| 1344173 | USP4 | ubiquitin specific peptidase 4 | The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding differen t isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | 3 | 49277144 | 49340053 | Human | 118 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558494 | Usp4 | ubiquitin specific peptidase 4 | Predicted to enable adenosine receptor binding activity; cysteine-type deubiquitinase activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of TORC1 signaling; protein localization to cell surface; and spliceosomal tri-snRNP co mplex assembly. Predicted to be located in cytosol and plasma membrane. Predicted to be active in nucleus. Is expressed in facial prominence ectoderm and facial prominence mesenchyme. Orthologous to human USP4 (ubiquitin specific peptidase 4). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 108223763 | 108269744 | Mouse | 140 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1587387 | Usp4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (ortholog); cysteine-type deubiquitinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); positive regulation of TORC1 signaling (ortholog); protein deubiquitina tion (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine; aconitine | 8 | 117912576 | 117957934 | Rat | 130 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8784985 | Usp4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (ortholog); cysteine-type deubiquitinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); positive regulation of TORC1 signaling (ortholog); protein deubiquitina tion (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955532 | 1247110 | 1284564 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12277246 | USP4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); positive regulation of TORC1 signaling (inferred); protein deubi quitination (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred); INTERACTS WITH bisphenol A | 20 | 39899880 | 39952959 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12716638 | Usp4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); positive regulation of TORC1 signaling (inferred); protein deubi quitination (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936529 | 941042 | 989781 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14017967 | USP4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); positive regulation of TORC1 signaling (inferred); protein deubi quitination (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18783266 | USP4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); positive regulation of TORC1 signaling (inferred); protein deubi quitination (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914184 | Usp4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of protein ubiquitination (inferred); positive regulation of TORC1 signaling (inferred); protein deubi quitination (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256596 | usp4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625917448 | Usp4 | ubiquitin specific peptidase 4 | ENCODES a protein that exhibits adenosine receptor binding (ortholog); cysteine-type deubiquitinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); positive regulation of TORC1 signaling (ortholog); protein deubiquitina tion (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252301 | usp4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258884 | usp4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11705520 | LOC100967331 | ubiquitin carboxyl-terminal hydrolase 4 | ENCODES a protein that exhibits adenosine receptor binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN axon extension (inferred); negative regulation of protein ubiquitination (inferred); positive regulation of TORC1 signalin g (inferred); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN axon (inferred); centrosome (inferred); ciliary basal body (inferred) | 3 | 49199328 | 49263861 | Bonobo | 40 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1309613 | Usp40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 96055741 | 96126766 | Rat | 87 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320045 | USP40 | ubiquitin specific peptidase 40 | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiq uitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008] | 2 | 233475526 | 233566782 | Human | 82 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1320046 | Usp40 | ubiquitin specific peptidase 40 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP40 (ubiquitin specific peptidase 40). [provided by Alliance of Genome R esources, Jul 2025] | 1 | 87872841 | 87936308 | Mouse | 81 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8936924 | Usp40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | NW_004955453 | 2661233 | 2739742 | Chinchilla | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11717569 | USP40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | 2B | 120704893 | 120796084 | Bonobo | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12059625 | USP40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | 25 | 44965276 | 45021539 | Dog | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12615908 | Usp40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936525 | 3759982 | 3826190 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14293477 | USP40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | | | | Pig | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18614069 | USP40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | | | | Green Monkey | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917605 | Usp40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238151 | usp40 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625841166 | Usp40 | ubiquitin specific peptidase 40 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); FOUND IN cytoplasm (ortholog) | | | | Black Rat | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1305231 | Usp42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acrylamide | 12 | 15903110 | 15954429 | Rat | 79 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313136 | USP42 | ubiquitin specific peptidase 42 | Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination; regulation of apoptotic process; and regulation of protein stability. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 6081241 | 6161564 | Human | 78 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1623119 | Usp42 | ubiquitin specific peptidase 42 | Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human USP4 USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 143696077 | 143741600 | Mouse | 93 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11759174 | USP42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); regulation of apoptotic process (inferred); FOUND IN cytosol (inferre d); nucleus (inferred) | 7 | 7283212 | 7339854 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12211050 | USP42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred) | 6 | 11504491 | 11554720 | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12506123 | Usp42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); regulation of apoptotic process (inferred); FOUND IN cytosol (inferre d); nucleus (inferred) | NW_004936750 | 307517 | 349212 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13853643 | USP42 | ubiquitin specific peptidase 42 | ENCODES an ncrna that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred) | | | | Pig | 16 | symbol | gene, ncrna, MODEL [RefSeq] |
