MCM7 (minichromosome maintenance complex component 7) - Rat Genome Database

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Gene: MCM7 (minichromosome maintenance complex component 7) Sus scrofa
Analyze
Symbol: MCM7
Name: minichromosome maintenance complex component 7
RGD ID: 13910900
Description: ENCODES a protein that exhibits DNA helicase activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH astigmatism (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN CMG complex (ortholog); MCM complex (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA replication licensing factor MCM7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,005,900 - 8,014,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,005,890 - 8,014,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
CMG complex  (IEA,ISO)
cytosol  (IEA)
intracellular organelle  (IEA)
MCM complex  (IBA,IEA,ISO)
nucleolus  (ISO)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MCM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,005,900 - 8,014,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,005,890 - 8,014,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MCM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,092,728 - 100,101,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,092,233 - 100,101,940 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,690,351 - 99,699,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,528,340 - 99,537,363 (-)NCBINCBI36Build 36hg18NCBI36
Build 34799,335,054 - 99,343,031NCBI
Celera794,425,063 - 94,434,086 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,326,002 - 94,335,214 (-)NCBIHuRef
CHM1_1799,620,508 - 99,629,720 (-)NCBICHM1_1
T2T-CHM13v2.07101,332,574 - 101,341,242 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,050,471 - 99,059,682 (-)NCBI
Mcm7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,162,845 - 138,170,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,162,845 - 138,170,684 (-)EnsemblGRCm39 Ensembl
GRCm385138,164,583 - 138,172,111 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,164,583 - 138,172,422 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,605,817 - 138,613,090 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,394,377 - 138,401,650 (-)NCBIMGSCv36mm8
Celera5135,143,921 - 135,151,194 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.97NCBI
Mcm7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,155,921 - 22,163,320 (-)NCBIGRCr8
mRatBN7.21217,042,207 - 17,049,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,042,212 - 17,050,063 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,865,595 - 17,872,850 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,489,339 - 18,496,594 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,542,745 - 17,550,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,306,615 - 19,313,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,306,607 - 19,314,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,364,245 - 21,371,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,607,250 - 17,614,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,596,771 - 17,604,030 (-)NCBI
Celera1218,972,382 - 18,979,639 (-)NCBICelera
Cytogenetic Map12q11NCBI
Mcm7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573763,358 - 775,489 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955573763,358 - 770,782 (+)NCBIChiLan1.0ChiLan1.0
MCM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,012,249 - 118,021,166 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,276,881 - 166,285,798 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,128,037 - 92,136,976 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,561,591 - 105,570,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,561,591 - 105,570,720 (-)Ensemblpanpan1.1panPan2
MCM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,492,654 - 9,499,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,492,573 - 9,499,855 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,429,534 - 9,436,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,429,021 - 9,436,847 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,278,839 - 9,286,173 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,259,163 - 9,266,473 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,438,765 - 9,446,084 (+)NCBIUU_Cfam_GSD_1.0
