Wnt7a (Wnt family member 7A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Wnt7a (Wnt family member 7A) Rattus norvegicus
Analyze
Symbol: Wnt7a
Name: Wnt family member 7A
RGD ID: 69079
Description: Enables frizzled binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of JNK cascade; and response to estradiol. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in Schaffer collateral - CA1 synapse; extracellular space; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family, member 7A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,420,276 - 125,466,149 (-)NCBIGRCr8
mRatBN7.24123,863,108 - 123,908,981 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,329,923 - 129,375,873 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,104,358 - 125,150,304 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04123,728,903 - 123,774,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,994,425 - 123,040,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04187,505,391 - 187,551,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,541,281 - 125,586,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14125,786,638 - 125,787,010 (-)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatExperimental Mammary Neoplasms  ISOWnt7a (Mus musculus)2298848in vitro transformation of transfected C57MG mammary epithelial cell lineRGD 
Wnt7aRatExperimental Mammary Neoplasms  ISOWnt7a (Mus musculus)2298863in vitro transformation of transfected C57MG mammary epithelial cell lineRGD 
Wnt7aRatleiomyoma  ISOWNT7A (Homo sapiens)2298847 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRat3p deletion syndrome  ISOWNT7A (Homo sapiens)8554872ClinVar Annotator: match by term: 3p- syndromeClinVarPMID:31690835
Wnt7aRatbladder exstrophy-epispadias-cloacal exstrophy complex  ISOWNT7A (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder exstrophy-epispadias-cloacal exstrophy complexClinVar 
Wnt7aRatFuhrmann syndrome  ISOWNT7A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12809666 more ...
Wnt7aRatgenetic disease  ISOWNT7A (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Wnt7aRatSantos Syndrome  ISOWNT7A (Homo sapiens)8554872ClinVar Annotator: match by term: Santos syndromeClinVarPMID:19012338 and PMID:28855715
Wnt7aRatSchinzel type phocomelia  ISOWNT7A (Homo sapiens)8554872ClinVar Annotator: match by term: Schinzel phocomelia syndromeClinVarPMID:12809666 more ...
Wnt7aRatsyndromic microphthalmia 5  ISOWNT7A (Homo sapiens)8554872ClinVar Annotator: match by term: Anophthalmia-microphthalmia syndromeClinVarPMID:26893459
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatamyotrophic lateral sclerosis type 1  ISOWNT7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11796754
Wnt7aRatFemale Urogenital Diseases  ISOWNT7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16002989
Wnt7aRatFuhrmann syndrome  ISOWNT7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Wnt7aRatOvarian Neoplasms  ISOWNT7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25174399
Wnt7aRatSchinzel type phocomelia  ISOWNT7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Wnt7aRatUrogenital Neoplasms  ISOWNT7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15751030
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatFuhrmann syndrome  ISSWnt7a (Mus musculus)13592920OMIM:228930MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatFuhrmann syndrome  ISOWNT7A (Homo sapiens)7240710 OMIM 
Wnt7aRatSantos Syndrome  ISOWNT7A (Homo sapiens)7240710 OMIM 
Wnt7aRatSchinzel type phocomelia  ISOWNT7A (Homo sapiens)7240710 OMIM 

