Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
RGD ID: 69325
Description: Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity and heme binding activity. Involved in several processes, including cellular response to cytokine stimulus; nervous system development; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-citrinin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholesterol desmolase; cholesterol side-chain cleavage cytochrome P450; cholesterol side-chain cleavage enzyme; cholesterol side-chain cleavage enzyme, mitochondrial; Cyp11a; Cypxia1; cytochrome P450 11a cholesterol side chain cleavage; cytochrome P450 11A1; cytochrome P450 family 11 subfamily a; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; cytochrome P450(scc); cytochrome P450, 11a, cholesterol side; cytochrome P450, subfamily 11A; P450(scc); P450scc
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,318,665 - 67,330,196 (+)NCBIGRCr8
mRatBN7.2858,422,807 - 58,434,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,404,669 - 58,434,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,953,220 - 63,964,751 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,230,774 - 62,242,305 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,095,340 - 60,106,871 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,798,317 - 62,809,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,779,875 - 62,809,893 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,525,349 - 62,585,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,793,976 - 61,805,308 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,812,986 - 61,824,536 (+)NCBI
Celera857,887,124 - 57,898,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-citrinin  (EXP)
(E)-thiamethoxam  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,3-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-dibromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2-bromophenol  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (EXP)
20-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP,ISO)
acetaldehyde  (ISO)
acetamiprid  (EXP,ISO)
Acetyl tributyl citrate  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
aminoglutethimide  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amoxicillin  (ISO)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (EXP)
androstane-3,17-diol  (EXP)
antalarmin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apigenin  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
astressin  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
beta-naphthoflavone  (ISO)
bicalutamide  (EXP)
bifenthrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromocriptine  (EXP)
bucladesine  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chitosan  (EXP)
chlordecone  (ISO)
chlormequat chloride  (EXP)
Chloroacetonitrile  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cholesterol sulfate  (ISO)
Chorionic gonadotropin  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-aspartic acid  (EXP)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (EXP)
dichlorine  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl hydrogen phosphate  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diheptyl phthalate  (EXP)
diiodine  (ISO)
diisobutyl phthalate  (EXP,ISO)
Diisodecyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dimethoate  (EXP,ISO)
Dimethyl phthalate  (EXP,ISO)
dipentyl phthalate  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (ISO)
equol  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenvalerate  (EXP,ISO)
finasteride  (EXP)
fisetin  (EXP)
flavonoids  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
formestane  (EXP)
fulvestrant  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
gentamycin  (EXP)
glycine  (ISO)
glycitein  (EXP)
glycitin  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
GW 3965  (ISO)
herbicide  (EXP)
hexachlorobenzene  (ISO)
hexane  (EXP)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
hydroxyflutamide  (ISO)
icariin  (ISO)
imidacloprid  (EXP,ISO)
iodoacetic acid  (ISO)
isoflavones  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
letrozole  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lycopene  (EXP)
malathion  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
metyrapone  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
nimodipine  (ISO)
Nodularin  (EXP)
Nonylphenol  (EXP)
Octicizer  (ISO)
octreotide  (EXP,ISO)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pasireotide  (EXP,ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (ISO)
perflubron  (ISO)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Piperophos  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone  (EXP,ISO)
prochloraz  (ISO)
procymidone  (EXP,ISO)
profenofos  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rutin  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
senecionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulpiride  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
taurine  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
tetrachloroethene  (ISO)
thiacloprid  (ISO)
thiamethoxam  (EXP)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
torcetrapib  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichlorfon  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (EXP)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
undecane  (EXP)
uranium atom  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vitamin K  (EXP)
wortmannin  (EXP)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc oxide  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biphenyl metabolic process  (IEP)
C21-steroid hormone biosynthetic process  (IBA,IDA,IEA,ISO)
C21-steroid hormone metabolic process  (IEA)
cellular response to antibiotic  (IEP)
cellular response to cadmium ion  (IEP)
cellular response to cAMP  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to peptide hormone stimulus  (IBA,IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cerebellum development  (IEP)
cholesterol metabolic process  (IBA,IEA,ISO,ISS)
cortisol metabolic process  (IBA)
dibenzo-p-dioxin metabolic process  (IEP)
glucocorticoid biosynthetic process  (IBA)
granulosa cell differentiation  (IEP)
hippocampus development  (IEP)
hormone biosynthetic process  (IEA)
Leydig cell differentiation  (IEP)
male gonad development  (IEP)
maternal process involved in female pregnancy  (IEP)
mating behavior  (IMP)
organic acid metabolic process  (IEP)
phenol-containing compound metabolic process  (IEP)
response to alkaloid  (IEP)
response to amino acid  (IEP)
response to cadmium ion  (IEP)
response to cAMP  (IEP)
response to corticosterone  (IEP)
response to estrogen  (IEP)
response to fungicide  (IEP)
response to gamma radiation  (IEP)
response to genistein  (IEP)
response to gonadotropin  (IEP)
response to hydrogen peroxide  (IMP)
response to insecticide  (IEP)
response to ionizing radiation  (IEP)
response to L-ascorbic acid  (IEP)
response to nutrient  (IEP)
response to peptide hormone  (IEP)
response to salt stress  (IEP)
response to steroid hormone  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
Schwann cell differentiation  (IEP)
steroid biosynthetic process  (IEA,IMP)
testosterone biosynthetic process  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Adamsson A, etal., Int J Androl. 2009 Oct;32(5):575-85. Epub 2008 Jul 9.
2. Parabens inhibit the early phase of folliculogenesis and steroidogenesis in the ovaries of neonatal rats. Ahn HJ, etal., Mol Reprod Dev. 2012 Sep;79(9):626-36. doi: 10.1002/mrd.22070. Epub 2012 Jul 26.
3. Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element. Ben-Zimra M, etal., Mol Endocrinol 2002 Aug;16(8):1864-80.
4. Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. Biagini G, etal., Exp Neurol. 2006 Oct;201(2):519-24. Epub 2006 Jun 14.
5. Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis. Brokken LJ, etal., Endocrinology. 2009 Jan;150(1):445-51. Epub 2008 Sep 4.
6. Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy. Cermenati G, etal., J Neurosci. 2010 Sep 8;30(36):11896-901.
7. Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells. Chabrolle C, etal., Reprod Biol Endocrinol. 2008 Mar 19;6:11.
8. Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat. Chen M, etal., Exp Toxicol Pathol. 2007 Nov;59(3-4):245-51. Epub 2007 Sep 19.
9. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Chen YJ, etal., Endocrinology. 2008 Sep;149(9):4658-68. Epub 2008 May 29.
10. Changes in cytochrome P450 side chain cleavage expression in the rat hippocampus after kainate injury. Chia WJ, etal., Exp Brain Res. 2008 Mar;186(1):143-9. Epub 2007 Nov 27.
11. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. Couto JA, etal., Reprod Biol Endocrinol. 2010 Feb 9;8:13.
12. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
13. Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Elumalai P, etal., Reprod Toxicol. 2009 Jan;27(1):41-5. Epub 2008 Nov 24.
14. Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation. Escamilla-Hernandez R, etal., Mol Endocrinol. 2008 Aug;22(8):1842-52. Epub 2008 Jun 5.
15. Fenvalerate inhibits the growth of primary cultured rat preantral ovarian follicles. Fei J, etal., Toxicology. 2010 Jan 12;267(1-3):1-6. Epub 2009 Nov 3.
16. Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Feng Y, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Basic concepts and recent developments in human steroid hormone biosynthesis. Ghayee HK and Auchus RJ, Rev Endocr Metab Disord. 2007 Dec;8(4):289-300.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Grasfeder LL, etal., Mol Endocrinol. 2009 Aug;23(8):1171-82. Epub 2009 Apr 23.
21. In vivo effects of chronic contamination with 137 cesium on testicular and adrenal steroidogenesis. Grignard E, etal., Arch Toxicol. 2008 Sep;82(9):583-9. Epub 2007 Nov 29.
22. Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat. Grignard E, etal., Int J Toxicol. 2008 Jul-Aug;27(4):323-8.
23. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
24. Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc). Han DY, etal., Toxicol Ind Health. 2010 Jun;26(5):287-96. Epub 2010 Mar 31.
25. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, etal., J Cell Biol. 1990 Oct;111(4):1373-81.
26. Lipopolysaccharide directly stimulates aldosterone production via toll-like receptor 2 and toll-like receptor 4 related PI(3)K/Akt pathway in rat adrenal zona glomerulosa cells. Huang HL, etal., J Cell Biochem. 2010 Nov 1;111(4):872-80.
27. Differences in adrenocortical secretory and gene expression responses to stimulation in vitro by ACTH or prolactin between high- and low-avoidance Hatano rats. Jaroenporn S, etal., Stress. 2009;12(1):22-9.
28. Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans. Katsumata N, etal., J Clin Endocrinol Metab. 2002 Aug;87(8):3808-13.
29. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
30. Effects of maternal exposure to low doses of DES on testicular steroidogenesis and spermatogenesis in male rat offspring. Kobayashi T, etal., J Reprod Dev. 2009 Dec;55(6):629-37. Epub 2009 Sep 7.
31. Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat. Kubota K, etal., J Reprod Dev. 2003 Oct;49(5):403-12.
32. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones. Kumar V, etal., Food Chem Toxicol. 2008 Dec;46(12):3563-70. Epub 2008 Aug 31.
33. Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system. Kumar V, etal., J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):208-16. Epub 2008 Jun 18.
34. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan. Kumar V, etal., Reprod Toxicol. 2009 Apr;27(2):177-85. Epub 2008 Dec 11.
35. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9.
36. Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome p450scc, and aromatase in the olivocerebellar system. Lavaque E, etal., J Neurobiol. 2006 Feb 15;66(3):308-18.
37. Interferon-alpha is involved in the luteinizing hormone-induced differentiation of rat preovulatory granulosa cells. Lee da L, etal., J Interferon Cytokine Res. 2009 Dec;29(12):801-8.
38. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
39. Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels. Lin T, etal., J Endocrinol. 1998 Mar;156(3):461-7.
40. Recombinant murine tumor necrosis factor-alpha inhibits cholesterol side-chain cleavage cytochrome P450 and insulin-like growth factor-I gene expression in rat Leydig cells. Lin T, etal., Mol Cell Endocrinol. 1994 May;101(1-2):111-9.
41. Rat cholesterol side-chain cleavage enzyme (P-450scc): use of a cDNA probe to study the hormonal regulation of P-450scc mRNA levels in ovarian granulosa cells. McMasters KM, etal., Gene 1987;57(1):1-9.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
44. In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity. Murono EP, etal., Reprod Toxicol. 2006 Feb;21(2):148-53. Epub 2005 Oct 12.
45. Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Murrell JR, etal., Circulation. 2005 Aug 30;112(9):1301-8. Epub 2005 Aug 22.
46. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Murugesan P, etal., Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16.
47. Exposure of neonatal rats to diethylstilbestrol affects the expression of genes involved in ovarian differentiation. Nagai A, etal., J Med Dent Sci. 2003 Mar;50(1):35-40.
48. Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats. Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34.
49. A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. Nakamura E, etal., Endocrinology. 2010 Nov;151(11):5506-18. Epub 2010 Sep 1.
50. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Development of relevant assay system to identify steroidogenic enzyme inhibitors. Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7.
52. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
53. Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure. Ohtani T, etal., J Hypertens. 2009 May;27(5):1074-83.
54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
55. Cyclic AMP-dependent and -independent regulation of cholesterol side chain cleavage cytochrome P-450 (P-450scc) in rat ovarian granulosa cells and corpora lutea. cDNA and deduced amino acid sequence of rat P-450scc. Oonk RB, etal., J Biol Chem 1989 Dec 25;264(36):21934-42.
56. Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitro. Oonk RB, etal., J Biol Chem 1990 Dec 25;265(36):22392-401.
