Dnaaf5 (dynein, axonemal, assembly factor 5)

Gene: Dnaaf5 (dynein, axonemal, assembly factor 5) Rattus norvegicus

Analyze

Symbol:

Dnaaf5

Name:

dynein, axonemal, assembly factor 5

RGD ID:

1566028

Description:

Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium movement; inner dynein arm assembly; and outer dynein arm assembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 18. Orthologous to human DNAAF5 (dynein axonemal assembly factor 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dynein assembly factor 5, axonemal; dynein axonemal assembly factor 5; HEAT repeat containing 2; HEAT repeat-containing protein 2; Heatr2; MGC125214; similar to hypothetical protein FLJ20397

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DNAAF5 (dynein axonemal assembly factor 5)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dnaaf5 (dynein, axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dnaaf5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DNAAF5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DNAAF5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dnaaf5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DNAAF5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DNAAF5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dnaaf5 (dynein axonemal assembly factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DNAAF5 (dynein axonemal assembly factor 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dnaaf5 (dynein, axonemal assembly factor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dnaaf5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,567,482 - 20,606,600 (-)	NCBI		GRCr8
mRatBN7.2	12	15,453,636 - 15,492,722 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,453,636 - 15,492,739 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	16,263,773 - 16,302,914 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	16,887,515 - 16,926,655 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	15,913,508 - 15,952,552 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,545,468 - 17,584,466 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,545,468 - 17,584,466 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	19,531,842 - 19,570,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	15,955,971 - 15,994,971 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	17,207,707 - 17,246,686 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

male infertility (ISS)

primary ciliary dyskinesia (ISO,ISS)

primary ciliary dyskinesia 18 (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dicrotophos (ISO)

flutamide (EXP)

fulvestrant (ISO)

hydralazine (ISO)

indometacin (ISO)

ivermectin (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium movement (IBA,ISO)

inner dynein arm assembly (IBA,ISO)

outer dynein arm assembly (IBA,ISO)

Cellular Component

cytoplasm (IBA,ISO)

motile cilium (ISO)

Molecular Function

dynein intermediate chain binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:23040496	PMID:25232951

Genomics

Comparative Map Data

Dnaaf5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,567,482 - 20,606,600 (-)	NCBI		GRCr8
mRatBN7.2	12	15,453,636 - 15,492,722 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,453,636 - 15,492,739 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	16,263,773 - 16,302,914 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	16,887,515 - 16,926,655 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	15,913,508 - 15,952,552 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,545,468 - 17,584,466 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,545,468 - 17,584,466 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	19,531,842 - 19,570,964 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	15,955,971 - 15,994,971 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	17,207,707 - 17,246,686 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

DNAAF5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	726,699 - 786,475 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	726,699 - 786,475 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	766,336 - 826,112 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	732,864 - 792,642 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	734,101 - 794,859 (+)	NCBI		Celera
Cytogenetic Map	7	p22.3	NCBI
HuRef	7	685,022 - 744,516 (+)	NCBI		HuRef
CHM1_1	7	765,930 - 825,538 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	829,794 - 889,570 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	827,519 - 884,476 (+)	NCBI

Dnaaf5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	139,135,888 - 139,172,265 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	139,135,978 - 139,172,265 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	139,150,133 - 139,186,510 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	139,150,223 - 139,186,510 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	139,626,177 - 139,662,459 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	139,403,865 - 139,440,147 (+)	NCBI		MGSCv36	mm8
Celera	5	136,204,057 - 136,240,283 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	78.02	NCBI

Dnaaf5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	8,479,274 - 8,526,342 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955460	8,479,274 - 8,525,828 (+)	NCBI	ChiLan1.0	ChiLan1.0

DNAAF5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	5,659,982 - 5,723,017 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	53,980,009 - 54,047,714 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	875,482 - 938,560 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	1,097,336 - 1,155,559 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	1,095,732 - 1,154,740 (+)	Ensembl	panpan1.1		panPan2

DNAAF5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	16,075,099 - 16,121,917 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	16,075,364 - 16,121,917 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	17,546,874 - 17,593,724 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	16,204,601 - 16,251,246 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	16,204,607 - 16,251,246 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	16,007,016 - 16,053,901 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	15,933,474 - 15,980,345 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	16,223,254 - 16,270,084 (-)	NCBI		UU_Cfam_GSD_1.0

Dnaaf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	143,975,601 - 144,031,629 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936754	978,737 - 1,034,758 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936754	978,726 - 1,034,748 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNAAF5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	417,324 - 461,817 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	424,514 - 462,297 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	307,532 - 398,685 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DNAAF5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	20,785,240 - 20,839,784 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666090	841,559 - 898,024 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dnaaf5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	26,299,742 - 26,362,086 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	26,315,229 - 26,362,086 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dnaaf5
138 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	33
Interacting mature miRNAs:	36
Transcripts:	ENSRNOT00000035545
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1600391	Edcs2	Endometrial carcinoma susceptibility QTL2	3.5	0.01	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	12	6833190	17870186	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	11073825	24234895	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	28064557	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	13008296	19212979	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	15025183	20794014	Rat

