGD PMID:10727981 RGD:2298570 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TFRC transferrin receptor IEP protein:increased expression:uterine cervix RGD PMID:9739406 RGD:2292022 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153 		JBrowse link
G TP53 tumor protein p53 disease_progression IEP RGD PMID:17354237 RGD:2298527 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
cervical mucinous adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STK11 serine/threonine kinase 11 disease_progression IAGP DNA:mutations RGD PMID:12533684 RGD:2291947 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
cervical squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific disease_progression IEP protein:increased expression:cervix squamous epithelium (human) RGD PMID:28109322 RGD:125097518 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator IEP protein:increased expression:uterine cervix RGD PMID:17694953 RGD:1643352 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 disease_progression IEP DNA, protein:amplification, increased expression:uterine cervix, nucleus RGD PMID:12208731 RGD:1643529 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BRIP1 BRCA1 interacting helicase 1 severity IEP mRNA, protein:increased expression:uterine cervix, nucleus (human) RGD PMID:24708616 RGD:11252104 NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 severity IEP RGD PMID:28086903 RGD:38455996 NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189 		JBrowse link
G CCR4 C-C motif chemokine receptor 4 severity IEP RGD PMID:28086903 RGD:38455996 NCBI chr 3:32,951,644...32,956,349
Ensembl chr 3:32,951,644...32,956,349 		JBrowse link
G CD82 CD82 molecule IEP protein:decreased expression:uterine cervix RGD PMID:15642213 RGD:2289399 NCBI chr11:44,564,409...44,620,358
Ensembl chr11:44,564,427...44,620,358 		JBrowse link
G CSF1R colony stimulating factor 1 receptor IEP protein:increased expression:uterine cervix RGD PMID:18565574 RGD:2299119 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372 		JBrowse link
G FGF7 fibroblast growth factor 7 IEP cervical squamous cell carcinoma; mRNA:increased expression:cervical squamous cells RGD PMID:17306351 RGD:2289084 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 no_association IAGP DNA:missense mutation:cds: p.S249G (human) RGD PMID:11605053 RGD:38500202 NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit disease_progression IEP protein:increased expression:uterine cervix RGD PMID:15514944 RGD:2293757 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit IEP protein:decreased expression:uterine cervix RGD PMID:15514944 RGD:2293757 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573 		JBrowse link
G FOXP3 forkhead box P3 severity IEP RGD PMID:28086903 RGD:38455996 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G MIR21 microRNA 21 IEP RNA:increased expression:cervical cell RGD PMID:26010154 RGD:41404529 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR31 microRNA 31 IEP RNA:increased expression:blood serum (human) RGD PMID:21658006 RGD:152998938 NCBI chr 9:21,512,115...21,512,185
Ensembl chr 9:21,512,115...21,512,185 		JBrowse link
G PDPN podoplanin disease_progression IEP RGD PMID:16528371 RGD:2292237 NCBI chr 1:13,583,757...13,617,957
Ensembl chr 1:13,583,465...13,617,957 		JBrowse link
G SMAD3 SMAD family member 3 severity IEP RGD PMID:28086903 RGD:38455996 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 IEP protein:decreased expression:uterine cervix RGD PMID:16619570 RGD:2290402 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 disease_progression IEP mRNA:increased expression:uterine cervix RGD PMID:15337562 RGD:2291959 NCBI chr12:49,741,557...49,764,934
Ensembl chr12:49,707,725...49,764,934 		JBrowse link
G TNFRSF4 TNF receptor superfamily member 4 severity IEP RGD PMID:28086903 RGD:38455996 NCBI chr 1:1,211,340...1,214,153
Ensembl chr 1:1,211,326...1,214,153 		JBrowse link
G TNFSF4 TNF superfamily member 4 severity IEP RGD PMID:28086903 RGD:38455996 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,183,731...173,207,331 		JBrowse link
G TP53 tumor protein p53 disease_progression IEP RGD PMID:17969407 RGD:2298526 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TYMP thymidine phosphorylase disease_progression IEP RGD PMID:16803522 RGD:2293719 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
cervix carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 IAGP DNA:SNPs (human) RGD PMID:19202550 RGD:2315691 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772 		JBrowse link
