Ppt1 (palmitoyl-protein thioesterase 1) - Rat Genome Database

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Gene: Ppt1 (palmitoyl-protein thioesterase 1) Rattus norvegicus
Analyze
Symbol: Ppt1
Name: palmitoyl-protein thioesterase 1
RGD ID: 61994
Description: Predicted to enable lysophosphatidic acid binding activity; sulfatide binding activity; and thiolester hydrolase activity. Predicted to be involved in several processes, including lysosomal lumen acidification; negative regulation of toll-like receptor 9 signaling pathway; and positive regulation of endocytosis. Predicted to act upstream of or within several processes, including endocytosis; grooming behavior; and macromolecule depalmitoylation. Located in neuronal cell body and synaptic vesicle. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1); PARTICIPATES IN fatty acid elongation pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bexarotene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase; Ppt; PPT-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,406,318 - 140,427,201 (+)NCBIGRCr8
mRatBN7.25135,121,164 - 135,142,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,121,163 - 135,142,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,827,992 - 137,847,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,598,471 - 139,618,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,605,087 - 139,624,952 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,538,260 - 140,558,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,538,260 - 140,558,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,329,263 - 144,349,162 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,153,498 - 142,173,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,158,725 - 142,179,598 (+)NCBI
Celera5133,659,813 - 133,679,711 (+)NCBICelera
RH 3.4 Map5890.0RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chloroquine  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucitol  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
finasteride  (EXP)
folic acid  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (ISO)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (EXP,ISO)
hydroxychloroquine  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
orlistat  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of palmitoyl-protein thioesterase. Camp LA, etal., J Biol Chem 1994 Sep 16;269(37):23212-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, etal., Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13566-71.
5. Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis. Hellsten E, etal., EMBO J. 1996 Oct 1;15(19):5240-5.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1. Suopanki J, etal., Neurobiol Dis 2002 Aug;10(3):247-57.
16. Palmitoyl-protein thioesterase, an enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain. Suopanki J, etal., Neurosci Lett. 1999 Apr 9;265(1):53-6.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7637805   PMID:7901201   PMID:8816748   PMID:9685319   PMID:10611498   PMID:10658183   PMID:10737604   PMID:10992246   PMID:11020216   PMID:11722572   PMID:12477932   PMID:12483688  
PMID:15647513   PMID:15649713   PMID:15885820   PMID:15929065   PMID:16242638   PMID:16368712   PMID:16542649   PMID:17341491   PMID:18317235   PMID:19941651   PMID:19946888   PMID:23376485  
PMID:23533145   PMID:24302477  


Genomics

Comparative Map Data
Ppt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,406,318 - 140,427,201 (+)NCBIGRCr8
mRatBN7.25135,121,164 - 135,142,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,121,163 - 135,142,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,827,992 - 137,847,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,598,471 - 139,618,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,605,087 - 139,624,952 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,538,260 - 140,558,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,538,260 - 140,558,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,329,263 - 144,349,162 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,153,498 - 142,173,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,158,725 - 142,179,598 (+)NCBI
Celera5133,659,813 - 133,679,711 (+)NCBICelera
RH 3.4 Map5890.0RGD
Cytogenetic Map5q36NCBI
PPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,071,461 - 40,097,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,072,710 - 40,097,260 (-)EnsemblGRCh38hg38GRCh38
GRCh37140,537,133 - 40,562,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,310,969 - 40,335,555 (-)NCBINCBI36Build 36hg18NCBI36
Build 34140,207,476 - 40,232,061NCBI
Celera138,820,669 - 38,845,442 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,656,433 - 38,681,192 (-)NCBIHuRef
CHM1_1140,653,983 - 40,678,773 (-)NCBICHM1_1
T2T-CHM13v2.0139,940,889 - 39,966,711 (-)NCBIT2T-CHM13v2.0
Ppt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394122,729,879 - 122,752,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4122,730,035 - 122,752,968 (+)EnsemblGRCm39 Ensembl
GRCm384122,836,077 - 122,859,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4122,836,242 - 122,859,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv374122,513,485 - 122,536,418 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364122,338,558 - 122,360,685 (+)NCBIMGSCv36mm8
Celera4121,166,717 - 121,189,624 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.27NCBI
Ppt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,529,115 - 17,549,664 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545217,518,345 - 17,549,112 (-)NCBIChiLan1.0ChiLan1.0
PPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,729,114 - 186,753,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,866,794 - 185,891,455 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,358,424 - 39,383,087 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,683,841 - 40,708,609 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,683,841 - 40,708,609 (-)Ensemblpanpan1.1panPan2
PPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,815,428 - 2,886,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,859,979 - 2,894,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,117,325 - 3,143,210 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,902,313 - 2,973,313 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,946,653 - 2,981,365 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,854,181 - 2,880,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,914,086 - 2,939,964 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,930,482 - 2,956,365 (+)NCBIUU_Cfam_GSD_1.0
Ppt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,056,908 - 56,081,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,881,712 - 21,906,569 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,881,692 - 21,906,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,840,908 - 95,860,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1695,840,906 - 95,860,858 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,280,518 - 89,300,475 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,809,373 - 92,833,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,809,552 - 92,833,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,006,277 - 24,030,955 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,543,857 - 22,577,121 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,542,892 - 22,577,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppt1
205 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:115
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000017998
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5134972980138113556Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
Ppt  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,351 - 135,141,556 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,439 - 140,558,643NCBIRnor6.0
Rnor_5.05144,349,438 - 144,349,642UniSTSRnor5.0
RGSC_v3.45142,173,677 - 142,173,881UniSTSRGSC3.4
Celera5133,679,987 - 133,680,191UniSTS
Cytogenetic Map5q36UniSTS
RH142418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,673 - 135,141,856 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,761 - 140,558,943NCBIRnor6.0
Rnor_5.05144,349,760 - 144,349,942UniSTSRnor5.0
RGSC_v3.45142,173,999 - 142,174,181UniSTSRGSC3.4
Celera5133,680,309 - 133,680,491UniSTS
RH 3.4 Map5890.0UniSTS
Cytogenetic Map5q36UniSTS
RH127550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,796 - 135,142,005 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,884 - 140,559,092NCBIRnor6.0
Rnor_5.05144,349,883 - 144,350,091UniSTSRnor5.0
RGSC_v3.45142,174,122 - 142,174,330UniSTSRGSC3.4
Celera5133,680,432 - 133,680,640UniSTS
RH 3.4 Map5876.9UniSTS
Cytogenetic Map5q36UniSTS
AA851880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,142,185 - 135,142,377 (+)MAPPERmRatBN7.2
Rnor_6.05140,559,273 - 140,559,463NCBIRnor6.0
Rnor_5.05144,350,272 - 144,350,462UniSTSRnor5.0
RGSC_v3.45142,174,511 - 142,174,701UniSTSRGSC3.4
Celera5133,680,821 - 133,681,011UniSTS
RH 3.4 Map5900.7UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017998   ⟹   ENSRNOP00000017998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,121,173 - 135,141,080 (+)Ensembl
Rnor_6.0 Ensembl5140,538,260 - 140,558,162 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109802   ⟹   ENSRNOP00000084196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,126,095 - 135,142,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111724   ⟹   ENSRNOP00000093361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,121,163 - 135,132,782 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112154   ⟹   ENSRNOP00000091845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,121,163 - 135,142,048 (+)Ensembl
RefSeq Acc Id: NM_022502   ⟹   NP_071947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,406,318 - 140,427,201 (+)NCBI
mRatBN7.25135,121,164 - 135,142,048 (+)NCBI
Rnor_6.05140,538,260 - 140,558,163 (+)NCBI
Rnor_5.05144,329,263 - 144,349,162 (+)NCBI
RGSC_v3.45142,153,498 - 142,173,401 (+)RGD
Celera5133,659,813 - 133,679,711 (+)RGD
Sequence:
RefSeq Acc Id: NP_071947   ⟸   NM_022502
- Peptide Label: precursor
- UniProtKB: A0JN20 (UniProtKB/Swiss-Prot),   P45479 (UniProtKB/Swiss-Prot),   A6IS08 (UniProtKB/TrEMBL),   A0A8I6A0R6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017998   ⟸   ENSRNOT00000017998
Ensembl Acc Id: ENSRNOP00000093361   ⟸   ENSRNOT00000111724
Ensembl Acc Id: ENSRNOP00000091845   ⟸   ENSRNOT00000112154
Ensembl Acc Id: ENSRNOP00000084196   ⟸   ENSRNOT00000109802

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45479-F1-model_v2 AlphaFold P45479 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693998
Promoter ID:EPDNEW_R4523
Type:multiple initiation site
Name:Ppt1_1
Description:palmitoyl-protein thioesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05140,538,248 - 140,538,308EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61994 AgrOrtholog
BioCyc Gene G2FUF-40031 BioCyc
Ensembl Genes ENSRNOG00000012616 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012979 UniProtKB/Swiss-Prot
  ENSRNOG00060017932 UniProtKB/Swiss-Prot
  ENSRNOG00065015608 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017998.6 UniProtKB/TrEMBL
  ENSRNOT00000109802.1 UniProtKB/TrEMBL
  ENSRNOT00000111724.1 UniProtKB/TrEMBL
  ENSRNOT00000112154.1 UniProtKB/Swiss-Prot
  ENSRNOT00055022229 UniProtKB/Swiss-Prot
  ENSRNOT00060030796 UniProtKB/Swiss-Prot
  ENSRNOT00065025966 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8361877 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Palm_thioest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156647 IMAGE-MGC_LOAD
NCBI Gene 29411 ENTREZGENE
PANTHER PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11247:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Palm_thioest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppt1 PhenoGen
PRINTS PPTHIESTRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012616 RatGTEx
  ENSRNOG00055012979 RatGTEx
  ENSRNOG00060017932 RatGTEx
  ENSRNOG00065015608 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217109
UniProt A0A8I6A0R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJP6_RAT UniProtKB/TrEMBL
  A0A8L2Q8Z6_RAT UniProtKB/TrEMBL
  A0JN20 ENTREZGENE
  A6IS08 ENTREZGENE, UniProtKB/TrEMBL
  P45479 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JN20 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ppt1  palmitoyl-protein thioesterase 1  Ppt  palmitoyl-protein thioesterase  Name updated 1299863 APPROVED
2002-06-10 Ppt  palmitoyl-protein thioesterase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation induced by epileptic seizures 633701