NUCLEOTIDE EXCISION REPAIR PATHWAY (PW:0000130)

View Ontology Report

Description

DNA lesions, induced by endogenous or exogenous agents, affect the faithful replication of the genome resulting in genetic aberrations that can be deleterious to the cell and organism. Multiple systems have evolved to detect single and double-strand DNA lesions, initiate signals that can be amplified and propagated, and set in motion effectors that can impinge upon DNA repair and checkpoint, various signaling and/or regulatory pathways, as necessary. Together, this vast response mechanism is kn

Pathway Diagram:

Ariadne Genomics Inc. pold complex Rpa complex Ercc5 Ercc4 Hmgn1 Gtf2h1 Ercc3 Ercc2 Ddb2 pole complex Ercc8 ---- Gtf2h2 Ercc8 stalled polrII complex Gtf2h1 ---- Xpc Ercc3 ---- Xpc pole complex ---- Rpa complex pold complex ---- Rpa complex Polk ---- Rpa complex Ercc5 ---- Rpa complex Xrcc1 Lig1 Lig3 ---- Xrcc1 Lig3 Ercc1 ---- Ercc4 Ercc6 ---- Ercc8 DNA incision helix unwinding Ercc8 ---- Xab2 Ercc8 ---- Hmgn1 Ercc6 ---- stalled polrII complex TFIIH complex Ercc6 Xab2 Pcna ---- Rfc complex Pcna ---- pole complex Ddb1 ---- Ddb2 Ddb1 Rad23b ---- Xpc Xpc Cetn2 Cetn2 ---- Xpc Rad23b Pcna ---- pold complex Pcna Polk Pcna ---- Polk Ercc4 ---- Rpa complex Rpa complex ---- Xpa Xpa Ercc1 Ercc1 ---- Xpa Gtf2h2 Rfc complex chromatin modification/remodeling pathway
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns
nucleotide excision repair pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnh cyclin H JBrowse link 2 13,593,100 13,613,910 RGD:6907045
G Cdk7 cyclin-dependent kinase 7 JBrowse link 2 30,710,642 30,735,522 RGD:6907045
G Cetn2 centrin 2 JBrowse link X 152,927,852 152,933,095 RGD:6907045
RGD:7246920
G Cul4a cullin 4A JBrowse link 16 81,718,784 81,756,653 RGD:6907045
G Cul4b cullin 4B JBrowse link X 124,831,391 124,870,329 RGD:6907045
G Ddb1 damage-specific DNA binding protein 1 JBrowse link 1 226,657,561 226,683,356 RGD:6907045
RGD:7246920
G Ddb2 damage specific DNA binding protein 2 JBrowse link 3 80,030,437 80,052,984 RGD:7246920
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6907045
RGD:7246926
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:6907045
RGD:7246920
RGD:10402751
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit JBrowse link 18 25,037,668 25,068,380 RGD:6907045
RGD:7246920
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:6907045
RGD:7246926
RGD:10402751
G Ercc4l1 excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1 JBrowse link 10 92,631 117,648 RGD:6907045
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:6907045
RGD:7246926
RGD:10402751
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:6907045
RGD:7246919
RGD:7246923
G Ercc8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 39,434,617 39,473,392 RGD:6907045
RGD:7246919
