GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp11a1 | decreases expression | ISO | CYP11A1 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of CYP11A1 mRNA | PMID:21641976 | Cyp11a1 | decreases expression | ISO | Cyp11a1 (Mus musculus) | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of CYP11A1 mRNA; perfluorooctanoic acid results in decreased expression of CYP11A1 protein | PMID:21712084 PMID:22414604 PMID:28219760 PMID:29721586 PMID:35104888 | Cyp11a1 | multiple interactions | ISO | Cyp11a1 (Mus musculus) | 6480464 | CTD | PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of CYP11A1 protein]; SERPINA6 protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of CYP11A1 protein] | PMID:22414604 PMID:29721586 | |
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