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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDlead acetate results in decreased expression of CYP11A1 proteinPMID:25981801
Cyp11a1multiple interactionsEXP 6480464CTD[cadmium acetate co-treated with lead acetate] results in decreased expression of CYP11A1 mRNAPMID:21182167
Cyp11a1decreases activityISOCyp11a1 (Mus musculus)6480464CTDlead acetate results in decreased activity of CYP11A1 proteinPMID:12647776
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDlead acetate results in decreased expression of CYP11A1 mRNA; lead acetate results in decreased expression of CYP11A1 proteinPMID:22806249 PMID:25270620 PMID:36088639
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of CYP11A1 mRNA; Glycine inhibits the reaction [lead acetate results in decreased expression of CYP11A1 mRNA]; Taurine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CYP11A1 mRNA]PMID:36088639 PMID:36484981
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