1 to 20 of 103 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of WNT7A mRNACTDPMID:30723492
Wnt7aRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of WNT7A mRNACTDPMID:16551644
Wnt7aRat17beta-estradiol decreases expressionISOWNT7A (Homo sapiens)6480464Estradiol results in decreased expression of WNT7A mRNACTDPMID:16534752
Wnt7aRat17beta-estradiol multiple interactionsISOWNT7A (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of WNT7A mRNA and Fulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT7A mRNA]CTDPMID:16534752 and PMID:30165855
Wnt7aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of WNT7A mRNACTDPMID:32109520
Wnt7aRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Wnt7aRat4,4'-sulfonyldiphenol decreases expressionISOWnt7a (Mus musculus)6480464bisphenol S results in decreased expression of WNT7A mRNACTDPMID:30951980
Wnt7aRat5-aza-2'-deoxycytidine increases expressionISOWnt7a (Mus musculus)6480464Decitabine results in increased expression of WNT7A mRNACTDPMID:27915011
Wnt7aRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of WNT7A mRNACTDPMID:24780913
Wnt7aRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of WNT7A mRNACTDPMID:25825206
Wnt7aRatacetamide increases expressionEXP 6480464acetamide results in increased expression of WNT7A mRNACTDPMID:31881176
Wnt7aRatacrylamide decreases expressionISOWNT7A (Homo sapiens)6480464Acrylamide results in decreased expression of WNT7A mRNACTDPMID:32763439
Wnt7aRatAflatoxin B2 alpha increases methylationISOWNT7A (Homo sapiens)6480464aflatoxin B2 results in increased methylation of WNT7A intronCTDPMID:30157460
Wnt7aRataldehydo-D-glucose multiple interactionsISOWnt7a (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of WNT7A mRNACTDPMID:37567420
Wnt7aRatall-trans-retinoic acid increases expressionISOWnt7a (Mus musculus)6480464Tretinoin results in increased expression of WNT7A mRNACTDPMID:17064353 and PMID:36189433
Wnt7aRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of WNT7A mRNACTDPMID:16483693
Wnt7aRatamosite asbestos decreases methylationISOWNT7A (Homo sapiens)6480464Asbestos and Amosite results in decreased methylation of WNT7A promoterCTDPMID:29626692
Wnt7aRatantimycin A increases expressionISOWnt7a (Mus musculus)6480464Antimycin A results in increased expression of WNT7A mRNACTDPMID:19304788
Wnt7aRatarsenite(3-) decreases expressionISOWnt7a (Mus musculus)6480464arsenite results in decreased expression of WNT7A mRNACTDPMID:33053406
Wnt7aRatasarone multiple interactionsEXP 6480464asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A mRNA] and asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A protein]CTDPMID:27936013

1 to 20 of 103 rows

Biological Process
1 to 20 of 146 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatangiogenesis acts_upstream_of_or_withinISOWnt7a (Mus musculus)1624291MGI:98962 PMID:19129494RGDPMID:19129494
Wnt7aRatangiogenesis acts_upstream_of_or_withinIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatanimal organ development involved_inIEAARBA:ARBA000292471600115GO_REF:0000117UniProtGO_REF:0000117
Wnt7aRatapoptotic process acts_upstream_ofISOWnt7a (Mus musculus)1624291MGI:1857704 PMID:15070830RGDPMID:15070830
Wnt7aRatapoptotic process acts_upstream_ofIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatasymmetric protein localization involved in cell fate determination acts_upstream_of_or_withinIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatasymmetric protein localization involved in cell fate determination acts_upstream_of_or_withinISOWnt7a (Mus musculus)1624291 PMID:19497282RGDPMID:19497282
Wnt7aRatcanonical Wnt signaling pathway  IMP 4107045 RGD 
Wnt7aRatcanonical Wnt signaling pathway involved_inIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatcanonical Wnt signaling pathway involved_inIEAUniProtKB:O00755 and ensembl:ENSP000002850181600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatcanonical Wnt signaling pathway involved_inISOWnt7a (Mus musculus)1624291 PMID:12937339RGDPMID:12937339
Wnt7aRatcanonical Wnt signaling pathway involved_inIBAFB:FBgn0004360 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnt7aRatcanonical Wnt signaling pathway acts_upstream_of_or_withinISOWnt7a (Mus musculus)1624291MGI:98962 PMID:19023080RGDPMID:19023080
Wnt7aRatcanonical Wnt signaling pathway involved_inISOWNT7A (Homo sapiens)1624291 PMID:12857724 more ...RGDPMID:12857724 more ...
Wnt7aRatcartilage condensation involved_inISOWNT7A (Homo sapiens)1624291 PMID:17202865RGDPMID:17202865
Wnt7aRatcartilage condensation involved_inIEAUniProtKB:O00755 and ensembl:ENSP000002850181600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatcartilage development involved_inIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatcartilage development involved_inISOWnt7a (Mus musculus)1624291 PMID:16826533RGDPMID:16826533
Wnt7aRatcell differentiation involved_inIEAARBA:ARBA000274291600115GO_REF:0000117UniProtGO_REF:0000117
Wnt7aRatcell fate commitment involved_inIBAFB:FBgn0284084 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 20 of 146 rows

