RGD Reference Report - CCR2 deficiency results in increased osteolysis in experimental periapical lesions in mice. - Rat Genome Database

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CCR2 deficiency results in increased osteolysis in experimental periapical lesions in mice.

Authors: Garlet, TP  Fukada, SY  Saconato, IF  Avila-Campos, MJ  Da Silva, TA  Garlet, GP  Cunha Fde, Q 
Citation: Garlet TP, etal., J Endod. 2010 Feb;36(2):244-50. doi: 10.1016/j.joen.2009.09.004. Epub 2009 Oct 23.
RGD ID: 8661683
Pubmed: (View Article at PubMed) PMID:20113782
DOI: Full-text: DOI:10.1016/j.joen.2009.09.004

INTRODUCTION: Periapical lesions are chronic inflammatory disorders of periradicular tissues caused by etiologic agents of endodontic origin. The inflammatory chemokines are thought to be involved in the latter observed osteolysis. With a murine model of experimental periapical lesion, the objective of this study was to evaluate the role of the chemokine receptor CCR2 in the lesion progression, osteoclast differentiation and activation, and expression of inflammatory osteolysis-related mediators. METHODS: For lesion induction, right mandibular first molars were opened surgically with a 1/4 carbine bur, and 4 bacterial strains were inoculated in the exposed dental pulp; left mandibular first molars were used as controls. Animals were killed at 3, 7, 14, and 21 days after surgeries to evaluate the kinetics of lesion development. RESULTS: CCR2 KO mice showed wider lesions than WT mice. CCR2 KO mice also expressed higher levels of the osteoclastogenic and osteolytic factors, receptor activator of nuclear factor kappa B ligand (RANKL) and cathepsin K, of the proinflammatory cytokine tumor necrosis factor-alpha, and of the neutrophil migration related chemokine, KC. CONCLUSIONS: These results suggest that CCR2 is important in host protection to periapical osteolysis.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Mus musculus)
Ccr2  (chemokine (C-C motif) receptor 2)

Genes (Homo sapiens)
CCR2  (C-C motif chemokine receptor 2)

Additional Information