RGD Reference Report - Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. - Rat Genome Database

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Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria.

Authors: Brzoza, Z  Grzeszczak, W  Rogala, B  Trautsolt, W  Moczulski, D 
Citation: Brzoza Z, etal., Allergol Immunopathol (Madr). 2013 May 30. pii: S0301-0546(13)00103-1. doi: 10.1016/j.aller.2013.02.003.
RGD ID: 8551831
Pubmed: PMID:23727176   (View Abstract at PubMed)
DOI: DOI:10.1016/j.aller.2013.02.003   (Journal Full-text)

BACKGROUND: Autoimmune mechanisms play a role in the pathophysiology of chronic urticaria. As the genetic background of autoimmunity is well proven, the role of genetics in chronic urticaria is hypothesised. METHODS: 153 unrelated chronic spontaneous urticaria patients with a positive result of autologous serum skin test were included into the study, as were 115 healthy volunteers as control group. In all subjects we analysed CCR2 G190A and CCR5 d32 polymorphisms. RESULTS: We noticed higher prevalence of CCR2 A allele as well as lower frequency of CCR5 d32 in chronic urticaria group in comparison to control group, with borderline statistical significance. Additionally, we assumed haplotype Gd statistically significant negative chronic urticaria association with tendency to higher frequency of Aw haplotype in this group. CONCLUSIONS: The results of our study imply the role of autoimmune components in chronic urticaria pathogenesis and present chronic urticaria as possibly genetically related disorder.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
urticaria susceptibilityIAGP 8551831DNA:polymorphism and haplotype::190G>A(human)RGD 
urticaria  IAGP 8551831DNA:frameshift mutation and haplotype: :p.S185_T195del (rs333) (human)RGD 
urticaria susceptibilityISOCCR2 (Homo sapiens)8551831; 8551831DNA:polymorphism and haplotype::190G>A(human)RGD 
urticaria  ISOCCR5 (Homo sapiens)8551831; 8551831DNA:frameshift mutation and haplotype: :p.S185_T195del (rs333) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr2  (C-C motif chemokine receptor 2)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr2  (C-C motif chemokine receptor 2)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR2  (C-C motif chemokine receptor 2)
CCR5  (C-C motif chemokine receptor 5)


Additional Information