TP53INP1 (tumor protein p53 inducible nuclear protein 1) - Rat Genome Database

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Gene: TP53INP1 (tumor protein p53 inducible nuclear protein 1) Homo sapiens
Analyze
Symbol: TP53INP1
Name: tumor protein p53 inducible nuclear protein 1
RGD ID: 1349699
HGNC Page HGNC
Description: Predicted to have antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Localizes to autophagosome; cytosol; and nucleus; INTERACTS WITH (-)-demecolcine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp434M1317; FLJ22139; p53-dependent damage-inducible nuclear protein 1; p53-inducible p53DINP1; p53DINP1; SIP; stress-induced protein; Teap; TP53DINP1; TP53INP1A; TP53INP1B; tumor protein p53-inducible nuclear protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl894,925,972 - 94,949,378 (-)EnsemblGRCh38hg38GRCh38
GRCh38894,925,972 - 94,949,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37895,938,200 - 95,961,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36896,007,377 - 96,030,767 (-)NCBINCBI36hg18NCBI36
Build 34896,007,376 - 96,030,767NCBI
Celera892,123,395 - 92,146,810 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef891,146,079 - 91,169,530 (-)NCBIHuRef
CHM1_1895,978,531 - 96,001,887 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
adefovir pivoxil  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenic trichloride  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
chlorendic acid  (ISO)
chloroacetaldehyde  (EXP)
chloroethene  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dimethylarsinous acid  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP)
doxorubicin  (ISO)
doxycycline  (ISO)
Enterolactone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenofibrate  (EXP,ISO)
ferric oxide  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gemcitabine  (EXP)
genistein  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxyurea  (ISO)
ibuprofen  (EXP)
ifosfamide  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
lucanthone  (EXP)
metformin  (EXP,ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zoledronic acid  (EXP)

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11511362   PMID:12067065   PMID:12438758   PMID:12477932   PMID:12851404   PMID:14702039   PMID:15489334   PMID:15706352   PMID:16044147   PMID:16344560   PMID:16521180   PMID:17393983  
PMID:17537403   PMID:18277906   PMID:18277909   PMID:18974142   PMID:19322201   PMID:20581827   PMID:20889853   PMID:21219856   PMID:21339733   PMID:21538421   PMID:21873635   PMID:22213058  
PMID:22421968   PMID:22470510   PMID:22730212   PMID:23333058   PMID:23568502   PMID:24152184   PMID:24447717   PMID:24509480   PMID:24551280   PMID:24608790   PMID:24922517   PMID:25490449  
PMID:25601564   PMID:25633840   PMID:26252115   PMID:26367773   PMID:26512655   PMID:26813458   PMID:27341836   PMID:28437838   PMID:28514442   PMID:28611215   PMID:28674078   PMID:29048685  
PMID:29146309   PMID:29329575   PMID:29655255   PMID:30365045   PMID:30855679   PMID:31646552   PMID:31669646   PMID:32268073   PMID:32296183   PMID:32432745   PMID:32527448   PMID:32841649  