RGD:7246923
G Gtf2h1 general transcription factor IIH subunit 1 JBrowse link 1 102,849,618 102,877,939 RGD:6907045
RGD:7246920
G Gtf2h2 general transcription factor IIH subunit 2 JBrowse link 2 30,494,718 30,522,716 RGD:6907045
RGD:7246922
G Gtf2h3 general transcription factor IIH subunit 3 JBrowse link 12 37,427,556 37,444,027 RGD:6907045
G Gtf2h4 general transcription factor 2H subunit 4 JBrowse link 20 3,582,688 3,588,373 RGD:6907045
G Gtf2h5 general transcription factor IIH subunit 5 JBrowse link 1 46,978,345 46,985,032 RGD:6907045
G Hmgn1 high mobility group nucleosome binding domain 1 JBrowse link 11 36,474,028 36,479,947 RGD:7246919
G Lig1 DNA ligase 1 JBrowse link 1 75,356,212 75,394,757 RGD:1358139
RGD:6907045
RGD:7246935
RGD:10402751
G Lig3 DNA ligase 3 JBrowse link 10 70,134,734 70,158,051 RGD:7246935
G LOC100362333 DNA-directed DNA polymerase epsilon 3 JBrowse link 7 118,816,053 118,816,725 RGD:7246936
G Mnat1 MNAT1, CDK activating kinase assembly factor JBrowse link 6 95,995,341 96,153,331 RGD:6907045
G Papd7 poly(A) RNA polymerase D7, non-canonical JBrowse link 1 36,400,056 36,433,238 RGD:10402751
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6907045
RGD:7246931
RGD:7246932
RGD:10402751
G Pold1 DNA polymerase delta 1, catalytic subunit JBrowse link 1 100,538,066 100,554,105 RGD:1358139
RGD:6907045
RGD:7246935
G Pold2 DNA polymerase delta 2, accessory subunit JBrowse link 14 86,111,416 86,117,578 RGD:6907045
RGD:7246935
G Pold3 DNA polymerase delta 3, accessory subunit JBrowse link 1 165,085,142 165,122,385 RGD:6907045
RGD:7246935
G Pold4 DNA polymerase delta 4, accessory subunit JBrowse link 1 219,480,841 219,483,244 RGD:6907045
RGD:7246935
G Pole DNA polymerase epsilon, catalytic subunit JBrowse link 12 52,403,533 52,452,075 RGD:6907045
RGD:7246935
RGD:7246936
RGD:10402751
G Pole2 DNA polymerase epsilon 2, accessory subunit JBrowse link 6 91,494,348 91,532,355 RGD:6907045
RGD:7246936
G Pole3 DNA polymerase epsilon 3, accessory subunit JBrowse link 5 78,380,813 78,384,047 RGD:6907045
RGD:7246936
G Pole4 DNA polymerase epsilon 4, accessory subunit JBrowse link 4 113,491,644 113,497,455 RGD:6907045
RGD:7246936
G Polk DNA polymerase kappa JBrowse link 2 27,305,718 27,364,906 RGD:7246935
G Polr1a RNA polymerase I subunit A JBrowse link 4 99,822,964 99,903,969 RGD:10402751
G Rad23a RAD23 homolog A, nucleotide excision repair protein JBrowse link 19 25,949,488 25,956,677 RGD:6907045
RGD:10402751
G Rad23b RAD23 homolog B, nucleotide excision repair protein JBrowse link 5 72,103,704 72,141,701 RGD:6907045
RGD:7246920
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6907045
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:6907045
RGD:7246932
RGD:10402751
G Rfc2 replication factor C subunit 2 JBrowse link 12 25,130,375 25,143,480 RGD:6907045
