RGD Reference Report - Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population. - Rat Genome Database

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Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population.

Authors: Jin, J J  Wang, H Q  Kuang, H P  Kang, B B  Liu, Y H  Wang, J 
Citation: Jin JJ, etal., Genet Mol Res. 2016 Jun 10;15(2). pii: gmr4661. doi: 10.4238/gmr.15024661.
RGD ID: 151236316
Pubmed: PMID:27323144   (View Abstract at PubMed)
DOI: DOI:10.4238/gmr.15024661   (Journal Full-text)


UNLABELLED: Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of 703 subjects were recruited for this study. Genotyping of c.1804C>A genetic variant was performed using the created restriction site-polymerase chain reaction. Statistically significant differences in allele frequencies and genotype were found between lung cancer patients and cancer-free controls. The genotype AA was statistically associated with the increased risk of lung cancer when compared to the wild genotype, CC, and the carrier genotype, CA/CC (AA vs CC: OR = 2.71, 95%CI = 1.57-4.67, P < 0.001; AA vs
CA/CC: OR = 2.54, 95%CI = 1.50-4.29, P < 0.001). The allele A likely contributes to the susceptibility to lung cancer (A vs C: OR = 1.47, 95%CI = 1.17-1.84, P = 0.001). Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
XRCC1Humanlung cancer susceptibilityIAGP DNA:missense mutation:exon 17: c.1804C>A and p.P602T (human)RGD 
Xrcc1Ratlung cancer susceptibilityISOXRCC1 (Homo sapiens)DNA:missense mutation:exon 17: c.1804C>A and p.P602T (human)RGD 
Xrcc1Mouselung cancer susceptibilityISOXRCC1 (Homo sapiens)DNA:missense mutation:exon 17: c.1804C>A and p.P602T (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
XRCC1HumanNeoplasm of the lung susceptibilityIAGP DNA:missense mutation:exon 17: c.1804C>A and p.P602T (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Xrcc1  (X-ray repair cross complementing 1)

Genes (Mus musculus)
Xrcc1  (X-ray repair complementing defective repair in Chinese hamster cells 1)

Genes (Homo sapiens)
XRCC1  (X-ray repair cross complementing 1)


Additional Information