Genomics

Comparative Map Data
TP53INP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl894,925,972 - 94,949,378 (-)EnsemblGRCh38hg38GRCh38
GRCh38894,925,972 - 94,949,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37895,938,200 - 95,961,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36896,007,377 - 96,030,767 (-)NCBINCBI36hg18NCBI36
Build 34896,007,376 - 96,030,767NCBI
Celera892,123,395 - 92,146,810 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef891,146,079 - 91,169,530 (-)NCBIHuRef
CHM1_1895,978,531 - 96,001,887 (-)NCBICHM1_1
Trp53inp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,156,441 - 11,174,379 (+)NCBIGRCm39mm39
GRCm39 Ensembl411,156,431 - 11,174,379 (+)Ensembl
GRCm38411,156,441 - 11,174,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,156,431 - 11,174,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv37411,083,588 - 11,101,524 (+)NCBIGRCm37mm9NCBIm37
MGSCv36411,083,588 - 11,101,524 (+)NCBImm8
Celera410,967,133 - 10,985,072 (+)NCBICelera
Cytogenetic Map4A1NCBI
Tp53inp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2524,253,986 - 24,272,250 (+)NCBI
Rnor_6.0 Ensembl524,410,863 - 24,416,888 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0524,402,895 - 24,419,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0529,128,794 - 29,144,271 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,008,253 - 25,014,263 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1524,729,972 - 25,014,263 (+)NCBI
Celera523,480,259 - 23,486,276 (+)NCBICelera
Cytogenetic Map5q13NCBI
Tp53inp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541711,067,715 - 11,073,635 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541711,063,217 - 11,079,389 (-)NCBIChiLan1.0ChiLan1.0
TP53INP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1893,747,162 - 93,767,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl893,747,162 - 93,767,196 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0891,545,655 - 91,569,535 (-)NCBIMhudiblu_PPA_v0panPan3
TP53INP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,575,782 - 39,593,389 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2939,580,496 - 39,593,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,737,342 - 39,755,264 (-)NCBI
ROS_Cfam_1.02939,779,940 - 39,797,257 (-)NCBI
UMICH_Zoey_3.12939,805,773 - 39,819,363 (-)NCBI
UNSW_CanFamBas_1.02939,787,781 - 39,805,733 (-)NCBI
UU_Cfam_GSD_1.02940,229,451 - 40,247,160 (-)NCBI
Tp53inp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530339,896,536 - 39,911,591 (+)NCBI
SpeTri2.0NW_0049365447,882,710 - 7,891,668 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53INP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,747,726 - 41,766,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,747,654 - 41,766,688 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,000,130 - 45,015,123 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TP53INP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,893,531 - 89,918,054 (-)NCBI
ChlSab1.1 Ensembl889,893,419 - 89,908,228 (-)Ensembl
Vero_WHO_p1.0NW_02366603950,916,705 - 50,940,375 (+)NCBI
Tp53inp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247632,278,751 - 2,297,149 (-)NCBI

Position Markers
RH103322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,938,258 - 95,938,444UniSTSGRCh37
Build 36896,007,434 - 96,007,620RGDNCBI36
Celera892,123,453 - 92,123,639RGD
Cytogenetic Map8q22UniSTS
HuRef891,146,137 - 91,146,323UniSTS
GeneMap99-GB4 RH Map8439.42UniSTS
SHGC-146998  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,960,084 - 95,960,430UniSTSGRCh37
Build 36896,029,260 - 96,029,606RGDNCBI36
Celera892,145,278 - 92,145,624RGD
Cytogenetic Map8q22UniSTS
HuRef891,167,982 - 91,168,328UniSTS
TNG Radiation Hybrid Map846206.0UniSTS
STS-T19436  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,938,213 - 95,938,354UniSTSGRCh37
Build 36896,007,389 - 96,007,530RGDNCBI36
Celera892,123,408 - 92,123,549RGD
Cytogenetic Map8q22UniSTS
HuRef891,146,092 - 91,146,233UniSTS
GeneMap99-GB4 RH Map8440.32UniSTS
NCBI RH Map8990.8UniSTS
STS-N63582  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,938,233 - 95,938,356UniSTSGRCh37
Build 36896,007,409 - 96,007,532RGDNCBI36
Celera892,123,428 - 92,123,551RGD
Cytogenetic Map8q22UniSTS
HuRef891,146,112 - 91,146,235UniSTS
GeneMap99-GB4 RH Map8439.83UniSTS
NCBI RH Map8977.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR125B1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21970405
MIR93hsa-miR-93-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18974142
MIR130Bhsa-miR-130b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18974142
MIR130Bhsa-miR-130b-3pOncomiRDBexternal_infoNANA21112564
MIR125B2hsa-miR-125b-5pOncomiRDBexternal_infoNANA21970405
MIR17hsa-miR-17-5pOncomiRDBexternal_infoNANA22730212
MIR155hsa-miR-155-5pOncomiRDBexternal_infoNANA17911264
MIR155hsa-miR-155-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Reporter Functional MTI17911264
MIR155hsa-miR-155-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI21093163

