Ccr2 (C-C motif chemokine receptor 2) - Rat Genome Database

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Gene: Ccr2 (C-C motif chemokine receptor 2) Rattus norvegicus
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Symbol: Ccr2
Name: C-C motif chemokine receptor 2
RGD ID: 620876
Description: Enables identical protein binding activity. Involved in several processes, including positive regulation of tumor necrosis factor production; regulation of signal transduction; and response to hyperoxia. Located in perikaryon; perinuclear region of cytoplasm; and primary dendrite. Biomarker of demyelinating disease and periapical periodontitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; chemokine (C-C motif) receptor 2; chemokine receptor CCR2; chemokine receptor CCR2 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Ccr2m1Mcwi   Ccr2m2Mcwi  
Genetic Models: BN-Ccr2m2Mcwi FHH-Ccr2m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,611,883 - 132,619,106 (+)NCBIGRCr8
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,328,887 - 129,330,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,528,007 - 127,529,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,345,931 - 125,347,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration  (ISS)
aggressive periodontitis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Toxoplasmosis  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISS)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
Cystic Disease of Lung  (ISO)
demyelinating disease  (IEP)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
fungal infectious disease  (ISO)
Geographic Atrophy  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Herpes Simplex Encephalitis  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
ileitis  (ISO)
inclusion body myositis  (ISO)
intermediate uveitis  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Disease  (IEP)
Intimal Hyperplasia  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
limited scleroderma  (ISO)
lipoatrophic diabetes mellitus  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
macular degeneration  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Mouth Neoplasms  (ISO)
myeloid sarcoma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
oral squamous cell carcinoma  (ISO)
Pain  (IMP,ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
Periapical Diseases  (ISO)
periapical granuloma  (ISO)
periapical periodontitis  (IEP)
Periodontal Cyst  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
posterior uveitis  (ISO)
prediabetes syndrome  (ISO)
Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
retinal degeneration  (ISO)
retinitis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
sciatic neuropathy  (ISO)
sialadenitis  (ISO)
Spinal Cord Injuries  (IEP)
status epilepticus  (ISO)
systemic scleroderma  (ISO)
Thoracic Injuries  (IEP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP,ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3-chlorophenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
AM6545  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
amphotericin B  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
asperentin  (ISO)
Azoxymethane  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
flumequine  (ISO)
folic acid  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
isoniazide  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
LY294002  (ISO)
mechlorethamine  (EXP)
MeIQx  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mevalonic acid  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
olaparib  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perindopril  (ISO)
picrotoxin  (EXP)
piperidines  (ISO)
proanthocyanidin  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (ISO)
sodium fluoride  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
telmisartan  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)
zinc sulfate  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEP)
calcium-mediated signaling  (IBA)
cell chemotaxis  (IBA)
cellular defense response  (ISO)
cellular homeostasis  (ISO,ISS)
chemokine-mediated signaling pathway  (IMP)
cytokine-mediated signaling pathway  (IMP,ISO)
G protein-coupled receptor signaling pathway  (IMP)
hemopoiesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
humoral immune response  (ISO)
immune response  (IBA,ISO)
inflammatory response  (IBA,ISO)
inflammatory response to antigenic stimulus  (IEP)
inflammatory response to wounding  (ISO,ISS)
intracellular calcium ion homeostasis  (IDA)
leukocyte adhesion to vascular endothelial cell  (ISO)
macrophage migration  (ISO,ISS)
monocyte chemotaxis  (ISO)
monocyte extravasation  (ISO,ISS)
