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Gene: Wnt3 (Wnt family member 3) Rattus norvegicus

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Symbol:

Wnt3

Name:

Wnt family member 3

RGD ID:

3972

Description:

Predicted to enable cytokine activity; frizzled binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including limb bud formation; midbrain dopaminergic neuron differentiation; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within several processes, including axis specification; embryonic morphogenesis; and regulation of extent of cell growth. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

INT4; proto-oncogene Wnt-3; wingless-related MMTV integration site 3; Wingless-type MMTV integration site 3, homolog; wingless-type MMTV integration site family, member 3; wingless-type MMTV integration site family, member 3 (mapped); Wnt3_mapped

RGD Orthologs

Human

Mouse

Dog

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WNT3 (Wnt family member 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Wnt3 (wingless-type MMTV integration site family, member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WNT3 (Wnt family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TBC1D23 (TBC1 domain family member 23)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Wnt3 (wingless-type MMTV integration site family, member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Wnt3 (wingless-type MMTV integration site family, member 3)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Homo sapiens (human):	WNT3 (Wnt family member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	WNT3 (Wnt family member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	wnt3 (wingless-type MMTV integration site family, member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wnt3 (wingless-type MMTV integration site family, member 3)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	wnt3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	wnt3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	89,180,224 - 89,224,195 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	89,216,801 - 89,224,195 (+)	Ensembl				GRCr8
mRatBN7.2	10	88,680,198 - 88,724,170 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	88,680,248 - 88,724,099 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	93,718,545 - 93,762,264 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	93,183,701 - 93,227,397 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	88,577,058 - 88,620,776 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	91,830,709 - 91,874,907 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	91,830,654 - 91,874,793 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	91,597,106 - 91,641,213 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	92,925,605 - 92,969,613 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	87,379,436 - 87,423,461 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Mammary Neoplasms (ISO)

atrial fibrillation (ISO)

Desbuquois dysplasia (ISO)

Ectromelia (ISO)

endometrial carcinoma (ISO)

Experimental Mammary Neoplasms (ISO)

hereditary breast ovarian cancer syndrome (ISO)

malignant mesothelioma (ISO)

mantle cell lymphoma (ISO)

tetraamelia syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-bromoindirubin-3'-oxime (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

atrazine (ISO)

azithromycin (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzylpenicillin (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Bufotalin (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

celastrol (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

curcumin (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethosuximide (EXP)

fisetin (EXP)

folic acid (ISO)

indometacin (ISO)

lithium chloride (ISO)

luteolin (ISO)

melatonin (EXP)

methoxyacetic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (ISO)

nickel atom (ISO)

niclosamide (ISO)

nitrofen (EXP)

paclitaxel (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

phenytoin (ISO)

Ptaquiloside (ISO)

saccharin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

vorinostat (ISO)

zearalenone (EXP)

zinc sulfate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure formation involved in morphogenesis (ISO)

animal organ development (IEA)

anterior/posterior axis specification (ISO)

anterior/posterior pattern specification (ISO)

axon guidance (ISO)

canonical Wnt signaling pathway (IEA,ISO)

cell morphogenesis (ISO)

dorsal/ventral axis specification (ISO)

embryonic forelimb morphogenesis (ISO)

embryonic hindlimb morphogenesis (ISO)

gamete generation (ISO)

head morphogenesis (ISO)

limb bud formation (ISO)

limb development (ISO)

mammary gland epithelium development (ISO)

mesoderm formation (ISO)

midbrain dopaminergic neuron differentiation (ISO)

negative regulation of axon extension involved in axon guidance (ISO)

positive regulation of collateral sprouting in absence of injury (ISO)

positive regulation of gene expression (ISO)

positive regulation of macromolecule biosynthetic process (IEA)

positive regulation of osteoblast differentiation (ISO)

positive regulation of Wnt signaling pathway (ISO)

regulation of cell differentiation (TAS)

regulation of cell growth (TAS)

regulation of gene expression (IEA)

regulation of mesenchymal stem cell differentiation (ISO)

regulation of neurogenesis (ISO)

