WNT7A (Wnt family member 7A) - Rat Genome Database

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Gene: WNT7A (Wnt family member 7A) Canis lupus familiaris
Analyze
Symbol: WNT7A
Name: Wnt family member 7A
RGD ID: 12113941
Description: ENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); asymmetric protein localization involved in cell fate determination (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH 3p deletion syndrome (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN cell surface (ortholog); extracellular matrix (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein Wnt-7a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,072,010 - 4,139,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,073,929 - 4,139,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,112,838 - 4,179,523 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,096,079 - 4,162,950 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,096,088 - 4,163,110 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1203,815,330 - 3,882,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,137,783 - 4,204,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,102,223 - 4,168,959 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ development  (IEA)
apoptotic process  (ISO)
asymmetric protein localization involved in cell fate determination  (ISO)
canonical Wnt signaling pathway  (ISO)
cartilage condensation  (ISO)
cartilage development  (ISO)
cell differentiation  (IEA)
cell proliferation in forebrain  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
central nervous system vasculogenesis  (ISO)
cerebellar granule cell differentiation  (ISO)
chondrocyte differentiation  (ISO)
dendritic spine morphogenesis  (ISO)
dorsal/ventral pattern formation  (ISO)
embryonic axis specification  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
establishment of blood-brain barrier  (ISO)
establishment of cell polarity  (ISO)
forelimb morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
limb development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of neurogenesis  (ISO)
neurotransmitter secretion  (ISO)
non-canonical Wnt signaling pathway  (ISO)
oviduct development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epithelial cell proliferation involved in wound healing  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of excitatory synapse assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of axon diameter  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of postsynapse organization  (ISO)
regulation of presynapse assembly  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
reproductive structure development  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
secondary palate development  (ISO)
skeletal muscle satellite cell activation  (ISO)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (ISO)
skeletal system morphogenesis  (ISO)
skin morphogenesis  (ISO)
somatic stem cell division  (ISO)
somatic stem cell population maintenance  (ISO)
stem cell development  (ISO)
synapse assembly  (ISO)
synapse organization  (ISO)
system development  (IEA)
tissue development  (IEA)
uterus development  (ISO)
uterus morphogenesis  (ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway, planar cell polarity pathway  (ISO)
wound healing, spreading of epidermal cells  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WNT7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,072,010 - 4,139,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,073,929 - 4,139,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,112,838 - 4,179,523 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,096,079 - 4,162,950 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,096,088 - 4,163,110 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1203,815,330 - 3,882,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,137,783 - 4,204,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,102,223 - 4,168,959 (-)NCBIUU_Cfam_GSD_1.0
WNT7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38313,816,258 - 13,880,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl313,816,258 - 13,880,071 (-)EnsemblGRCh38hg38GRCh38
GRCh37313,857,755 - 13,921,568 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36313,835,083 - 13,896,619 (-)NCBINCBI36Build 36hg18NCBI36
Build 34313,835,082 - 13,896,619NCBI
Celera313,798,391 - 13,859,925 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef313,793,735 - 13,855,835 (-)NCBIHuRef
CHM1_1313,810,090 - 13,871,973 (-)NCBICHM1_1
T2T-CHM13v2.0313,816,895 - 13,880,668 (-)NCBIT2T-CHM13v2.0
Wnt7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,340,963 - 91,388,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl691,340,963 - 91,388,345 (-)EnsemblGRCm39 Ensembl
GRCm38691,363,981 - 91,411,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,363,981 - 91,411,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37691,313,977 - 91,361,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36691,329,487 - 91,376,873 (-)NCBIMGSCv36mm8
Celera693,257,779 - 93,305,821 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.45NCBI
Wnt7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84125,420,276 - 125,466,149 (-)NCBIGRCr8
mRatBN7.24123,863,108 - 123,908,981 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,863,108 - 123,908,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,329,923 - 129,375,873 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04125,104,358 - 125,150,304 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04123,728,903 - 123,774,853 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04122,994,425 - 123,040,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,994,425 - 123,040,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04187,505,391 - 187,551,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,541,281 - 125,586,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14125,786,638 - 125,787,010 (-)NCBI
Celera4112,782,267 - 112,828,322 (-)NCBICelera
Cytogenetic Map4q34NCBI
Wnt7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542912,647,993 - 12,694,895 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542912,647,993 - 12,693,998 (+)NCBIChiLan1.0ChiLan1.0
WNT7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,792,607 - 13,856,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1313,797,369 - 13,861,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0313,733,487 - 13,797,189 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1314,075,359 - 14,138,386 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,077,839 - 14,138,386 (-)Ensemblpanpan1.1panPan2
Wnt7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494219,620,674 - 19,645,097 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493689845,115 - 70,326 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493689845,903 - 70,313 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1370,538,894 - 70,602,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11370,538,802 - 70,602,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,997,741 - 78,061,325 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12249,805,415 - 49,863,115 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2249,805,463 - 49,862,830 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041116,634,304 - 116,694,158 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479612,431,959 - 12,472,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479612,431,310 - 12,472,303 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WNT7A
646 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 1 3 18 11 10 1 6 1 6 17 15 8 10 9

