Hsp90aa1 (heat shock protein 90 alpha family class A member 1) - Rat Genome Database

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Gene: Hsp90aa1 (heat shock protein 90 alpha family class A member 1) Rattus norvegicus
Analyze
Symbol: Hsp90aa1
Name: heat shock protein 90 alpha family class A member 1
RGD ID: 631409
Description: Enables several functions, including Rho GDP-dissociation inhibitor binding activity; nucleotide binding activity; and sulfonylurea receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; positive regulation of cardiac muscle contraction; and positive regulation of cell size. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and sperm mitochondrial sheath. Part of protein-containing complex. Biomarker of portal hypertension. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; chaperone mediated autophagy pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock 86 kDa; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein HSP 90-alpha; HSP 86; Hsp86; Hsp90; Hspca; MGC105293
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Hsp90aa1-ps16   Hsp90aa1-ps17  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,523,604 - 135,529,687 (-)NCBIGRCr8
mRatBN7.26129,702,376 - 129,707,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,702,383 - 129,707,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,879,675 - 129,884,976 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,175,668 - 130,180,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,539,256 - 129,544,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,107,262 - 135,112,793 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,045,363 - 135,049,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,107,271 - 135,112,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,182,009 - 144,187,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46135,413,616 - 135,419,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16135,419,806 - 135,425,334 (-)NCBI
Celera6127,272,361 - 127,277,892 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-anilino-5,8-quinolinedione  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
alachlor  (EXP)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
antimycin A  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
ATP  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (EXP,ISO)
bromuconazole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
celastrol  (EXP,ISO)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
coumarin  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
Cruentaren A  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endrin  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP)
felbamate  (EXP)
fenofibrate  (ISO)
fenthion  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gabapentin  (EXP)
gallic acid  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
hypochlorous acid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indoles  (EXP)
indometacin  (ISO)
iodide salt  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
linalool  (ISO)
maneb  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylparaben  (ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
Nonidet P-40  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
organoselenium compound  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
Panaxytriol  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin A1  (ISO)
protoporphyrin  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulpiride  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiopental  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO,ISS)
cardiac muscle cell apoptotic process  (IEP)
cellular response to heat  (IBA,ISO)
cellular response to virus  (ISO,ISS)
chaperone-mediated autophagy  (NAS)
chaperone-mediated protein complex assembly  (ISO)
neurofibrillary tangle assembly  (IEA,ISO)
neuron migration  (IMP)
positive regulation of cardiac muscle contraction  (IEP)
positive regulation of cell size  (IMP)
positive regulation of defense response to virus by host  (ISO,ISS)
positive regulation of interferon-beta production  (ISO,ISS)
positive regulation of lamellipodium assembly  (IMP)
positive regulation of nitric oxide biosynthetic process  (ISO,ISS)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein polymerization  (ISO)
protein folding  (IBA,ISO,TAS)
protein insertion into mitochondrial outer membrane  (ISO)
protein stabilization  (IBA,ISO)
regulation of apoptotic process  (ISO,ISS)
regulation of postsynaptic membrane neurotransmitter receptor levels  (EXP,IDA)
regulation of protein complex stability  (NAS)
regulation of protein localization  (ISO)
regulation of protein ubiquitination  (ISO)
response to antibiotic  (ISS)
response to cocaine  (IEP)
response to cold  (ISS)
response to estrogen  (IEP)
response to heat  (ISS)
response to salt stress  (IEP)
response to xenobiotic stimulus  (IEP)
skeletal muscle contraction  (IEP)
telomerase holoenzyme complex assembly  (ISO)
telomere maintenance via telomerase  (ISO)

References

References - curated
# Reference Title Reference Citation
1. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Bandyopadhyay U, etal., Mol Cell Biol. 2008 Sep;28(18):5747-63. doi: 10.1128/MCB.02070-07. Epub 2008 Jul 21.
