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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDLead results in decreased expression of CYP11A1 proteinPMID:25981801
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of CYP11A1 mRNA; Taurine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CYP11A1 mRNA]PMID:36484981
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