RPRM (reprimo, TP53 dependent G2 arrest mediator homolog)

Gene: RPRM (reprimo, TP53 dependent G2 arrest mediator homolog) Homo sapiens

Analyze

Symbol:

RPRM

Name:

reprimo, TP53 dependent G2 arrest mediator homolog

RGD ID:

1350669

HGNC Page

HGNC:24201

Description:

Predicted to be involved in regulation of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in membrane. Predicted to be active in cytoplasm.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

candidate mediator of the p53 dependent G2 arrest; candidate mediator of the p53-dependent G2 arrest; FLJ90327; REPRIMO; reprimo, TP53 dependant G2 arrest mediator candidate; reprimo, TP53 dependent G2 arrest mediator candidate

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	153,477,338 - 153,478,762 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	153,477,338 - 153,478,762 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	154,333,852 - 154,335,276 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	154,042,098 - 154,043,568 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	154,159,359 - 154,160,830	NCBI
Celera	2	147,948,311 - 147,949,781 (-)	NCBI		Celera
Cytogenetic Map	2	q23.3	NCBI
HuRef	2	146,220,733 - 146,222,203 (-)	NCBI		HuRef
CHM1_1	2	154,339,787 - 154,341,257 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	153,929,892 - 153,931,316 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Barrett's esophagus (EXP)

Esophageal Neoplasms (EXP)

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-naringenin (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-acetamidofluorene (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (EXP,ISO)

amitrole (ISO)

arsenite(3-) (EXP)

benzo[a]pyrene (EXP,ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (ISO)

butanal (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

copper atom (EXP)

copper(0) (EXP)

coumarin (ISO)

coumestrol (EXP)

diazinon (ISO)

diuron (ISO)

dorsomorphin (EXP)

entinostat (EXP)

furan (ISO)

GW 4064 (ISO)

hexane (ISO)

iron(III) nitrilotriacetate (ISO)

maneb (ISO)

mercury dibromide (EXP)

methapyrilene (ISO)

methimazole (ISO)

methylmercury chloride (EXP)

mifepristone (EXP)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (EXP)

N-nitrosodiethylamine (ISO)

nevirapine (ISO)

ochratoxin A (ISO)

p-chloromercuribenzoic acid (EXP)

p-toluidine (ISO)

panobinostat (EXP)

paracetamol (EXP)

paraquat (ISO)

pentanal (EXP)

phenobarbital (ISO)

phenylmercury acetate (EXP)

potassium dichromate (ISO)

progesterone (ISO)

resveratrol (EXP,ISO)

SB 431542 (EXP)

sodium arsenite (ISO)

streptozocin (ISO)

sulfadimethoxine (ISO)

sulforaphane (EXP,ISO)

tetraphene (ISO)

thioacetamide (ISO)

trichloroethene (ISO)

trichostatin A (EXP,ISO)

triphenyl phosphate (ISO)

valdecoxib (ISO)

valproic acid (EXP)

vitamin E (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of cell cycle (IEA,ISO,TAS)

regulation of mitotic cell cycle (IBA,IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA,TAS)

membrane (IEA)

Molecular Function

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:10930422	PMID:12395409	PMID:16303743	PMID:16752411	PMID:17207965	PMID:17353931	PMID:18197409	PMID:18829507	PMID:19322201	PMID:19917725	PMID:20949468	PMID:21516116
PMID:21873635	PMID:22562171	PMID:23312294	PMID:23720494	PMID:23982217	PMID:24623722	PMID:25416956	PMID:25629980	PMID:25954972	PMID:26823831	PMID:27992600	PMID:28562620
PMID:28809778	PMID:29401170	PMID:29941787	PMID:32296183	PMID:33961781	PMID:35549646

Genomics

Comparative Map Data

RPRM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	153,477,338 - 153,478,762 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	153,477,338 - 153,478,762 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	154,333,852 - 154,335,276 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	154,042,098 - 154,043,568 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	154,159,359 - 154,160,830	NCBI
Celera	2	147,948,311 - 147,949,781 (-)	NCBI		Celera
Cytogenetic Map	2	q23.3	NCBI
HuRef	2	146,220,733 - 146,222,203 (-)	NCBI		HuRef
CHM1_1	2	154,339,787 - 154,341,257 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	153,929,892 - 153,931,316 (-)	NCBI		T2T-CHM13v2.0

Rprm
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	53,974,105 - 53,975,564 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	53,974,105 - 53,975,564 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	54,084,093 - 54,085,552 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	54,084,093 - 54,085,552 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	53,936,504 - 53,937,963 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	53,899,479 - 53,900,938 (-)	NCBI		MGSCv36	mm8
Celera	2	55,823,429 - 55,824,888 (-)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	30.69	NCBI