G BAG1 BAG cochaperone 1 IEP protein:increased expression:uterine cervix RGD PMID:10047462 RGD:2293889 NCBI chr 9:33,252,471...33,264,708
Ensembl chr 9:33,247,820...33,264,720 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 IAGP DNA:missense mutations:exon:multiple (human) RGD PMID:12771926 RGD:2315701 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G CCND3 cyclin D3 IEP RGD PMID:14751136 RGD:2316013 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357 		JBrowse link
G CD9 CD9 molecule disease_progression IEP RGD PMID:14695144 RGD:2326206 NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271 		JBrowse link
G EFEMP2 EGF containing fibulin extracellular matrix protein 2 exacerbates IEP mRNA, protein:increased expression:cervix epithelium (human) RGD PMID:24737201 RGD:42722607 NCBI chr11:65,866,441...65,872,800
Ensembl chr11:65,866,441...65,873,592 		JBrowse link
G ERAP1 endoplasmic reticulum aminopeptidase 1 IAGP DNA:SNPs (human) RGD PMID:19202550 RGD:2315691 NCBI chr 5:96,760,813...96,935,854
Ensembl chr 5:96,760,810...96,808,100 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 IAGP DNA:missense mutations:CDS:somatic mutations found in 3/12 (25%) of cervix carcinomas, all mutations are equivalent to activating germline mutations which cause thanatophoric dysplasia
DNA:missense mutation:CDS:amino acid S249C, only found in 1/51 primary tumors and no cell lines tested implying that mutation frequency is much lower than previously reported		 RGD PMID:10471491 PMID:11114733 RGD:2289864, RGD:2289865 NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 onset IAGP associated with Papillomavirus Infections;DNA:deletion:cds (human) RGD PMID:10813720 RGD:7495819 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 susceptibility IAGP DNA:deletion:cds (human) RGD PMID:10813720 RGD:7495819
G H19 H19 imprinted maternally expressed transcript IEP mRNA:decreased expression:uterine cervix RGD PMID:11997082 RGD:2306179 NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,166...2,004,552 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase IAGP DNA:polymorphisms:cds:p.I143V, p.K178R (human) RGD PMID:17234722 RGD:2317690 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 disease_progression IEP RGD PMID:16803521 RGD:2300207 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTK2 protein tyrosine kinase 2 IEP protein:increased tyrosine phosphorylation:cervix RGD PMID:14675348 RGD:2292568 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G SPARC secreted protein acidic and cysteine rich IDA DNA:hypermethylation RGD PMID:16434596 RGD:2300022 NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member susceptibility IAGP DNA:SNP: :(rs4148876)(human) RGD PMID:17366619 RGD:6482264 NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,739 		JBrowse link
G TK1 thymidine kinase 1 IEP protein:increased expression:serum (human) RGD PMID:11474248 RGD:2317243 NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233 		JBrowse link
G TSG101 tumor susceptibility 101 IDA mRNA:alternative form:uterine cervix
mRNA:alternative forms:uterine cervix:multiple		 RGD PMID:10600297 PMID:10505033 RGD:2291851, RGD:2291852 NCBI chr11:18,480,311...18,526,942
Ensembl chr11:18,468,336...18,526,951 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 35753
    disease of anatomical entity 32492
      reproductive system disease 4028
        reproductive organ cancer 1431
          female reproductive organ cancer 730
            uterine cancer 363
              cervical cancer 100
                cervical alveolar soft part sarcoma 0
                cervical carcinosarcoma + 0
                cervix carcinoma + 44
                cervix endometrial stromal tumor + 0
                cervix melanoma + 0
                epithelioid trophoblastic tumor 0
Path 2
Term Annotations click to browse term
  disease 35753
    disease of anatomical entity 32492
      Urogenital Diseases 6480
        Female Urogenital Diseases and Pregnancy Complications 3025
          Female Urogenital Diseases 2492
            female reproductive system disease 2489
              uterine disease 594
                Uterine Neoplasms 540
                  uterine cancer 363
                    cervical cancer 100
                      cervical alveolar soft part sarcoma 0
                      cervical carcinosarcoma + 0
                      cervix carcinoma + 44
                      cervix endometrial stromal tumor + 0
                      cervix melanoma + 0
                      epithelioid trophoblastic tumor 0
paths to the root