2. Proteins participating to the post-transcriptional regulation of the mitochondrial cytochrome c oxidase subunit IV via elements located in the 3'UTR. Cannino G, etal., Mitochondrion. 2009 Nov;9(6):471-80. Epub 2009 Aug 22.
3. Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. Chen MH, etal., Oncotarget. 2014 May 15;5(9):2372-89. doi: 10.18632/oncotarget.1706.
4. The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. Chen MS, etal., J Biol Chem. 1996 Dec 13;271(50):32315-20.
5. HSP90alpha, HSP90beta, and p53 expression following in vitro hyperthermia exposure in gestation day 10 rat embryos. Dugyala RR, etal., Toxicol Sci. 2002 Sep;69(1):183-90.
6. Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK). Forner F, etal., Biochim Biophys Acta. 2010 Jun;1804(6):1334-41. Epub 2010 Feb 25.
7. Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. Garcia-Fuster MJ, etal., PLoS One. 2012;7(7):e42092. doi: 10.1371/journal.pone.0042092. Epub 2012 Jul 30.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors. Gerges NZ, etal., J Neurosci. 2004 May 19;24(20):4758-66. doi: 10.1523/JNEUROSCI.0594-04.2004.
10. BDNF, TNFalpha, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment. Gezen-Ak D, etal., J Alzheimers Dis. 2013;37(1):185-95. doi: 10.3233/JAD-130497.
11. Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. Herskowitz JH, etal., J Proteome Res. 2010 Dec 3;9(12):6368-79. doi: 10.1021/pr100666c. Epub 2010 Oct 22.
12. Early response of heat shock proteins to functional overload of the soleus and plantaris in rats and mice. Huey KA, etal., Exp Physiol. 2010 Dec;95(12):1145-55. Epub 2010 Sep 17.
13. Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90. Krzemień-Ojak Ł, etal., J Cell Biochem. 2017 Feb;118(2):420-429. doi: 10.1002/jcb.25669. Epub 2016 Oct 17.
14. Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain. Lappalainen J, etal., Cell Biochem Funct. 2010 Dec 2;28(8):644-50. doi: 10.1002/cbf.1702. Epub 2010 Oct 29.
15. Heat shock protein 90 regulates IkappaB kinase complex and NF-kappaB activation in angiotensin II-induced cardiac cell hypertrophy. Lee KH, etal., Exp Mol Med. 2010 Oct 31;42(10):703-11.
16. Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
17. Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Lei H, etal., Circ Res. 2004 Apr 16;94(7):902-9. Epub 2004 Mar 4.
18. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. Liou ST and Wang C, Arch Biochem Biophys. 2005 Mar 15;435(2):253-63.
19. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. Marshall KW, etal., Osteoarthritis Cartilage. 2005 Oct;13(10):861-71.
20. Paternal exposure to testis cancer chemotherapeutics alters sperm fertilizing capacity and affects gene expression in the eight-cell stage rat embryo. Maselli J, etal., Andrology. 2014 Mar;2(2):259-66. doi: 10.1111/j.2047-2927.2014.00185.x. Epub 2014 Jan 29.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
23. Isoflavone-deprived soy peptide suppresses mammary tumorigenesis by inducing apoptosis. Park K, etal., Exp Mol Med. 2009 Jun 30;41(6):371-81.
24. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Park KA, etal., Carcinogenesis. 2007 Jan;28(1):71-80. doi: 10.1093/carcin/bgl094. Epub 2006 Jun 14.
25. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. Peng X, etal., J Biol Chem. 2005 Apr 1;280(13):13148-52. Epub 2005 Jan 25.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
30. Molecular chaperones throughout the life cycle of the androgen receptor. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
31. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. Quinta HR, etal., J Neurochem. 2010 Nov;115(3):716-34. doi: 10.1111/j.1471-4159.2010.06970.x. Epub 2010 Sep 28.
