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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11a1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CYP11A1 mRNA; Cadmium Chloride results in decreased expression of CYP11A1 proteinPMID:17719163 PMID:25981801 PMID:29214744
Cyp11a1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of CYP11A1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of CYP11A1 proteinPMID:31654709
Cyp11a1decreases activityISOCYP11A1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased activity of CYP11A1 proteinPMID:12080015
Cyp11a1decreases expressionISOCYP11A1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of CYP11A1 mRNAPMID:12080015
Cyp11a1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of CYP11A1 mRNA; Cadmium Chloride results in decreased expression of CYP11A1 proteinPMID:19897027 PMID:24982889 PMID:31014900
Cyp11a1multiple interactionsISOCyp11a1 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CYP11A1 mRNA; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [Cadmium Chloride results in decreased expression of CYP11A1 protein]PMID:31014900 PMID:32199951
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