57. Localization and functional activity of Cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney. Pagotto MA, etal., Mol Cell Endocrinol. 2010 Nov 11.
58. Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis. Parthasarathy C and Balasubramanian K, J Cell Biochem. 2008 Aug 1;104(5):1671-83.
59. Neurogenic pain and steroid synthesis in the spinal cord. Patte-Mensah C, etal., J Mol Neurosci. 2006;28(1):17-31.
60. Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. Pelletier G, etal., J Endocrinol. 2001 Nov;171(2):373-83.
61. Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum. Peluffo MC, etal., Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1215-23. Epub 2007 Aug 28.
62. Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome. Pena-Rico M, etal., Life Sci. 2006 Jul 10;79(7):702-8. Epub 2006 Feb 28.
63. Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus. Petralia SM, etal., J Neuroendocrinol. 2005 Sep;17(9):545-52.
64. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
65. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
66. GOA pipeline RGD automated data pipeline
67. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. Expression of prepro-ghrelin and related receptor genes in the rat adrenal gland and evidences that ghrelin exerts a potent stimulating effect on corticosterone secretion by cultured rat adrenocortical cells. Rucinski M, etal., Peptides. 2009 Aug;30(8):1448-55. Epub 2009 May 4.
70. Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate. Ryu JY, etal., J Toxicol Environ Health A. 2008;71(23):1542-9.
71. Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Sen Gupta R, etal., Mol Cell Endocrinol. 2004 Jun 30;221(1-2):57-66.
72. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Shi Z, etal., Toxicol Sci. 2007 Jul;98(1):206-15. Epub 2007 Mar 30.
73. Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats. Shirakawa H, etal., Biochim Biophys Acta. 2006 Oct;1760(10):1482-8. Epub 2006 Jun 6.
74. The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats. Song L, etal., Steroids. 2010 Mar;75(3):213-8. Epub 2009 Dec 2.
75. Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis. Svechnikov K, etal., J Endocrinol. 2005 Oct;187(1):117-24.
76. Transcriptional activation of adrenocortical steroidogenic genes by high potassium or low sodium intake. Tremblay A and LeHoux JG, FEBS Lett. 1993 Feb 15;317(3):211-5.
77. Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. Tsai SC, etal., J Cell Biochem. 2003 Dec 15;90(6):1276-86.
78. Differential effects of nonylphenol on testosterone secretion in rat Leydig cells. Wu JJ, etal., Toxicology. 2010 Jan 31;268(1-2):1-7. Epub 2009 Oct 31.
79. Zhonghua nan ke xue = National journal of andrology Wu XY, etal., Zhonghua Nan Ke Xue. 2008 Apr;14(4):371-6.
80. Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Yacobi K, etal., Endocrinology. 2007 Apr;148(4):1717-26. Epub 2007 Jan 11.
81. Effect and mechanism of cadmium on the progesterone synthesis of ovaries. Zhang W and Jia H, Toxicology. 2007 Oct 8;239(3):204-12. Epub 2007 Jul 13.
82. Gonadotropin stimulation of ovarian fractalkine expression and fractalkine augmentation of progesterone biosynthesis by luteinizing granulosa cells. Zhao P, etal., Endocrinology. 2008 Jun;149(6):2782-9. Epub 2008 Feb 21.
83. Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells. Zhou W, etal., Mol Cell Endocrinol. 2008 Feb 13;283(1-2):12-8. Epub 2007 Oct 25.
84. Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells. Zhu TS and Glaser M, Mol Cell Biochem. 2008 Jun;313(1-2):79-89. Epub 2008 Mar 31.
Additional References at PubMed
PMID:7527351   PMID:8111631   PMID:11502818   PMID:12477932   PMID:12911631   PMID:14651853   PMID:15026086   PMID:16098191   PMID:16354159   PMID:17400582   PMID:18065196   PMID:18182448  
PMID:18296822   PMID:18410379   PMID:18614015   PMID:20568448   PMID:21273442   PMID:21636783   PMID:22217827   PMID:22674924   PMID:22798247   PMID:23332974   PMID:24713504   PMID:24760842  
PMID:27428926   PMID:30884106   PMID:34038751   PMID:34215832   PMID:39094930  


Genomics

Comparative Map Data
Cyp11a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,318,665 - 67,330,196 (+)NCBIGRCr8
mRatBN7.2858,422,807 - 58,434,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,404,669 - 58,434,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,953,220 - 63,964,751 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,230,774 - 62,242,305 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,095,340 - 60,106,871 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,798,317 - 62,809,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,779,875 - 62,809,893 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,525,349 - 62,585,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,793,976 - 61,805,308 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,812,986 - 61,824,536 (+)NCBI
Celera857,887,124 - 57,898,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
CYP11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,337,762 - 74,367,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,337,759 - 74,367,646 (-)EnsemblGRCh38hg38GRCh38
GRCh371574,630,103 - 74,659,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,417,156 - 72,447,134 (-)NCBINCBI36Build 36hg18NCBI36
Build 341572,417,156 - 72,447,020NCBI
Celera1551,578,744 - 51,607,311 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,425,968 - 51,455,911 (-)NCBIHuRef
CHM1_11574,748,248 - 74,778,221 (-)NCBICHM1_1
T2T-CHM13v2.01572,205,513 - 72,235,390 (-)NCBIT2T-CHM13v2.0
Cyp11a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,905,307 - 57,934,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,913,694 - 57,934,306 (+)EnsemblGRCm39 Ensembl
GRCm38957,998,024 - 58,027,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,006,411 - 58,027,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv37957,862,824 - 57,874,830 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,813,153 - 57,825,158 (+)NCBIMGSCv36mm8
Celera955,247,551 - 55,259,829 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.63NCBI
LOC102014960
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,474,491 - 3,484,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,433,310 - 3,484,462 (+)NCBIChiLan1.0ChiLan1.0
CYP11A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,565,244 - 63,596,156 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11567,728,964 - 67,759,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,280,110 - 53,310,868 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11572,901,274 - 72,931,614 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1572,901,286 - 72,931,164 (-)Ensemblpanpan1.1panPan2
CYP11A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,474,997 - 37,487,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,473,901 - 37,487,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,409,316 - 37,421,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03037,680,903 - 37,692,929 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,677,046 - 37,692,855 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,633,421 - 37,645,467 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,658,685 - 37,670,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,914,475 - 37,926,521 (-)NCBIUU_Cfam_GSD_1.0
LOC101975820
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,519,508 - 115,532,788 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,367,810 - 33,380,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,367,810 - 33,380,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP11A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl759,175,758 - 59,188,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1759,172,829 - 59,188,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP11A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1269,122,008 - 9,151,844 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048132,473,434 - 132,503,785 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101704598
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781288,594 - 300,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624781288,594 - 298,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp11a1