Cellular Component
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatcell surface located_inISOWnt7a (Mus musculus)1624291 PMID:8167409RGDPMID:8167409
Wnt7aRatcell surface located_inIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatextracellular matrix located_inIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatextracellular matrix located_inISOWnt7a (Mus musculus)1624291 PMID:8167409RGDPMID:8167409
Wnt7aRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Wnt7aRatextracellular region located_inIEAInterPro:IPR005817 and InterPro:IPR0133001600115GO_REF:0000002InterProGO_REF:0000002
Wnt7aRatextracellular space is_active_inIBAFB:FBgn0284084 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnt7aRatglutamatergic synapse is_active_inISOWNT7A (Homo sapiens)1624291 PMID:20530549RGDPMID:20530549
Wnt7aRatglutamatergic synapse is_active_inIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatglutamatergic synapse is_active_inISOWnt7a (Mus musculus)1624291 PMID:21670302RGDPMID:21670302
Wnt7aRatglutamatergic synapse is_active_inIEAUniProtKB:O00755 and ensembl:ENSP000002850181600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatpresynapse located_inIEAGO:00072691600115GO_REF:0000108GOCGO_REF:0000108
Wnt7aRatSchaffer collateral - CA1 synapse is_active_inIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatSchaffer collateral - CA1 synapse is_active_inISOWnt7a (Mus musculus)1624291 PMID:26400647RGDPMID:26400647
1 to 14 of 14 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatcytokine activity enablesISOWNT7A (Homo sapiens)1624291 PMID:18986540RGDPMID:18986540
Wnt7aRatcytokine activity enablesIEAUniProtKB:O00755 and ensembl:ENSP000002850181600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatcytokine activity enablesIBAMGI:98953 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnt7aRatfrizzled binding  IPIFzd5 (Rattus norvegicus)4107045 RGD 
Wnt7aRatfrizzled binding enablesIEAUniProtKB:P24383 and ensembl:ENSMUSP000000321801600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatfrizzled binding enablesIBAFB:FBgn0004360 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnt7aRatfrizzled binding enablesISOWnt7a (Mus musculus)1624291PR:Q61090 PMID:19497282RGDPMID:19497282
Wnt7aRatprotein binding enablesISOWNT7A (Homo sapiens)1624291UniProtKB:P06396 more ...RGDPMID:22784633 more ...
Wnt7aRatprotein binding  IPISfrp4 (Rattus norvegicus)4107045 RGD 
Wnt7aRatprotein binding enablesISOWnt7a (Mus musculus)1624291UniProtKB:Q9CWT0 and PMID:10866835RGDPMID:10866835
Wnt7aRatreceptor ligand activity enablesISOWNT7A (Homo sapiens)1624291 PMID:18986540 and PMID:28733458RGDPMID:18986540 and PMID:28733458
Wnt7aRatreceptor ligand activity enablesIEAUniProtKB:O00755 and ensembl:ENSP000002850181600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatsignaling receptor binding enablesISOWNT7A (Homo sapiens)1624291UniProtKB:Q13467 and PMID:12857724RGDPMID:12857724
Wnt7aRatsignaling receptor binding enablesIEAUniProtKB:O00755 and ensembl:ENSP000002850181600115GO_REF:0000107EnsemblGO_REF:0000107
Wnt7aRatsignaling receptor binding enablesIEAInterPro:IPR005817 and InterPro:IPR0133001600115GO_REF:0000002InterProGO_REF:0000002
1 to 15 of 15 rows

RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt7aRatbasal cell carcinoma pathway  IEA 6907045 KEGGrno:05217
Wnt7aRatHedgehog signaling pathway   IEA 6907045 KEGGrno:04340
Wnt7aRatWnt signaling pathway  IEA 6907045 KEGGrno:04310

