| 70502 | TP53 | tumor protein p53 | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or ch anges in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] | 17 | 7668421 | 7687490 | Human | 8246 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317577 | TP53BP1 | tumor protein p53 binding protein 1 | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling followi ng DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] | 15 | 43403061 | 43510640 | Human | 238 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1345809 | TP53TG1 | TP53 target 1 | ASSOCIATED WITH Colorectal Neoplasms; INTERACTS WITH (-)-demecolcine; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one | 7 | 87325347 | 87345492 | Human | 58 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, PREDICTED [RefSeq] |
| 1602331 | TP53TG3 | TP53 target 3 | Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 32673530 | 32676165 | Human | 18 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350426 | TP53TG5 | TP53 target 5 | Predicted to be involved in intracellular signal transduction and negative regulation of cell growth. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 45372557 | 45378325 | Human | 18 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 3302253 | TP53TG3B | TP53 target 3B | Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 33360841 | 33363478 | Human | 7 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 5685709 | TP53TG3C | TP53 target 3C | Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 33192510 | 33196858 | Human | 5 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 7205173 | TP53TG3D | TP53 target 3D | Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 32253286 | 32255928 | Human | 4 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1317644 | TP53RK | TP53 regulating kinase | Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 46684365 | 46689444 | Human | 151 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 38661684 | LOC102723655 | TP53-target gene 3 protein | FOUND IN cytoplasm; nucleus | | | | Human | 4 | ensembl_gene_symbol , old_gene_name , name , ensembl_full_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 38633276 | LOC102723713 | TP53-target gene 3 protein | FOUND IN cytoplasm; nucleus | | | | Human | 4 | ensembl_gene_symbol , old_gene_name , name , ensembl_full_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10045726 | TP53TG3E | TP53 target 3 family member E | Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 33302590 | 33306945 | Human | 4 | symbol , ensembl_gene_symbol , COSMIC , name , ensembl_full_name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10045737 | TP53TG3F | TP53 target 3 family member F | Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 33459612 | 33462249 | Human | 5 | symbol , ensembl_gene_symbol , COSMIC , name , ensembl_full_name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16553933 | AC006455.3 | TP53 target 3 (TP53TG3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552725 | AC073188.1 | TP53 target 3 (TP53TG3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16553927 | AC092634.3 | TP53 target 3 (TP53TG3) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 1605665 | WRAP53 | WD repeat containing antisense to TP53 | This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011] | 17 | 7686071 | 7703502 | Human | 220 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1602327 | TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic signaling pathway; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 120443964 | 120446384 | Human | 103 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 38643538 | LOC100129725 | PERP, TP53 apoptosis effector pseudogene | | 3 | 191951115 | 191951947 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 10402028 | TP53TG3GP | TP53 target 3 family member G, pseudogene | | 16 | 35207903 | 35208236 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10401722 | TP53TG3HP | TP53 target 3 family member H, pseudogene | | 16 | 35505087 | 35507170 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 1317526 | TIGAR | TP53 induced glycolysis regulatory phosphatase | This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosp hate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008] | 12 | 4321213 | 4360028 | Human | 172 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 16554288 | AC091167.1 | PERP, TP53 apoptosis effector (PERP) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16552324 | AL021407.2 | PERP, TP53 apoptosis effector (PERP) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562741 | AC138869.2 | novel transcript, antisense to TP53-target gene 3 | | | | | Human | | name | gene, lncrna |
| 1350669 | RPRM | reprimo, TP53 dependent G2 arrest mediator homolog | Predicted to be involved in regulation of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025] | 2 | 153477338 | 153478762 | Human | 113 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1347268 | TRIAP1P1 | TP53 regulated inhibitor of apoptosis 1 pseudogene 1 | | 10 | 27376951 | 27378374 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16559121 | TRINGS | TP53 regulated inhibitor of necrosis under glucose starvation | | | | | Human | | name | gene, lncrna |
| 629021554 | TRINGS | TP53 regulated inhibitor of necrosis under glucose starvation | | | | | Human | | name | gene, ncrna |
| 1314438 | RRM2B | ribonucleotide reductase regulatory TP53 inducible subunit M2B | This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been ass ociated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] | 8 | 102204501 | 102238961 | Human | 475 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1344708 | LETMD1 | LETM1 domain containing 1 | This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011] | 12 | 51048220 | 51068958 | Human | 95 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 2303856 | MTLN | mitoregulin | Involved in several processes, including positive regulation of mitochondrial membrane potential; positive regulation of sequestering of calcium ion; and triglyceride homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 110211529 | 110212547 | Human | 46 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1321113 | PERP | p53 apoptosis effector related to PMP22 | Involved in positive regulation of neutrophil chemotaxis and positive regulation of proteolysis. Predicted to be located in desmosome and plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorifi cial keratotic plaques. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 138088505 | 138107419 | Human | 208 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 38623276 | PERPP3 | PERP pseudogene 3 | | 6 | 16160934 | 16162667 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 16556918 | PERPP1 | PERP pseudogene 1 | | | | | Human | | old_gene_name | gene, processed_pseudogene |