negative regulation of angiogenesis  (ISO,ISS)
negative regulation of eosinophil degranulation  (ISO,ISS)
negative regulation of type 2 immune response  (ISO,ISS)
neutrophil clearance  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO,ISS)
positive regulation of astrocyte chemotaxis  (ISO,ISS)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (ISO,ISS)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of hematopoietic stem cell migration  (ISO,ISS)
positive regulation of immune complex clearance by monocytes and macrophages  (ISO,ISS)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of interleukin-2 production  (ISO,ISS)
positive regulation of leukocyte tethering or rolling  (ISO)
positive regulation of monocyte chemotaxis  (ISO,ISS)
positive regulation of monocyte extravasation  (ISO,ISS)
positive regulation of NMDA glutamate receptor activity  (IGI)
positive regulation of p38MAPK cascade  (IDA)
positive regulation of synaptic transmission, glutamatergic  (ISO,ISS)
positive regulation of T cell activation  (ISO,ISS)
positive regulation of T cell chemotaxis  (ISO,ISS)
positive regulation of T-helper 1 type immune response  (ISO,ISS)
positive regulation of thymocyte migration  (ISO,ISS)
positive regulation of tumor necrosis factor production  (IMP,ISO,ISS)
positive regulation of type II interferon production  (ISO,ISS)
regulation of inflammatory response  (ISO,ISS)
regulation of macrophage migration  (ISO)
regulation of mononuclear cell migration  (ISO)
regulation of T cell cytokine production  (ISO,ISS)
regulation of T cell differentiation  (ISO,ISS)
regulation of T cell migration  (ISO)
regulation of vascular endothelial growth factor production  (ISO,ISS)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
sensory perception of pain  (ISO,ISS)
T-helper 17 cell chemotaxis  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis. Ahad MA, etal., Mol Vis. 2007 Mar 23;13:388-96.
2. Inhibition of corneal neovascularization by genetic ablation of CCR2. Ambati BK, etal., Cornea. 2003 Jul;22(5):465-7.
3. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
4. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
5. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
6. Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. Banisadr G, etal., J Comp Neurol. 2005 Nov 14;492(2):178-92.
7. Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice. Barros SP, etal., J Periodontal Res. 2011 Apr;46(2):246-51. doi: 10.1111/j.1600-0765.2010.01340.x. Epub 2011 Jan 18.
8. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
9. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Clin Invest. 2001 Aug;108(4):547-56.
10. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
11. Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. Blease K, etal., J Immunol. 2000 Sep 1;165(5):2603-11.
12. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
13. Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Breunis WB, etal., Clin Exp Immunol. 2007 Oct;150(1):83-90. Epub 2007 Aug 2.
14. Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Allergol Immunopathol (Madr). 2013 May 30. pii: S0301-0546(13)00103-1. doi: 10.1016/j.aller.2013.02.003.
15. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. Campbell EM, etal., J Immunol. 1999 Aug 15;163(4):2160-7.
16. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
17. Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent. Chen YF, etal., Am J Pathol. 2014 Jun;184(6):1695-705. doi: 10.1016/j.ajpath.2014.02.024. Epub 2014 Apr 13.
18. The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells. Cho J and Gruol DL, J Neuroimmunol. 2008 Aug 13;199(1-2):94-103. Epub 2008 Jun 27.
19. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease. Craven M, etal., PLoS One. 2012;7(7):e41594. doi: 10.1371/journal.pone.0041594. Epub 2012 Jul 25.
20. Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2. Dagkalis A, etal., Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4288-94. doi: 10.1167/iovs.09-3434. Epub 2009 Apr 8.
21. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Dansereau MA, etal., J Neurochem. 2008 Jul;106(2):757-69. Epub 2008 Apr 17.
22. Beta-chemokine receptor expression in idiopathic inflammatory myopathies. De Paepe B and De Bleecker JL, Muscle Nerve. 2005 May;31(5):621-7.
23. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
24. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
25. Retinal neuronal MCP-1 induced by AGEs stimulates TNF-alpha expression in rat microglia via p38, ERK, and NF-kappaB pathways. Dong N, etal., Mol Vis. 2014 May 2;20:616-28. eCollection 2014.
26. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Egan CE, etal., Mucosal Immunol. 2009 Nov;2(6):527-35. doi: 10.1038/mi.2009.105. Epub 2009 Sep 9.
27. Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7. Faaij CM, etal., Pediatr Blood Cancer. 2010 Aug;55(2):344-8. doi: 10.1002/pbc.22500.
28. [Expression of chemokine receptor CCR2 in cerebral tissue of newborn rat with experimental hypoxic-ischemic brain damage] Feng X and Yao YJ, Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Nov;38(6):942-4, 964.
29. Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults. Gambelunghe G, etal., Hum Immunol. 2003 Jun;64(6):629-32.
30. CCR2 deficiency results in increased osteolysis in experimental periapical lesions in mice. Garlet TP, etal., J Endod. 2010 Feb;36(2):244-50. doi: 10.1016/j.joen.2009.09.004. Epub 2009 Oct 23.
31. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
32. Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. Goodyear A, etal., J Immunol. 2010 Feb 1;184(3):1445-54. Epub 2009 Dec 30.
33. Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2. Goyal S, etal., Arch Ophthalmol. 2009 Jul;127(7):882-7. doi: 10.1001/archophthalmol.2009.125.
34. Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degeneration. Grunin M, etal., Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5292-300. doi: 10.1167/iovs.11-9165.
35. Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis. Guazzone VA, etal., J Reprod Immunol 2003 Dec;60(2):143-57.
36. Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa. Guo C, etal., Exp Eye Res. 2012 Nov;104:39-47. doi: 10.1016/j.exer.2012.08.013. Epub 2012 Sep 26.
37. Chemokine receptor expression in rat adjuvant-induced arthritis. Haas CS, etal., Arthritis Rheum. 2005 Dec;52(12):3718-30.
38. A role for MCP-1/CCR2 in interstitial lung disease in children. Hartl D, etal., Respir Res. 2005 Aug 11;6:93.
39. Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice. Hasegawa H, etal., Arthritis Res Ther. 2007;9(1):R15.
40. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Hildebrandt GC, etal., Blood. 2004 Mar 15;103(6):2417-26. Epub 2003 Nov 13.
41. Changes in protein expression and distribution of spinal CCR2 in a rat model of bone cancer pain. Hu JH, etal., Brain Res. 2013 May 6;1509:1-7. doi: 10.1016/j.brainres.2013.03.002. Epub 2013 Mar 17.
42. Deficiency of lymph node resident dendritic cells and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection. Ibrahim MK, etal., Infect Immun. 2014 May 12.
43. Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation. Jerath MR, etal., Thromb J. 2010 Sep 13;8:14. doi: 10.1186/1477-9560-8-14.
44. Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis. Ji J, etal., Infect Immun. 2003 Aug;71(8):4278-88.
45. Expression of chemokine receptors CXCR4, CCR2, CCR5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain. Ji JF, etal., Neurosci Lett. 2004 Jan 30;355(3):236-40.
46. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. Jiang Y, etal., J Neuroimmunol 1998 Jun 1;86(1):1-12.
47. Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy. Kanamori H, etal., Biochem Biophys Res Commun. 2007 Sep 7;360(4):772-7. Epub 2007 Jul 6.
48. Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in mice. Keino H, etal., Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):111-5. Epub 2003 Jan 28.
49. Association between a genetic variation of CC chemokine receptor-2 and atopic asthma. Kim YK, etal., Allergy. 2007 Feb;62(2):208-9.
50. Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat. Knerlich-Lukoschus F, etal., J Neurotrauma. 2008 May;25(5):427-48.
51. Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body. Lam SY, etal., Histochem Cell Biol. 2008 Sep;130(3):549-59. Epub 2008 May 1.
52. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
53. The expression of MCP-1 and CCR2 in induced rats periapical lesions. Liu L, etal., Arch Oral Biol. 2014 May;59(5):492-9. doi: 10.1016/j.archoralbio.2014.02.008. Epub 2014 Feb 22.
54. Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Lu P, etal., Cornea. 2009 Jun;28(5):562-9. doi: 10.1097/ICO.0b013e3181930bcd.
55. Important role of CCR2 in a murine model of coronary vasculitis. Martinez HG, etal., BMC Immunol. 2012 Oct 17;13:56. doi: 10.1186/1471-2172-13-56.
56. Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus. McMillan TR, etal., Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80. Epub 2008 Jan 10.
57. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
58. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Miller RE, etal., Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20602-7. doi: 10.1073/pnas.1209294110. Epub 2012 Nov 26.
59. Increased expression levels of monocyte CCR2 and monocyte chemoattractant protein-1 in patients with diabetes mellitus. Mine S, etal., Biochem Biophys Res Commun. 2006 Jun 9;344(3):780-5. Epub 2006 Apr 17.
60. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Moore BB, etal., Am J Pathol. 2005 Mar;166(3):675-84.
61. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. Na TY, etal., J Pathol. 2015 Apr;235(5):710-20. doi: 10.1002/path.4494. Epub 2015 Jan 5.
62. Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes. Nakajima K, etal., Diabetes. 2002 Jan;51(1):238-42.
63. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
64. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
65. MCP-1/CCR2 signalling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production. Okuma T, etal., Int J Exp Pathol. 2006 Dec;87(6):475-83.
66. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. Ortlepp JR, etal., J Mol Med. 2003 Jun;81(6):363-7. Epub 2003 Apr 29.
67. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Peters W, etal., Proc Natl Acad Sci U S A 2001 Jul 3;98(14):7958-63.
68. CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction. Petrkova J, etal., Immunol Lett. 2003 Jul 3;88(1):53-5.
69. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
70. Differential upregulation of chemokine receptors on CD56 NK cells and their transmigration to the site of infection in tuberculous pleurisy. Pokkali S, etal., FEMS Immunol Med Microbiol. 2009 Apr;55(3):352-60. Epub 2009 Jan 12.
71. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Qiu Y, etal., Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.
72. GOA pipeline RGD automated data pipeline
73. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
74. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
75. The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals. Rittig K, etal., Atherosclerosis. 2008 Jun;198(2):338-46. Epub 2007 Dec 21.
76. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. Sato N, etal., J Exp Med. 2000 Jul 17;192(2):205-18.
77. CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice. Sautter NB, etal., J Assoc Res Otolaryngol. 2006 Dec;7(4):361-72. Epub 2006 Oct 31.
78. The suppression of bone marrow-derived microglia in the amygdala improves the anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice. Sawada A, etal., Pain. 2014 Jun 4. pii: S0304-3959(14)00264-4. doi: 10.1016/j.pain.2014.05.031.
79. Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation. Sbrana S, etal., Cytometry B Clin Cytom. 2005 May;65(1):14-21.
80. Blunt chest trauma induces mediator-dependent monocyte migration to the lung. Seitz DH, etal., Crit Care Med. 2010 Sep;38(9):1852-9.
81. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
82. Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Shahrara S, etal., Arthritis Rheum. 2003 Dec;48(12):3568-83.
83. Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation. Shao Z, etal., J Immunol. 2009 Dec 1;183(11):7531-8. doi: 10.4049/jimmunol.0901341. Epub 2009 Nov 16.
84. Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases. Silva TA, etal., Oral Microbiol Immunol. 2005 Oct;20(5):310-6.
85. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. Sivakumar V, etal., J Pathol. 2011 Jan 17. doi: 10.1002/path.2858.
86. Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction. Sonekatsu M, etal., Mol Pain. 2016 Apr 18;12. pii: 12/0/1744806916644927. doi: 10.1177/1744806916644927. Print 2016.
87. Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritis. Soto-Sanchez J, etal., Cytokine. 2010 May;50(2):114-6. doi: 10.1016/j.cyto.2010.01.006. Epub 2010 Feb 12.