32. Hsp90 Co-localizes with Rab-GDI-1 and regulates agonist-induced amylase release in AR42J cells. Raffaniello R, etal., Cell Physiol Biochem. 2009;24(5-6):369-78. doi: 10.1159/000257429. Epub 2009 Nov 4.
33. Upregulation and intrarenal redistribution of heat shock proteins 90alpha and 90beta by low-sodium diet in the rat. Ramirez V, etal., Cell Stress Chaperones. 2004 Summer;9(2):198-206.
34. C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins. Ramsey AJ, etal., Biochem J. 2009 Oct 12;423(3):411-9.
35. GOA pipeline RGD automated data pipeline
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. Sakisaka T, etal., EMBO J 2002 Nov 15;21(22):6125-35.
38. Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls. Sedlackova L, etal., Scand J Rheumatol. 2011;40(5):354-7. doi: 10.3109/03009742.2011.552522. Epub 2011 Mar 21.
39. Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system. Sidera K, etal., J Biol Chem. 2004 Oct 29;279(44):45379-88. Epub 2004 Aug 9.
40. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
41. Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. Soti C, etal., Eur J Biochem 2003 Jun;270(11):2421-8.
42. Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model. Takahashi K, etal., Osteoarthritis Cartilage. 1997 Sep;5(5):321-9.
43. Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats. Tominaga M, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1136-41. Epub 2009 Mar 11.
44. Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein. Tortosa E, etal., J Alzheimers Dis. 2009;17(2):319-25. doi: 10.3233/JAD-2009-1049.
45. Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes. Wang Y, etal., Biol Reprod. 2004 Nov;71(5):1652-64. Epub 2004 Jun 30.
46. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
47. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
48. Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. Yan FF, etal., Mol Biol Cell. 2010 Jun 15;21(12):1945-54. Epub 2010 Apr 28.
49. Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of Bid in hypothermic preservation rat hearts. Yang F, etal., J Heart Lung Transplant. 2011 Aug;30(8):928-34. Epub 2011 May 28.
50. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:8289821   PMID:9122205   PMID:9488468   PMID:9660753   PMID:10197982   PMID:10409742   PMID:10791971   PMID:11487543   PMID:11732320   PMID:12145311   PMID:12477932   PMID:12489981  
PMID:12519789   PMID:12676772   PMID:12855682   PMID:12885400   PMID:14990148   PMID:15100099   PMID:15489334   PMID:15644312   PMID:15713458   PMID:15791211   PMID:15937123   PMID:15951401  
PMID:16169070   PMID:16207813   PMID:16489110   PMID:16809764   PMID:16854843   PMID:16910874   PMID:16968702   PMID:17202141   PMID:17349580   PMID:17517623   PMID:17634366   PMID:17908927  
PMID:17923681   PMID:18006464   PMID:18056992   PMID:18078967   PMID:18087244   PMID:18292230   PMID:18320580   PMID:18726712   PMID:19199708   PMID:19268660   PMID:19308988   PMID:19356729  
PMID:19401463   PMID:19751963   PMID:19920082   PMID:19946888   PMID:20353823   PMID:20397260   PMID:20458337   PMID:20492351   PMID:20619278   PMID:20669351   PMID:21063103   PMID:21083699  
PMID:21360678   PMID:21439793   PMID:21460846   PMID:21519787   PMID:21630459   PMID:22082260   PMID:22120110   PMID:22176470   PMID:22215678   PMID:22350213   PMID:22431752   PMID:22658674  
PMID:22681889   PMID:22964853   PMID:23064900   PMID:23106098   PMID:23349634   PMID:23376485   PMID:23484111   PMID:23533145   PMID:23666904   PMID:23904609   PMID:23965991   PMID:24096135  
PMID:24286867   PMID:24301679   PMID:24337748   PMID:24338402   PMID:24625528   PMID:24742623   PMID:25036637   PMID:25287672   PMID:25649190   PMID:26085096   PMID:26316108   PMID:27076094  
PMID:27353360   PMID:27686098   PMID:27919679   PMID:27956030   PMID:28031326   PMID:28414930   PMID:29127155   PMID:29179175   PMID:29476059   PMID:30582930   PMID:31606837   PMID:31686426  
PMID:32357304   PMID:32360748   PMID:32676275   PMID:33373917   PMID:36497031   PMID:37054848   PMID:37902841   PMID:38909785  


Genomics

Comparative Map Data
Hsp90aa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,523,604 - 135,529,687 (-)NCBIGRCr8
