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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1increases activityEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased activity of CYP11A1 proteinPMID:22525294
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of CYP11A1 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of CYP11A1 proteinPMID:22401849 PMID:34627990
Cyp11a1increases expressionISOCYP11A1 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of CYP11A1 mRNAPMID:29089286
Cyp11a1increases expressionISOCyp11a1 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of CYP11A1 mRNAPMID:27181934
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of CYP11A1 mRNA; [monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in decreased expression of CYP11A1 mRNAPMID:27181934 PMID:31884101
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