Gene: XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1)  Homo sapiens
Symbol: XRCC1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Description: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA repair protein XRCC1; RCC; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster
Orthologs: Mus musculus : Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1)  MGI
Rattus norvegicus : Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11944,237,299 - 44,269,653-NCBI
Human Genome Assembly HuRef1940,478,136 - 40,510,489-NCBI
Human Genome Assembly GRCh371944,047,464 - 44,079,730-NCBI
Human Genome Assembly Build 361948,739,304 - 48,771,555-NCBI
Human Cytogenetic Map19q13.2 NCBI
Human Genome Assembly1948,739,303 - 48,771,555 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
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Gene Ontology Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on XRCC1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 732968
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2013-06-11
Status: ACTIVE



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