| 1602900 | TP53I3 | tumor protein p53 inducible protein 3 | The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] | 2 | 24077433 | 24084834 | Human | 137 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313500 | TP53BP2 | tumor protein p53 binding protein 2 | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 223779893 | 223845947 | Human | 154 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1318140 | TP53I11 | tumor protein p53 inducible protein 11 | Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 44932348 | 44951306 | Human | 123 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1605319 | TP53I13 | tumor protein p53 inducible protein 13 | Involved in negative regulation of cell cycle; response to UV; and response to xenobiotic stimulus. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 29566300 | 29582340 | Human | 55 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1625644 | TP53AIP1 | tumor protein p53 regulated apoptosis inducing protein 1 | This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding diffe rent isoforms have been described for this gene. [provided by RefSeq, Oct 2011] | 11 | 128934731 | 128942871 | Human | 27 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9850236 | TP53COR1 | tumor protein p53 pathway corepressor 1 | Predicted to act upstream of or within negative regulation of gene expression. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025] | | | | Human | 11 | symbol , GTEx , COSMIC , Human Proteome Map | gene, ncrna |
| 1349699 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 | Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of DNA-templated transcription; and positive regulation of autophagy. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 94925972 | 94949378 | Human | 268 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1352381 | TP53INP2 | tumor protein p53 inducible nuclear protein 2 | The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a tr anscriptional activator for some genes. [provided by RefSeq, Jul 2016] | 20 | 34704344 | 34713436 | Human | 168 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 15037080 | TP53BP2P1 | tumor protein p53 binding protein 2 pseudogene 1 | | | | | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo |
| 16566120 | TP53RK-DT | TP53RK divergent transcript | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, lncrna |
| 39128308 | TP53RK-DT | TP53RK divergent transcript | | 20 | 46689299 | 46690289 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1604844 | TP63 | tumor protein p63 | This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters result s in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016] | 3 | 189596746 | 189897276 | Human | 862 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1345920 | ANO9 | anoctamin 9 | The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phosphol ipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016] | 11 | 417938 | 442011 | Human | 64 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1320441 | EI24 | EI24 autophagy associated transmembrane protein | This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochon drial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014] | 11 | 125569477 | 125584684 | Human | 131 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732024 | GAMT | guanidinoacetate N-methyltransferase | The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidin oacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012] | 19 | 1397026 | 1401542 | Human | 431 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735583 | LITAF | lipopolysaccharide induced TNF factor | Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expressio n by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] | 16 | 11547722 | 11640317 | Human | 343 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312218 | MAD1L1 | mitotic arrest deficient 1 like 1 | MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Altern ative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] | 7 | 1815795 | 2232945 | Human | 203 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1343717 | PRODH | proline dehydrogenase 1 | This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with t he contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010] | 22 | 18912781 | 18936553 | Human | 239 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1317420 | SAA1 | serum amyloid A1 | This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also pl ays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Jul 2020] | 11 | 18266264 | 18269967 | Human | 237 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352868 | ENC1 | ectodermal-neural cortex 1 | This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcri pt variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] | 5 | 74627409 | 74640728 | Human | 296 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 69032 | PTGES | prostaglandin E synthase | The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53 an>, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] | 9 | 129738349 | 129753042 | Human | 373 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313199 | TOPORS | TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase | This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced tr anscript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010] | 9 | 32540544 | 32552586 | Human | 396 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 14700637 | BCAR3-AS1 | BCAR3 antisense RNA 1 | INTERACTS WITH perfluorononanoic acid; perfluorooctanoic acid; sodium arsenite | 1 | 93591968 | 93600030 | Human | 3 | old_gene_symbol | gene, ncrna, PREDICTED [RefSeq] |
| 38619700 | FAM169A-AS1 | FAM169A antisense RNA 1 | | 5 | 74865893 | 74867275 | Human | | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 27373330 | KLRK1-AS1 | KLRK1 antisense RNA 1 | INTERACTS WITH dimethylarsinous acid | 12 | 10363769 | 10398506 | Human | 1 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 16565055 | LIF-AS2 | LIF antisense RNA 2 | INTERACTS WITH aristolochic acid A; okadaic acid | 22 | 30246210 | 30246993 | Human | 2 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 2303883 | LINC00324 | long intergenic non-protein coding RNA 324 | ENCODES an ncrna that exhibits triplet codon-amino acid adaptor activity (inferred); INVOLVED IN translation (inferred); INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; actinomycin D | 17 | 8220630 | 8224043 | Human | 26 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1342701 | LINC00526 | long intergenic non-protein coding RNA 526 | INTERACTS WITH 4,4'-sulfonyldiphenol; all-trans-retinoic acid; antirheumatic drug | 18 | 5236724 | 5238029 | Human | 21 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 12904781 | LINC02525 | long intergenic non-protein coding RNA 2525 | INTERACTS WITH Aflatoxin B2 alpha; dicrotophos; N-methyl-4-phenylpyridinium | 6 | 3182817 | 3195767 | Human | 4 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 152025315 | LINC03036 | long intergenic non-protein coding RNA 3036 | INTERACTS WITH okadaic acid | 10 | 118784544 | 119029571 | Human | 1 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 152025269 | LINC03037 | long intergenic non-protein coding RNA 3037 | | | | | Human | | old_gene_symbol | gene, ncrna |
| 11563765 | LNCTAM34A | long non coding transcriptional activator of miR34a | INTERACTS WITH okadaic acid | 1 | 9182204 | 9192086 | Human | 1 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 5487919 | MRPL23-AS1 | MRPL23 antisense RNA 1 | INTERACTS WITH benzo[a]pyrene; fipronil; N,N-diethyl-m-toluamide | 11 | 1983209 | 1989920 | Human | 6 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 2300351 | NEAT1 | nuclear paraspeckle assembly transcript 1 | This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including so me genes involved in cancer progression. [provided by RefSeq, Mar 2015] | 11 | 65422798 | 65445540 | Human | 187 | old_gene_symbol | gene, ncrna, REVIEWED [RefSeq] |
| 1348372 | PVT1 | Pvt1 oncogene | This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of th is gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015] | 8 | 127794524 | 128101256 | Human | 103 | old_gene_symbol | gene, ncrna, REVIEWED [RefSeq] |
| 7246835 | RBPMS-AS1 | RBPMS antisense RNA 1 | INTERACTS WITH bisphenol A; cadmium dichloride; cisplatin | 8 | 30382119 | 30385401 | Human | 5 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1603252 | SNHG10 | small nucleolar RNA host gene 10 | This gene is small nucleolar RNA host gene 10 and represents a non-protein coding RNA. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013] | 14 | 95532912 | 95534872 | Human | 27 | old_gene_symbol | gene, ncrna, REVIEWED [RefSeq] |
| 152025378 | SYNM-AS2 | SYNM antisense RNA 2 | | | | | Human | | old_gene_symbol | gene, ncrna |
| 7240921 | UNC5B-AS1 | UNC5B antisense RNA 1 | INTERACTS WITH 17beta-estradiol; aflatoxin B1; avobenzone | 10 | 71217224 | 71218228 | Human | 15 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 9588876 | ABHD15-AS1 | ABHD15 antisense RNA 1 | | | | | Human | | old_gene_symbol | gene, ncrna |
| 732861 | CHEK2 | checkpoint kinase 2 | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] | 22 | 28687742 | 28741834 | Human | 3000 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1314380 | CUL7 | cullin 7 | The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] | 6 | 43037617 | 43053851 | Human | 265 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1314890 | ING1 | inhibitor of growth family member 1 | This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expr ession and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 13 | 110712623 | 110723339 | Human | 100 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1321527 | ING3 | inhibitor of growth family member 3 | The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008] | 7 | 120950777 | 120977216 | Human | 111 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1319738 | ING4 | inhibitor of growth family member 4 | This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involv ement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008] | 12 | 6650301 | 6663119 | Human | 126 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 731572 | PPM1A | protein phosphatase, Mg2+/Mn2+ dependent 1A | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases . It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] | 14 | 60245750 | 60299087 | Human | 193 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1313498 | PPM1D | protein phosphatase, Mg2+/Mn2+ dependent 1D | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. W hile being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008] | 17 | 60600193 | 60666280 | Human | 335 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1347285 | PPP1R13L | protein phosphatase 1 regulatory subunit 13 like | IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] | 19 | 45379638 | 45406361 | Human | 188 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606702 | PYHIN1 | pyrin and HIN domain family member 1 | The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiat ion, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | 1 | 158931552 | 158990870 | Human | 55 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1603050 | TPRKB | TP53RK binding protein | Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 73729873 | 73737345 | Human | 141 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 7204809 | TPRKBP1 | TP53RK binding protein pseudogene 1 | | 10 | 28658979 | 28659529 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 10413775 | TPRKBP2 | TP53RK binding protein pseudogene 2 | | 16 | 28111173 | 28111647 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16562816 | AC133485.3 | novel transcript, antisense to TP53TG3 | | | | | Human | | name | gene, lncrna |
| 16563028 | AC138907.3 | novel transcript, antisense to TP53TG3 | | | | | Human | | name | gene, lncrna |