Predicted Target Of
Summary Value
Count of predictions:3515
Count of miRNA genes:898
Interacting mature miRNAs:1084
Transcripts:ENST00000342697, ENST00000378776, ENST00000448464
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3
Medium 2172 1961 1596 606 1610 451 3558 1125 1047 292 1343 1471 160 1052 2107 2
Low 262 1027 126 18 331 14 793 1069 2675 125 110 136 14 1 152 681 3 2
Below cutoff 2 2 2 4 2 3 11 1 5 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001135733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB017926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB017927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB062056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF409114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF409115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB086880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000342697   ⟹   ENSP00000344215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,925,972 - 94,949,378 (-)Ensembl
RefSeq Acc Id: ENST00000448464   ⟹   ENSP00000390063
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,925,972 - 94,949,366 (-)Ensembl
RefSeq Acc Id: NM_001135733   ⟹   NP_001129205
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,925,972 - 94,949,378 (-)NCBI
GRCh37895,938,200 - 95,961,615 (-)ENTREZGENE
HuRef891,146,079 - 91,169,530 (-)ENTREZGENE
CHM1_1895,978,531 - 96,001,887 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033285   ⟹   NP_150601
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,925,972 - 94,949,378 (-)NCBI
GRCh37895,938,200 - 95,961,615 (-)ENTREZGENE
Build 36896,007,377 - 96,030,767 (-)NCBI Archive
HuRef891,146,079 - 91,169,530 (-)ENTREZGENE
CHM1_1895,978,531 - 96,001,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517386   ⟹   XP_011515688
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,925,972 - 94,945,599 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_150601   ⟸   NM_033285
- Peptide Label: isoform a
- UniProtKB: Q96A56 (UniProtKB/Swiss-Prot),   A0A024R9C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129205   ⟸   NM_001135733
- Peptide Label: isoform b
- UniProtKB: Q96A56 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011515688   ⟸   XM_011517386
- Peptide Label: isoform X1
- UniProtKB: Q96A56 (UniProtKB/Swiss-Prot),   A0A024R9C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000390063   ⟸   ENST00000448464
RefSeq Acc Id: ENSP00000344215   ⟸   ENST00000342697

Promoters
RGD ID:7213807
Promoter ID:EPDNEW_H12649
Type:initiation region
Name:TP53INP1_1
Description:tumor protein p53 inducible nuclear protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,949,366 - 94,949,426EPDNEW
RGD ID:6806668
Promoter ID:HG_KWN:61739
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000378776
Position:
Human AssemblyChrPosition (strand)Source
Build 36896,022,896 - 96,023,396 (-)MPROMDB
RGD ID:6807078
Promoter ID:HG_KWN:61740
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid
Transcripts:NM_001135733,   NM_033285
Position:
Human AssemblyChrPosition (strand)Source
Build 36896,030,771 - 96,031,527 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1(chr8:94283890-94959597)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053675]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053675]|See cases [RCV000053675] Chr8:94283890..94959597 [GRCh38]
Chr8:95296118..95971825 [GRCh37]
Chr8:95365294..96041001 [NCBI36]
Chr8:8q22.1
benign
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-22.1(chr8:78672463-95366868)x1 copy number loss See cases [RCV000054262] Chr8:78672463..95366868 [GRCh38]
Chr8:79584698..96379096 [GRCh37]
Chr8:79747253..96448272 [NCBI36]
Chr8:8q21.13-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:92283179-95786443)x1 copy number loss See cases [RCV000054265] Chr8:92283179..95786443 [GRCh38]
Chr8:93295407..96798671 [GRCh37]
Chr8:93364583..96867847 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:92287062-95786443)x1 copy number loss See cases [RCV000054277] Chr8:92287062..95786443 [GRCh38]
Chr8:93299290..96798671 [GRCh37]
Chr8:93368466..96867847 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q22.1(chr8:92755532-97792132)x1 copy number loss See cases [RCV000054278] Chr8:92755532..97792132 [GRCh38]
Chr8:93767760..98804360 [GRCh37]
Chr8:93836936..98873536 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.1(chr8:93038175-95667782)x1 copy number loss See cases [RCV000136519] Chr8:93038175..95667782 [GRCh38]
Chr8:94050403..96680010 [GRCh37]
Chr8:94119579..96749186 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:93391781-96572606)x1 copy number loss See cases [RCV000512300] Chr8:93391781..96572606 [GRCh37]
Chr8:8q22.1
likely pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:95803280-97802022)x3 copy number gain not provided [RCV001259019] Chr8:95803280..97802022 [GRCh37]
Chr8:8q22.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18022 AgrOrtholog
COSMIC TP53INP1 COSMIC
Ensembl Genes ENSG00000164938 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000344215 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390063 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000342697 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000448464 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000164938 GTEx
HGNC ID HGNC:18022 ENTREZGENE
Human Proteome Map TP53INP1 Human Proteome Map
InterPro TP53INP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TP53INP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:94241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 94241 ENTREZGENE
OMIM 606185 OMIM
PANTHER PTHR31671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31671:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38278 PharmGKB
UniProt A0A024R9C8 ENTREZGENE, UniProtKB/TrEMBL
  Q96A56 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RCE5 UniProtKB/Swiss-Prot
  Q969R9 UniProtKB/Swiss-Prot