1 to 20 of 20 rows
#
Reference Title
Reference Citation
1. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. Caricasole A, etal., J Biol Chem 2003 Sep 26;278(39):37024-31.
2. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Carmon KS and Loose DS, Mol Cancer Res. 2008 Jun;6(6):1017-28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol. Katayama S, etal., Toxicol Sci. 2006 Jun;91(2):419-30. Epub 2006 Mar 21.
6. Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. Li S, etal., J Clin Endocrinol Metab. 2001 Jan;86(1):454-7.
7. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Lyu J and Joo CK, Cornea. 2006 Dec;25(10 Suppl 1):S24-8.
8. Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis. Maekawa M, etal., Genes Cells. 2005 Oct;10(10):1001-14.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
17. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
18. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
19. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
20. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
1 to 20 of 20 rows
PMID:7885472   PMID:8167409   PMID:9362463   PMID:9405095   PMID:12399112   PMID:12843296   PMID:12937339   PMID:14695376   PMID:15040835   PMID:15070830   PMID:15073149   PMID:15242796  
PMID:15756457   PMID:15802269   PMID:15880584   PMID:16805831   PMID:16818724   PMID:16826533   PMID:17202865   PMID:17507554   PMID:17988238   PMID:18096705   PMID:18413325   PMID:18986540  
PMID:19023080   PMID:19129494   PMID:19497282   PMID:20530549   PMID:21670302   PMID:24502851   PMID:26400647   PMID:28733458   PMID:31852613   PMID:32949181   PMID:38597273  



Wnt7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,420,276 - 125,466,149 (-)NCBIGRCr8
mRatBN7.24123,863,108 - 123,908,981 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,329,923 - 129,375,873 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,104,358 - 125,150,304 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04123,728,903 - 123,774,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,994,425 - 123,040,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04187,505,391 - 187,551,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,541,281 - 125,586,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14125,786,638 - 125,787,010 (-)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBICelera
Cytogenetic Map4q34NCBI
WNT7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38313,816,258 - 13,880,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl313,816,258 - 13,880,071 (-)EnsemblGRCh38hg38GRCh38
GRCh37313,857,755 - 13,921,568 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36313,835,083 - 13,896,619 (-)NCBINCBI36Build 36hg18NCBI36
Build 34313,835,082 - 13,896,619NCBI
Celera313,798,391 - 13,859,925 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef313,793,735 - 13,855,835 (-)NCBIHuRef
CHM1_1313,810,090 - 13,871,973 (-)NCBICHM1_1
T2T-CHM13v2.0313,816,895 - 13,880,668 (-)NCBIT2T-CHM13v2.0
Wnt7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,340,963 - 91,388,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl691,340,963 - 91,388,345 (-)EnsemblGRCm39 Ensembl
GRCm38691,363,981 - 91,411,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,363,981 - 91,411,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37691,313,977 - 91,361,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36691,329,487 - 91,376,873 (-)NCBIMGSCv36mm8
Celera693,257,779 - 93,305,821 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.45NCBI
Wnt7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542912,647,993 - 12,694,895 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542912,647,993 - 12,693,998 (+)NCBIChiLan1.0ChiLan1.0
WNT7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,792,607 - 13,856,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1313,797,369 - 13,861,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0313,733,487 - 13,797,189 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1314,075,359 - 14,138,386 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,077,839 - 14,138,386 (-)Ensemblpanpan1.1panPan2
WNT7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,072,010 - 4,139,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,073,929 - 4,139,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,112,838 - 4,179,523 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,096,079 - 4,162,950 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,096,088 - 4,163,110 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1203,815,330 - 3,882,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,137,783 - 4,204,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,102,223 - 4,168,959 (-)NCBIUU_Cfam_GSD_1.0
Wnt7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494219,620,674 - 19,645,097 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493689845,115 - 70,326 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493689845,903 - 70,313 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1370,538,894 - 70,602,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11370,538,802 - 70,602,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,997,741 - 78,061,325 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12249,805,415 - 49,863,115 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2249,805,463 - 49,862,830 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041116,634,304 - 116,694,158 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479612,431,959 - 12,472,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479612,431,310 - 12,472,303 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Wnt7a
223 total Variants

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:175
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000070832
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 51 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat

1 to 10 of 51 rows
RH132187  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84125,420,401 - 125,421,354 (+)Marker Load Pipeline
mRatBN7.24123,863,233 - 123,864,186 (+)MAPPERmRatBN7.2
Rnor_6.04122,994,551 - 122,995,503NCBIRnor6.0
Rnor_5.04187,550,526 - 187,551,478UniSTSRnor5.0
RGSC_v3.44125,540,371 - 125,541,323UniSTSRGSC3.4
Celera4112,782,393 - 112,783,345UniSTS
RH 3.4 Map4735.73UniSTS
Cytogenetic Map4q34UniSTS
BE106651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,864,606 - 123,864,766 (+)MAPPERmRatBN7.2
Rnor_6.04122,995,924 - 122,996,083NCBIRnor6.0
Rnor_5.04187,549,946 - 187,550,105UniSTSRnor5.0
RGSC_v3.44125,541,744 - 125,541,903UniSTSRGSC3.4
Celera4112,783,766 - 112,783,925UniSTS
RH 3.4 Map4736.63UniSTS
Cytogenetic Map4q34UniSTS
Wnt7a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,863,936 - 123,864,483 (+)MAPPERmRatBN7.2
Rnor_6.04122,995,254 - 122,995,800NCBIRnor6.0
Rnor_5.04187,550,229 - 187,550,775UniSTSRnor5.0
RGSC_v3.44125,541,074 - 125,541,620UniSTSRGSC3.4
Celera4112,783,096 - 112,783,642UniSTS
Cytogenetic Map4q34UniSTS
UNH1042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,870,702 - 123,871,013 (+)MAPPERmRatBN7.2
Rnor_6.04123,002,020 - 123,002,330NCBIRnor6.0
Rnor_5.04187,543,698 - 187,544,009NCBIRnor5.0
RGSC_v3.44125,547,840 - 125,548,150UniSTSRGSC3.4
Celera4112,789,809 - 112,790,119UniSTS
Cytogenetic Map4q34UniSTS
Wnt7a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,865,107 - 123,865,314 (+)MAPPERmRatBN7.2
Rnor_6.04122,996,425 - 122,996,631NCBIRnor6.0
Rnor_5.04187,549,398 - 187,549,604UniSTSRnor5.0
RGSC_v3.44125,542,245 - 125,542,451UniSTSRGSC3.4
Celera4112,784,267 - 112,784,473UniSTS
Cytogenetic Map4q34UniSTS




appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 15 99 47 60 31 23 31 6 107 41 91 31 56 29



Ensembl Acc Id: ENSRNOT00000070832   ⟹   ENSRNOP00000066101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)Ensembl
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)Ensembl
RefSeq Acc Id: NM_001100473   ⟹   NP_001093943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,420,276 - 125,466,149 (-)NCBI
mRatBN7.24123,863,108 - 123,908,981 (-)NCBI
Rnor_6.04122,994,425 - 123,040,609 (-)NCBI
Rnor_5.04187,505,391 - 187,551,604 (+)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106916   ⟹   XP_038962844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,420,289 - 125,464,337 (-)NCBI
mRatBN7.24123,863,114 - 123,907,174 (-)NCBI
RefSeq Acc Id: XM_039106917   ⟹   XP_038962845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84125,420,289 - 125,464,343 (-)NCBI
mRatBN7.24123,863,114 - 123,907,177 (-)NCBI
Protein RefSeqs NP_001093943 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962844 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN51978 (Get FASTA)   NCBI Sequence Viewer  
  AAN51979 (Get FASTA)   NCBI Sequence Viewer  
  EDL91365 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066101
  ENSRNOP00000066101.1
RefSeq Acc Id: NP_001093943   ⟸   NM_001100473
- Peptide Label: precursor
- UniProtKB: M0R9D3 (UniProtKB/TrEMBL),   A6IB96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066101   ⟸   ENSRNOT00000070832
RefSeq Acc Id: XP_038962845   ⟸   XM_039106917
- Peptide Label: isoform X2
- UniProtKB: A6IB97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962844   ⟸   XM_039106916
- Peptide Label: isoform X1

Name Modeler Protein Id AA Range Protein Structure
AF-M0R9D3-F1-model_v2 AlphaFold M0R9D3 1-349 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-43724 BioCyc
Ensembl Genes ENSRNOG00000048782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070832 ENTREZGENE
  ENSRNOT00000070832.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt7 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report rno:114850 UniProtKB/TrEMBL
NCBI Gene 114850 ENTREZGENE
PANTHER PROTEIN WNT-7A UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt7a PhenoGen
PRINTS WNT7PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048782 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A6IB96 ENTREZGENE, UniProtKB/TrEMBL
  A6IB97 ENTREZGENE, UniProtKB/TrEMBL
  M0R9D3 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt7a  Wnt family member 7A  Wnt7a  wingless-type MMTV integration site family, member 7A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt7a  wingless-type MMTV integration site family, member 7A  Wnt7a  wingless-related MMTV integration site 7A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Wnt7a  wingless-type MMTV integration site 7A      Name updated 70584 APPROVED

Note Type Note Reference