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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631409
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90aa1
Name: heat shock protein 90 alpha family class A member 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90aa1increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of HSP90AA1 mRNAPMID:19162173 PMID:21318169
Hsp90aa1decreases expressionISOHsp90aa1 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of HSP90AA1 proteinPMID:36214631
Hsp90aa1increases expressionISOHsp90aa1 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of HSP90AA1 mRNA; perfluorooctanoic acid results in increased expression of HSP90AA1 proteinPMID:21318169 PMID:37422089
Hsp90aa1multiple interactionsISOHsp90aa1 (Mus musculus)6480464CTDPPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA]PMID:21318169
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