mRatBN7.26129,702,376 - 129,707,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,702,383 - 129,707,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,879,675 - 129,884,976 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,175,668 - 130,180,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,539,256 - 129,544,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,107,262 - 135,112,793 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,045,363 - 135,049,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,107,271 - 135,112,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,182,009 - 144,187,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46135,413,616 - 135,419,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16135,419,806 - 135,425,334 (-)NCBI
Celera6127,272,361 - 127,277,892 (-)NCBICelera
Cytogenetic Map6q32NCBI
HSP90AA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814102,080,742 - 102,139,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14102,080,742 - 102,139,699 (-)EnsemblGRCh38hg38GRCh38
GRCh3714102,547,079 - 102,606,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,616,828 - 101,675,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414101,617,144 - 101,623,135NCBI
Celera1482,601,564 - 82,660,582 (-)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1482,725,979 - 82,785,051 (-)NCBIHuRef
CHM1_114102,484,935 - 102,543,941 (-)NCBICHM1_1
T2T-CHM13v2.01496,316,329 - 96,375,332 (-)NCBIT2T-CHM13v2.0
Hsp90aa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912110,657,470 - 110,662,829 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12110,657,039 - 110,669,162 (-)EnsemblGRCm39 Ensembl
GRCm3812110,691,036 - 110,696,395 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,690,605 - 110,702,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712111,929,246 - 111,934,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,138,843 - 111,144,202 (-)NCBIMGSCv36mm8
Celera12111,881,002 - 111,886,365 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.75NCBI
Hsp90aa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555381,469,544 - 1,475,019 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555381,469,544 - 1,475,010 (-)NCBIChiLan1.0ChiLan1.0
HSP90AA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215103,233,362 - 103,292,106 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114102,449,856 - 102,456,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01482,700,881 - 82,707,020 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114102,519,033 - 102,524,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14102,519,699 - 102,576,723 (-)Ensemblpanpan1.1panPan2
HSP90AA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1870,091,203 - 70,096,107 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl870,092,217 - 70,095,243 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha869,605,578 - 69,611,507 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0870,369,324 - 70,375,263 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl870,369,667 - 70,374,704 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1870,033,441 - 70,039,369 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0870,098,797 - 70,104,717 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0870,498,429 - 70,504,357 (-)NCBIUU_Cfam_GSD_1.0
Hsp90aa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086403,873,950 - 3,879,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936835316,767 - 321,990 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936835316,767 - 321,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90AA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27129,758,754 - 129,760,542 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90AA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12480,016,352 - 80,019,130 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2480,016,232 - 80,019,120 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605367,207,536 - 67,213,629 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsp90aa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247342,233,547 - 2,241,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247342,233,932 - 2,239,687 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsp90aa1
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:301
Count of miRNA genes:195
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000009556
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
15 11 55 144 125 120 77 31 77 12 276 121 112 55 79 43

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_175761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ297736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ428213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY683455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009556   ⟹   ENSRNOP00000009556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6135,045,363 - 135,049,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086310   ⟹   ENSRNOP00000075715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6129,702,383 - 129,707,268 (-)Ensembl
Rnor_6.0 Ensembl6135,107,271 - 135,112,775 (-)Ensembl
RefSeq Acc Id: NM_175761   ⟹   NP_786937
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86135,523,609 - 135,529,140 (-)NCBI
mRatBN7.26129,702,376 - 129,707,907 (-)NCBI
Rnor_6.06135,107,262 - 135,112,793 (-)NCBI
Rnor_5.06144,182,009 - 144,187,540 (-)NCBI
RGSC_v3.46135,413,616 - 135,419,147 (-)RGD
Celera6127,272,361 - 127,277,892 (-)RGD
Sequence:
RefSeq Acc Id: XM_063261784   ⟹   XP_063117854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86135,523,604 - 135,529,687 (-)NCBI
RefSeq Acc Id: NP_786937   ⟸   NM_175761
- UniProtKB: Q91XW0 (UniProtKB/Swiss-Prot),   P82995 (UniProtKB/Swiss-Prot),   A6KBM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075715   ⟸   ENSRNOT00000086310
Ensembl Acc Id: ENSRNOP00000009556   ⟸   ENSRNOT00000009556
RefSeq Acc Id: XP_063117854   ⟸   XM_063261784
- Peptide Label: isoform X1
Protein Domains
Histidine kinase/HSP90-like ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P82995-F1-model_v2 AlphaFold P82995 1-733 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694828
Promoter ID:EPDNEW_R5353
Type:multiple initiation site
Name:LOC103692716_1
Description:heat shock protein HSP 90-alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06135,112,793 - 135,112,853EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631409 AgrOrtholog
BioCyc Gene G2FUF-35875 BioCyc
Ensembl Genes ENSRNOG00000007219 Ensembl
  ENSRNOG00000059714 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055030136 UniProtKB/Swiss-Prot
  ENSRNOG00060018740 UniProtKB/Swiss-Prot
  ENSRNOG00065028353 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086310.2 UniProtKB/Swiss-Prot
  ENSRNOT00055052290 UniProtKB/Swiss-Prot
  ENSRNOT00060032268 UniProtKB/Swiss-Prot
  ENSRNOT00065048834 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot
  3.30.230.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot
  3.40.50.11260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat shock protein 90, C-terminal domain UniProtKB/TrEMBL
  Histidine kinase-like ATPase, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105514 IMAGE-MGC_LOAD
  IMAGE:7114546 IMAGE-MGC_LOAD
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105293 IMAGE-MGC_LOAD
  MGC:91423 IMAGE-MGC_LOAD
NCBI Gene 299331 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN 90 FAMILY MEMBER UniProtKB/TrEMBL
  HEAT SHOCK PROTEIN HSP 90-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11528 UniProtKB/Swiss-Prot
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HSP90AA1 RGD
PhenoGen Hsp90aa1 PhenoGen
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007219 RatGTEx
  ENSRNOG00000059714 RatGTEx
  ENSRNOG00055030136 RatGTEx
  ENSRNOG00060018740 RatGTEx
  ENSRNOG00065028353 RatGTEx
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase UniProtKB/TrEMBL
  HSP90 C-terminal domain UniProtKB/TrEMBL
  Ribosomal protein S5 domain 2-like UniProtKB/TrEMBL
  SSF110942 UniProtKB/Swiss-Prot
  SSF54211 UniProtKB/Swiss-Prot
  SSF55874 UniProtKB/Swiss-Prot
UniProt A6KBM6 ENTREZGENE, UniProtKB/TrEMBL
  HS90A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q91XW0 ENTREZGENE
UniProt Secondary Q91XW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Hsp90aa1  heat shock protein 90 alpha family class A member 1  Hsp90aa1  heat shock protein 90kDa alpha family class A member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hsp90aa1  heat shock protein 90kDa alpha family class A member 1  Hsp90aa1  heat shock protein 90, alpha (cytosolic), class A member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Hsp90aa1  heat shock protein 90, alpha (cytosolic), class A member 1  Hspca  heat shock protein 1, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Hspca  heat shock protein 1, alpha  Hsp86  heat shock protein 86  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a C-terminal nucleotide binding site and a N-terminal geldanamycin-sensitive ATP-binding site 724444