Sequence


Ensembl Acc Id: ENSCAFT00000046986   ⟹   ENSCAFP00000039833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl204,073,929 - 4,139,436 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845041764   ⟹   ENSCAFP00845032757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl204,096,088 - 4,163,110 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845041793   ⟹   ENSCAFP00845032780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl204,096,088 - 4,157,892 (-)Ensembl
RefSeq Acc Id: XM_038426822   ⟹   XP_038282750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0204,096,079 - 4,162,950 (-)NCBI
RefSeq Acc Id: XM_038502618   ⟹   XP_038358546
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1203,815,330 - 3,882,330 (-)NCBI
RefSeq Acc Id: XM_038565531   ⟹   XP_038421459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0204,102,223 - 4,168,959 (-)NCBI
RefSeq Acc Id: XM_038629665   ⟹   XP_038485593
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0204,137,783 - 4,204,657 (-)NCBI
RefSeq Acc Id: XM_844117   ⟹   XP_849210
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1204,072,010 - 4,139,521 (-)NCBI
Dog10K_Boxer_Tasha204,112,838 - 4,179,523 (-)NCBI
Sequence:
RefSeq Acc Id: XP_849210   ⟸   XM_844117
- UniProtKB: A0A8C0SXG7 (UniProtKB/TrEMBL),   A0A8C0JXY5 (UniProtKB/TrEMBL),   A0A8I3PNZ6 (UniProtKB/TrEMBL),   A0A8I3PJ74 (UniProtKB/TrEMBL),   A0A8P0PLL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000039833   ⟸   ENSCAFT00000046986
RefSeq Acc Id: XP_038358546   ⟸   XM_038502618
RefSeq Acc Id: XP_038485593   ⟸   XM_038629665
RefSeq Acc Id: XP_038282750   ⟸   XM_038426822
- UniProtKB: A0A8C0SXG7 (UniProtKB/TrEMBL),   A0A8C0JXY5 (UniProtKB/TrEMBL),   A0A8I3PNZ6 (UniProtKB/TrEMBL),   A0A8I3PJ74 (UniProtKB/TrEMBL),   A0A8P0PLL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421459   ⟸   XM_038565531
- UniProtKB: A0A8C0JXY5 (UniProtKB/TrEMBL),   A0A8C0SXG7 (UniProtKB/TrEMBL),   A0A8I3PJ74 (UniProtKB/TrEMBL),   A0A8I3PNZ6 (UniProtKB/TrEMBL),   A0A8P0PLL1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845032757   ⟸   ENSCAFT00845041764
Ensembl Acc Id: ENSCAFP00845032780   ⟸   ENSCAFT00845041793

Promoters
RGD ID:13686760
Promoter ID:EPDNEW_C4830
Type:single initiation site
Name:WNT7A_1
Description:Wnt family member 7A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1204,139,636 - 4,139,696EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032632 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016784 UniProtKB/TrEMBL
  ENSCAFG00040016916 UniProtKB/TrEMBL
  ENSCAFG00845023657 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046986.3 UniProtKB/TrEMBL
  ENSCAFT00000097998.1 UniProtKB/TrEMBL
  ENSCAFT00030030967.1 UniProtKB/TrEMBL
  ENSCAFT00040031184.1 UniProtKB/TrEMBL
  ENSCAFT00845041764 ENTREZGENE
  ENSCAFT00845041764.1 UniProtKB/TrEMBL
  ENSCAFT00845041793.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt7 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report cfa:607180 UniProtKB/TrEMBL
NCBI Gene WNT7A ENTREZGENE
PANTHER PROTEIN WNT-7A UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT7PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8C0JXY5 ENTREZGENE
  A0A8C0SXG7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PJ74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PNZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PLL1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48428 ENTREZGENE