Rprm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	58,948,618 - 58,950,035 (-)	NCBI		GRCr8
mRatBN7.2	3	38,539,581 - 38,540,998 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	38,539,581 - 38,540,998 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	41,889,827 - 41,891,244 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	50,474,659 - 50,476,076 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	48,259,479 - 48,260,896 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	39,595,301 - 39,596,718 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	39,595,301 - 39,596,718 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	44,691,127 - 44,692,544 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	35,590,166 - 35,591,583 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	36,675,136 - 36,676,553 (-)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

RPRM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	56,159,632 - 56,161,056 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	56,174,610 - 56,176,034 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	40,772,338 - 40,773,805 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	158,008,875 - 158,010,364 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	158,009,772 - 158,010,101 (-)	Ensembl	panpan1.1		panPan2

RPRM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	36	417,673 - 418,083 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	398,084 - 398,494 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	36	404,013 - 404,423 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	466,787 - 467,197 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	480,488 - 480,898 (-)	NCBI		UU_Cfam_GSD_1.0

Rprm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	117,302,404 - 117,303,962 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	24,314,105 - 24,314,434 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	24,313,850 - 24,315,318 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPRM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	61,140,688 - 61,142,607 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	61,140,687 - 61,143,397 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	68,110,736 - 68,112,836 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPRM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	38,863,940 - 38,865,912 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	38,864,844 - 38,865,170 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	160,678,631 - 160,681,473 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rprm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	12,540,610 - 12,540,939 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	12,540,265 - 12,541,118 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RPRM
2 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 2q22.3-24.1(chr2:147251948-157856378)x1	copy number loss	See cases [RCV000054090]	Chr2:147251948..157856378 [GRCh38] Chr2:148009516..158712890 [GRCh37] Chr2:147725986..158421136 [NCBI36] Chr2:2q22.3-24.1	pathogenic
GRCh38/hg38 2q22.3-23.3(chr2:147590324-153496674)x1	copy number loss	See cases [RCV000054091]	Chr2:147590324..153496674 [GRCh38] Chr2:148347892..154353187 [GRCh37] Chr2:148064362..154061433 [NCBI36] Chr2:2q22.3-23.3	pathogenic
GRCh38/hg38 2q23.1-24.3(chr2:148917286-163204623)x1	copy number loss	See cases [RCV000054093]	Chr2:148917286..163204623 [GRCh38] Chr2:149674855..164061133 [GRCh37] Chr2:149391325..163769379 [NCBI36] Chr2:2q23.1-24.3	pathogenic
GRCh38/hg38 2q22.3-24.1(chr2:143900149-158321624)x3	copy number gain	See cases [RCV000135402]	Chr2:143900149..158321624 [GRCh38] Chr2:144657717..159178136 [GRCh37] Chr2:144374187..158886382 [NCBI36] Chr2:2q22.3-24.1	pathogenic
GRCh38/hg38 2q23.3-24.2(chr2:151932344-159419734)x1	copy number loss	See cases [RCV000142664]	Chr2:151932344..159419734 [GRCh38] Chr2:152788858..160276245 [GRCh37] Chr2:152497104..159984491 [NCBI36] Chr2:2q23.3-24.2	pathogenic\|likely pathogenic
GRCh38/hg38 2q22.3-24.1(chr2:146324191-156219125)x3	copy number gain	See cases [RCV000142582]	Chr2:146324191..156219125 [GRCh38] Chr2:147081759..157075637 [GRCh37] Chr2:146798229..156783883 [NCBI36] Chr2:2q22.3-24.1	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3	copy number gain	not provided [RCV000752802]	Chr2:14238..243048760 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q22.3-23.3(chr2:147063452-154796058)x1	copy number loss	See cases [RCV000448667]	Chr2:147063452..154796058 [GRCh37] Chr2:2q22.3-23.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)	copy number gain	See cases [RCV000512056]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3	copy number gain	See cases [RCV000511212]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1	copy number loss	Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436]	Chr2:104172062..168223828 [GRCh37] Chr2:2q12.1-24.3	drug response
GRCh37/hg19 2q23.2-23.3(chr2:150134077-154848282)x1	copy number loss	not provided [RCV000682154]	Chr2:150134077..154848282 [GRCh37] Chr2:2q23.2-23.3	likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3	copy number gain	not provided [RCV000752804]	Chr2:15672..243101834 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q23.3-31.2(chr2:152409978-179325736)x3	copy number gain	not provided [RCV000740654]	Chr2:152409978..179325736 [GRCh37] Chr2:2q23.3-31.2	pathogenic
GRCh37/hg19 2q23.3(chr2:153999219-154487261)x1	copy number loss	not provided [RCV001005339]	Chr2:153999219..154487261 [GRCh37] Chr2:2q23.3	uncertain significance
GRCh37/hg19 2q22.3-24.1(chr2:147173792-158346266)x1	copy number loss	not provided [RCV001005326]	Chr2:147173792..158346266 [GRCh37] Chr2:2q22.3-24.1	pathogenic
GRCh37/hg19 2q23.3(chr2:154164995-154511449)x1	copy number loss	not provided [RCV001259775]	Chr2:154164995..154511449 [GRCh37] Chr2:2q23.3	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373)	copy number gain	Mosaic trisomy 2 [RCV002280628]	Chr2:1..243199373 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q23.3-24.2(chr2:152967964-160089210)x3	copy number gain	not provided [RCV001825170]	Chr2:152967964..160089210 [GRCh37] Chr2:2q23.3-24.2	not provided
GRCh37/hg19 2q23.3-24.1(chr2:154328530-158759642)x1	copy number loss	not provided [RCV001827767]	Chr2:154328530..158759642 [GRCh37] Chr2:2q23.3-24.1	pathogenic
NM_019845.3(RPRM):c.150C>G (p.Ser50Arg)	single nucleotide variant	Inborn genetic diseases [RCV002708168]	Chr2:153478416 [GRCh38] Chr2:154334930 [GRCh37] Chr2:2q23.3	uncertain significance
NM_019845.3(RPRM):c.77C>T (p.Ala26Val)	single nucleotide variant	Inborn genetic diseases [RCV002680244]	Chr2:153478489 [GRCh38] Chr2:154335003 [GRCh37] Chr2:2q23.3	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	537
Count of miRNA genes:	400
Interacting mature miRNAs:	440
Transcripts:	ENST00000325926
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