Spemann organizer formation at the anterior end of the primitive streak (ISO)

stem cell proliferation (ISO)

Wnt signaling pathway (IEA)

Cellular Component

extracellular matrix (ISO)

extracellular region (IEA)

Molecular Function

frizzled binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

receptor ligand activity (ISO)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Hedgehog signaling pathway (IEA)

Wnt signaling pathway (IEA,ISO)

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma.	Bui TD, etal., Br J Cancer. 1997;75(8):1131-6.
2.	Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a.	Castelo-Branco G, etal., Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12747-52. Epub 2003 Oct 13.
3.	Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression.	Erdreich-Epstein A and Shackleford GM, Growth Factors 1998;15(2):149-58.
4.	Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats.	Fujise T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1150-6. Epub 2006 Dec 28.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family.	Niemann S, etal., Am J Hum Genet. 2004 Mar;74(3):558-63. Epub 2004 Feb 5.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
15.	Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts.	Schroeder JA, etal., Oncogene. 2000 Jun 29;19(28):3193-9.
16.	Transformation by Wnt family proteins correlates with regulation of beta-catenin.	Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
17.	Alternative wnt signaling is initiated by distinct receptors.	van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.

Additional References at PubMed

PMID:1300513	PMID:8167409	PMID:8168088	PMID:10431240	PMID:10557084	PMID:12569130	PMID:15194435	PMID:15588944	PMID:17558443	PMID:17921881	PMID:18028899	PMID:18044981
PMID:18313787	PMID:18403408	PMID:18716223	PMID:19000841	PMID:19690384	PMID:20039315	PMID:22922600	PMID:23324743	PMID:23469192	PMID:24363087	PMID:24562386	PMID:25640183
PMID:27226528	PMID:28733458	PMID:31694396	PMID:32949181

Genomics

Comparative Map Data

Wnt3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	89,180,224 - 89,224,195 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	89,216,801 - 89,224,195 (+)	Ensembl				GRCr8
mRatBN7.2	10	88,680,198 - 88,724,170 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	88,680,248 - 88,724,099 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	93,718,545 - 93,762,264 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	93,183,701 - 93,227,397 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	88,577,058 - 88,620,776 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	91,830,709 - 91,874,907 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	91,830,654 - 91,874,793 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	91,597,106 - 91,641,213 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	92,925,605 - 92,969,613 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	87,379,436 - 87,423,461 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

WNT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	46,762,506 - 46,818,692 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	46,762,506 - 46,833,154 (-)	Ensembl			hg38	GRCh38
GRCh37	17	44,839,872 - 44,896,058 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	17	q21.31-q21.32	NCBI
HuRef	17	40,218,240 - 40,274,537 (-)	NCBI		HuRef
CHM1_1	17	44,903,996 - 44,960,278 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	47,623,975 - 47,680,171 (-)	NCBI		T2T-CHM13v2.0

Wnt3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	103,665,000 - 103,708,854 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	103,664,976 - 103,708,783 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	103,774,175 - 103,818,021 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	103,774,150 - 103,817,957 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	103,635,489 - 103,679,335 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	103,590,314 - 103,634,047 (+)	NCBI		MGSCv36	mm8
Celera	11	115,489,203 - 115,533,047 (+)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	67.5	NCBI

WNT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	10,073,019 - 10,124,454 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	10,077,567 - 10,124,508 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	10,173,950 - 10,225,430 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	11,663,529 - 11,714,749 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	11,668,090 - 11,714,594 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	10,674,575 - 10,725,693 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	16,796,275 - 16,847,494 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	16,743,753 - 16,795,272 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Variants

