Mcm7 (minichromosome maintenance complex component 7) - Rat Genome Database

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Gene: Mcm7 (minichromosome maintenance complex component 7) Rattus norvegicus
Analyze
Symbol: Mcm7
Name: minichromosome maintenance complex component 7
RGD ID: 1303018
Description: Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in cellular response to epidermal growth factor stimulus and response to xenobiotic stimulus. Predicted to be located in chromosome. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and hyperthyroidism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cdc47; DNA replication licensing factor MCM7; MGC93853; minichromosome maintenance deficient 7; minichromosome maintenance deficient 7 (S. cerevisiae); minichromosome maintenance protein 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,155,921 - 22,163,320 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1222,155,921 - 22,163,771 (-)EnsemblGRCr8
mRatBN7.21217,042,207 - 17,049,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,042,212 - 17,050,063 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1217,865,595 - 17,872,850 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,489,339 - 18,496,594 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,542,745 - 17,550,000 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,306,615 - 19,313,877 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,306,607 - 19,314,016 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,364,245 - 21,371,507 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41217,607,250 - 17,614,508 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1218,972,382 - 18,979,639 (-)NCBICelera
RGSC_v3.11217,596,771 - 17,604,030 (-)NCBI
Cytogenetic Map12q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lapatinib  (ISO)
lead(0)  (ISO)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin RR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simazine  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
CMG complex  (IEA,ISO)
MCM complex  (IEA,ISO)
nucleolus  (ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Bruemmer D, etal., Eur J Pharmacol. 2003 Feb 21;462(1-3):15-23.
2. Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Bruemmer D, etal., Mol Endocrinol 2003 Jun;17(6):1005-18. Epub 2003 Apr 03.
3. Histomorphometry and expression of Cdc47 and caspase-3 in hyperthyroid rat uteri and placentas during gestation and postpartum associated with fetal development. Freitas ES, etal., Reprod Fertil Dev. 2007;19(3):498-509.
4. Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration. Garnier D, etal., Hepatology. 2009 Dec;50(6):1946-56.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Grutzmann R, etal., Neoplasia. 2004 Sep-Oct;6(5):611-22.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. A genetic variant in the promoter region of miR-106b-25 cluster predict clinical outcome of HBV-related hepatocellular carcinoma in Chinese. Qi F, etal., PLoS One. 2014 Jan 8;9(1):e85394. doi: 10.1371/journal.pone.0085394. eCollection 2014.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma. Yen CS, etal., World J Gastroenterol. 2016 Jun 14;22(22):5183-92. doi: 10.3748/wjg.v22.i22.5183.
Additional References at PubMed
PMID:9305914   PMID:12972605   PMID:15538388   PMID:15917436   PMID:16557521   PMID:17296731   PMID:19135898   PMID:19946888   PMID:21383955   PMID:22082260   PMID:23526403   PMID:24726645  
PMID:31505169  


Genomics

Comparative Map Data
Mcm7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,155,921 - 22,163,320 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1222,155,921 - 22,163,771 (-)EnsemblGRCr8
mRatBN7.21217,042,207 - 17,049,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,042,212 - 17,050,063 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1217,865,595 - 17,872,850 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,489,339 - 18,496,594 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,542,745 - 17,550,000 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,306,615 - 19,313,877 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,306,607 - 19,314,016 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,364,245 - 21,371,507 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41217,607,250 - 17,614,508 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1218,972,382 - 18,979,639 (-)NCBICelera
RGSC_v3.11217,596,771 - 17,604,030 (-)NCBI
Cytogenetic Map12q11NCBI
MCM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,092,728 - 100,101,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,092,233 - 100,101,940 (-)Ensemblhg38GRCh38
GRCh37799,690,351 - 99,699,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,528,340 - 99,537,363 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34799,335,054 - 99,343,031NCBI
Celera794,425,063 - 94,434,086 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,326,002 - 94,335,214 (-)NCBIHuRef
CHM1_1799,620,508 - 99,629,720 (-)NCBICHM1_1
T2T-CHM13v2.07101,332,574 - 101,341,242 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,050,471 - 99,059,682 (-)NCBI
Mcm7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,162,845 - 138,170,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,162,845 - 138,170,684 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385138,164,583 - 138,172,111 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,164,583 - 138,172,422 (-)Ensemblmm10GRCm38
MGSCv375138,605,817 - 138,613,090 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365138,394,377 - 138,401,650 (-)NCBIMGSCv36mm8
Celera5135,143,921 - 135,151,194 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.97NCBI
Mcm7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573763,358 - 775,489 (+)Ensembl
ChiLan1.0NW_004955573763,358 - 770,782 (+)NCBIChiLan1.0ChiLan1.0
MCM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,012,249 - 118,021,166 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,276,881 - 166,285,798 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,128,037 - 92,136,976 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,561,591 - 105,570,720 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,561,591 - 105,570,720 (-)EnsemblpanPan2panpan1.1
MCM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,492,654 - 9,499,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,492,573 - 9,499,855 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.069,429,534 - 9,436,847 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,429,021 - 9,436,847 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,278,839 - 9,286,173 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,259,163 - 9,266,473 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,438,765 - 9,446,084 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mcm7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,790,295 - 133,797,914 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543233,960 - 246,746 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936543238,573 - 246,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,005,900 - 8,014,053 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.138,005,890 - 8,014,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MCM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,976,487 - 12,985,354 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,977,013 - 12,985,898 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660703,287,553 - 3,295,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,887,775 - 16,899,934 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474016,887,699 - 16,895,224 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mcm7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11615,536,829 - 15,544,601 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mcm7
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:44
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000001825
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH128042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21217,042,360 - 17,042,716 (+)MAPPERmRatBN7.2
Rnor_6.01219,306,769 - 19,307,124NCBIRnor6.0
Rnor_5.01221,364,399 - 21,364,754UniSTSRnor5.0
RGSC_v3.41217,607,399 - 17,607,754UniSTSRGSC3.4
Celera1218,972,531 - 18,972,886UniSTS
RH 3.4 Map4659.63UniSTS
Cytogenetic Map12q11UniSTS
RH139725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21217,041,890 - 17,042,094 (+)MAPPERmRatBN7.2
Rnor_6.01219,306,299 - 19,306,502NCBIRnor6.0
Rnor_5.01221,363,929 - 21,364,132UniSTSRnor5.0
RGSC_v3.41217,606,929 - 17,607,132UniSTSRGSC3.4
Celera1218,972,061 - 18,972,264UniSTS
RH 3.4 Map12254.4UniSTS
Cytogenetic Map12q11UniSTS
AI747533  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81222,156,415 - 22,157,251 (+)Marker Load Pipeline
mRatBN7.21217,042,705 - 17,043,542 (+)MAPPERmRatBN7.2
Rnor_6.01219,307,114 - 19,307,950NCBIRnor6.0
Rnor_5.01221,364,744 - 21,365,580UniSTSRnor5.0
RGSC_v3.41217,607,744 - 17,608,580UniSTSRGSC3.4
Celera1218,972,876 - 18,973,712UniSTS
Cytogenetic Map12q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001825   ⟹   ENSRNOP00000001825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1217,042,212 - 17,048,939 (-)Ensembl