| 18415071 | USP42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); regulation of apoptotic process (inferred); FOUND IN cytosol (inferre d); nucleus (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931546 | Usp42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); regulation of apoptotic process (inferred); FOUND IN cytosol (inferre d); nucleus (inferred) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252568 | usp42 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625889335 | Usp42 | ubiquitin specific peptidase 42 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1317758 | USP43 | ubiquitin specific peptidase 43 | Predicted to enable ISG15-specific peptidase activity. Predicted to be involved in translesion synthesis. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 9645260 | 9729687 | Human | 92 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1317759 | Usp43 | ubiquitin specific peptidase 43 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to human USP43 (ubiquitin specific peptidase 43). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 67745349 | 67812979 | Mouse | 89 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2303824 | Usp43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 10 | 53047368 | 53110099 | Rat | 89 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9018676 | Usp43 | ubiquitin specific peptidase 43 | ASSOCIATED WITH congenital heart disease (ortholog) | NW_004955467 | 7392393 | 7458852 | Chinchilla | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11821267 | USP43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred) | 17 | 41927406 | 42012712 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12100383 | USP43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred) | 5 | 34136066 | 34186593 | Dog | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12690476 | Usp43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred) | NW_004936595 | 2631589 | 2704903 | Squirrel | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14076257 | USP43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18598109 | USP43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904030 | Usp43 | ubiquitin specific peptidase 43 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH congenital heart disease (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857029 | usp43 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863496 | usp43 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863950 | usp43 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405864010 | usp43 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598151770 | usp43 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625834757 | Usp43 | ubiquitin specific peptidase 43 | ASSOCIATED WITH congenital heart disease (ortholog) | | | | Black Rat | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1308216 | Usp44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); chromosome segregation (ortholog); negative regulation of mitotic metaphase/anaphase transition (ortholog); PARTICIPATES IN a taxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN fibrillar center (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; amphetamine | 7 | 30251142 | 30301185 | Rat | 99 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317864 | USP44 | ubiquitin specific peptidase 44 | The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting com plex/cyclosome. [provided by RefSeq, Dec 2016] | 12 | 95516560 | 95551681 | Human | 101 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622843 | Usp44 | ubiquitin specific peptidase 44 | Predicted to enable cysteine-type deubiquitinase activity. Involved in chromosome segregation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of mitotic cell cycle spindle assembly checkpoint. Located in nucleus. Orthologous to human USP4 USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 93655831 | 93696792 | Mouse | 105 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8771708 | Usp44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); chromosome segregation (ortholog); negative regulation of mitotic metaphase/anaphase transition (ortholog); PARTICIPATES IN a taxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN fibrillar center (ortholog); nucleus (ortholog) | NW_004955405 | 31977045 | 32006733 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11998632 | USP44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of ubiquitin protein ligase activity (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) sign aling pathway; histone modification pathway; FOUND IN nucleus (ortholog) | 12 | 93111293 | 93146889 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12395859 | USP44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of ubiquitin protein ligase activity (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) sign aling pathway; histone modification pathway; FOUND IN nucleus (ortholog) | 15 | 35401486 | 35454351 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12525853 | Usp44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of ubiquitin protein ligase activity (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) sign aling pathway; histone modification pathway; FOUND IN nucleus (ortholog) | NW_004936507 | 11663069 | 11692174 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14219372 | USP44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of ubiquitin protein ligase activity (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) sign aling pathway; histone modification pathway; FOUND IN nucleus (ortholog) | | | | Pig | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18620582 | USP44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of ubiquitin protein ligase activity (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) sign aling pathway; histone modification pathway; FOUND IN nucleus (ortholog) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914158 | Usp44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); chromosome segregation (ortholog); negative regulation of mitotic metaphase/anaphase transition (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathw ay; histone modification pathway; FOUND IN fibrillar center (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241339 | usp44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625869985 | Usp44 | ubiquitin specific peptidase 44 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); chromosome segregation (ortholog); negative regulation of mitotic metaphase/anaphase transition (ortholog); PARTICIPATES IN a taxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; FOUND IN fibrillar center (ortholog); nucleus (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310976 | Usp45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN cell migration (ortholog); DNA repair (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Laterality Defects, Autosomal Dominant (ortholo g); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine | 5 | 40115394 | 40188861 | Rat | 105 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322181 | USP45 | ubiquitin specific peptidase 45 | The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016] | 6 | 99432325 | 99517846 | Human | 167 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551688 | Usp45 | ubiquitin specific petidase 45 | Predicted to enable cysteine-type deubiquitinase activity. Involved in photoreceptor cell maintenance. Predicted to be located in cytosol; nucleoplasm; and photoreceptor inner segment. Used to study Leber congenital amaurosis 19. Human ortholog(s) of this gene implicated in Leber congenital amaurosi s 19. Orthologous to human USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 21767161 | 21837872 | Mouse | 115 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8760726 | Usp45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN cell migration (ortholog); DNA repair (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Laterality Defects, Autosomal Dominant (ortholo g); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955411 | 25315536 | 25375283 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11710129 | USP45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA repair (ortholog); protein deubiquitination (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Late rality Defects, Autosomal Dominant (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 6 | 97273498 | 97356749 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12168044 | USP45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN cell migration (ortholog); DNA repair (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Laterality Defects, Autosomal Dominant (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | 12 | 57637890 | 57706562 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12612349 | Usp45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA repair (ortholog); protein deubiquitination (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Late rality Defects, Autosomal Dominant (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936651 | 1031328 | 1119344 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14155345 | USP45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA repair (ortholog); protein deubiquitination (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Late rality Defects, Autosomal Dominant (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18607170 | USP45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA repair (ortholog); protein deubiquitination (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Late rality Defects, Autosomal Dominant (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921568 | Usp45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN cell migration (ortholog); DNA repair (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Laterality Defects, Autosomal Dominant (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243732 | usp45 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626163756 | Usp45 | ubiquitin specific peptidase 45 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN cell migration (ortholog); DNA repair (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Laterality Defects, Autosomal Dominant (ortholo g); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1344409 | USP46 | ubiquitin specific peptidase 46 | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiq uitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009] | 4 | 52590960 | 52659301 | Human | 104 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1557334 | Usp46 | ubiquitin specific peptidase 46 | Enables deubiquitinase activity. Involved in regulation of GABAergic synaptic transmission. Acts upstream of or within several processes, including adult feeding behavior; behavioral fear response; and behavioral response to ethanol. Predicted to be located in cytoplasm. Predicted to be active in cy tosol; glutamatergic synapse; and nucleus. Is expressed in cerebral cortex intermediate zone; cortical plate; and pancreas epithelium. Orthologous to human USP46 (ubiquitin specific peptidase 46). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 74159387 | 74229070 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564808 | Usp46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN regulation of postsynaptic neurotransmitter receptor internalization; adult feeding behavior (ortholog); behavioral fear response (ortholog); ASSOCIATED WITH Cocaine-Rela ted Disorders (ortholog); FOUND IN glutamatergic synapse; synapse; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; all-trans-retinoic acid | 14 | 34504074 | 34573318 | Rat | 111 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8909085 | Usp46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); F OUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); synapse (ortholog) | NW_004955447 | 17915451 | 17975149 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11799628 | USP46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | 4 | 71305286 | 71373257 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12277687 | USP46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | 13 | 45381974 | 45475212 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12566298 | Usp46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | NW_004936482 | 15539123 | 15603733 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14204362 | USP46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18402893 | USP46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926945 | Usp46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626028361 | Usp46 | ubiquitin specific peptidase 46 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); ASSOCIATED WITH Cocaine-Related Disorders (ortholog); F OUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); synapse (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310411 | Usp47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); WD40-repeat domain binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); FOUND IN cy toplasm (ortholog); nucleus (ortholog); SCF ubiquitin ligase complex (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 175586758 | 175669904 | Rat | 128 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321301 | USP47 | ubiquitin specific peptidase 47 | Enables WD40-repeat domain binding activity and cysteine-type deubiquitinase activity. Involved in base-excision repair; monoubiquitinated protein deubiquitination; and positive regulation of canonical Wnt signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. Is active in nu cleus. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 11841972 | 11961887 | Human | 125 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1553480 | Usp47 | ubiquitin specific peptidase 47 | Predicted to enable WD40-repeat domain binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase com plex. Predicted to be active in cytosol and nucleus. Orthologous to human USP47 (ubiquitin specific peptidase 47). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 111622692 | 111710591 | Mouse | 143 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8718456 | Usp47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); WD40-repeat domain binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); FOUND IN cy toplasm (ortholog); nucleus (ortholog); SCF ubiquitin ligase complex (ortholog) | NW_004955414 | 27357602 | 27462481 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11832156 | USP47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); FOUND IN cytoplasm (inferr ed); cytosol (inferred); nucleus (inferred) | 11 | 12009770 | 12127425 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12285947 | USP47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); FOUND IN cytoplasm (inferr ed); nucleus (inferred); SCF ubiquitin ligase complex (inferred) | 21 | 34917664 | 35027969 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12733416 | Usp47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); FOUND IN cytoplasm (inferr ed); cytosol (inferred); nucleus (inferred) | NW_004936528 | 6483898 | 6596136 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14185529 | USP47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); FOUND IN cytoplasm (inferr ed); nucleus (inferred); SCF ubiquitin ligase complex (inferred) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14379577 | Usp47 | | | | | | Fly | | symbol | gene, null |
| 18518316 | USP47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); FOUND IN cytoplasm (inferr ed); cytosol (inferred); nucleus (inferred) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917501 | Usp47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); WD40-repeat domain binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); SCF ubiqui tin ligase complex (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238704 | usp47 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626110804 | Usp47 | ubiquitin specific peptidase 47 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); WD40-repeat domain binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); monoubiquitinated protein deubiquitination (ortholog); FOUND IN cy toplasm (ortholog); nucleus (ortholog); SCF ubiquitin ligase complex (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 735213 | Usp48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autosomal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membran e; cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 5 | 155083520 | 155151208 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1351270 | USP48 | ubiquitin specific peptidase 48 | This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 1 | 21678298 | 21783149 | Human | 165 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551945 | Usp48 | ubiquitin specific peptidase 48 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be located in mitochondrion; nucleoplasm; and postsynaptic membrane. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including germ cell of testis; intestine; liver and biliary system; salivary gland; and thymus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 85. Orthologous to human USP48 (ubiquitin specific peptidase 48). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 137321079 | 137385842 | Mouse | 89 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8783313 | Usp48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); ASSOCIATED WITH amphetamine abuse (ortholog); autosomal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); nucleoplasm (ortholog) | NW_004955452 | 1959396 | 2031829 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11699529 | USP48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autos omal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membrane (ortholog) | 1 | 20870023 | 20974251 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12294297 | USP48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autos omal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membrane (ortholog) | 2 | 77401101 | 77484139 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12653327 | Usp48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autos omal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membrane (ortholog) | NW_004936474 | 7307475 | 7376086 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14261831 | USP48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autos omal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membrane (ortholog) | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18587638 | USP48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autos omal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN postsynaptic membrane (ortholog) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907103 | Usp48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); autosomal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN mitochondrion (ortho log); nucleoplasm (ortholog); postsynaptic membrane (ortholog) | | | | Naked Mole-Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237015 | usp48 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625934817 | Usp48 | ubiquitin specific peptidase 48 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); ASSOCIATED WITH amphetamine abuse (ortholog); autosomal dominant nonsyndromic deafness 85 (ortholog); prostate cancer (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310513 | Usp49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); INVOLVED IN mRNA splicing, via spliceosome (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduct ion (ortholog); protein deubiquitination (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A | 9 | 20803177 | 20867681 | Rat | 106 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1601875 | USP49 | ubiquitin specific peptidase 49 | Enables histone binding activity and peptidase activity. Involved in mRNA splicing, via spliceosome; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. [ provided by Alliance of Genome Resources, Jul 2025] | 6 | 41789896 | 41895375 | Human | 104 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1614183 | Usp49 | ubiquitin specific peptidase 49 | Predicted to enable histone binding activity and peptidase activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is e xpressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human USP49 (ubiquitin specific peptidase 49). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 47941615 | 47997664 | Mouse | 119 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9014038 | Usp49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); INVOLVED IN mRNA splicing, via spliceosome (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduct ion (ortholog); protein deubiquitination (ortholog) | NW_004955437 | 8187118 | 8237910 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11730469 | USP49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN chromatin organization (inferred); chromatin remodeling (inferred); mRNA processing (inferred); FOUND IN cytopla sm (inferred); nucleus (inferred) | 6 | 41375083 | 41479143 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12091899 | USP49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN chromatin organization (inferred); chromatin remodeling (inferred); mRNA processing (inferred); FOUND IN cytopla sm (inferred); nucleus (inferred) | 12 | 10474873 | 10556900 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12690496 | Usp49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN chromatin organization (inferred); chromatin remodeling (inferred); mRNA processing (inferred); FOUND IN cytopla sm (inferred); nucleus (inferred) | NW_004936476 | 17946875 | 18002081 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14193683 | USP49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN chromatin organization (inferred); chromatin remodeling (inferred); DNA-templated transcription (inferred); FOUN D IN cytoplasm (inferred); mediator complex (inferred); nucleus (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18666981 | USP49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN chromatin remodeling (inferred); mRNA splicing, via spliceosome (inferred); negative regulation of phosphatidyli nositol 3-kinase/protein kinase B signal transduction (inferred); FOUND IN nucleus (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904426 | Usp49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); histone H2B deubiquitinase activity (ortholog); INVOLVED IN mRNA splicing, via spliceosome (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductio n (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242691 | usp49 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625951703 | Usp49 | ubiquitin specific peptidase 49 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); histone binding (ortholog); INVOLVED IN mRNA splicing, via spliceosome (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduct ion (ortholog); protein deubiquitination (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1604943 | USP41P | ubiquitin specific peptidase 41, pseudogene | INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; 4,4'-sulfonyldiphenol; all-trans-retinoic acid | 22 | 20363616 | 20377260 | Human | 12 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 155238150 | usp40.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243449 | usp42.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857028 | usp43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861423 | usp43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863951 | usp43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864869 | usp43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359446 | usp43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359564 | usp43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857219 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857944 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863495 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864011 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171959 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177410 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177451 | usp43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250853 | usp44.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241340 | usp44.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253743 | usp45.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252837 | usp47.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255666 | usp47.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155260001 | usp48.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242692 | usp49.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6484002 | USP46-DT | USP46 divergent transcript | INTERACTS WITH all-trans-retinoic acid; aristolochic acid A; bisphenol A | 4 | 52659406 | 52661498 | Human | 7 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1613071 | Usp46os1 | ubiquitin specific peptidase 46, opposite strand 1 | | 5 | 74174648 | 74175996 | Mouse | 3 | symbol , old_gene_name , PhenoGen | gene, ncrna, MODEL [RefSeq] |
| 1609259 | Usp46os2 | ubiquitin specific peptidase 46, opposite strand 2 | INTERACTS WITH sodium fluoride | | | | Mouse | 4 | symbol , PhenoGen | gene, ncrna |
| 1308151 | Cfap52 | cilia and flagella associated protein 52 | INVOLVED IN establishment of left/right asymmetry (ortholog); flagellated sperm motility (ortholog); gene expression (ortholog); ASSOCIATED WITH visceral heterotaxy 10 (ortholog); visceral heterotaxy 5 (ortholog); FOUND IN 9+2 motile cilium (ortholog); axonemal B tubule inner sheath (ortholog); axon emal microtubule (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 10 | 53112692 | 53153844 | Rat | 84 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8892583 | LOC102025094 | ubiquitin carboxyl-terminal hydrolase 42 | | NW_004955460 | 13645785 | 13690072 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 32729071 | LOC117978839 | putative ubiquitin carboxyl-terminal hydrolase 41 | | | | | Bonobo | | old_gene_symbol | gene, pseudo, MODEL [RefSeq] |
| 1306415 | Med20 | mediator complex subunit 20 | ENCODES a protein that exhibits ubiquitin protein ligase activity; INVOLVED IN protein ubiquitination; skeletal muscle cell differentiation (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; FOUND IN ubiquitin ligase complex; mediator complex (ortholog); nucleus (ortholog); INTERAC TS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A | 9 | 20867681 | 20880288 | Rat | 76 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16563548 | AC118755.1 | novel transcript, antisense to USP43 | | | | | Human | | name | gene, lncrna |
| 16565044 | AL365205.3 | novel transcript, antisense to USP49 | | | | | Human | | name | gene, lncrna |
| 16564058 | AC118755.2 | novel transcript, antisense to WDR16 and USP43 | | | | | Human | | name | gene, lncrna |
| 16559644 | AC010306.1 | ubiquitin specific peptidase 46 (USP46) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16564247 | AP001180.5 | ubiquitin specific peptidase 41 (USP41) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 13702997 | Gm20517 | predicted gene 20517 | This locus represents naturally-occurring readthrough transcription between the neighboring mediator complex subunit 20 (Med20) and ubiquitin specific peptidase 49 (Usp49) genes. Readthrough transcripts may be candidates for nonsense mediated decay (NMD) or enco de proteins with similarity to the Med20 gene. [provided by RefSeq, Jul 2018] | 17 | 47922510 | 47997664 | Mouse | | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |