Mir25 (microRNA 25) - Rat Genome Database

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Gene: Mir25 (microRNA 25) Rattus norvegicus
Analyze
Symbol: Mir25
Name: microRNA 25
RGD ID: 2325594
Description: Involved in negative regulation of cardiac muscle hypertrophy and negative regulation of cardiac muscle tissue growth. Predicted to be part of RISC complex. Biomarker of hepatocellular carcinoma. Orthologous to human MIR25 (microRNA 25); INTERACTS WITH bis(2-ethylhexyl) phthalate; bisphenol A; bleomycin A2.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-25
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,156,641 - 22,156,724 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21217,042,932 - 17,043,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,042,932 - 17,043,015 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1217,866,315 - 17,866,398 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,490,059 - 18,490,142 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,543,465 - 17,543,548 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,307,340 - 19,307,423 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,307,340 - 19,307,423 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,364,970 - 21,365,053 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1218,973,102 - 18,973,185 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon. Hong H, etal., Basic Res Cardiol. 2017 Sep 8;112(6):60. doi: 10.1007/s00395-017-0649-7.
2. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Li LM, etal., Cancer Res. 2010 Dec 1;70(23):9798-807. doi: 10.1158/0008-5472.CAN-10-1001. Epub 2010 Nov 23.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. Sanchez-Mejias A, etal., Int J Cancer. 2019 Jan 15;144(2):311-321. doi: 10.1002/ijc.31857. Epub 2018 Nov 9.
5. Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma. Su ZX, etal., Diagn Pathol. 2014 Mar 4;9:47. doi: 10.1186/1746-1596-9-47.
6. miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma. Yen CS, etal., World J Gastroenterol. 2016 Jun 14;22(22):5183-92. doi: 10.3748/wjg.v22.i22.5183.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:18329372   PMID:20403161   PMID:21993888   PMID:23390484   PMID:23646144   PMID:23722270   PMID:24084692   PMID:24161931   PMID:25751060  
PMID:25764156   PMID:25858512   PMID:27513215   PMID:27648837   PMID:29210651   PMID:29440462   PMID:31058341   PMID:31539106   PMID:31809304   PMID:31954517   PMID:33576470   PMID:35025075  
PMID:36289253   PMID:36994450  


Genomics

Comparative Map Data
Mir25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,156,641 - 22,156,724 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21217,042,932 - 17,043,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,042,932 - 17,043,015 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1217,866,315 - 17,866,398 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,490,059 - 18,490,142 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,543,465 - 17,543,548 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,307,340 - 19,307,423 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,307,340 - 19,307,423 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,364,970 - 21,365,053 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1218,973,102 - 18,973,185 (-)NCBICelera
Cytogenetic Map12q11NCBI
MIR25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,093,560 - 100,093,643 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,093,560 - 100,093,643 (-)Ensemblhg38GRCh38
GRCh37799,691,183 - 99,691,266 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,529,118 - 99,529,201 (-)NCBIBuild 36Build 36hg18NCBI36
Celera794,425,842 - 94,425,925 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,326,834 - 94,326,917 (-)NCBIHuRef
CHM1_1799,621,340 - 99,621,423 (-)NCBICHM1_1
T2T-CHM13v2.07101,333,406 - 101,333,489 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,051,303 - 99,051,386 (-)NCBI
Mir25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,163,583 - 138,163,666 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,163,583 - 138,163,666 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385138,165,321 - 138,165,404 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,165,321 - 138,165,404 (-)Ensemblmm10GRCm38
MGSCv375138,606,549 - 138,606,632 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera5135,144,653 - 135,144,736 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.97NCBI
MIR25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,498,993 - 9,499,051 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,498,993 - 9,499,051 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.069,435,994 - 9,436,052 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,435,994 - 9,436,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,285,320 - 9,285,378 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,265,616 - 9,265,674 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,445,231 - 9,445,289 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vsnl1rno-miR-25-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Nox4rno-miR-25-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI21071935

Predicted Targets
Summary Value
Count of predictions:14774
Count of gene targets:7721
Count of transcripts:8345
Interacting mature miRNAs:rno-miR-25-3p, rno-miR-25-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
AI747533  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81222,156,415 - 22,157,251 (+)Marker Load Pipeline
mRatBN7.21217,042,705 - 17,043,542 (+)MAPPERmRatBN7.2
Rnor_6.01219,307,114 - 19,307,950NCBIRnor6.0
Rnor_5.01221,364,744 - 21,365,580UniSTSRnor5.0
RGSC_v3.41217,607,744 - 17,608,580UniSTSRGSC3.4
Celera1218,972,876 - 18,973,712UniSTS
Cytogenetic Map12q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 8 48 103 74 73 42 25 42 6 185 93 83 35 51 31 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1217,042,932 - 17,043,015 (-)Ensembl
Rnor_6.0 Ensembl1219,307,340 - 19,307,423 (-)Ensembl
RefSeq Acc Id: NR_031829
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,156,641 - 22,156,724 (-)NCBI
mRatBN7.21217,042,932 - 17,043,015 (-)NCBI
Rnor_6.01219,307,340 - 19,307,423 (-)NCBI
Rnor_5.01221,364,970 - 21,365,053 (-)NCBI
Celera1218,973,102 - 18,973,185 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325594 AgrOrtholog
BioCyc Gene G2FUF-19815 BioCyc
Ensembl Genes ENSRNOG00000035531 Ensembl
miRBase MI0000856 ENTREZGENE
NCBI Gene 100314004 ENTREZGENE
PhenoGen Mir25 PhenoGen
RatGTEx ENSRNOG00000035531 RatGTEx
RNAcentral URS00004F9744 RNACentral
  URS0000624211 RNACentral
  URS000075BF87 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir25  microRNA 25  Mir25  microRNA mir-25  Name updated 61478 APPROVED
2010-06-02 Mir25  microRNA mir-25      Symbol and Name status set to provisional 70820 PROVISIONAL