Rad51c (RAD51 paralog C) - Rat Genome Database

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Gene: Rad51c (RAD51 paralog C) Rattus norvegicus
Analyze
Symbol: Rad51c
Name: RAD51 paralog C
RGD ID: 1563765
Description: Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA recombination and positive regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within female meiosis sister chromatid cohesion; male meiosis I; and spermatogenesis. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex and Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C); PARTICIPATES IN homologous recombination pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; furan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA repair protein RAD51 homolog 3; LOC497976; Rad51 homolog c; Rad51 homolog c (S. cerevisiae); RGD1563765; similar to RAD51L2/RAD51C protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81072,702,299 - 72,728,980 (-)NCBIGRCr8
mRatBN7.21072,205,032 - 72,231,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,205,032 - 72,231,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,815,543 - 76,841,717 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,320,458 - 76,346,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,784,976 - 71,811,148 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,697,713 - 74,724,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,697,716 - 74,724,472 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,376,876 - 75,403,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,692,205 - 75,718,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,121,557 - 71,147,722 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-methylcholine  (ISO)
5-fluorouracil  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
hydroxyurea  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
metformin  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
taurine  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11751635   PMID:12477932   PMID:12966089   PMID:14716019   PMID:16215984   PMID:17312021   PMID:19327148   PMID:19451272   PMID:20207730   PMID:20413593   PMID:21076401   PMID:23108668  
PMID:23149936  


Genomics

Comparative Map Data
Rad51c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81072,702,299 - 72,728,980 (-)NCBIGRCr8
mRatBN7.21072,205,032 - 72,231,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,205,032 - 72,231,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,815,543 - 76,841,717 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,320,458 - 76,346,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,784,976 - 71,811,148 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,697,713 - 74,724,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,697,716 - 74,724,472 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,376,876 - 75,403,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,692,205 - 75,718,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,121,557 - 71,147,722 (-)NCBICelera
Cytogenetic Map10q26NCBI
RAD51C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,692,573 - 58,735,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,692,573 - 58,735,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371756,769,934 - 56,812,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361754,124,962 - 54,166,691 (+)NCBINCBI36Build 36hg18NCBI36
Build 341754,124,961 - 54,166,685NCBI
Celera1753,231,717 - 53,273,527 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1752,130,436 - 52,172,218 (+)NCBIHuRef
CHM1_11756,835,470 - 56,877,217 (+)NCBICHM1_1
T2T-CHM13v2.01759,560,405 - 59,603,693 (+)NCBIT2T-CHM13v2.0
Rad51c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,267,471 - 87,295,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,267,471 - 87,295,780 (-)EnsemblGRCm39 Ensembl
GRCm381187,376,645 - 87,404,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,376,645 - 87,404,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv371187,191,109 - 87,217,997 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,192,840 - 87,220,634 (-)NCBIMGSCv36mm8
Celera1196,979,493 - 97,006,381 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.08NCBI
Rad51c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,145,226 - 4,178,487 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,053,195 - 4,178,226 (-)NCBIChiLan1.0ChiLan1.0
RAD51C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,865,211 - 74,905,901 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,676,584 - 79,717,351 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,769,446 - 52,808,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,621,552 - 57,658,920 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,621,552 - 57,660,701 (+)Ensemblpanpan1.1panPan2
RAD51C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1933,289,675 - 33,347,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl933,289,742 - 33,326,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,524,483 - 32,581,843 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0934,095,493 - 34,153,075 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl934,095,486 - 34,132,470 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,882,005 - 32,939,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0933,171,057 - 33,228,397 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0933,257,474 - 33,314,872 (+)NCBIUU_Cfam_GSD_1.0
Rad51c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,601,741 - 32,634,425 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,439,097 - 4,473,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,440,638 - 4,473,301 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD51C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,975,957 - 35,019,016 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,975,949 - 35,018,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21235,750,071 - 35,786,767 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAD51C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11634,666,934 - 34,708,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1634,666,162 - 34,708,457 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,470,623 - 5,519,489 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad51c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624871708,048 - 746,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rad51c
115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:181
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000008846
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12903245Cm110Cardiac mass QTL 1100.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)107111521772606468Rat
12903246Cm111Cardiac mass QTL 1110.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)107111521772606468Rat
12903247Cm112Cardiac mass QTL 1120.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107111521772606468Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
12902615Bw185Body weight QTL 1850.01body mass (VT:0001259)body weight (CMO:0000012)107111521772606468Rat
12903248Am14Aortic mass QTL 140.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107111521772606468Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
12903249Kidm68Kidney mass QTL 680.02kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)107111521772606468Rat
1579918Bp279Blood pressure QTL 2790.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107111521772606468Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Rat194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,219,294 - 72,219,541 (+)MAPPERmRatBN7.2
Rnor_6.01074,712,046 - 74,712,288NCBIRnor6.0
Rnor_5.01075,388,613 - 75,388,855UniSTSRnor5.0
RGSC_v3.41075,706,467 - 75,706,710RGDRGSC3.4
RGSC_v3.41075,706,468 - 75,706,710UniSTSRGSC3.4
RGSC_v3.11075,720,837 - 75,721,080RGD
Celera1071,135,820 - 71,136,063UniSTS
FHH x ACI Map1059.1599RGD
FHH x ACI Map1059.1599UniSTS
Cytogenetic Map10q26UniSTS
D10Chm242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,212,407 - 72,212,657 (+)MAPPERmRatBN7.2
Rnor_6.01074,705,159 - 74,705,408NCBIRnor6.0
Rnor_5.01075,395,493 - 75,395,742UniSTSRnor5.0
RGSC_v3.41075,699,581 - 75,699,830UniSTSRGSC3.4
Celera1071,128,933 - 71,129,182UniSTS
Cytogenetic Map10q26UniSTS
RH128578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,205,083 - 72,205,274 (+)MAPPERmRatBN7.2
Rnor_6.01074,697,765 - 74,697,955NCBIRnor6.0
Rnor_5.01075,402,946 - 75,403,136UniSTSRnor5.0
RGSC_v3.41075,692,257 - 75,692,447UniSTSRGSC3.4
Celera1071,121,609 - 71,121,799UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000008846   ⟹   ENSRNOP00000008846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,205,062 - 72,231,248 (-)Ensembl
Rnor_6.0 Ensembl1074,697,716 - 74,724,472 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103842   ⟹   ENSRNOP00000078134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,205,032 - 72,231,248 (-)Ensembl
RefSeq Acc Id: NM_001129777   ⟹   NP_001123249
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81072,702,299 - 72,728,464 (-)NCBI
mRatBN7.21072,205,032 - 72,231,201 (-)NCBI
Rnor_6.01074,697,713 - 74,723,947 (-)NCBI
Rnor_5.01075,376,876 - 75,403,188 (+)NCBI
RGSC_v3.41075,692,205 - 75,718,369 (-)RGD
Celera1071,121,557 - 71,147,722 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086623   ⟹   XP_038942551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81072,702,305 - 72,728,980 (-)NCBI
mRatBN7.21072,205,032 - 72,231,643 (-)NCBI
RefSeq Acc Id: XM_039086624   ⟹   XP_038942552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81072,702,305 - 72,728,980 (-)NCBI
mRatBN7.21072,205,032 - 72,231,643 (-)NCBI
RefSeq Acc Id: XM_063269653   ⟹   XP_063125723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81072,722,261 - 72,728,980 (-)NCBI
RefSeq Acc Id: NP_001123249   ⟸   NM_001129777
- UniProtKB: G3V6U0 (UniProtKB/TrEMBL),   A6HHT5 (UniProtKB/TrEMBL),   B2RYQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008846   ⟸   ENSRNOT00000008846
RefSeq Acc Id: XP_038942552   ⟸   XM_039086624
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y707 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942551   ⟸   XM_039086623
- Peptide Label: isoform X1
- UniProtKB: B2RYQ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078134   ⟸   ENSRNOT00000103842
RefSeq Acc Id: XP_063125723   ⟸   XM_063269653
- Peptide Label: isoform X3
Protein Domains
RecA family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6U0-F1-model_v2 AlphaFold G3V6U0 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563765 AgrOrtholog
BioCyc Gene G2FUF-23767 BioCyc
Ensembl Genes ENSRNOG00000006661 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008846.6 UniProtKB/TrEMBL
  ENSRNOT00000103842.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9101883 IMAGE-MGC_LOAD
InterPro DNA_recomb/repair_Rad51_C UniProtKB/TrEMBL
  DNA_recomb/repair_RecA-like UniProtKB/TrEMBL
  DNA_recomb_RecA/RadB_ATP-bd UniProtKB/TrEMBL
  DNA_repair_Rad51/TF_NusA_a-hlx UniProtKB/TrEMBL
  HR_Repair_Mediator UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:497976 UniProtKB/TrEMBL
MGC_CLONE MGC:188771 IMAGE-MGC_LOAD
NCBI Gene 497976 ENTREZGENE
PANTHER DNA REPAIR PROTEIN RAD51 HOMOLOG 3 UniProtKB/TrEMBL
  DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C UniProtKB/TrEMBL
Pfam Rad51 UniProtKB/TrEMBL
PhenoGen Rad51c PhenoGen
PIRSF Rad51 UniProtKB/TrEMBL
PROSITE RECA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006661 RatGTEx
Superfamily-SCOP SSF47794 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5Y707 ENTREZGENE, UniProtKB/TrEMBL
  A6HHT5 ENTREZGENE, UniProtKB/TrEMBL
  B2RYQ3 ENTREZGENE, UniProtKB/TrEMBL
  G3V6U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-23 Rad51c  RAD51 paralog C  Rad51c  Rad51 homolog c (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Rad51c  Rad51 homolog c (S. cerevisiae)  RGD1563765_predicted  similar to RAD51L2/RAD51C protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563765_predicted  similar to RAD51L2/RAD51C protein (predicted)  LOC497976  similar to RAD51L2/RAD51C protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497976  similar to RAD51L2/RAD51C protein      Symbol and Name status set to provisional 70820 PROVISIONAL