Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases activityISOCyp11a1 (Mus musculus)6480464CTDGlyphosate results in decreased activity of CYP11A1 proteinPMID:10964798
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDGlyphosate results in decreased expression of CYP11A1 mRNAPMID:33957581
Cyp11a1increases expressionISOCyp11a1 (Mus musculus)6480464CTDGlyphosate results in increased expression of CYP11A1 mRNAPMID:30245445
Go Back to source page   Continue to Ontology report