Variants in Wnt3
254 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	556
Count of miRNA genes:	264
Interacting mature miRNAs:	327
Transcripts:	ENSRNOT00000005176
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	51071897	96071897	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	35509383	91417879	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	81012077	91729860	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	58073360	103073360	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	83061236	92869129	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50464802	95464802	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	79272424	102982300	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44939359	89939359	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	95464802	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50860288	95860288	Rat
2313856	Bp342	Blood pressure QTL 342	4.4	0.0001	life span trait (VT:0005372)	age at time of death (CMO:0001193)	10	87807758	96620484	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44939359	89939359	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	67241334	98502431	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61843496	98710773	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	73695339	97272278	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	81012077	101828297	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	73049656	94495280	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	49495492	94495492	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	88900501	96620484	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	55307972	93608131	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61843496	100198886	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49943710	94943710	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44939359	89939359	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61843496	100198886	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47869129	92869129	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	84503487	96432422	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76743133	95604677	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	84503487	96432422	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50604677	95604677	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73950353	96620293	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

M32502

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	88,722,606 - 88,722,689 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	91,873,344 - 91,873,426	NCBI	Rnor6.0
Rnor_5.0	10	91,639,721 - 91,639,803	UniSTS	Rnor5.0
RGSC_v3.4	10	92,968,121 - 92,968,203	UniSTS	RGSC3.4
Celera	10	87,421,969 - 87,422,051	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Wnt3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	88,723,759 - 88,723,958 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	91,874,497 - 91,874,695	NCBI	Rnor6.0
Rnor_5.0	10	91,640,874 - 91,641,072	UniSTS	Rnor5.0
RGSC_v3.4	10	92,969,274 - 92,969,472	UniSTS	RGSC3.4
Celera	10	87,423,122 - 87,423,320	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

GDB:196138

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	88,718,377 - 88,718,847 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	91,869,115 - 91,869,584	NCBI	Rnor6.0
Rnor_5.0	10	91,635,492 - 91,635,961	UniSTS	Rnor5.0
RGSC_v3.4	10	92,963,892 - 92,964,361	UniSTS	RGSC3.4
Celera	10	87,417,740 - 87,418,209	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Wnt3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	88,718,479 - 88,718,637 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	91,869,217 - 91,869,374	NCBI	Rnor6.0
Rnor_5.0	10	91,635,594 - 91,635,751	UniSTS	Rnor5.0
RGSC_v3.4	10	92,963,994 - 92,964,151	UniSTS	RGSC3.4
Celera	10	87,417,842 - 87,417,999	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Wnt3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	88,717,543 - 88,718,499 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	91,868,281 - 91,869,236	NCBI	Rnor6.0
Rnor_5.0	10	91,634,658 - 91,635,613	UniSTS	Rnor5.0
RGSC_v3.4	10	92,963,058 - 92,964,013	UniSTS	RGSC3.4
Celera	10	87,416,909 - 87,417,861	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	3	26	125	34	33	8	58	8	6	182	101	1	115	55	70	25	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005176 ⟹ ENSRNOP00000005176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	88,680,248 - 88,724,099 (+)	Ensembl
Rnor_6.0 Ensembl	10	91,830,654 - 91,874,793 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096241 ⟹ ENSRNOP00000097138

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	89,216,801 - 89,224,195 (+)	Ensembl
mRatBN7.2 Ensembl	10	88,716,834 - 88,724,099 (+)	Ensembl

RefSeq Acc Id:

NM_001105715 ⟹ NP_001099185

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	89,180,224 - 89,224,195 (+)	NCBI
mRatBN7.2	10	88,680,198 - 88,724,170 (+)	NCBI
Rnor_6.0	10	91,830,709 - 91,874,836 (+)	NCBI
Rnor_5.0	10	91,597,106 - 91,641,213 (+)	NCBI
RGSC_v3.4	10	92,925,605 - 92,969,613 (+)	RGD
Celera	10	87,379,436 - 87,423,461 (+)	RGD

Sequence:

show sequence

CCTCTTCATGATCGCCGGCAAACTTCCTCCTCGGCGCTGCTTCTAATGGAGCCCCACCTGCTCG
GGCTGCTACTCGGCCTCCTGCTCAGTGGCACCAGGGTCCTCGCCGGCTACCCAATTTGGTGGTC
CCTGGCCCTGGGCCAGCAGTACACGTCTCTGGCCTCCCAGCCTCTGCTCTGCGGCTCTATCCCA
GGCCTGGTCCCCAAGCAACTGCGTTTCTGCCGCAATTACATCGAGATCATGCCCAGTGTAGCGG
AAGGCGTGAAGCTGGGCATCCAGGAGTGCCAGCATCAGTTCCGGGGACGCCGCTGGAACTGTAC
CACCATAGATGACAGCCTGGCCATCTTTGGGCCTGTCCTGGACAAAGCCACCCGCGAATCGGCC
TTCGTGCATGCCATCGCCTCGGCTGGTGTAGCCTTCGCAGTCACGCGCTCCTGTGCCGAGGGAA
CCTCTACCATCTGCGGCTGCGACTCGCATCATAAGGGGCCACCTGGAGAAGGCTGGAAATGGGG
CGGCTGCAGCGAGGACGCCGACTTCGGGGTGCTGGTGTCCCGGGAGTTTGCGGATGCACGGGAG
AACAGGCCAGATGCCCGCTCAGCTATGAACAAGCACAACAACGAGGCAGGCCGAACGACCATCC
TGGATCACATGCACCTGAAGTGCAAATGCCATGGGTTGTCTGGCAGCTGTGAGGTGAAGACCTG
CTGGTGGGCCCAGCCTGACTTCCGAGCCATTGGTGACTTCCTCAAGGACAAGTACGACAGTGCC
TCAGAGATGGTGGTGGAGAAGCATCGGGAGTCCCGAGGCTGGGTGGAGACCCTTCGGGCCAAGT
ATGCACTCTTTAAGCCACCCACGGAGAGGGACCTGGTCTACTACGAGAACTCCCCCAACTTTTG
TGAGCCCAACCCAGAGACGGGCTCCTTTGGTACCAGGGACCGGACTTGCAATGTCACCTCCCAC
GGCATTGATGGCTGCGATCTGCTGTGCTGTGGCAGGGGCCACAACACCAGGACGGAGAAGCGGA
AGGAGAAATGTCATTGCGTCTTCCACTGGTGCTGCTACGTCAGCTGCCAGGAGTGCATTCGCAT
CTACGATGTACACACCTGCAAGTAGGGAAGCCAGGGCACAGGGAAGGGGTAGATTGTACGGCTG
GATCCATTCGTCGAAGTCCCATGGGAAGCAGGATCTAGATCTGGGCCAGCCTTTGACACGGGCC
AGCAAGGAGCAAGGACGATTGCCAGCTGCATGTGATAAACAACCTGGACCCAGCTGGCCTCGGA
TGGGCGGCTTCTTTCTCAACTAACGTCTCTCACCCTGCTCTGGATGGTGTGTGGCTTCACAGAG
GGGCTTTCTTTATGGTTTCCCAGGGTCTGCTGGGGACAGACCTGAGGCTTACCTTTGCACATGT
TAAAGAAAATAAAAATGAAAAAAAAAATCTACTGCAACAGAACAGGCTGGGCTAGTGTGAGCTC
TTGGCCTGGTGGGAGAGACAAGAACATGGCGAGATTCTGTGTCCAAGCTGCCTCTTGCTCGTGA
CATTCCAAGATGCCTCTGAGGTAGGAATTGTAAAATAGGATAAGACCCCTGCAGTCTCCTTTTG
TCCGTTGACTTCCATTCAAATTGGGCACACTTTGCCACTCTCAGAAAAGCCATAGGTATAGCCG
GGATGCAGTGGTGGGGAGGCCCTTGGCCAACGGTCTTGAGTTTTGAAGACCTCAGAGATCTGGG
CAGCTTGGGAAGCCATCTGCAGAACAGCTGAGTTCCTTGTAGCTCATGTTTTCTCTAGCCCTGC
TCTGCTGTAGTCAGATCTCCACACCCCTTTCTGTTGTTCTGCATTGCCCCCCTTTACTACGCAT
TTTTCATGATGACCATCTAAATAGGTTAGATGTCTAGGTTAGGCAAGGCTCTTCGGGCTCCATC
CACCATATGCAGAAAGAATGGCTGTTCTGCCCTTCTCAGCCCTGCTAACCGACAGACACTAGGG
AGAGCAGCTGGGCAAGTCTATGTGGCCGGCAGGTGGGGAGGGTGAAGAGACCCTTTTTCCTTCG
TGTTAGGAAGCAGGCCACCCTGCGTCCTTTTCTCCCATTGGCTGAAGTAACCCAAAAGACAAGA
GATCCTCCCTGACTTGTGAATGGGATAGCCTATCTCAGTTCCCAAGGATCTGGACTAGATCTTC
AAAAGAGGCAAGCAGTGAATGGACACAGCTCCCAGCTCCGTTCCTGATGCATGATGGTCCTGGT
TGGGGTCAGTAAGATGGGCGGGGCAGCATGGATCGATTCATCAACTCTGTCTTGAGGAAAATCA
GAAGGAGGAGATAAAATGGGGGGAACAAGGCGGAACAAAGACTTTGTCCTTCCCCCGCTTCTGT
CTGGGGTCTGTTAATGCTGACTTGATGTGGGGTCAGCCACTTATGCTGCAGTTGTGCAGTTAGC
TTGCCAAGCAGGCTCCAATAGGCCCTTGCCTGCACTCTCTACCCTATGACCATGAGCACTGCTC
TCCGTACACCTCCCATCCCTTCCTAGCACCCCAAACGCCCCTTCCCATCTCTCCTTCCGGAAGT
TGGAAATCAAGTCAACTGGATAACGCTTGCTTGTTGTGAGGACTTGAGCAGAACGGATACAACA
ATTTACAAGTCTCTTCATATCTATGTATTCTATATTAAAGGTGATAAAGTCATGTTTCTGGGGC
GTATTCAAGTAGCTGACAAGTAATTATTTAATAATAGTACCTGAGCGCATTGTAATTTTCCTCG
CTATAGTCAGGATAGTTGGGAGTTTCCTGCCAACCTGCTGTATCCAAAGTTTTGTAAAAAGTTG
TAGAAGTTGTTGATCTTTTTGATTTTATATTCAAAAAGTCTCTTTTTATAAATATTATTTATTA
TACAATGTATATACCTTTGAGTTAACTAAGATTATATATTATATAAATATATATATATT

hide sequence

RefSeq Acc Id:

XM_017597028 ⟹ XP_017452517

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	89,215,581 - 89,224,195 (+)	NCBI
mRatBN7.2	10	88,714,509 - 88,724,170 (+)	NCBI
Rnor_6.0	10	91,867,179 - 91,874,907 (+)	NCBI

Sequence:

show sequence

CGAAAGGGCCCGGAGGCCCGGATCACCGCCGCGCGCAGTCTGCGGGCCTGGCTCGACTGCTGCG
CCAGCTCCCGCTCCGCGCTCCCCGCCGGGCTGCGGGGAAAGTGGGACGCGCCCCTGCTGTGCAG
GTGGCGCACGAGGGCTTCGTGTCTGCAAAGGCTTCTGTGGCTCTGAGTATCTCGTTCCCTGCAT
ATTCAGGACGGGTCACGACCTAGGAAAGGAGATCCGGGTCCAACCACCTGTGCAGTATAGCACG
ACCCGCTCTGGGGACCTATAATAAGAGATGGCCGGGCCTCTGGCCTCGCCGGGCCCTGTCCGTA
AAATAGGGTTTAGAACATTGTATGGAATAAAGCATACGAAAGACAGATCTGCGCGTATGCAGCA
TTCAGGGAGTGGCTTTCACTGTAACAAGGCTGGTGATACCCGTTGAGAATCTCCTGTTCTCCGA
ACCCTGGGCCCGAGGCTGAGAAACTGCCTTGTCTTGACCCCTTTGAAGGAGGAGGAGGACAGGG
AATGGGCAGCCATGGCTGAAGATGCTGTACCATTTTACAGAGTGTACTGTGAGGCGCAATGAGG
AATCTGCCTATGGGGAACTGAGGTTCGGGCGGAATGGCTGCATTAGTAGGTTAAGGCTGCAGGT
CCCAGTCTCCAGAATGGAAGGCACTGAATTGATTGGTGGAGTGCTTGCGAAGGTGCAAGGTTGG
AAGCCAAGAGCCCAAGGACAGGGTGTGGCCAATTTAGCTCTTCAGGGAGCATTCCGGTCCCATC
ATAGACCCCTCTATCTTAGCATTGTAGCCCTGAACTCAGTCTGCCCATCCACAAAGAGAATAAT
ACTAAGGTCTGGACTCTTAAGAGCAACAGGAGGGAGTCTGGCTCTTCACCCCATGACTGCCACC
CGCGAATCGGCCTTCGTGCATGCCATCGCCTCGGCTGGTGTAGCCTTCGCAGTCACGCGCTCCT
GTGCCGAGGGAACCTCTACCATCTGCGGCTGCGACTCGCATCATAAGGGGCCACCTGGAGAAGG
CTGGAAATGGGGCGGCTGCAGCGAGGACGCCGACTTCGGGGTGCTGGTGTCCCGGGAGTTTGCG
GATGCACGGGAGAACAGGCCAGATGCCCGCTCAGCTATGAACAAGCACAACAACGAGGCAGGCC
GAACGACCATCCTGGATCACATGCACCTGAAGTGCAAATGCCATGGGTTGTCTGGCAGCTGTGA
GGTGAAGACCTGCTGGTGGGCCCAGCCTGACTTCCGAGCCATTGGTGACTTCCTCAAGGACAAG
TACGACAGTGCCTCAGAGATGGTGGTGGAGAAGCATCGGGAGTCCCGAGGCTGGGTGGAGACCC
TTCGGGCCAAGTATGCACTCTTTAAGCCACCCACGGAGAGGGACCTGGTCTACTACGAGAACTC
CCCCAACTTTTGTGAGCCCAACCCAGAGACGGGCTCCTTTGGTACCAGGGACCGGACTTGCAAT
GTCACCTCCCACGGCATTGATGGCTGCGATCTGCTGTGCTGTGGCAGGGGCCACAACACCAGGA
CGGAGAAGCGGAAGGAGAAATGTCATTGCGTCTTCCACTGGTGCTGCTACGTCAGCTGCCAGGA
GTGCATTCGCATCTACGATGTACACACCTGCAAGTAGGGAAGCCAGGGCACAGGGAAGGGGTAG
ATTGTACGGCTGGATCCATTCGTCGAAGTCCCATGGGAAGCAGGATCTAGATCTGGGCCAGCCT
TTGACACGGGCCAGCAAGGAGCAAGGACGATTGCCAGCTGCATGTGATAAACAACCTGGACCCA
GCTGGCCTCGGATGGGCGGCTTCTTTCTCAACTAACGTCTCTCACCCTGCTCTGGATGGTGTGT
GGCTTCACAGAGGGGCTTTCTTTATGGTTTCCCAGGGTCTGCTGGGGACAGACCTGAGGCTTAC
CTTTGCACATGTTAAAGAAAATAAAAATGAAAAAAAAAATCTACTGCAACAGAACAGGCTGGGC
TAGTGTGAGCTCTTGGCCTGGTGGGAGAGACAAGAACATGGCGAGATTCTGTGTCCAAGCTGCC
TCTTGCTCGTGACATTCCAAGATGCCTCTGAGGTAGGAATTGTAAAATAGGATAAGACCCCTGC
AGTCTCCTTTTGTCCGTTGACTTCCATTCAAATTGGGCACACTTTGCCACTCTCAGAAAAGCCA
TAGGTATAGCCGGGATGCAGTGGTGGGGAGGCCCTTGGCCAACGGTCTTGAGTTTTGAAGACCT
CAGAGATCTGGGCAGCTTGGGAAGCCATCTGCAGAACAGCTGAGTTCCTTGTAGCTCATGTTTT
CTCTAGCCCTGCTCTGCTGTAGTCAGATCTCCACACCCCTTTCTGTTGTTCTGCATTGCCCCCC
TTTACTACGCATTTTTCATGATGACCATCTAAATAGGTTAGATGTCTAGGTTAGGCAAGGCTCT
TCGGGCTCCATCCACCATATGCAGAAAGAATGGCTGTTCTGCCCTTCTCAGCCCTGCTAACCGA
CAGACACTAGGGAGAGCAGCTGGGCAAGTCTATGTGGCCGGCAGGTGGGGAGGGTGAAGAGACC
CTTTTTCCTTCGTGTTAGGAAGCAGGCCACCCTGCGTCCTTTTCTCCCATTGGCTGAAGTAACC
CAAAAGACAAGAGATCCTCCCTGACTTGTGAATGGGATAGCCTATCTCAGTTCCCAAGGATCTG
GACTAGATCTTCAAAAGAGGCAAGCAGTGAATGGACACAGCTCCCAGCTCCGTTCCTGATGCAT
GATGGTCCTGGTTGGGGTCAGTAAGATGGGCGGGGCAGCATGGATCGATTCATCAACTCTGTCT
TGAGGAAAATCAGAAGGAGGAGATAAAATGGGGGGAACAAGGCGGAACAAAGACTTTGTCCTTC
CCCCGCTTCTGTCTGGGGTCTGTTAATGCTGACTTGATGTGGGGTCAGCCACTTATGCTGCAGT
TGTGCAGTTAGCTTGCCAAGCAGGCTCCAATAGGCCCTTGCCTGCACTCTCTACCCTATGACCA
TGAGCACTGCTCTCCGTACACCTCCCATCCCTTCCTAGCACCCCAAACGCCCCTTCCCATCTCT
CCTTCCGGAAGTTGGAAATCAAGTCAACTGGATAACGCTTGCTTGTTGTGAGGACTTGAGCAGA
ACGGATACAACAATTTACAAGTCTCTTCATATCTATGTATTCTATATTAAAGGTGATAAAGTCA
TGTTTCTGGGGCGTATTCAAGTAGCTGACAAGTAATTATTTAATAATAGTACCTGAGCGCATTG
TAATTTTCCTCGCTATAGTCAGGATAGTTGGGAGTTTCCTGCCAACCTGCTGTATCCAAAGTTT
TGTAAAAAGTTGTAGAAGTTGTTGATCTTTTTGATTTTATATTCAAAAAGTCTCTTTTTATAAA
TATTATTTATTATACAATGTATATACCTTTGAGTTAACTAAGATTATATATTATATAAATATAT
ATATATTTGGAGAAAATCTATTTCATCATGCAGTTTTTTTCTGTTAAATCATTAAAGAGAAGGT
AAACTTCAGACGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099185	(Get FASTA)	NCBI Sequence Viewer
	XP_017452517	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM06286	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000097138
	ENSRNOP00000097138.1