Rnor_6.0 Ensembl1219,306,607 - 19,314,016 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105826   ⟹   ENSRNOP00000076814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1222,155,921 - 22,163,771 (-)Ensembl
mRatBN7.2 Ensembl1217,042,212 - 17,050,063 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118343   ⟹   ENSRNOP00000081743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1222,156,034 - 22,163,771 (-)Ensembl
mRatBN7.2 Ensembl1217,042,325 - 17,050,063 (-)Ensembl
RefSeq Acc Id: NM_001004203   ⟹   NP_001004203
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,155,921 - 22,163,178 (-)NCBI
mRatBN7.21217,042,212 - 17,049,470 (-)NCBI
Rnor_6.01219,306,620 - 19,313,877 (-)NCBI
Rnor_5.01221,364,245 - 21,371,507 (-)NCBI
RGSC_v3.41217,607,250 - 17,614,508 (-)RGD
Celera1218,972,382 - 18,979,639 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249005   ⟹   XP_006249067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,155,921 - 22,162,408 (-)NCBI
mRatBN7.21217,042,207 - 17,048,695 (-)NCBI
Rnor_6.01219,306,615 - 19,313,223 (-)NCBI
Rnor_5.01221,364,245 - 21,371,507 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249006   ⟹   XP_006249068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,155,921 - 22,162,641 (-)NCBI
mRatBN7.21217,042,207 - 17,048,932 (-)NCBI
Rnor_6.01219,306,615 - 19,313,368 (-)NCBI
Rnor_5.01221,364,245 - 21,371,507 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063271143   ⟹   XP_063127213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,156,498 - 22,163,320 (-)NCBI
RefSeq Acc Id: NP_001004203   ⟸   NM_001004203
- UniProtKB: Q6AYN8 (UniProtKB/TrEMBL),   A6KSS8 (UniProtKB/TrEMBL),   Q1PS21 (UniProtKB/TrEMBL),   A0A8I5Y509 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249068   ⟸   XM_006249006
- Peptide Label: isoform X2
- UniProtKB: A6KST0 (UniProtKB/TrEMBL),   F7F0X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249067   ⟸   XM_006249005
- Peptide Label: isoform X2
- UniProtKB: A6KST0 (UniProtKB/TrEMBL),   F7F0X7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001825   ⟸   ENSRNOT00000001825
Ensembl Acc Id: ENSRNOP00000081743   ⟸   ENSRNOT00000118343
Ensembl Acc Id: ENSRNOP00000076814   ⟸   ENSRNOT00000105826
RefSeq Acc Id: XP_063127213   ⟸   XM_063271143
- Peptide Label: isoform X1
- UniProtKB: Q1PS21 (UniProtKB/TrEMBL)
Protein Domains
MCM   MCM N-terminal   MCM OB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYN8-F1-model_v2 AlphaFold Q6AYN8 1-719 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698493
Promoter ID:EPDNEW_R9018
Type:multiple initiation site
Name:Mcm7_1
Description:minichromosome maintenance complex component 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01219,313,923 - 19,313,983EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303018 AgrOrtholog
BioCyc Gene G2FUF-19818 BioCyc
Ensembl Genes ENSRNOG00000001349 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000105826 ENTREZGENE
  ENSRNOT00000105826.2 UniProtKB/TrEMBL
  ENSRNOT00000118343.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  mini-chromosome maintenance (MCM) complex, chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111847 IMAGE-MGC_LOAD
InterPro ATPase_AAA+_core UniProtKB/TrEMBL
  DNA-dep_ATPase_MCM UniProtKB/TrEMBL
  DNA-dep_ATPase_MCM_CS UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
  MCM_7 UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:288532 UniProtKB/TrEMBL
MGC_CLONE MGC:93853 IMAGE-MGC_LOAD
NCBI Gene 288532 ENTREZGENE
PANTHER PTHR11630 UniProtKB/TrEMBL
  PTHR11630:SF26 UniProtKB/TrEMBL
Pfam HTH_MCM7 UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
PhenoGen Mcm7 PhenoGen
PRINTS MCMFAMILY UniProtKB/TrEMBL
  MCMPROTEIN7 UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/TrEMBL
  MCM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001349 RatGTEx
SMART AAA UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
Superfamily-SCOP Nucleic_acid_OB UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5Y509 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTF3_RAT UniProtKB/TrEMBL
  A6KSS8 ENTREZGENE, UniProtKB/TrEMBL
  A6KST0 ENTREZGENE, UniProtKB/TrEMBL
  F7F0X7 ENTREZGENE
  Q1PS21 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYN8 ENTREZGENE
UniProt Secondary Q6AYN8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Mcm7  minichromosome maintenance complex component 7  Mcm7  minichromosome maintenance deficient 7 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Mcm7  minichromosome maintenance deficient 7 (S. cerevisiae)      Name updated 1299863 APPROVED
2005-02-14 Mcm7  minichromosome maintenance protein 7      Symbol and Name status set to provisional 70820 PROVISIONAL