Mcm7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,790,295 - 133,797,914 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543233,960 - 246,746 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543238,573 - 246,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,976,487 - 12,985,354 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,977,013 - 12,985,898 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,287,553 - 3,295,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,887,775 - 16,899,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,887,699 - 16,895,224 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MCM7
99 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 3 1
Low 8 3 3 2 2 23 2 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000040573   ⟹   ENSSSCP00000054494
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl38,006,059 - 8,014,053 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000041433   ⟹   ENSSSCP00000050669
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl38,005,900 - 8,014,053 (-)Ensembl
RefSeq Acc Id: XM_021086193   ⟹   XP_020941852
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.138,005,890 - 8,014,047 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086194   ⟹   XP_020941853
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.138,005,890 - 8,012,879 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021086195   ⟹   XP_020941854
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.138,005,890 - 8,012,879 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020941852   ⟸   XM_021086193
- Peptide Label: isoform X1
- UniProtKB: A0A286ZJM4 (UniProtKB/TrEMBL),   A0A8D0HXR8 (UniProtKB/TrEMBL),   A0A8D0QS62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941853   ⟸   XM_021086194
- Peptide Label: isoform X2
- UniProtKB: A0A8D1S2W4 (UniProtKB/TrEMBL),   A0A8D0QS62 (UniProtKB/TrEMBL),   A0A8D1S2Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941854   ⟸   XM_021086195
- Peptide Label: isoform X2
- UniProtKB: A0A8D1S2W4 (UniProtKB/TrEMBL),   A0A8D0QS62 (UniProtKB/TrEMBL),   A0A8D1S2Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000054494   ⟸   ENSSSCT00000040573
RefSeq Acc Id: ENSSSCP00000050669   ⟸   ENSSSCT00000041433
Protein Domains
MCM   MCM N-terminal   MCM OB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032180 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005002028 UniProtKB/TrEMBL
  ENSSSCG00015057445 UniProtKB/TrEMBL
  ENSSSCG00025010825 UniProtKB/TrEMBL
  ENSSSCG00030003635 UniProtKB/TrEMBL
  ENSSSCG00035036417 UniProtKB/TrEMBL
  ENSSSCG00040035881 UniProtKB/TrEMBL
  ENSSSCG00045017084 UniProtKB/TrEMBL
  ENSSSCG00050034685 UniProtKB/TrEMBL
  ENSSSCG00055027906 UniProtKB/TrEMBL
  ENSSSCG00060045038 UniProtKB/TrEMBL
  ENSSSCG00065048936 UniProtKB/TrEMBL
  ENSSSCG00070015334 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040573.2 UniProtKB/TrEMBL
  ENSSSCT00000041433 ENTREZGENE
  ENSSSCT00000041433.2 UniProtKB/TrEMBL
  ENSSSCT00005003040.1 UniProtKB/TrEMBL
  ENSSSCT00005003110.1 UniProtKB/TrEMBL
  ENSSSCT00005003131.1 UniProtKB/TrEMBL
  ENSSSCT00015076695.1 UniProtKB/TrEMBL
  ENSSSCT00025014224.1 UniProtKB/TrEMBL
  ENSSSCT00025014245.1 UniProtKB/TrEMBL
  ENSSSCT00030004754.1 UniProtKB/TrEMBL
  ENSSSCT00035048272.1 UniProtKB/TrEMBL
  ENSSSCT00040048230.1 UniProtKB/TrEMBL
  ENSSSCT00045029121.1 UniProtKB/TrEMBL
  ENSSSCT00050046638.1 UniProtKB/TrEMBL
  ENSSSCT00055055410.1 UniProtKB/TrEMBL
  ENSSSCT00055055560.1 UniProtKB/TrEMBL
  ENSSSCT00055055623.1 UniProtKB/TrEMBL
  ENSSSCT00060061100.1 UniProtKB/TrEMBL
  ENSSSCT00065066984.1 UniProtKB/TrEMBL
  ENSSSCT00065067002.1 UniProtKB/TrEMBL
  ENSSSCT00065067008.1 UniProtKB/TrEMBL
  ENSSSCT00070030148.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  mini-chromosome maintenance (MCM) complex, chain A, domain 1 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
  MCM7 UniProtKB/TrEMBL
  MCM_CS UniProtKB/TrEMBL
  MCM_dom UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene MCM7 ENTREZGENE
PANTHER PTHR11630 UniProtKB/TrEMBL
  PTHR11630:SF26 UniProtKB/TrEMBL
Pfam MCM UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
PRINTS MCMFAMILY UniProtKB/TrEMBL
  MCMPROTEIN7 UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/TrEMBL
  MCM_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A286ZJM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BDU2_PIG UniProtKB/TrEMBL
  A0A480Y209_PIG UniProtKB/TrEMBL
  A0A481D866_PIG UniProtKB/TrEMBL
  A0A4X1UAX8_PIG UniProtKB/TrEMBL
  A0A8D0HXR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QRK3_PIG UniProtKB/TrEMBL
  A0A8D0QS62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1S2W4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1S2Z8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90076 ENTREZGENE