|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions increases activity |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein] |
CTD |
PMID:32172062 PMID:32810514 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ache |
acetylcholinesterase |
increases expression multiple interactions increases activity |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of ACHE protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 protein |
CTD |
PMID:38282657 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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|
G |
Ada |
adenosine deaminase |
multiple interactions increases activity |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] |
CTD |
PMID:15502880 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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|
G |
Agtr1b |
angiotensin II receptor, type 1b |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] |
CTD |
PMID:32479886 |
|
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
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|
G |
Alcam |
activated leukocyte cell adhesion molecule |
multiple interactions decreases expression |
ISO |
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of ALCAM protein] |
CTD |
PMID:34995009 |
|
NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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|
G |
Alkbh5 |
alkB homolog 5, RNA demethylase |
multiple interactions increases expression increases response to substance |
ISO |
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of ALCAM protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of CTNNB1 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of PPARG protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of VIM protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein] NG-Nitroarginine Methyl Ester results in increased expression of ALKBH5 protein ALKBH5 protein results in increased susceptibility to NG-Nitroarginine Methyl Ester |
CTD |
PMID:34995009 |
|
NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331
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G |
Atf3 |
activating transcription factor 3 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 protein |
CTD |
PMID:38282657 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Bche |
butyrylcholinesterase |
multiple interactions increases activity |
EXP |
[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein] |
CTD |
PMID:32172062 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [bisphenol A results in increased expression of CASP9 protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein] |
CTD |
PMID:29423081 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein] |
CTD |
PMID:34995009 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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|
G |
Celf2 |
CUGBP, Elav-like family member 2 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 protein |
CTD |
PMID:38282657 |
|
NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
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|
G |
Cpeb2 |
cytoplasmic polyadenylation element binding protein 2 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB2 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB2 protein] |
CTD |
PMID:38282657 |
|
NCBI chr14:67,787,503...67,839,973
Ensembl chr14:67,787,507...67,840,743
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|
G |
Cpeb4 |
cytoplasmic polyadenylation element binding protein 4 |
multiple interactions |
ISO |
[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB4 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB4 protein |
CTD |
PMID:38282657 |
|
NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression |
ISO |
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of CTNNB1 protein] |
CTD |
PMID:34995009 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cybb |
cytochrome b-245 beta chain |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] |
CTD |
PMID:32479886 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of DDIT3 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of DDIT3 mRNA |
CTD |
PMID:38282657 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Edem3 |
ER degradation enhancing alpha-mannosidase like protein 3 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 protein |
CTD |
PMID:38282657 |
|
NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523
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G |
Ednra |
endothelin receptor type A |
multiple interactions increases expression |
EXP |
Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNA] |
CTD |
PMID:34102242 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Ednrb |
endothelin receptor type B |
decreases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA] |
CTD |
PMID:34102242 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Eng |
endoglin |
increases expression multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester results in increased expression of ENG protein ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein] |
CTD |
PMID:34995009 |
|
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of FN1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of FN1 protein |
CTD |
PMID:38282657 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] |
CTD |
PMID:28624453 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of HSPA5 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of HSPA5 mRNA |
CTD |
PMID:38282657 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein] |
CTD |
PMID:29423081 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1A mRNA] |
CTD |
PMID:32142722 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of IL1B protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein] |
CTD |
PMID:29423081 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Lama1 |
laminin subunit alpha 1 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of LAMA1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of LAMA1 protein |
CTD |
PMID:38282657 |
|
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
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G |
Maoa |
monoamine oxidase A |
increases expression multiple interactions increases activity |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of MAOA protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
EXP |
NG-Nitroarginine Methyl Ester results in decreased expression of MCL1 mRNA |
CTD |
PMID:36260529 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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|
G |
Mir377 |
microRNA 377 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR377]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR377 |
CTD |
PMID:38282657 |
|
NCBI chr 6:128,755,051...128,755,122
|
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G |
Mir494 |
microRNA 494 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR494]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR494 |
CTD |
PMID:38282657 |
|
NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
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|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]] |
CTD |
PMID:33301711 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein] |
CTD |
PMID:34995009 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NFKBIB mRNA]] |
CTD |
PMID:37483153 |
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NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein] |
CTD |
PMID:29423081 PMID:37483153 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
decreases expression multiple interactions |
ISO EXP |
NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein [Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 protein Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein] |
CTD |
PMID:28624453 PMID:32479886 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Panx3 |
pannexin 3 |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PANX3 mRNA] |
CTD |
PMID:32142722 |
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NCBI chr 8:37,366,758...37,377,640
Ensembl chr 8:37,366,862...37,377,640
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] |
CTD |
PMID:15502880 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pde5a |
phosphodiesterase 5A |
increases activity multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
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NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
ISO |
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of PPARG protein] |
CTD |
PMID:34995009 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]] |
CTD |
PMID:28624453 PMID:37483153 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Setd2 |
SET domain containing 2, histone lysine methyltransferase |
decreases expression |
EXP |
NG-Nitroarginine Methyl Ester results in decreased expression of SETD2 mRNA alternative form |
CTD |
PMID:36260529 |
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NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein |
CTD |
PMID:38282657 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein |
CTD |
PMID:38282657 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Spn |
sialophorin |
multiple interactions increases expression |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein] |
CTD |
PMID:32172062 PMID:32428650 |
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NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions decreases expression |
EXP |
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] |
CTD |
PMID:32479886 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Tbxa2r |
thromboxane A2 receptor |
increases expression |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of TBXA2R mRNA |
CTD |
PMID:34102242 |
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NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TGFB1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TGFB1 protein |
CTD |
PMID:38282657 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
decreases expression |
ISO |
NG-Nitroarginine Methyl Ester results in decreased expression of TH protein |
CTD |
PMID:31187328 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP ISO |
[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein] [NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein |
CTD |
PMID:29423081 PMID:30529211 PMID:32172062 PMID:32428650 PMID:32810514 PMID:34678311 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein [bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of TP53 protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
decreases response to substance |
ISO |
TRPA1 gene mutant form results in decreased susceptibility to NG-Nitroarginine Methyl Ester |
CTD |
PMID:32634517 |
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NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein] |
CTD |
PMID:29423081 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vim |
vimentin |
multiple interactions decreases expression |
ISO |
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of VIM protein] |
CTD |
PMID:34995009 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Vwf |
von Willebrand factor |
multiple interactions |
ISO |
[NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein |
CTD |
PMID:34678311 |
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NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
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G |
Wnt2 |
Wnt family member 2 |
decreases expression multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein] |
CTD |
PMID:34995009 |
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NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
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