Markers in Region

RH127397

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	15,453,841 - 15,454,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	17,545,674 - 17,545,856	NCBI	Rnor6.0
Rnor_5.0	12	19,532,048 - 19,532,230	UniSTS	Rnor5.0
RGSC_v3.4	12	15,956,177 - 15,956,359	UniSTS	RGSC3.4
Celera	12	17,207,913 - 17,208,095	UniSTS
Cytogenetic Map	12	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		8	12	12		12			16	19	36	3
Low	3	35	45	29	19	29	8	11	58	16	5	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC127903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000035545 ⟹ ENSRNOP00000035454

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	15,453,636 - 15,492,739 (-)	Ensembl
Rnor_6.0 Ensembl	12	17,545,468 - 17,584,466 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088813 ⟹ ENSRNOP00000070729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	17,546,123 - 17,578,737 (-)	Ensembl

RefSeq Acc Id:

NM_001134857 ⟹ NP_001128329

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,567,482 - 20,606,480 (-)	NCBI
mRatBN7.2	12	15,453,636 - 15,492,640 (-)	NCBI
Rnor_6.0	12	17,545,468 - 17,584,466 (-)	NCBI
Rnor_5.0	12	19,531,842 - 19,570,964 (-)	NCBI
RGSC_v3.4	12	15,955,971 - 15,994,971 (-)	RGD
Celera	12	17,207,707 - 17,246,686 (-)	RGD

Sequence:

show sequence

ATGGCGGCGCCGGCGGAGGCGGAGGTGGCCGCGGGCTTCGCCGAGGCGGATGAAGCAGCGGAAC
TGACCCGCGCGCTAGGTCGTCTGTTACCGGGACTGGAGACCGAAAGTAAGCTGGGGCGGCGGCG
CGCGCTGGAAGCTCTGGAGCACGCACTGGAAGAGGCGGTGCGGCCCGGAACGGATTCCGCTGCC
TTCCAGGGCCCATGGGCTCGTCTGCTGCTGCCTCGCCTGCTGCGACTTCTGACCGACCCAGCCG
AGGGCTGCCGCGCGCTGGCTGCTCACCTGCTGGACTTAGGCCTTCGCCGTGCCGCGCGGCCCCG
CGATGCTCTGCCGCGCCTGTTGCCCGCGCTCACCGCACGCCTTGCCCGACCAGAATCCACGCGG
CCACCGCCTGAACCCTGCGAAGAGCTGCGTCTTGCCCTCGTGCAACTGCTTCACCTGGCCGTGG
ACCTGGGCGGCGCCGCGCTCGCGCCCCACCTGGACGACGCGGTGCGCGCGTTGCGGGGTGCGCT
GCTCGACCCCTTCGCCGCGGTGCGCCGGGAGGGTTGCGAGTGCGCAGCCGCTCTGGCGCGTGCC
ATTCCGGAGCACTTCCACATGCAGTCGGAGTCCCTCATAGGCCCCCTGATGCAGACCATCTCCC
ACCAGCACTGGAAGGTCCGGGTAGCTGTCATCGAAGCCACAGGCACTGTAATCCAGTTTGGCAA
TGGGAATTCGGTGGATGATGTTCTTTCCCACTTTGCTCAAAGACTCTTCGATGATGTCCCTCAG
GTCCGGCAGGCAGTGACCTCGGTGGTGGGGGGATGGCTGCTCAATCTCCGTGACCGATACTCCT
TCTTTCACAAACTCACCCCACTGTTACTCAGCAGCTTCAGTGACGAAATGCCTGAGGTCCGACA
GACAGCCACCAGCCTCTGGGAGAAGGTCGGGCTGCAGTGGCAGGAGGAAAATGAGGCAGATCTA
AAGGACAAGCTGGACTTTGCTTCACCTCCTCCTCCTAACTACCCTGAGCACGAGAGCCGTCCTG
GCCTGGGCTGCCGAGAGCTGGTCTTCAGGAACCTCTCCAAGGTGCTTCCTGCCATCTGTCACGA
TATCACCGACTGGGTGGTGGGGACCCGGCTGAAGGCAGCGCAGCTGCTGCCGGTGCTGCTGCTG
CATGCAGAGGACCACATCACACAGCACCTGGAGATCGTCCTCAGAACCCTGCATCAGGCGTGCA
CCGATGAGGAGAAGGCTGTGGTCAGCAGCTGCGTGAGAGCCGCAGAGCTCATTGGCACCTTCGT
CAGCCCAGAAGTATTTCTGAAACTGATCTTAGCCATGCTGAAGAAAGCACCCTCGGCCTCTGGC
CTCTTGATCCTTGCTTCTGTCATCCGAGGCTGTCCCCGCAATGCCCTTCAGCCACACCTCAAGG
TCATAGCCACAGAGCTGGCCCAGGAGCACATCTGCCAGGGGTCTGAGAATAATAGCTACCTGGA
GCATCTGCTGCTGTGTGTGCAGACTCTGCTGTCTGTGTGTCAGGAAGACTGCTGTGCTGCCAGC
CTGCAGCTCTCGGAGGTGCTGGTGACAATAATGGCAGTCTCAGATGCCGTGAGTCTTGAGAAGA
AGGCTCAGAAGACCATGGACACCCTGGCTGAGGTGGAGGATATCCCCAGCAGTCAGGACCTCTA
CCGCAAGCATCTGGGTGCACTACTGGAACGGCTGACAGCCTCTCATGGCGAGTGGACGGTGCAC
TCTGTGCAGCTGCTGAAGTTCACTGTGCTCCTCACCCAGGCAGGCCCAGCTGTGGGAGAGGCTC
TGCAGCATGTGATCCCCACTCTCAGGGCCTGTCTCCAGCCCACCACAGACCCACACATGCGCCT
GAAGCTCTTCTCTATCCTGTCTTCATTGCTGCTGAGGCCTAAGGACACCGTCGACTCTCAGGGA
CAGTTCCATGGCTACTTGGATATGGTAATAAATGACATCCTAGCCCCCAACCTACAGTGGCATG
CAGGCAGGACAGCTGCAGCCATCCGGACGGCCACCATATCCTGTCTGTGGGCACTTATCAGCAG
TGACATCTTATCGGCCAAGCAGGTTCAAGAGGCACAGGAGACCCTGATGCCACAAGTGCTGGCC
ACGCTGGAGGACGACTCCCAGACCACACGCCTGATCTCCTGCCGTATCATCAGCAGGTTCCTCA
AGAACTCAGGGGATACCATGGAGCCAGAGAAATTTCTCAAGGTCTATCCTGAGCTCTTGAAGCG
CCTAGATGATGTCTCCAATGACGTGAGAATGGCAGCTGCTTCCGCCTTGCTCACCTGGCTGAAG
TGCATTGAGAGCGTGGATGGGAAATCCGCCTATCAGAGCAGCGTTCAGTTCCTGTACAGGGAGC
TGCTGGTCCACCTGGATGACCCAGAAAGTGCCATCCAAGACACTGTGCTAGAAGTCCTCAAGGA
GGGCAGCGTCCTGTTTCCAGATGTGCTGGTGCGGGAGACGGAGGCTGTTGTCCACAAACACCGC
TCAGCTACCTACTGCGAGCAGCTGCTGCAGCATATGCAAACCATGGCTGCCGCTCGGTGACCAT
GCACATCAGCCACTGAAGGAAGACAGCGGTACCCAGAGACCCCGCATTTAAGACAGCCGTGTCC
ACAGCCTCAGGATCCCACCAGCCACCAGATGGTGCTTGAGCATCAGCTTCTGTTTTTCCTAAGC
AGATTCTGGGATTTTGTAACATGCCTACTTTTCACAGAGGCCTCAGAAAGCTAAAATTAAATTT
AAATGCCCCCACCCACGCCAGCTTCCCAATTAGCTGCTTGAACATAATGTTTTTATCACAGGCC
CCGAGGGGTCCTGGGCTGCTTCAGATTCACATGCAGGAAAGCCAACTCGATTGTAAAAACAACC
AACCATCCTCTCCTTTGGGCTCTGCTCCATCAGCCTGTGACGAAGACAATGTCAGTCTTGACTC
GCTGATAAAATTTCTCCAAATTTTTTGGGGTTTTGACACCGGGTTTCTCTGTGAGCCTTTGGCT
ATTCTGGAACTCACTCTGTAGACCAGTCTGGCCTTGAACTCTCAGAGATCCGCCTGCCTCTTCC
TCCCAAGTACTGGGATTAAAGGCCTGTACCACTACCACCCGGCTCCTTTAAAATACACTGGAAT
GTCTTGCAATGTGGGTGCAATGTCCTGGTGTTGTTTCTCAGTGTTAGTGATGCCCGTGGGTAAA
GGATAGACAGGAAACCAGCCTTCATCCCTACCACTTGCTTATAGCAGTCAGTAGGTGGTCATTC
TCCAGTGTCTTTTCCACCAAGTGCCTAAAAGATGTTTAAATGGTTGTTATCAGCAGCCAATATT
TTTGTTAAGATAATGTTGGGGGGCGAGTTTCCAACAAATTTTAACATTTCTGCTTTGCCTTTTA
TGGAATTAAATTATTCTTGCAGTTA

hide sequence

RefSeq Acc Id:

XM_039089394 ⟹ XP_038945322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,567,482 - 20,606,600 (-)	NCBI
mRatBN7.2	12	15,453,636 - 15,492,722 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128329	(Get FASTA)	NCBI Sequence Viewer
	XP_038945322	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05841	(Get FASTA)	NCBI Sequence Viewer
	EDL89787	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035454
	ENSRNOP00000035454.4

RefSeq Acc Id:

NP_001128329 ⟸ NM_001134857

- UniProtKB:

G3V943 (UniProtKB/TrEMBL), A6K1X9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAPAEAEVAAGFAEADEAAELTRALGRLLPGLETESKLGRRRALEALEHALEEAVRPGTDSAA
FQGPWARLLLPRLLRLLTDPAEGCRALAAHLLDLGLRRAARPRDALPRLLPALTARLARPESTR
PPPEPCEELRLALVQLLHLAVDLGGAALAPHLDDAVRALRGALLDPFAAVRREGCECAAALARA
IPEHFHMQSESLIGPLMQTISHQHWKVRVAVIEATGTVIQFGNGNSVDDVLSHFAQRLFDDVPQ
VRQAVTSVVGGWLLNLRDRYSFFHKLTPLLLSSFSDEMPEVRQTATSLWEKVGLQWQEENEADL
KDKLDFASPPPPNYPEHESRPGLGCRELVFRNLSKVLPAICHDITDWVVGTRLKAAQLLPVLLL
HAEDHITQHLEIVLRTLHQACTDEEKAVVSSCVRAAELIGTFVSPEVFLKLILAMLKKAPSASG
LLILASVIRGCPRNALQPHLKVIATELAQEHICQGSENNSYLEHLLLCVQTLLSVCQEDCCAAS
LQLSEVLVTIMAVSDAVSLEKKAQKTMDTLAEVEDIPSSQDLYRKHLGALLERLTASHGEWTVH
SVQLLKFTVLLTQAGPAVGEALQHVIPTLRACLQPTTDPHMRLKLFSILSSLLLRPKDTVDSQG
QFHGYLDMVINDILAPNLQWHAGRTAAAIRTATISCLWALISSDILSAKQVQEAQETLMPQVLA
TLEDDSQTTRLISCRIISRFLKNSGDTMEPEKFLKVYPELLKRLDDVSNDVRMAAASALLTWLK
CIESVDGKSAYQSSVQFLYRELLVHLDDPESAIQDTVLEVLKEGSVLFPDVLVRETEAVVHKHR
SATYCEQLLQHMQTMAAAR

hide sequence

RefSeq Acc Id:

ENSRNOP00000035454 ⟸ ENSRNOT00000035545

RefSeq Acc Id:

ENSRNOP00000070729 ⟸ ENSRNOT00000088813

RefSeq Acc Id:	XP_038945322 ⟸ XM_039089394
- Peptide Label:	isoform X1

Protein Domains

TOG

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V943-F1-model_v2	AlphaFold	G3V943	1-851	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698472

Promoter ID:

EPDNEW_R8996

Type:

multiple initiation site

Name:

Dnaaf5_1

Description:

dynein, axonemal, assembly factor 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	17,584,478 - 17,584,538	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566028	AgrOrtholog
BioCyc Gene	G2FUF-19880	BioCyc
Ensembl Genes	ENSRNOG00000021312	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000035545	ENTREZGENE
	ENSRNOT00000035545.6	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	TOG	UniProtKB/TrEMBL
KEGG Report	rno:304332	UniProtKB/TrEMBL
NCBI Gene	304332	ENTREZGENE
PANTHER	DYNEIN ASSEMBLY FACTOR 5, AXONEMAL	UniProtKB/TrEMBL
	DYNEIN AXONEMAL ASSEMBLY FACTOR 5	UniProtKB/TrEMBL
Pfam	Vac14_Fab1_bd	UniProtKB/TrEMBL
PhenoGen	Dnaaf5	PhenoGen
RatGTEx	ENSRNOG00000021312	RatGTEx
SMART	TOG	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A6K1X9	ENTREZGENE, UniProtKB/TrEMBL
	G3V943	ENTREZGENE, UniProtKB/TrEMBL
	Q3KR87_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-12-17	Dnaaf5	dynein, axonemal, assembly factor 5	Heatr2	HEAT repeat containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Heatr2	HEAT repeat containing 2	MGC125214	similar to hypothetical protein FLJ20397	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	MGC125214	similar to hypothetical protein FLJ20397			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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