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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:16422
Term: androst-4-ene-3,17-dione
Definition: A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Chemical ID: MESH:D000735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1increases expressionEXP 6480464CTDAndrostenedione results in increased expression of CYP11A1 mRNAPMID:21273442
Cyp11a1multiple interactionsEXP 6480464CTD[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione; bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]; Finasteride promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]PMID:21273442 PMID:23873838
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