TIMP2 (TIMP metallopeptidase inhibitor 2)

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Keyword

Gene: TIMP2 (TIMP metallopeptidase inhibitor 2) Homo sapiens

Symbol:

TIMP2

Name:

TIMP metallopeptidase inhibitor 2

Description:

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CSC-21K; DDC8; metalloproteinase inhibitor 2; OTTHUMP00000205879; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2

Orthologs:

Mus musculus : Timp2 (tissue inhibitor of metalloproteinase 2) MGI
Rattus norvegicus : Timp2 (TIMP metallopeptidase inhibitor 2)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	17	77,934,290 - 78,006,376	-	NCBI
Human Genome Assembly HuRef	17	72,271,475 - 72,343,528	-	NCBI
Human Genome Assembly GRCh37	17	76,849,059 - 76,921,472	-	NCBI
Human Genome Assembly Build 36	17	74,360,654 - 74,433,067	-	NCBI
Human Cytogenetic Map	17	q25		NCBI
Human Genome Assembly	17	74,360,655 - 74,433,067		NCBI