RGD Reference Report - COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. - Rat Genome Database

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COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival.

Authors: Athavale, R  Clooney, K  O'Hagan, J  Shawki, H  Clark, AH  Green, JA 
Citation: Athavale R, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1303-8.
RGD ID: 2300207
Pubmed: PMID:16803521   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1525-1438.2006.00372.x   (Journal Full-text)

COX-1 and COX-2 are members of the cyclooxygenase (COX) family, which influence tumor invasion and apoptosis. The objective of the study was to assess the relationship between COX-1 and COX-2 expression in early-stage disease and subsequent disease relapse and long-term survival. Women with FIGO stage I and II cervical carcinoma, younger than 50 years, treated between 1981 and 1990 were included. COX-1 and COX-2 expressions in the tumors were assessed by immunohistochemistry. COX-1 and COX-2 were expressed in 61% (17/28) and 57% (16/28) of tumors, respectively. COX-1 nonexpressers showed an improved overall survival compared to expressers (log-rank test, P= 0.09). There was no significant difference in the overall survival in COX-2 nonexpressers compared to expressers (P= 0.6). Out of eight women with disease relapse, COX-1 or COX-2 expression was noted in six of eight tumors, and both were expressed in five of eight tumors. Our preliminary data suggest an adverse prognosis with COX-1 expression in early-stage cervical carcinoma and a trend toward COX-1 expression in disease relapse. The association between COX-2 expression and a worse prognosis was not proven in this study.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix carcinoma disease_progressionIEP 2300207 RGD 
cervix carcinoma disease_progressionISOPTGS1 (Homo sapiens)2300207; 2300207 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)

Genes (Mus musculus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)

Genes (Homo sapiens)
PTGS1  (prostaglandin-endoperoxide synthase 1)


Additional Information