USP46 (ubiquitin specific peptidase 46) - Rat Genome Database

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Gene: USP46 (ubiquitin specific peptidase 46) Chlorocebus sabaeus
Analyze
Symbol: USP46
Name: ubiquitin specific peptidase 46
RGD ID: 18402893
Description: ENCODES a protein that exhibits deubiquitinase activity (ortholog); INVOLVED IN adult feeding behavior (ortholog); behavioral fear response (ortholog); behavioral response to ethanol (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal hydrolase 46
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1715,821,206 - 15,891,058 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl715,821,284 - 15,887,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606616,787,584 - 16,860,932 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
USP46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1715,821,206 - 15,891,058 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl715,821,284 - 15,887,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606616,787,584 - 16,860,932 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
USP46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38452,590,960 - 52,659,301 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl452,590,960 - 52,659,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37453,457,126 - 53,525,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36453,155,957 - 53,220,197 (-)NCBINCBI36Build 36hg18NCBI36
Build 34453,302,137 - 53,366,368NCBI
Celera450,953,085 - 51,021,473 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef449,398,932 - 49,469,641 (-)NCBIHuRef
CHM1_1453,493,107 - 53,561,400 (-)NCBICHM1_1
T2T-CHM13v2.0456,077,847 - 56,146,196 (-)NCBIT2T-CHM13v2.0
Usp46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39574,159,387 - 74,229,070 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl574,159,114 - 74,229,092 (-)EnsemblGRCm39 Ensembl
GRCm38573,998,726 - 74,068,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl573,998,453 - 74,068,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv37574,396,062 - 74,464,436 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36574,281,734 - 74,350,108 (-)NCBIMGSCv36mm8
Celera571,261,248 - 71,329,058 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.33NCBI
Usp46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81434,504,074 - 34,573,318 (+)NCBIGRCr8
mRatBN7.21434,150,055 - 34,219,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1434,150,004 - 34,219,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1434,498,501 - 34,567,643 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01435,806,080 - 35,875,235 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01434,291,567 - 34,360,710 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01436,687,134 - 36,755,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1436,687,134 - 36,755,360 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01436,514,023 - 36,582,331 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41436,537,951 - 36,609,397 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1433,411,301 - 33,480,344 (+)NCBICelera
Cytogenetic Map14p11NCBI
Usp46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544717,900,611 - 17,971,601 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544717,915,451 - 17,975,149 (+)NCBIChiLan1.0ChiLan1.0
USP46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2377,158,903 - 77,226,968 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1477,363,811 - 77,431,907 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0471,305,286 - 71,373,257 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1477,861,053 - 77,926,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl477,861,053 - 77,920,759 (+)Ensemblpanpan1.1panPan2
USP46
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11345,381,974 - 45,475,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1345,384,641 - 45,439,096 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1345,333,292 - 45,426,735 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01345,989,512 - 46,083,600 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1345,989,456 - 46,083,672 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11345,656,947 - 45,752,306 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01345,192,629 - 45,286,238 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01346,069,223 - 46,162,546 (-)NCBIUU_Cfam_GSD_1.0
Usp46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528530,694,489 - 30,760,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648215,538,504 - 15,603,693 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648215,539,123 - 15,603,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl839,517,512 - 39,581,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1839,518,155 - 39,581,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2841,642,107 - 41,703,244 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Usp46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476116,939,590 - 17,009,037 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476116,939,562 - 17,014,069 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 19
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002992   ⟹   ENSCSAP00000001285
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl715,821,284 - 15,887,550 (+)Ensembl
RefSeq Acc Id: XM_007998723   ⟹   XP_007996914
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1715,821,206 - 15,891,058 (+)NCBI
Vero_WHO_p1.0NW_02366606616,787,584 - 16,860,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007998724   ⟹   XP_007996915
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1715,821,225 - 15,891,058 (+)NCBI
Vero_WHO_p1.0NW_02366606616,787,599 - 16,860,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007998726   ⟹   XP_007996917
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1715,821,224 - 15,888,850 (+)NCBI
Vero_WHO_p1.0NW_02366606616,787,599 - 16,860,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037989441   ⟹   XP_037845369
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606616,787,599 - 16,860,379 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007996914 (Get FASTA)   NCBI Sequence Viewer  
  XP_007996915 (Get FASTA)   NCBI Sequence Viewer  
  XP_007996917 (Get FASTA)   NCBI Sequence Viewer  
  XP_037845369 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001285
  ENSCSAP00000001285.1
Reference Protein Sequences
RefSeq Acc Id: XP_007996914   ⟸   XM_007998723
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QY46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007996917   ⟸   XM_007998726
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007996915   ⟸   XM_007998724
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000001285   ⟸   ENSCSAT00000002992
RefSeq Acc Id: XP_037845369   ⟸   XM_037989441
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004963 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002992.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
KEGG Report csab:103235695 UniProtKB/TrEMBL
NCBI Gene USP46 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
PROSITE USP_1 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A0D9QY46 ENTREZGENE, UniProtKB/TrEMBL