RGD:7246932
G Rfc3 replication factor C subunit 3 JBrowse link 12 1,460,581 1,471,344 RGD:6907045
RGD:7246932
G Rfc4 replication factor C subunit 4 JBrowse link 11 81,358,592 81,373,044 RGD:6907045
RGD:7246932
G Rfc5 replication factor C subunit 5 JBrowse link 12 44,931,494 44,941,051 RGD:6907045
RGD:7246932
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:6907045
RGD:7246926
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:6907045
RGD:7246926
G Rpa3 replication protein A3 JBrowse link 4 34,279,320 34,282,351 RGD:6907045
RGD:7246926
G Xab2 XPA binding protein 2 JBrowse link 12 2,158,391 2,170,397 RGD:7246919
G Xpa XPA, DNA damage recognition and repair factor JBrowse link 5 61,749,767 61,793,641 RGD:6907045
RGD:7246926
RGD:10402751
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:6907045
RGD:7246920
RGD:7246922
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:7246935
altered nucleotide excision repair pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddb1 damage-specific DNA binding protein 1 JBrowse link 1 226,657,561 226,683,356 RGD:7246919
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:7246919
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit JBrowse link 18 25,037,668 25,068,380 RGD:7246919
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:7246919
RGD:9588971
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:7246919
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:7246919
G Ercc8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 39,434,617 39,473,392 RGD:7246919
G Xpa XPA, DNA damage recognition and repair factor JBrowse link 5 61,749,767 61,793,641 RGD:7246919
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:7246919

Altered Pathway:

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nucleotide excision repair pathway
Disease TermsGene Symbols
Abnormalities, MultipleCul4b , Pold1
Acquired Immunodeficiency SyndromeErcc2
ACROFACIAL DYSOSTOSIS, CINCINNATI TYPEPolr1a
AdenocarcinomaPcna
Adenocarcinoma of EsophagusErcc1
Adenocarcinoma of LungErcc1 , Xpc
ADENOCARCINOMA OF STOMACHPole
Aging, PrematureErcc1 , Ercc6
AlcoholismErcc1
Alzheimer DiseaseCdk7 , Ercc2 , Ercc3
Amino Acid Metabolism, Inborn ErrorsXpc
AnemiaErcc1
Anthracycline-induced CardiotoxicityErcc2
Arrhythmias, CardiacLig3
Arrhythmogenic Right Ventricular DysplasiaXpc
Arsenic PoisoningErcc1 , Ercc3 , Ercc4
ArthrogryposisErcc6
Asphyxia NeonatorumErcc2 , Ercc3 , Xrcc1
Ataxia-telangiectasia-like disorder 2Pcna
Autism Spectrum DisorderRfc2
Autistic DisorderXpc
AzoospermiaErcc1
Birth WeightXrcc1
Bloom SyndromeLig1
Brain IschemiaPcna
Brain NeoplasmsPcna
Breast NeoplasmsErcc1 , Ercc2 , Pcna , Pole , Xrcc1
Burn-Mckeown SyndromeXpc
Capillary Malformation-Arteriovenous MalformationCcnh
CarcinomaCcnh
Carcinoma in SituXrcc1
Carcinoma, Basal CellCcnh , Xpa
Carcinoma, Ductal, BreastPcna , Xrcc1
Carcinoma, HepatocellularPcna , Xrcc1
Carcinoma, Non-Small-Cell LungErcc1 , Ercc2 , Ercc3
Carcinoma, Renal CellPcna , Xrcc1
Carcinoma, Squamous CellErcc2 , Ercc6
Carcinoma, Transitional CellXrcc1
CataractErcc2 , Ercc6 , Xrcc1
Cell Transformation, NeoplasticHmgn1
Cerebrooculofacioskeletal Syndrome 1Ercc2 , Ercc6
Cerebrooculofacioskeletal Syndrome 2Ercc2
Cerebrooculofacioskeletal Syndrome 3Ercc5
Cerebrooculofacioskeletal Syndrome 4Ercc1
Chagas CardiomyopathyPcna
ChloracneRpa1
Chromosome AberrationsErcc1 , Ercc2 , Xpc
Cockayne SyndromeErcc1 , Ercc2 , Ercc3 , Ercc4 , Ercc5 , Ercc6 , Ercc8 , Xpa
Cockayne syndrome AErcc8
Cockayne syndrome BErcc6
Cognition DisordersErcc5
colon cancerPold1
Colonic NeoplasmsPcna , Pold1 , Rfc1
colorectal cancerPold1 , Pole
Colorectal NeoplasmsErcc1 , Ercc2 , Pold1 , Pold3 , Pole
Coronary Artery DiseaseErcc2
Craniofacial AbnormalitiesErcc6 , Rad23b
Cystadenocarcinoma, SerousXpc
De Sanctis-Cacchione SyndromeErcc6
DeafnessPold1
Diabetes Mellitus, ExperimentalErcc1 , Ercc4
Disease ProgressionDdb1 , Rad23a
Down SyndromeErcc2 , Ercc3
Drug-induced NeutropeniaErcc1 , Ercc2
Drug-Related Side Effects and Adverse ReactionsErcc1 , Ercc2
DysarthriaErcc5
Endometrial NeoplasmsErcc2 , Pold1
Erectile DysfunctionXrcc1
ErythemaXrcc1
Esophageal Atresia with or without Tracheoesophageal FistulaErcc4
Esophageal Squamous Cell CarcinomaErcc1 , Xrcc1
Facial Dysmorphism, Immunodeficiency, Livedo, and Short StaturePole
Fanconi Anemia, Complementation Group QErcc4
FibrosarcomaErcc6
Foot DeformitiesErcc5
Fragile X SyndromeErcc6
Funnel ChestErcc5
Gallbladder NeoplasmsErcc2 , Xrcc1
Gastrointestinal NeoplasmsErcc1
Genetic Diseases, InbornCul4b
Genetic Predisposition to DiseaseErcc1 , Ercc4
GlioblastomaPole , Polk
GliomaErcc1 , Ercc2 , Xrcc1
Glomerulosclerosis, Focal SegmentalPcna
Growth DisordersErcc6
Head and Neck NeoplasmsErcc2
Hearing LossErcc6
Hearing Loss, SensorineuralErcc6 , Ercc8
HepatoblastomaPcna
Hyperkeratosis, EpidermolyticErcc2
HypogonadismPold1
HypothyroidismPcna
Ichthyosiform Erythroderma, CongenitalErcc2
Ichthyosis, Congenital, with TrichothiodystrophyErcc2 , Gtf2h5
Immunologic Deficiency SyndromesLig1
Infarction, Middle Cerebral ArteryErcc6
Infertility, MaleRad23b
InflammationErcc1
Intellectual DisabilityCul4b
Intervertebral Disc DegenerationErcc1
Intestinal NeoplasmsXpa
Intimal HyperplasiaPcna
IschemiaPcna
Ischemic Attack, TransientCcnh , Ercc1 , Ercc6 , Pcna , Xrcc1
Jaundice, ObstructivePcna
Jaw AbnormalitiesPold1
Laryngeal NeoplasmsErcc1
Leigh DiseaseErcc8
LeiomyomaPcna , Xrcc1
Leukemia, Lymphocytic, Chronic, B-CellErcc2 , Xrcc1
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveErcc2 , Xrcc1
Leukemia, Myeloid, AcuteErcc1 , Ercc2
Leukemia, Myeloid, Chronic-PhaseErcc1
LeukoencephalopathiesGtf2h3
Leukoplakia, OralErcc2 , Xrcc1
Lewy Body DiseasePcna
LipodystrophyErcc1 , Pold1
Liver InjuryPcna
Liver NeoplasmsXpa , Xpc
Lung NeoplasmsErcc1 , Ercc2 , Ercc3 , Ercc6 , Pcna , Xpc
LymphomaErcc6
Macular DegenerationErcc2 , Ercc6
Macular Degeneration, Age-Related, 5Ercc6
Mammary Neoplasms, AnimalCcnh
Mammary Neoplasms, ExperimentalCcnh , Pcna
Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy SyndromePold1
MelanomaErcc1 , Ercc2 , Ercc5
Mental Retardation, X-Linked, Syndromic 5Cul4b
Mental Retardation, X-Linked, Syndromic, Cabezas TypeCul4b
MesotheliomaXrcc1
Metabolism, Inborn ErrorsLig1
MicrocephalyErcc6
Micronuclei, Chromosome-DefectiveErcc4 , Polk , Xpa , Xpc , Xrcc1
MicrophthalmosErcc6
Mitochondrial Complex I DeficiencyErcc8
Mixed Tumor, MullerianPole
Mouth NeoplasmsErcc2 , Xrcc1
MucositisPcna
Multiple MyelomaErcc1 , Ercc2
Myelodysplastic SyndromesErcc2 , Xrcc1
Myopathy, Central CorePold1
Nasopharyngeal CarcinomaErcc1
Neoplasm MetastasisErcc1 , Ercc4 , Pcna , Xrcc1
NeoplasmsErcc1
Neoplasms, ExperimentalPcna
Neoplasms, Germ Cell and EmbryonalErcc1 , Ercc4 , Pcna
Neoplastic Syndromes, HereditaryErcc4 , Pold1 , Pole
Neuroma, AcousticErcc2
Occupational DiseasesErcc2 , Xrcc1
Oculootofacial DysplasiaXpc
OsteoarthritisErcc1
OsteoporosisErcc1 , Pcna
OsteosarcomaErcc1 , Ercc2 , Rfc1
Ovarian NeoplasmsErcc1 , Ercc2
Pancreatic AdenocarcinomaPole
Pancreatic NeoplasmsErcc1 , Ercc2 , Ercc4 , Lig3 , Xpc , Xrcc1
ParaplegiaErcc5
Peripheral Nervous System DiseasesErcc1 , Ercc3 , Ercc4 , Ercc5
Phyllodes TumorPcna
Pleomorphic Xanthoastrocytoma Pold2 , Rfc2
PolyneuropathiesErcc5
Precursor Cell Lymphoblastic Leukemia-LymphomaErcc1 , Ercc2 , Xrcc1
Premature Ovarian Failure 11Ercc6
Primary MyelofibrosisErcc1 , Ercc2
Prostatic NeoplasmsErcc1 , Ercc2 , Polk , Rad23b , Xrcc1
PsoriasisPcna
Psychomotor DisordersErcc6
Radiation Injuries, ExperimentalPcna
RecurrenceErcc4
Renal InsufficiencyErcc1
Reperfusion InjuryErcc1 , Lig3 , Xrcc1
Retinal DiseasesErcc8
Sciatic NeuropathyPcna
SeizuresCul4b , Xrcc1
SeminomaPcna , Xrcc1
Senile CataractErcc2 , Xrcc1
Skin AbnormalitiesErcc2
Skin DiseasesErcc2
Skin NeoplasmsErcc2 , Xpa
Smith-Magenis SyndromeLig3
Spinal Cord InjuriesCcnh
Stevens-Johnson SyndromeCul4a , Rbx1
Stomach NeoplasmsDdb1 , Ercc1 , Ercc2 , Rad23a , Xrcc1
StomatitisXrcc1
Sturge-Weber SyndromeCcnh
SunburnErcc2
Testicular NeoplasmsErcc1 , Ercc4 , Pcna
Thyroid Hormone Metabolism, AbnormalErcc1
Trichothiodystrophy 1, PhotosensitiveErcc2 , Ercc3 , Gtf2h5
Trichothiodystrophy 2, photosensitive Ercc3
Trichothiodystrophy SyndromesErcc2 , Ercc3 , Gtf2h5
Urinary Bladder NeoplasmsErcc2 , Ercc4 , Lig1 , Xrcc1
Urofacial Syndrome 2Lig3
Uterine Cervical NeoplasmsErcc1 , Xrcc1
Uterine NeoplasmsPole
UV-Sensitive SyndromeErcc6
UV-Sensitive Syndrome 1Ercc6
UV-Sensitive Syndrome 2Ercc8
Wilms TumorPcna
Xeroderma PigmentosumDdb1 , Ddb2 , Ercc1 , Ercc2 , Ercc3 , Ercc4 , Ercc5 , Xpa , Xpc
