RGD Reference Report - Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. - Rat Genome Database

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Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population.

Authors: Zhao, Yi  Deng, Xin  Wang, Zhen  Wang, Qiang  Liu, Yixia 
Citation: Zhao Y, etal., Asian Pac J Cancer Prev. 2012;13(2):665-9. doi: 10.7314/apjcp.2012.13.2.665.
RGD ID: 150540340
Pubmed: PMID:22524842   (View Abstract at PubMed)
DOI: DOI:10.7314/apjcp.2012.13.2.665   (Journal Full-text)


AIM: The distribution of DNA repair gene XRCC1 and XRCC3 genotypes was used to assess the potential influence of genetic polymorphisms on risk of colorectal cancer, and interactions with other factors.
METHODS: A 1:2 matched case-control study was conducted with 485 cases and 970 controls. XRCC1 and XRCC2 genotype polymorphisms were based upon duplex polymerase-chain-reaction with the confronting-two-pairprimer (PCR-CTPP) method.
RESULTS: The XRCC1 399Cln allele polymorphism was found to be associated with an increased colorectal cancer risk, while an non-significant inversely association was noted for XRCC3 241Thr/Thr genotype. We also found that individuals with the XRCC1 399 Gln and XRCC3 241Met alleles had an elevated risk, while XRCC3241Thr/Thr was proctective.
CONCLUSION: This study is the first to provide evidence of importance of XRCC1 and XRCC3 gene polymorphisms for risk of colorectal cancer in the Chinese population.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
XRCC1Humancolorectal cancer susceptibilityIAGP DNA:SNP:exon 10: p.R399Q G>A (human)RGD 
Xrcc1Ratcolorectal cancer susceptibilityISOXRCC1 (Homo sapiens)DNA:SNP:exon 10: p.R399Q G>A (human)RGD 
Xrcc1Mousecolorectal cancer susceptibilityISOXRCC1 (Homo sapiens)DNA:SNP:exon 10: p.R399Q G>A (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
XRCC1HumanNeoplasm of the large intestine susceptibilityIAGP DNA:SNP:exon 10: p.R399Q G>A (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Xrcc1  (X-ray repair cross complementing 1)

Genes (Mus musculus)
Xrcc1  (X-ray repair complementing defective repair in Chinese hamster cells 1)

Genes (Homo sapiens)
XRCC1  (X-ray repair cross complementing 1)


Additional Information