USP48 (ubiquitin specific peptidase 48) - Rat Genome Database

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Gene: USP48 (ubiquitin specific peptidase 48) Chlorocebus sabaeus
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Symbol: USP48
Name: ubiquitin specific peptidase 48
RGD ID: 18587638
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); amphetamine abuse (ortholog); Autosomal Dominant Nonsyndromic Deafness 85 (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal hydrolase 48
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,854,966 - 110,958,140 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,854,758 - 110,960,529 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
USP48
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,854,966 - 110,958,140 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,854,758 - 110,960,529 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
USP48
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,678,298 - 21,783,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,678,298 - 21,783,606 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,004,791 - 22,109,642 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,877,378 - 21,982,275 (-)NCBINCBI36Build 36hg18NCBI36
Build 34121,750,393 - 21,854,960NCBI
Celera120,327,493 - 20,432,623 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,248,246 - 20,353,123 (-)NCBIHuRef
CHM1_1122,116,743 - 22,222,156 (-)NCBICHM1_1
T2T-CHM13v2.0121,502,254 - 21,607,091 (-)NCBIT2T-CHM13v2.0
Usp48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,321,079 - 137,385,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,321,066 - 137,385,848 (+)EnsemblGRCm39 Ensembl
GRCm384137,594,120 - 137,658,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,593,755 - 137,658,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv374137,150,104 - 137,214,452 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,261,884 - 135,263,495 (+)NCBIMGSCv36mm8
MGSCv364136,929,110 - 136,930,605 (+)NCBIMGSCv36mm8
Celera4135,805,168 - 135,866,736 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.0NCBI
Usp48
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,083,520 - 155,151,208 (+)NCBIGRCr8
mRatBN7.25149,800,189 - 149,867,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,800,179 - 149,867,719 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,496,642 - 152,563,755 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,270,935 - 154,338,044 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,252,948 - 154,320,051 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,935,102 - 156,002,722 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,934,490 - 156,002,721 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,690,824 - 159,758,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,351,117 - 156,418,283 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,361,155 - 156,428,321 (+)NCBI
Celera5148,196,521 - 148,263,977 (+)NCBICelera
Cytogenetic Map5q36NCBI
Usp48
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,959,396 - 2,031,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,959,396 - 2,031,829 (-)NCBIChiLan1.0ChiLan1.0
USP48
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21205,156,524 - 205,262,860 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,268,387 - 204,374,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0120,870,023 - 20,974,251 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,834,330 - 21,939,250 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,834,638 - 21,939,250 (-)Ensemblpanpan1.1panPan2
USP48
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,401,101 - 77,484,139 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,379,440 - 77,484,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,903,899 - 73,988,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,959,166 - 78,043,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,933,330 - 78,043,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,778,845 - 74,862,587 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,788,846 - 75,873,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,791,995 - 76,876,474 (+)NCBIUU_Cfam_GSD_1.0
Usp48
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,483,213 - 41,551,300 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,307,439 - 7,376,074 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,307,475 - 7,376,086 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP48
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,744,932 - 79,810,220 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,744,928 - 79,810,241 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Usp48
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,528,084 - 6,610,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 2 58
Low 18 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000017628   ⟹   ENSCSAP00000017102
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20110,854,758 - 110,960,529 (+)Ensembl
RefSeq Acc Id: XM_007980132   ⟹   XP_007978323
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120110,854,966 - 110,958,140 (+)NCBI
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007980133   ⟹   XP_007978324
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120110,854,970 - 110,958,140 (+)NCBI
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007980134   ⟹   XP_007978325
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120110,854,970 - 110,958,140 (+)NCBI
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007980135   ⟹   XP_007978326
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120110,854,970 - 110,958,140 (+)NCBI
Vero_WHO_p1.0NW_0236660335,331,713 - 5,436,227 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007978323 (Get FASTA)   NCBI Sequence Viewer  
  XP_007978324 (Get FASTA)   NCBI Sequence Viewer  
  XP_007978325 (Get FASTA)   NCBI Sequence Viewer  
  XP_007978326 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017102
  ENSCSAP00000017102.1
RefSeq Acc Id: XP_007978323   ⟸   XM_007980132
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S8B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007978324   ⟸   XM_007980133
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007978325   ⟸   XM_007980134
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007978326   ⟸   XM_007980135
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000017102   ⟸   ENSCSAT00000017628


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017628.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro DUSP-like_sf UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19_DUSP UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Ubl_USP48 UniProtKB/TrEMBL
  USP48 UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
KEGG Report csab:103225432 UniProtKB/TrEMBL
NCBI Gene USP48 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48 UniProtKB/TrEMBL
Pfam DUSP UniProtKB/TrEMBL
  UCH UniProtKB/TrEMBL
PROSITE DUSP UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF143791 UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0D9S8B3 ENTREZGENE, UniProtKB/TrEMBL