Xeroderma Pigmentosum, Complementation Group BErcc3
Xeroderma Pigmentosum, Complementation Group CXpc
Xeroderma Pigmentosum, Complementation Group DErcc2 , Ercc6
Xeroderma Pigmentosum, Complementation Group EDdb2
Xeroderma Pigmentosum, Complementation Group FErcc4
Xeroderma Pigmentosum, Complementation Group GErcc5
Xeroderma Pigmentosum, Type G/Cockayne SyndromeErcc5
XFE Progeroid SyndromeErcc4
Pathway Annotations Associated with Genes in the nucleotide excision repair pathway
Pathway TermsGene Symbols
altered nucleotide excision repair pathwayDdb1 , Ercc2 , Ercc3 , Ercc4 , Ercc5 , Ercc6 , Ercc8 , Xpa , Xpc
base excision repair pathwayLig1 , Lig3 , Pcna , Pold1 , Pold2 , Pold3 , Pold4 , Pole , Pole2 , Pole3 , Pole4 , Xrcc1
cell cycle pathway, mitoticCcnh , Cdk7 , Pcna , Rbx1
DNA replication pathwayLig1 , Pcna , Pold1 , Pold2 , Pold3 , Pold4 , Pole , Pole2 , Pole3 , Pole4 , Rfc1 , Rfc2 , Rfc3 , Rfc4 , Rfc5 , Rpa1 , Rpa2 , Rpa3
Endoplasmic Reticulum-associated degradation pathwayRad23a , Rad23b , Rbx1
FasL mediated signaling pathwayRfc1
homologous recombination pathway of double-strand break repairPold1 , Pold2 , Pold3 , Pold4 , Rpa1 , Rpa2 , Rpa3
hypoxia inducible factor pathwayRbx1
ISWI family mediated chromatin remodeling pathwayPole3
mismatch repair pathwayLig1 , Pcna , Pold1 , Pold2 , Pold3 , Pold4 , Rfc1 , Rfc2 , Rfc3 , Rfc4 , Rfc5 , Rpa1 , Rpa2 , Rpa3
neddylation pathwayRbx1
nuclear factor kappa B signaling pathwayRbx1
nuclear factor, erythroid 2 like 2 signaling pathwayRbx1
nucleotide excision repair pathwayCcnh , Cdk7 , Cetn2 , Cul4a , Cul4b , Ddb1 , Ddb2 , Ercc1 , Ercc2 , Ercc3 , Ercc4 , Ercc4l1 , Ercc5 , Ercc6 , Ercc8 , Gtf2h1 , Gtf2h2 , Gtf2h3 , Gtf2h4 , Gtf2h5 , Hmgn1 , Lig1 , Lig3 , LOC100362333 , Mnat1 , Papd7 , Pcna , Pold1 , Pold2 , Pold3 , Pold4 , Pole , Pole2 , Pole3 , Pole4 , Polk , Polr1a , Rad23a , Rad23b , Rbx1 , Rfc1 , Rfc2 , Rfc3 , Rfc4 , Rfc5 , Rpa1 , Rpa2 , Rpa3 , Xab2 , Xpa , Xpc , Xrcc1
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesRbx1
purine metabolic pathwayPold1 , Pold2 , Pold3 , Pold4 , Pole , Pole2 , Pole3 , Pole4 , Polr1a
pyrimidine metabolic pathwayPold1 , Pold2 , Pold3 , Pold4 , Pole , Pole2 , Pole3 , Pole4 , Polr1a
renal cell cancer pathwayRbx1
RNA polymerase I transcription pathwayPolr1a
RNA polymerase II transcription initiation pathwayCcnh , Cdk7 , Ercc2 , Ercc3 , Ercc5 , Gtf2h1 , Gtf2h2 , Gtf2h3 , Gtf2h4 , Gtf2h5 , Mnat1 , Pole3
RNA polymerase II transcription pathwayCdk7
spliceosome pathwayXab2
transforming growth factor-beta superfamily mediated signaling pathwayRbx1
ubiquitin/proteasome degradation pathwayCul4a , Cul4b , Ddb1 , Ercc8 , Rbx1
Wnt signaling pathwayRbx1

References Associated with the nucleotide excision repair pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: