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Gene: PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) Homo sapiens
Symbol: PPM1D
Name: protein phosphatase, Mg2+/Mn2+ dependent 1D
Description: Exhibits mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Involved in negative regulation of gene expression, epigenetic and peptidyl-threonine dephosphorylation. Localizes to cytosol and nucleus. Implicated in breast cancer. Biomarker of pre-malignant neoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IDDGIP; JDVS; p53-induced protein phosphatase 1; PP2C-DELTA; protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 2C delta isoform; protein phosphatase 2C isoform delta; protein phosphatase magnesium-dependent 1 delta; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; WIP1
Mus musculus (house mouse) : Ppm1d (protein phosphatase 1D magnesium-dependent, delta isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent, 1D)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Pan paniscus (bonobo/pygmy chimpanzee) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Canis lupus familiaris (dog) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Sus scrofa (pig) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Chlorocebus sabaeus (African green monkey) : PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D)
Heterocephalus glaber (naked mole-rat) : Ppm1d (protein phosphatase, Mg2+/Mn2+ dependent 1D)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1760,600,183 - 60,666,280 (+)EnsemblGRCh38hg38GRCh38
GRCh381760,600,187 - 60,666,280 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371758,677,544 - 58,743,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361756,032,336 - 56,096,818 (+)NCBINCBI36hg18NCBI36
Build 341756,032,335 - 56,096,818NCBI
Celera1757,778,184 - 57,842,819 (+)NCBI
Cytogenetic Map17q23.2NCBI
HuRef1754,048,263 - 54,112,992 (+)NCBIHuRef
CHM1_11758,742,292 - 58,808,407 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPM1D
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313498
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.