Fscn1 (fascin actin-bundling protein 1) - Rat Genome Database

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Gene: Fscn1 (fascin actin-bundling protein 1) Rattus norvegicus
Analyze
Symbol: Fscn1
Name: fascin actin-bundling protein 1
RGD ID: 1583309
Description: Enables actin binding activity. Involved in actin filament bundle assembly; cellular response to cell-matrix adhesion; and liver development. Located in several cellular components, including lamellipodium; ruffle; and stress fiber. Orthologous to human FSCN1 (fascin actin-bundling protein 1); PARTICIPATES IN protein kinase C (PKC) signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fascin; fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus); MGC188481
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,710,601 - 16,723,734 (-)NCBIGRCr8
mRatBN7.21211,597,042 - 11,610,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,597,048 - 11,610,211 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,407,106 - 12,420,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,030,380 - 13,043,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,056,462 - 12,069,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,655,459 - 13,668,595 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,656,554 - 13,668,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,688,989 - 15,702,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1213,390,657 - 13,403,285 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
FR900359  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
latrunculin A  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
lysophosphatidylcholine  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quartz  (ISO)
quinoline  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
succimer  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
warfarin  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IBA,ISO)
cell cortex  (IEA)
cell projection membrane  (IBA,IEA,ISO,ISS)
cell-cell junction  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IEA,ISO)
cytosol  (IEA,ISO)
dendrite  (IDA)
filopodium  (IBA,IDA,IEA,ISO)
growth cone  (IBA,IDA,IEA,ISO)
lamellipodium  (IBA,IDA,IEA,ISO)
microspike  (IEA,ISO,ISS)
microvillus  (IBA,IDA,IEA,ISO)
podosome  (IEA,ISO,ISS)
ruffle  (IBA,IDA,IEA,ISO)
stress fiber  (IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1. Adams JC J Cell Sci. 1995 May;108 ( Pt 5):1977-90.
2. Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary. Cao D, etal., Int J Gynecol Pathol. 2005 Jan;24(1):67-72.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development. Hayashi Y, etal., Cell Tissue Res. 2008 Nov;334(2):219-26. Epub 2008 Oct 15.
5. Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47. Maitra A, etal., Am J Clin Pathol. 2002 Jul;118(1):52-9.
6. Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. Mosialos G, etal., J Virol. 1994 Nov;68(11):7320-8.
7. Fascin expression is correlated with tumor progression of extrahepatic bile duct cancer. Okada K, etal., Hepatogastroenterology. 2007 Jan-Feb;54(73):17-21.
8. Fascin is involved in tumor necrosis factor-alpha-dependent production of MMP9 in cholangiocarcinoma. Onodera M, etal., Lab Invest. 2009 Nov;89(11):1261-74. Epub 2009 Aug 31.
9. PKC-interacting proteins: from function to pharmacology. Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Fascin overexpression correlates with positive thrombospondin-1 and syndecan-1 expressions and a more aggressive clinical course in patients with gallbladder cancer. Roh YH, etal., J Hepatobiliary Pancreat Surg. 2009;16(3):315-21. Epub 2009 Mar 4.
13. Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. Sasaki Y, etal., J Neurochem. 1996 Mar;66(3):980-8.
14. beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. Tao YS, etal., J Cell Biol. 1996 Sep;134(5):1271-81.
15. EMMPRIN and fascin overexpression associated with clinicopathologic parameters of pancreatobiliary adenocarcinoma in Chinese people. Tsai WC, etal., APMIS. 2007 Aug;115(8):929-38.
16. Gene expression profiling identifies markers of ampullary adenocarcinoma. Van Heek NT, etal., Cancer Biol Ther. 2004 Jul;3(7):651-6. Epub 2004 Jul 9.
17. Prognostic significance of fascin expression in extrahepatic bile duct carcinomas. Won KY, etal., Pathol Res Pract. 2009;205(11):742-8. Epub 2009 Jun 24.
Additional References at PubMed
PMID:3525578   PMID:7738015   PMID:8999969   PMID:9571235   PMID:12477932   PMID:15294161   PMID:15489334   PMID:17634366   PMID:17671164   PMID:19343716   PMID:20137952   PMID:20393565  
PMID:20458337   PMID:21685497   PMID:22082260   PMID:22658674   PMID:22871113   PMID:23884926   PMID:24369046   PMID:24720729   PMID:25159326   PMID:25468996   PMID:27169557   PMID:29052088  
PMID:32357304   PMID:38449390  


Genomics

Comparative Map Data
Fscn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,710,601 - 16,723,734 (-)NCBIGRCr8
mRatBN7.21211,597,042 - 11,610,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,597,048 - 11,610,211 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,407,106 - 12,420,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,030,380 - 13,043,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,056,462 - 12,069,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,655,459 - 13,668,595 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,656,554 - 13,668,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,688,989 - 15,702,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1213,390,657 - 13,403,285 (-)NCBICelera
Cytogenetic Map12p11NCBI
FSCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3875,592,816 - 5,606,655 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl75,592,816 - 5,606,655 (+)EnsemblGRCh38hg38GRCh38
GRCh3775,632,447 - 5,646,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,598,980 - 5,612,812 (+)NCBINCBI36Build 36hg18NCBI36
Build 3475,405,694 - 5,419,526NCBI
Celera75,592,071 - 5,605,904 (+)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef75,544,716 - 5,558,303 (+)NCBIHuRef
CHM1_175,632,035 - 5,645,887 (+)NCBICHM1_1
T2T-CHM13v2.075,710,346 - 5,724,185 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v275,678,781 - 5,692,632 (+)NCBI
Fscn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395142,946,110 - 142,958,944 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5142,946,098 - 142,958,940 (+)EnsemblGRCm39 Ensembl
GRCm385142,960,355 - 142,973,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5142,960,343 - 142,973,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv375143,722,034 - 143,734,868 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,225,511 - 143,238,323 (+)NCBIMGSCv36mm8
Celera5140,008,743 - 140,021,597 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map581.84NCBI
Fscn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546010,402,855 - 10,412,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546010,402,855 - 10,412,459 (+)NCBIChiLan1.0ChiLan1.0
FSCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2610,558,399 - 10,572,274 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1758,883,132 - 58,896,979 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v075,848,902 - 5,862,756 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.175,865,307 - 5,877,366 (+)NCBIpanpan1.1PanPan1.1panPan2
FSCN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1612,360,849 - 12,370,906 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl612,354,599 - 12,370,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,832,769 - 13,842,836 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0612,496,810 - 12,506,878 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl612,434,187 - 12,506,926 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1612,307,279 - 12,317,591 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0612,241,487 - 12,251,542 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0612,518,817 - 12,528,874 (-)NCBIUU_Cfam_GSD_1.0
Fscn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344140,618,834 - 140,628,367 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936765609,861 - 619,456 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936765609,894 - 619,417 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSCN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,134,177 - 4,143,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,134,173 - 4,143,275 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.234,776,501 - 4,785,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FSCN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12816,127,033 - 16,142,285 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2816,127,015 - 16,142,337 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660905,849,807 - 5,864,040 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fscn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474028,036,731 - 28,047,364 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474028,038,216 - 28,047,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fscn1
125 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 20 10 19 10 2 4 74 22 33 10 2
Low 3 8 37 31 31 6 7 13 8 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086847   ⟹   ENSRNOP00000075451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,598,137 - 11,610,211 (-)Ensembl
Rnor_6.0 Ensembl1213,656,554 - 13,668,515 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102305   ⟹   ENSRNOP00000093403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,597,048 - 11,610,158 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102873   ⟹   ENSRNOP00000078381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,597,048 - 11,610,103 (-)Ensembl
RefSeq Acc Id: NM_001100806   ⟹   NP_001094276
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,710,601 - 16,723,734 (-)NCBI
mRatBN7.21211,597,042 - 11,610,183 (-)NCBI
Rnor_6.01213,655,459 - 13,668,595 (-)NCBI
Rnor_5.01215,688,989 - 15,702,125 (-)NCBI
Celera1213,390,657 - 13,403,285 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094276 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68678 (Get FASTA)   NCBI Sequence Viewer  
  AAP31246 (Get FASTA)   NCBI Sequence Viewer  
  EDL89691 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075451.2
  ENSRNOP00000078381.1
  ENSRNOP00000093403
  ENSRNOP00000093403.1
GenBank Protein P85845 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001094276   ⟸   NM_001100806
- UniProtKB: P85845 (UniProtKB/Swiss-Prot),   B5DEI1 (UniProtKB/Swiss-Prot),   A0A8I6AK10 (UniProtKB/TrEMBL),   A6K1N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075451   ⟸   ENSRNOT00000086847
RefSeq Acc Id: ENSRNOP00000093403   ⟸   ENSRNOT00000102305
RefSeq Acc Id: ENSRNOP00000078381   ⟸   ENSRNOT00000102873
Protein Domains
Fascin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P85845-F1-model_v2 AlphaFold P85845 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698451
Promoter ID:EPDNEW_R8970
Type:single initiation site
Name:Fscn1_1
Description:Fascin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,668,608 - 13,668,668EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583309 AgrOrtholog
BioCyc Gene G2FUF-19985 BioCyc
Ensembl Genes ENSRNOG00000056585 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086847.2 UniProtKB/TrEMBL
  ENSRNOT00000102305 ENTREZGENE
  ENSRNOT00000102305.1 UniProtKB/TrEMBL
  ENSRNOT00000102873.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actin-crosslinking UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fascin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fascin-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fascin_metazoans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:683788 UniProtKB/Swiss-Prot
NCBI Gene 683788 ENTREZGENE
PANTHER PTHR10551 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10551:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fascin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fscn1 PhenoGen
PIRSF Fascin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056585 RatGTEx
Superfamily-SCOP SSF50405 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAM4_RAT UniProtKB/TrEMBL
  A0A8I5ZKQ7_RAT UniProtKB/TrEMBL
  A0A8I6AK10 ENTREZGENE, UniProtKB/TrEMBL
  A6K1N2 ENTREZGENE, UniProtKB/TrEMBL
  B5DEI1 ENTREZGENE
  FSCN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B5DEI1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-13 Fscn1  fascin actin-bundling protein 1  Fscn1  fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-15 Fscn1  fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)  LOC683788  similar to Fascin (Singed-like protein)  Name and Symbol changed 629549 APPROVED
2006-11-19 LOC683788  similar to Fascin (Singed-like protein)      Symbol and Name status set to provisional 70820 PROVISIONAL