88. A common haplotype of the C-C chemokine receptor 2 gene and HLA-DRB1*0301 are independent genetic risk factors for Lofgren's syndrome. Spagnolo P, etal., J Intern Med. 2008 Nov;264(5):433-41. Epub 2008 May 29.
89. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Spinetti G, etal., Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1397-402. Epub 2004 Jun 3.
90. Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus. Szalai C, etal., Pediatr Res. 1999 Jul;46(1):82-4.
91. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Valdes AM, etal., Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1924-8.
92. The chemokine CCL2 modulates Ca2+ dynamics and electrophysiological properties of cultured cerebellar Purkinje neurons. van Gassen KL, etal., Eur J Neurosci. 2005 Jun;21(11):2949-57.
93. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
94. Expression of CCR2 on monocytes and macrophages in chronically inflamed skin in atopic dermatitis and psoriasis. Vestergaard C, etal., Acta Derm Venereol. 2004;84(5):353-8.
95. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. White FA, etal., Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14092-7. Epub 2005 Sep 20.
96. Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344. Xie P, etal., PLoS One. 2011;6(12):e28933. doi: 10.1371/journal.pone.0028933. Epub 2011 Dec 19.
97. Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma. Yamamoto T and Nishioka K, J Invest Dermatol. 2003 Sep;121(3):510-6.
98. Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury. Yang D, etal., Respir Physiol Neurobiol. 2010 Mar 31;170(3):253-9. Epub 2010 Feb 10.
99. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Yang SJ, etal., Diabetologia. 2009 May;52(5):972-81. doi: 10.1007/s00125-009-1309-8. Epub 2009 Mar 10.
100. [Interaction of polymorphisms of monocyte chemoattractant protein-1 receptor CCR2 gene 190A/G, nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic fatty liver disease]. Zhang C and Guo L, Wei Sheng Yan Jiu. 2015 Sep;44(5):730-7.
101. CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury. Zhang J, etal., J Surg Res. 2016 May 15;202(2):352-62. doi: 10.1016/j.jss.2016.02.029. Epub 2016 Mar 3.
102. Genetic variations in CC chemokine receptors and hypertension. Zhang M, etal., Am J Hypertens. 2006 Jan;19(1):67-72.
103. MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS). Zhang R, etal., J Neuroimmunol. 2006 Oct;179(1-2):87-93. Epub 2006 Jul 20.
104. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. Zhang RX, etal., J Investig Allergol Clin Immunol. 2007;17(5):329-36.
105. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Zhang ZJ, etal., J Neuroinflammation. 2012 Jul 9;9:136. doi: 10.1186/1742-2094-9-136.
106. Contribution of chemokine CCL2/CCR2 signaling in the dorsal root ganglion and spinal cord to the maintenance of neuropathic pain in a rat model of lumbar disc herniation. Zhu X, etal., J Pain. 2014 May;15(5):516-26. doi: 10.1016/j.jpain.2014.01.492. Epub 2014 Jan 23.
107. Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
Additional References at PubMed
PMID:8631787   PMID:8662823   PMID:8996246   PMID:9342361   PMID:9366570   PMID:10657654   PMID:10854218   PMID:10993920   PMID:12271471   PMID:12808141   PMID:14566334   PMID:15995708  
PMID:16148108   PMID:17484785   PMID:18421085   PMID:18586982   PMID:18587271   PMID:18832716   PMID:20034406   PMID:20234092   PMID:21143971   PMID:22466130   PMID:23049171   PMID:23288990  
PMID:23594826   PMID:23610400   PMID:23913046   PMID:24806994   PMID:26062549   PMID:28507030   PMID:29142497   PMID:29359616   PMID:29632244   PMID:29930553   PMID:29993042   PMID:30201767  
PMID:31034839   PMID:31805255   PMID:32164451   PMID:32650794   PMID:36219898   PMID:36470227  


Genomics

Comparative Map Data
Ccr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,611,883 - 132,619,106 (+)NCBIGRCr8
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,328,887 - 129,330,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,528,007 - 127,529,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,345,931 - 125,347,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBIT2T-CHM13v2.0
Ccr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)EnsemblGRCm39 Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBIMGSCv36mm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
CCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,315,650 - 46,320,292 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,320,418 - 46,325,060 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
CCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,787,205 - 42,793,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBIUU_Cfam_GSD_1.0
CCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,369,122 - 29,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,795,192 - 7,801,242 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccr2
36 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat

Markers in Region
PMC164693P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.48128,893,811 - 128,893,893UniSTSRGSC3.4
Celera8122,834,572 - 122,834,654UniSTS
Cytogenetic Map8q32UniSTS


Genetic Models
This gene Ccr2 is modified in the following models/strains:
BN-Ccr2m2Mcwi     FHH-Ccr2m1Mcwi    


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000100998   ⟹   ENSRNOP00000095594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114724   ⟹   ENSRNOP00000081733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,735,941 - 123,742,100 (+)Ensembl
RefSeq Acc Id: NM_021866   ⟹   NP_068638
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,612,203 - 132,619,106 (+)NCBI
mRatBN7.28123,734,783 - 123,741,686 (+)NCBI
RGSC_v3.48128,892,784 - 128,893,905 (+)RGD
Celera8122,833,545 - 122,834,666 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082061   ⟹   XP_038937989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,612,836 - 132,619,103 (+)NCBI
mRatBN7.28123,735,404 - 123,741,686 (+)NCBI
RefSeq Acc Id: XM_039082063   ⟹   XP_038937991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,611,883 - 132,619,103 (+)NCBI
mRatBN7.28123,734,465 - 123,741,686 (+)NCBI
RefSeq Acc Id: NP_068638   ⟸   NM_021866
- UniProtKB: O55193 (UniProtKB/Swiss-Prot),   A6I4D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038937991   ⟸   XM_039082063
- Peptide Label: isoform X1
- UniProtKB: O55193 (UniProtKB/Swiss-Prot),   A6I4D2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937989   ⟸   XM_039082061
- Peptide Label: isoform X1
- UniProtKB: O55193 (UniProtKB/Swiss-Prot),   A6I4D2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095594   ⟸   ENSRNOT00000100998
Ensembl Acc Id: ENSRNOP00000081733   ⟸   ENSRNOT00000114724
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55193-F1-model_v2 AlphaFold O55193 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620876 AgrOrtholog
BioCyc Gene G2FUF-28596 BioCyc
Ensembl Genes ENSRNOG00000063127 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055002417 UniProtKB/Swiss-Prot
  ENSRNOG00060023353 UniProtKB/Swiss-Prot
  ENSRNOG00065000759 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000100998.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114724.1 UniProtKB/Swiss-Prot
  ENSRNOT00055003839 UniProtKB/Swiss-Prot
  ENSRNOT00055003841 UniProtKB/Swiss-Prot
  ENSRNOT00060040410 UniProtKB/Swiss-Prot
  ENSRNOT00060040443 UniProtKB/Swiss-Prot
  ENSRNOT00065001048 UniProtKB/Swiss-Prot
  ENSRNOT00065001049 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CCR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60463 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 60463 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr2 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000063127 RatGTEx
  ENSRNOG00055002417 RatGTEx
  ENSRNOG00060023353 RatGTEx
  ENSRNOG00065000759 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I4D2 ENTREZGENE, UniProtKB/TrEMBL
  CCR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr2  C-C motif chemokine receptor 2  Ccr2  chemokine (C-C motif) receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ccr2  chemokine (C-C motif) receptor 2    chemokine receptor CCR2 gene  Name updated 1299863 APPROVED
2002-08-07 Ccr2  chemokine receptor CCR2 gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen, lung, kidney, thymus, and macrophages 632391
gene_regulation increased after induction of experimental allergic encephalomyelitis (EAE) 632391