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:113
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000010831
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat

Markers in Region
PMC27916P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,434,073 - 58,434,223 (+)MAPPERmRatBN7.2
Rnor_6.0862,809,584 - 62,809,733NCBIRnor6.0
Rnor_5.0862,585,347 - 62,585,496UniSTSRnor5.0
RGSC_v3.4861,805,218 - 61,805,367UniSTSRGSC3.4
Celera857,898,391 - 57,898,540UniSTS
Cytogenetic Map8q24UniSTS
RH134353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,434,054 - 58,434,263 (+)MAPPERmRatBN7.2
Rnor_6.0862,809,565 - 62,809,773NCBIRnor6.0
Rnor_5.0862,585,328 - 62,585,536UniSTSRnor5.0
RGSC_v3.4861,805,199 - 61,805,407UniSTSRGSC3.4
Celera857,898,372 - 57,898,580UniSTS
RH 3.4 Map6783.7UniSTS
Cytogenetic Map8q24UniSTS
PMC140651P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,427,387 - 58,427,465 (+)MAPPERmRatBN7.2
Rnor_6.0862,802,898 - 62,802,975NCBIRnor6.0
Rnor_5.0862,578,661 - 62,578,738UniSTSRnor5.0
RGSC_v3.4861,798,532 - 61,798,609UniSTSRGSC3.4
Celera857,891,705 - 57,891,782UniSTS
Cytogenetic Map8q24UniSTS
UniSTS:464661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,432,511 - 58,432,901 (+)MAPPERmRatBN7.2
Rnor_6.0862,808,022 - 62,808,411NCBIRnor6.0
Rnor_5.0862,583,785 - 62,584,174UniSTSRnor5.0
RGSC_v3.4861,803,656 - 61,804,045UniSTSRGSC3.4
Celera857,896,829 - 57,897,218UniSTS
Cytogenetic Map8q24UniSTS
UniSTS:257092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,422,810 - 58,424,326 (+)MAPPERmRatBN7.2
Rnor_6.0862,798,321 - 62,799,836NCBIRnor6.0
Rnor_5.0862,574,084 - 62,575,599UniSTSRnor5.0
RGSC_v3.4861,793,955 - 61,795,470UniSTSRGSC3.4
Celera857,887,128 - 57,888,643UniSTS
Cytogenetic Map8q24UniSTS
UniSTS:474701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,432,441 - 58,433,521 (+)MAPPERmRatBN7.2
Rnor_6.0862,807,952 - 62,809,031NCBIRnor6.0
Rnor_5.0862,583,715 - 62,584,794UniSTSRnor5.0
RGSC_v3.4861,803,586 - 61,804,665UniSTSRGSC3.4
Celera857,896,759 - 57,897,838UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 49 109 66 64 34 25 34 6 189 93 89 45 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000010831   ⟹   ENSRNOP00000010831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,404,669 - 58,434,338 (+)Ensembl
Rnor_6.0 Ensembl862,779,875 - 62,809,893 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106594   ⟹   ENSRNOP00000088079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,422,807 - 58,434,169 (+)Ensembl
RefSeq Acc Id: NM_017286   ⟹   NP_058982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,318,665 - 67,330,196 (+)NCBI
mRatBN7.2858,422,807 - 58,434,338 (+)NCBI
Rnor_6.0862,798,317 - 62,809,848 (+)NCBI
Rnor_5.0862,525,349 - 62,585,615 (+)NCBI
RGSC_v3.4861,793,976 - 61,805,308 (+)RGD
Celera857,887,124 - 57,898,655 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058982   ⟸   NM_017286
- Peptide Label: precursor
- UniProtKB: Q5FWY8 (UniProtKB/Swiss-Prot),   Q6LDR9 (UniProtKB/Swiss-Prot),   P14137 (UniProtKB/Swiss-Prot),   A6J4Y6 (UniProtKB/TrEMBL),   A0A8I6AA11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010831   ⟸   ENSRNOT00000010831
Ensembl Acc Id: ENSRNOP00000088079   ⟸   ENSRNOT00000106594

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14137-F1-model_v2 AlphaFold P14137 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69325 AgrOrtholog
BioCyc Gene G2FUF-30282 BioCyc
BioCyc Pathway PWY66-377 [pregnenolone biosynthesis] BioCyc
BioCyc Pathway Image PWY66-377 BioCyc
Ensembl Genes ENSRNOG00000008074 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010831.7 UniProtKB/TrEMBL
  ENSRNOT00000106594.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7307104 IMAGE-MGC_LOAD
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29680 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105469 IMAGE-MGC_LOAD
NCBI Gene 29680 ENTREZGENE
PANTHER PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24279:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp11a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008074 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHG1_RAT UniProtKB/TrEMBL
  A0A8I6AA11 ENTREZGENE, UniProtKB/TrEMBL
  A6J4Y6 ENTREZGENE, UniProtKB/TrEMBL
  CP11A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FWY8 ENTREZGENE
  Q6LDR9 ENTREZGENE
UniProt Secondary Q5FWY8 UniProtKB/Swiss-Prot
  Q6LDR9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp11a1  cytochrome P450, family 11, subfamily a, polypeptide 1  Cyp11a  cytochrome P450, subfamily 11A  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cyp11a  cytochrome P450, subfamily 11A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed from placentation to midgestation 632560