RefSeq Acc Id:

NP_001099185 ⟸ NM_001105715

- UniProtKB:

D3ZCR1 (UniProtKB/TrEMBL), A6HJT1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPHLLGLLLGLLLSGTRVLAGYPIWWSLALGQQYTSLASQPLLCGSIPGLVPKQLRFCRNYIE
IMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVT
RSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNE
AGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWV
ETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHN
TRTEKRKEKCHCVFHWCCYVSCQECIRIYDVHTCK

hide sequence

RefSeq Acc Id:	XP_017452517 ⟸ XM_017597028
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AN69 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLYHFTECTVRRNEESAYGELRFGRNGCISRLRLQVPVSRMEGTELIGGVLAKVQGWKPRAQGQ GVANLALQGAFRSHHRPLYLSIVALNSVCPSTKRIILRSGLLRATGGSLALHPMTATRESAFVH AIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEM VVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGID GCDLLCCGRGHNTRTEKRKEKCHCVFHWCCYVSCQECIRIYDVHTCK hide sequence

Ensembl Acc Id:

ENSRNOP00000005176 ⟸ ENSRNOT00000005176

Ensembl Acc Id:

ENSRNOP00000097138 ⟸ ENSRNOT00000096241

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZCR1-F1-model_v2	AlphaFold	D3ZCR1	1-355	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697816

Promoter ID:

EPDNEW_R8340

Type:

single initiation site

Name:

Wnt3_1

Description:

Wnt family member 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	91,830,731 - 91,830,791	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3972	AgrOrtholog
BioCyc Gene	G2FUF-23026	BioCyc
Ensembl Genes	ENSRNOG00000003845	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000096241	ENTREZGENE
	ENSRNOT00000096241.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.2460.20	UniProtKB/TrEMBL
InterPro	Wnt	UniProtKB/TrEMBL
	Wnt3	UniProtKB/TrEMBL
	Wnt_C	UniProtKB/TrEMBL
	Wnt_grthfactor_CS	UniProtKB/TrEMBL
KEGG Report	rno:24882	UniProtKB/TrEMBL
NCBI Gene	24882	ENTREZGENE
PANTHER	PROTO-ONCOGENE WNT-3	UniProtKB/TrEMBL
	Wnt	UniProtKB/TrEMBL
Pfam	wnt	UniProtKB/TrEMBL
PhenoGen	Wnt3	PhenoGen
PRINTS	WNT3PROTEIN	UniProtKB/TrEMBL
	WNTPROTEIN	UniProtKB/TrEMBL
PROSITE	WNT1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003845	RatGTEx
SMART	WNT1	UniProtKB/TrEMBL
UniProt	A0A8I6AN69	ENTREZGENE, UniProtKB/TrEMBL
	A6HJT1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZCR1	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-29	Wnt3	Wnt family member 3	Wnt3	wingless-type MMTV integration site family, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-14	Wnt3	wingless-type MMTV integration site family, member 3	Wnt3	wingless-related MMTV integration site 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Wnt3	wingless-related MMTV integration site 3	Wnt3_predicted	wingless-type MMTV integration site family, member 3 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-17	Wnt3_predicted	wingless-type MMTV integration site family, member 3 (predicted)	Wnt3	wingless-type MMTV integration site family, member 3	Symbol and name updated to reflect predicted status	1299863	APPROVED
2007-02-19	Wnt3	wingless-type MMTV integration site family, member 3	Wnt3_mapped	wingless-type MMTV integration site family, member 3 (mapped)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	PROVISIONAL
2007-02-19	Wnt3_mapped	wingless-type MMTV integration site family, member 3 (mapped)	Wnt3_retired	wingless-type MMTV integration site family, member 3 (mapped)	Data merged from RGD:1597194	737654	PROVISIONAL
2007-02-19	Wnt3_retired		Wnt3	wingless-type MMTV integration site family, member 3 (mapped)	Symbol updated	1299863	PROVISIONAL
2006-11-20	Wnt3	wingless-type MMTV integration site family, member 3 (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Wnt3_mapped	wingless-type MMTV integration site family, member 3 (mapped)			Symbol and Name updated	1556543	APPROVED
2003-04-09	Wnt3	wingless-type MMTV integration site family, member 3		Wingless-type MMTV integration site 3, homolog	Name updated	629478	APPROVED
2002-06-10	Wnt3	Wingless-type MMTV integration site 3, homolog			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_product	predicted to be a member of the Wnt family of glycoproteins which regulate cell proliferation, cell differentiation, and determination of cell fate	1300513

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)