WI-18554

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	154,333,853 - 154,334,002	UniSTS	GRCh37
Build 36	2	154,042,099 - 154,042,248	RGD	NCBI36
Celera	2	147,948,312 - 147,948,461	RGD
Cytogenetic Map	2	q23.3	UniSTS
HuRef	2	146,220,734 - 146,220,883	UniSTS
GeneMap99-GB4 RH Map	2	511.9	UniSTS
Whitehead-RH Map	2	791.9	UniSTS

RH66328

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	154,333,915 - 154,334,071	UniSTS	GRCh37
Build 36	2	154,042,161 - 154,042,317	RGD	NCBI36
Celera	2	147,948,374 - 147,948,530	RGD
Cytogenetic Map	2	q23.3	UniSTS
HuRef	2	146,220,796 - 146,220,952	UniSTS
GeneMap99-GB4 RH Map	2	512.11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

1003

479

145

437

996

585

202

Low

1033

818

769

175

402

2208

502

2206

153

747

1055

152

619

1311

Below cutoff

307

1545

166

131

646

131

1804

1020

493

147

404

362

1357

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA452090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB043585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC012501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK074808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK311958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC002908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ782742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000325926 ⟹ ENSP00000314946

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	153,477,338 - 153,478,762 (-)	Ensembl

RefSeq Acc Id:

NM_019845 ⟹ NP_062819

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	153,477,338 - 153,478,762 (-)	NCBI
GRCh37	2	154,333,852 - 154,335,322 (-)	RGD
Build 36	2	154,042,098 - 154,043,568 (-)	NCBI Archive
Celera	2	147,948,311 - 147,949,781 (-)	RGD
HuRef	2	146,220,733 - 146,222,203 (-)	RGD
CHM1_1	2	154,339,787 - 154,341,257 (-)	NCBI
T2T-CHM13v2.0	2	153,929,892 - 153,931,316 (-)	NCBI

Sequence:

show sequence

AGAAGAGCCTAGCTGCTGCGCGCGTCGGAGAGGCTCCTGGGAAACTCCCACGGCCCAGGGACTT
TCGAAAGCAGAGCGAGGAGCCCTCGCACGCGCTAGTCTGCGAGTGAGCGCTCAGCCCGGCACCT
GTTCCTCCAGCGCCGCCGCCTTCCCACCCCTCGGACCCGCGCCGCTCGCGGCGCCCGCCCGTTC
CTGCGATGAATCCGGCCCTAGGCAACCAGACGGACGTGGCGGGCCTGTTCCTGGCCAACAGCAG
CGAGGCGCTGGAGCGAGCCGTGCGCTGCTGCACCCAGGCGTCCGTGGTGACCGACGACGGCTTC
GCGGAGGGAGGCCCGGACGAGCGTAGCCTGTACATAATGCGCGTGGTGCAGATCGCGGTCATGT
GCGTGCTCTCACTCACCGTGGTCTTCGGCATCTTCTTCCTCGGCTGCAATCTGCTCATCAAGTC
CGAGGGCATGATCAACTTCCTCGTGAAGGACCGGAGGCCGTCTAAGGAGGTGGAGGCGGTGGTC
GTGGGGCCCTACTGACCCGCCCTCTGCCCCCGCGGCAACCGCTCCCACGCCTGCCCACTTTGCT
AGCCCGGCTGTGCCCCTCACTATCAGAGACTGGGCGAAGCAAACCTGTCGGAGTCAATTATTTC
TCTCGACTTCGGCCTTTCGGAAAGAAGCGACCGGTTTCTCCCTCGCCCTCTGAAAGTCCTCATG
CCTGGCAGTCGGAGGAGAGCGCCCAGACTCTGAACTCAGCAGAAAGTGGCAAGAAGAGGGCGAT
TAGGGCGCAGAACTTTGGAAGCTGCTACTTACTTGGAATGCGGGGAGACCGACGGTGCGAAGGC
CCTTCTCCACCCGCAGGTGGGCCAAGCTCTGGGGGCAGGTGGAGAGGGCGGGCAGGGGAGAGAC
CCAGCGGCACTGATCGCCTTGTGACCGGAAGAGTGACCTGTTAAAAGCCACGCAGCAGACTCAT
GGGGTCTCACAAATCCGTGTCCGGGTGCGCTCCCACTCTTCTCCTGCTCCCCCCCTGCCCTGGA
GGGGAGGGGCGATAAATACCTTTGATTGTAACGTGCCGTTTTAAGAGGTTTTGTGTTTGTTTGC
TTGAATACAAATGTTTGATAAGTCTTTTTCTGCCCCAGTGGCCTGTTTGCCTGCCTGAGGAGTT
ACAGTTTTGTCATTGTGGGAGAAGGGGTGGGGGGAGGGGGAGCCTGCGAATTTGAACGGGGTGA
GTTGTTTCTTTTAGTGCATTTCCCACTGGGTCTTTTGGGAGGCGTCTAGCGTTCCTGCTGGCCC
TGGGACAAAGACCCAGAATAGAACTCGTAGCTCGTGACTGCACGGTTTACGCCACAAAAGTGCT
CTTGACATCCGTGACACCGTTTTGACTTTTTGTTTTTTTCTTATTTAACATTTCCTTAATAAAT
GCAACATTTAAGCGTTT

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Protein Sequences


Protein RefSeqs	NP_062819	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH02908	(Get FASTA)	NCBI Sequence Viewer
	AAY14783	(Get FASTA)	NCBI Sequence Viewer
	BAB01513	(Get FASTA)	NCBI Sequence Viewer
	BAG34898	(Get FASTA)	NCBI Sequence Viewer
	BAG52007	(Get FASTA)	NCBI Sequence Viewer
	CAF85975	(Get FASTA)	NCBI Sequence Viewer
	EAX11467	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000314946
	ENSP00000314946.3
GenBank Protein	Q9NS64	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062819 ⟸ NM_019845
- UniProtKB:	B2R4V1 (UniProtKB/Swiss-Prot), Q9NS64 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNPALGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCV LSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY hide sequence

RefSeq Acc Id:

ENSP00000314946 ⟸ ENST00000325926

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9NS64-F1-model_v2	AlphaFold	Q9NS64	1-109	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:24201	AgrOrtholog
COSMIC	RPRM	COSMIC
Ensembl Genes	ENSG00000177519	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000325926	ENTREZGENE
	ENST00000325926.4	UniProtKB/Swiss-Prot
GTEx	ENSG00000177519	GTEx
HGNC ID	HGNC:24201	ENTREZGENE
Human Proteome Map	RPRM	Human Proteome Map
InterPro	Reprimo_fam	UniProtKB/Swiss-Prot
KEGG Report	hsa:56475	UniProtKB/Swiss-Prot
NCBI Gene	56475	ENTREZGENE
OMIM	612171	OMIM
PANTHER	PTHR28649	UniProtKB/Swiss-Prot
	PTHR28649:SF2	UniProtKB/Swiss-Prot
PharmGKB	PA134937494	PharmGKB
UniProt	B2R4V1	ENTREZGENE
	Q9NS64	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	B2R4V1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-02-21	RPRM	reprimo, TP53 dependent G2 arrest mediator homolog		reprimo, TP53 dependent G2 arrest mediator candidate	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)