RGD Reference Report - Beta-chemokine receptor expression in idiopathic inflammatory myopathies. - Rat Genome Database

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Beta-chemokine receptor expression in idiopathic inflammatory myopathies.

Authors: De Paepe, B  De Bleecker, JL 
Citation: De Paepe B and De Bleecker JL, Muscle Nerve. 2005 May;31(5):621-7.
RGD ID: 8661727
Pubmed: PMID:15772970   (View Abstract at PubMed)
DOI: DOI:10.1002/mus.20294   (Journal Full-text)

Beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), dermatomyositis (DM), and control samples. CCR1-5 were localized to blood vessels in all samples. In addition, increased endothelial expression of CCR2A was observed in IIM. Subsets of inflammatory cells, identified as macrophages and T cells, in all three types of IIM expressed CCR2A, CCR2B, CCR3, CCR4, and CCR5. In contrast to an earlier report, we found CCR2B to be the most prominent MCP-1 receptor on inflammatory cells in IIM, especially in PM and sIBM. Strong CCR4 expression was present on myonuclei of regenerating muscle fibers. The prominence of the CCR2 receptors further underlines the importance of the interaction with their ligand MCP-1 in the immunopathogenesis of IIM and puts CCR2B forward as a potential target for future therapeutic intervention.



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Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CCR2Humandermatomyositis  IEP protein:increased expression:limb muscle:RGD 
Ccr2Ratdermatomyositis  ISOCCR2 (Homo sapiens)protein:increased expression:limb muscle:RGD 
Ccr2Mousedermatomyositis  ISOCCR2 (Homo sapiens)protein:increased expression:limb muscle:RGD 
CCR2Humaninclusion body myositis  IEP protein:increased expression:limb muscle:RGD 
Ccr2Ratinclusion body myositis  ISOCCR2 (Homo sapiens)protein:increased expression:limb muscle:RGD 
Ccr2Mouseinclusion body myositis  ISOCCR2 (Homo sapiens)protein:increased expression:limb muscle:RGD 
CCR2Humanpolymyositis  IEP protein:increased expression:limb muscle:RGD 
Ccr2Ratpolymyositis  ISOCCR2 (Homo sapiens)protein:increased expression:limb muscle:RGD 
Ccr2Mousepolymyositis  ISOCCR2 (Homo sapiens)protein:increased expression:limb muscle:RGD 
1 to 9 of 9 rows


Genes (Rattus norvegicus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Mus musculus)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Homo sapiens)
CCR2  (C-C motif chemokine receptor 2)