CYP11A1 (cytochrome P450 family 11 subfamily A member 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CYP11A1 (cytochrome P450 family 11 subfamily A member 1) Canis lupus familiaris
Analyze
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
RGD ID: 12288408
Description: ENCODES a protein that exhibits cholesterol binding (ortholog); cholesterol monooxygenase (side-chain-cleaving) activity (ortholog); heme binding (ortholog); INVOLVED IN biphenyl metabolic process (ortholog); C21-steroid hormone biosynthetic process (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH 46, XY Disorders of Sex Development (ortholog); Adrenal Insufficiency (ortholog); Bloom syndrome (ortholog); FOUND IN mitochondrial crista (ortholog); mitochondrial inner membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P450, family 11, subfamily A, polypeptide 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,474,997 - 37,487,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,473,901 - 37,487,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,409,316 - 37,421,325 (-)NCBI
ROS_Cfam_1.03037,680,903 - 37,692,929 (-)NCBI
UMICH_Zoey_3.13037,633,421 - 37,645,467 (-)NCBI
UNSW_CanFamBas_1.03037,658,685 - 37,670,696 (-)NCBI
UU_Cfam_GSD_1.03037,914,475 - 37,926,521 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biphenyl metabolic process  (ISO)
C21-steroid hormone biosynthetic process  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cAMP  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebellum development  (ISO)
cholesterol metabolic process  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
granulosa cell differentiation  (ISO)
hippocampus development  (ISO)
Leydig cell differentiation  (ISO)
male gonad development  (ISO)
maternal process involved in female pregnancy  (ISO)
mating behavior  (ISO)
organic acid metabolic process  (ISO)
phenol-containing compound metabolic process  (ISO)
phthalate metabolic process  (ISO)
response to alkaloid  (ISO)
response to amino acid  (ISO)
response to antibiotic  (ISO)
response to cadmium ion  (ISO)
response to cAMP  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to fungicide  (ISO)
response to gamma radiation  (ISO)
response to genistein  (ISO)
response to gonadotropin  (ISO)
response to hydrogen peroxide  (ISO)
response to insecticide  (ISO)
response to ionizing radiation  (ISO)
response to L-ascorbic acid  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to peptide hormone  (ISO)
response to salt stress  (ISO)
response to steroid hormone  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
Schwann cell differentiation  (ISO)
steroid biosynthetic process  (ISO)
testosterone biosynthetic process  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
CYP11A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,474,997 - 37,487,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,473,901 - 37,487,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,409,316 - 37,421,325 (-)NCBI
ROS_Cfam_1.03037,680,903 - 37,692,929 (-)NCBI
UMICH_Zoey_3.13037,633,421 - 37,645,467 (-)NCBI
UNSW_CanFamBas_1.03037,658,685 - 37,670,696 (-)NCBI
UU_Cfam_GSD_1.03037,914,475 - 37,926,521 (-)NCBI
CYP11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1574,337,759 - 74,367,646 (-)EnsemblGRCh38hg38GRCh38
GRCh381574,337,762 - 74,367,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371574,630,103 - 74,659,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,417,156 - 72,447,134 (-)NCBINCBI36hg18NCBI36
Build 341572,417,156 - 72,447,020NCBI
Celera1551,578,744 - 51,607,311 (-)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1551,425,968 - 51,455,911 (-)NCBIHuRef
CHM1_11574,748,248 - 74,778,221 (-)NCBICHM1_1
Cyp11a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,905,307 - 57,934,314 (+)NCBIGRCm39mm39
GRCm39 Ensembl957,913,694 - 57,934,306 (+)Ensembl
GRCm38957,998,024 - 58,027,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,006,411 - 58,027,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv37957,862,824 - 57,874,830 (+)NCBIGRCm37mm9NCBIm37
MGSCv36957,813,153 - 57,825,158 (+)NCBImm8
Celera955,247,551 - 55,259,829 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.63NCBI
Cyp11a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2858,422,807 - 58,434,342 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl858,404,669 - 58,434,338 (+)Ensembl
Rnor_6.0862,798,317 - 62,809,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,779,875 - 62,809,893 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,525,349 - 62,585,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,793,976 - 61,805,308 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1861,812,986 - 61,824,536 (+)NCBI
Celera857,887,124 - 57,898,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
LOC102014960
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,474,491 - 3,484,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,433,310 - 3,484,462 (+)NCBIChiLan1.0ChiLan1.0
CYP11A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11572,901,274 - 72,931,614 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1572,901,286 - 72,931,164 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01553,280,110 - 53,310,868 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101975820
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,519,508 - 115,532,788 (-)NCBI
SpeTri2.0NW_00493647133,367,810 - 33,380,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP11A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl759,175,758 - 59,188,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1759,172,829 - 59,188,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP11A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1269,122,008 - 9,151,844 (+)NCBI
Vero_WHO_p1.0NW_023666048132,473,434 - 132,503,785 (-)NCBI
LOC101704598
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624781288,594 - 298,876 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5
Medium
Low 3 2 3 8 4 1
Below cutoff 5 5 14 6 6 6 4 6 9 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028390   ⟹   ENSCAFP00000026404
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3037,473,901 - 37,487,507 (-)Ensembl
RefSeq Acc Id: XM_038442928   ⟹   XP_038298856
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03037,680,903 - 37,692,929 (-)NCBI
RefSeq Acc Id: XM_038517365   ⟹   XP_038373293
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13037,633,421 - 37,645,467 (-)NCBI
RefSeq Acc Id: XM_038580963   ⟹   XP_038436891
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03037,914,475 - 37,926,521 (-)NCBI
RefSeq Acc Id: XM_038645326   ⟹   XP_038501254
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03037,658,685 - 37,670,696 (-)NCBI
RefSeq Acc Id: XM_535539   ⟹   XP_535539
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13037,474,997 - 37,487,028 (-)NCBI
Dog10K_Boxer_Tasha3037,409,316 - 37,421,325 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038298856 (Get FASTA)   NCBI Sequence Viewer  
  XP_038373293 (Get FASTA)   NCBI Sequence Viewer  
  XP_038436891 (Get FASTA)   NCBI Sequence Viewer  
  XP_038501254 (Get FASTA)   NCBI Sequence Viewer  
  XP_535539 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_535539   ⟸   XM_535539
- Sequence:
RefSeq Acc Id: ENSCAFP00000026404   ⟸   ENSCAFT00000028390
RefSeq Acc Id: XP_038373293   ⟸   XM_038517365
RefSeq Acc Id: XP_038501254   ⟸   XM_038645326
RefSeq Acc Id: XP_038298856   ⟸   XM_038442928
RefSeq Acc Id: XP_038436891   ⟸   XM_038580963


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017888 Ensembl, ENTREZGENE
NCBI Gene CYP11A1 ENTREZGENE
VGNC ID VGNC:50329 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYP11A1  cytochrome P450 family 11 subfamily A member 1    cytochrome P450, family 11, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED