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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631409
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90aa1
Name: heat shock protein 90 alpha family class A member 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90aa1increases expressionISOHSP90AA1 (Homo sapiens)6480464CTDFulvestrant results in increased expression of HSP90AA1 mRNAPMID:31646340
Hsp90aa1multiple interactionsISOHSP90AA1 (Homo sapiens)6480464CTDarsenite inhibits the reaction [Fulvestrant results in increased expression of HSP90AA1 mRNA]; Cadmium inhibits the reaction [Fulvestrant results in increased expression of HSP90AA1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of HSP90AA1 mRNA]PMID:31646340
Hsp90aa1multiple interactionsISOHsp90aa1 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90AA1 protein]PMID:11568360
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