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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG1 mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1313092 | 6480464 | Tetrachlorodibenzodioxin affects the expression of BAG1 mRNA | CTD | PMID:21570461 | 4-hydroxyphenyl retinamide | affects localization | EXP | | 6480464 | Fenretinide affects the localization of BAG1 protein | CTD | PMID:17110918 | amiodarone | increases expression | EXP | | 6480464 | Amiodarone results in increased expression of BAG1 mRNA | CTD | PMID:19774075 | arsenite(3-) | increases expression | EXP | | 6480464 | arsenite results in increased expression of BAG1 mRNA | CTD | PMID:18585952 | arsenite(3-) | multiple interactions | EXP | | 6480464 | XPA protein affects the reaction [arsenite results in increased expression of BAG1 mRNA] | CTD | PMID:18585952 | benzene | increases expression | ISO | RGD:1305203 | 6480464 | Benzene results in increased expression of BAG1 protein | CTD | PMID:18093815 | benzo[a]pyrene | multiple interactions | ISO | RGD:1313092 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of BAG1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:1313092 | 6480464 | Benzo(a)pyrene results in increased expression of BAG1 mRNA | CTD | PMID:20504355 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of BAG1 mRNA; more ... | CTD | PMID:12160620 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BAG1 mRNA | CTD | PMID:12634122 | cadmium dichloride | decreases expression | ISO | RGD:1313092 | 6480464 | Cadmium Chloride results in decreased expression of BAG1 mRNA | CTD | PMID:15501611 | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of BAG1 protein alternative form | CTD | PMID:12479363 | carbendazim | increases expression | ISO | RGD:1305203 | 6480464 | mecarzole results in increased expression of BAG1 mRNA | CTD | PMID:22952946 | chlorpyrifos | decreases expression | ISO | RGD:1305203 | 6480464 | Chlorpyrifos results in decreased expression of BAG1 mRNA | CTD | PMID:17452286 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of BAG1 mRNA | CTD | PMID:19561079 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of BAG1 mRNA | CTD | PMID:19376846 PMID:19320972 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of BAG1 mRNA | CTD | PMID:19320972 PMID:19376846 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of BAG1 mRNA | CTD | PMID:17553155 | cocaine | affects expression | ISO | RGD:1313092 | 6480464 | Cocaine affects the expression of BAG1 mRNA | CTD | PMID:15681117 | copper atom | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of BAG1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of BAG1 mRNA | CTD | PMID:20971185 | copper(2+) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of BAG1 mRNA | CTD | PMID:19549813 | cyclophosphamide | multiple interactions | EXP | | 6480464 | [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BAG1 mRNA | CTD | PMID:16322899 | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of BAG1 mRNA | CTD | PMID:17530438 | diazinon | decreases expression | ISO | RGD:1305203 | 6480464 | Diazinon results in decreased expression of BAG1 mRNA | CTD | PMID:17452286 | diazoxide | decreases expression | ISO | RGD:1313092 | 6480464 | Isoproterenol results in decreased expression of BAG1 mRNA | CTD | PMID:21335049 | dibutyl phthalate | decreases expression | ISO | RGD:1313092 | 6480464 | Dibutyl Phthalate results in decreased expression of BAG1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:1313092 | 6480464 | Dibutyl Phthalate results in decreased expression of BAG1 mRNA | CTD | PMID:17361019 PMID:21266533 | dichromium trioxide | multiple interactions | EXP | | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BAG1 mRNA | CTD | PMID:12634122 | diethylstilbestrol | increases expression | ISO | RGD:1305203 | 6480464 | Diethylstilbestrol results in increased expression of BAG1 mRNA | CTD | PMID:17005392 | diethylstilbestrol | increases expression | ISO | RGD:1313092 | 6480464 | Diethylstilbestrol results in increased expression of BAG1 mRNA | CTD | PMID:21041162 | diuron | increases expression | ISO | RGD:1305203 | 6480464 | Diuron results in increased expression of BAG1 mRNA | CTD | PMID:21551480 | doxorubicin | multiple interactions | EXP | | 6480464 | [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BAG1 mRNA | CTD | PMID:16322899 | doxorubicin | decreases expression | ISO | RGD:1313092 | 6480464 | Doxorubicin results in decreased expression of BAG1 mRNA | CTD | PMID:16439991 | elemental selenium | increases expression | EXP | | 6480464 | Selenium results in increased expression of BAG1 mRNA | CTD | PMID:19244175 | hydralazine | multiple interactions | EXP | | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of BAG1 mRNA | CTD | PMID:17183730 | isoprenaline | decreases expression | ISO | RGD:1313092 | 6480464 | Isoproterenol results in decreased expression of BAG1 mRNA | CTD | PMID:21335049 | lead diacetate | multiple interactions | EXP | | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BAG1 mRNA | CTD | PMID:12634122 | lithium atom | increases expression | ISO | RGD:1305203 | 6480464 | Lithium results in increased expression of BAG1 mRNA; more ... | CTD | PMID:15872096 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | EXP | | 6480464 | Methylnitronitrosoguanidine results in increased expression of BAG1 mRNA | CTD | PMID:12634122 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of BAG1 mRNA | CTD | PMID:18836921 | phlorizin | decreases expression | ISO | RGD:1313092 | 6480464 | Phlorhizin results in decreased expression of BAG1 mRNA | CTD | PMID:22538082 | phorbol 13-acetate 12-myristate | multiple interactions | EXP | | 6480464 | BAG1 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of DUSP1 mRNA]; more ... | CTD | PMID:20858459 | pirinixic acid | increases expression | ISO | RGD:1313092 | 6480464 | pirinixic acid results in increased expression of BAG1 protein | CTD | PMID:10426811 | progesterone | decreases expression | EXP | | 6480464 | Progesterone results in decreased expression of BAG1 mRNA | CTD | PMID:18037150 | selenium atom | increases expression | EXP | | 6480464 | Selenium results in increased expression of BAG1 mRNA | CTD | PMID:19244175 | tamoxifen | affects response to substance | EXP | | 6480464 | BAG1 protein affects the susceptibility to Tamoxifen | CTD | PMID:19066611 | valproic acid | increases expression | ISO | RGD:1305203 | 6480464 | Valproic Acid results in increased expression of BAG1 mRNA; more ... | CTD | PMID:15872096 | valproic acid | multiple interactions | EXP | | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of BAG1 mRNA | CTD | PMID:17183730 | zinc atom | decreases expression | EXP | | 6480464 | Zinc results in decreased expression of BAG1 mRNA | CTD | PMID:15226459 | zinc sulfate | decreases expression | EXP | | 6480464 | Zinc Sulfate results in decreased expression of BAG1 mRNA | CTD | PMID:15226459 | zinc(0) | decreases expression | EXP | | 6480464 | Zinc results in decreased expression of BAG1 mRNA | CTD | PMID:15226459 | zoledronic acid | increases expression | EXP | | 6480464 | zoledronic acid results in increased expression of BAG1 mRNA | CTD | PMID:19036117 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Protein processing in endoplasmic reticulum |
| Pathway Interaction Database | AP-1 transcription factor network (PID:200137) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Protein processing in endoplasmic reticulum |
| Pathway Interaction Database | AP-1 transcription factor network (PID:200137) |
References - curated| 1. |
GOA_HUMAN data from the GO Consortium |
| 2. |
Maki HE, etal., J Pathol. 2007 Aug;212(4):395-401. |
| 3. |
Moriyama T, etal., Gynecol Oncol. 2004 Aug;94(2):289-95. |
| 4. |
Nadler Y, etal., Breast Cancer Res. 2008 Apr 22;10(2):R35. |
| 5. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 6. |
RGD automated import pipeline for gene-chemical interactions |
| 7. |
Sawitzki B, etal., Hum Gene Ther. 2002 Aug 10;13(12):1495-504. |
| 8. |
Turner BC, etal., J Clin Oncol. 2001 Feb 15;19(4):992-1000. |
| 9. |
Yang X, etal., Exp Cell Res. 1999 Feb 25;247(1):200-7. |
References - uncurated| PubMed | 10467399 |
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RGD Disease Portals| BAG1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| BAG1 (Homo sapiens) |
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| Bag1 (Mus musculus) |
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| Bag1 (Rattus norvegicus) |
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Position Markers| D9S1064E |
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| RH69938 |
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| A002S09 |
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| STS-S83171 |
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| RH18169 |
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| STS-Z35491 |
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| GDB:335751 |
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| RH47281 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_029018 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001172415 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_004323 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01065064 | (Get FASTA) | Search GEO for Microarray Profiles |
| AF022224 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF116273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK093238 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK096038 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK222749 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK316577 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL161445 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL356472 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01019322 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC001936 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC014774 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BG723775 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471071 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN478628 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U46917 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z35491 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_004323 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_004314 | |||||||||||||||||||||||||
| Peptide Label: | isoform BAG-1L | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001172415 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001165886 | ||||||||||||||||||||
| Peptide Label: | isoform BAG-1S | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001165886 | (Get FASTA) |
| NP_004314 | (Get FASTA) | |
| GenBank Protein | AAC34258 | (Get FASTA) |
| AAD11467 | (Get FASTA) | |
| AAD25045 | (Get FASTA) | |
| AAH01936 | (Get FASTA) | |
| AAH14774 | (Get FASTA) | |
| BAD96469 | (Get FASTA) | |
| CAA84624 | (Get FASTA) | |
| CAL37446 | (Get FASTA) | |
| EAW58514 | (Get FASTA) | |
| EAW58515 | (Get FASTA) | |
| EAW58516 | (Get FASTA) | |
| EAW58517 | (Get FASTA) | |
| Q99933 | (Get FASTA) |
Promoters| RGD ID: | 6807258 | ||||||||||
| Promoter ID: | HG_KWN:62906 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | HeLa_S3 | ||||||||||
| Transcripts: | OTTHUMT00000052047 | ||||||||||
| Position: |
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| RGD ID: | 6807498 | ||||||||||
| Promoter ID: | HG_KWN:62907 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | HeLa_S3 | ||||||||||
| Transcripts: | ENST00000379701, OTTHUMT00000052046 | ||||||||||
| Position: |
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| RGD ID: | 6807497 | ||||||||||
| Promoter ID: | HG_KWN:62909 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, HeLa_S3, K562, Lymphoblastoid, NB4 | ||||||||||
| Transcripts: | ENST00000317902, ENST00000379700 | ||||||||||
| Position: |
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| RGD ID: | 6807264 | ||||||||||
| Promoter ID: | HG_KWN:62910 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell | ||||||||||
| Transcripts: | UC003ZSI.1, UC003ZSJ.1, UC003ZSK.1 | ||||||||||
| Position: |
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| RGD ID: | 6853070 | ||||||||||
| Promoter ID: | EP74356 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | HS_BAG1 | ||||||||||
| Description: | BCL2-associated athanogene. | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Experiment Methods: | Mammalian gene collection (MGC) full-length cDNA cloning | ||||||||||
| Position: |
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| RGD ID: | 7212361 | ||||||||||
| Promoter ID: | EPDNEW_H11927 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | BAG1_3 | ||||||||||
| Description: | BCL2-associated athanogene | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
| RGD ID: | 7212363 | ||||||||||
| Promoter ID: | EPDNEW_H11928 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | BAG1_2 | ||||||||||
| Description: | BCL2-associated athanogene | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
| RGD ID: | 7212365 | ||||||||||
| Promoter ID: | EPDNEW_H11929 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | BAG1_1 | ||||||||||
| Description: | BCL2-associated athanogene | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | BAG1 | COSMIC |
| Ensembl Genes | ENSG00000107262 | ENTREZGENE |
| Ensembl Protein | ENSP00000420514 | ENTREZGENE |
| Ensembl Transcript | ENST00000472232 | ENTREZGENE |
| Entrez Gene | 573 | ENTREZGENE |
| Germonline | ENSG00000107262 | |
| HGNC ID | 937 | ENTREZGENE |
| HomoloGene Group ID | 3190 | ENTREZGENE |
| HPRD ID | 03292 | ENTREZGENE |
| InterPro | BAG_domain | UniProtKB/Swiss-Prot |
| Molecular_chp_reg_BAG_1 | UniProtKB/Swiss-Prot | |
| Ubiquitin | UniProtKB/Swiss-Prot | |
| Ubiquitin_supergroup | UniProtKB/Swiss-Prot | |
| IPI | IPI00218546 | UniProtKB/Swiss-Prot |
| IPI00300531 | UniProtKB/Swiss-Prot | |
| IPI00641336 | UniProtKB/Swiss-Prot | |
| IPI00945635 | UniProtKB/TrEMBL | |
| IPI00945861 | UniProtKB/TrEMBL | |
| IPI00954014 | UniProtKB/Swiss-Prot | |
| IPI01011709 | UniProtKB/TrEMBL | |
| KEGG Report | hsa:573 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 601497 | OMIM |
| Pfam | BAG | UniProtKB/Swiss-Prot |
| ubiquitin | UniProtKB/Swiss-Prot | |
| PharmGKB | PA25237 | PharmGKB |
| PIRSF | BAG_1 | UniProtKB/Swiss-Prot |
| PROSITE | BAG | UniProtKB/Swiss-Prot |
| UBIQUITIN_1; FALSE_NEG | UniProtKB/Swiss-Prot | |
| UBIQUITIN_2 | UniProtKB/Swiss-Prot | |
| SMART | BAG | UniProtKB/Swiss-Prot |
| UBQ | UniProtKB/Swiss-Prot | |
| UniGene | Hs.377484 | ENTREZGENE |
| UniProt | BAG1_HUMAN | UniProtKB/Swiss-Prot |
| C9J9Y9_HUMAN | UniProtKB/TrEMBL | |
| C9JYK5_HUMAN | UniProtKB/TrEMBL | |
| E2QRM7_HUMAN | UniProtKB/TrEMBL | |
| F1LLU6_HUMAN | UniProtKB/TrEMBL | |
| J3QTA2_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | BAG1 | BCL2-associated athanogene | BAG1 | BCL2-associated athanogene | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | BAG1 | BCL2-associated athanogene | BAG1 | BCL2-associated athanogene | Symbol and/or name change | 39860 | APPROVED |
| More on BAG1 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 1313091 |
| Created: | 2005-01-12 |
| Species: | Homo sapiens |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




