USP49 (ubiquitin specific peptidase 49) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: USP49 (ubiquitin specific peptidase 49) Homo sapiens
Analyze
Symbol: USP49
Name: ubiquitin specific peptidase 49
RGD ID: 1601875
HGNC Page HGNC:20078
Description: Enables histone binding activity and peptidase activity. Involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 49; MGC20741; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific protease 49; ubiquitin thioesterase 49; ubiquitin thiolesterase 49; ubiquitin-specific-processing protease 49
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,789,896 - 41,895,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,789,896 - 41,895,375 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,757,634 - 41,863,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,873,361 - 41,971,077 (-)NCBINCBI36Build 36hg18NCBI36
Celera643,318,714 - 43,416,439 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,484,106 - 41,581,878 (-)NCBIHuRef
CHM1_1641,768,743 - 41,866,405 (-)NCBICHM1_1
T2T-CHM13v2.0641,618,461 - 41,723,935 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IC,IEA)
nucleoplasm  (TAS)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12584197   PMID:14576168   PMID:14702039   PMID:14715245   PMID:15489334   PMID:18029348   PMID:19615732   PMID:20139978   PMID:21873635   PMID:23105109   PMID:23263863  
PMID:23824326   PMID:25036637   PMID:27801882   PMID:28363942   PMID:29669287   PMID:29748582   PMID:30246457   PMID:30323974   PMID:30943264   PMID:31001918   PMID:31397674   PMID:32076268  
PMID:32296183   PMID:32691951   PMID:32737772   PMID:33961781   PMID:34431227   PMID:34610959   PMID:35072515   PMID:35273362   PMID:35279684   PMID:35318441   PMID:35367823   PMID:35598681  
PMID:36037364  


Genomics

Comparative Map Data
USP49
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,789,896 - 41,895,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,789,896 - 41,895,375 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,757,634 - 41,863,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,873,361 - 41,971,077 (-)NCBINCBI36Build 36hg18NCBI36
Celera643,318,714 - 43,416,439 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,484,106 - 41,581,878 (-)NCBIHuRef
CHM1_1641,768,743 - 41,866,405 (-)NCBICHM1_1
T2T-CHM13v2.0641,618,461 - 41,723,935 (-)NCBIT2T-CHM13v2.0
Usp49
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,941,615 - 47,997,664 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,941,615 - 47,997,663 (+)EnsemblGRCm39 Ensembl
GRCm381747,630,690 - 47,686,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,630,690 - 47,686,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv371747,767,639 - 47,821,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,093,881 - 47,147,258 (+)NCBIMGSCv36mm8
Celera1751,067,647 - 51,120,972 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.72NCBI
Usp49
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,803,177 - 20,867,681 (-)NCBIGRCr8
mRatBN7.2913,305,640 - 13,366,132 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,308,178 - 13,366,132 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,888,201 - 21,945,900 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,952,281 - 27,010,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,251,607 - 25,309,304 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,314,875 - 15,375,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,317,413 - 15,375,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,239,085 - 14,299,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,774,333 - 8,832,285 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,778,351 - 8,786,793 (-)NCBI
Celera911,060,638 - 11,117,551 (-)NCBICelera
Cytogenetic Map9q12NCBI
Usp49
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,191,236 - 8,198,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,187,118 - 8,237,910 (-)NCBIChiLan1.0ChiLan1.0
USP49
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,282,907 - 56,389,693 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,152,885 - 52,256,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,375,083 - 41,479,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,678,680 - 42,781,748 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,683,149 - 42,695,707 (-)Ensemblpanpan1.1panPan2
USP49
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,474,873 - 10,556,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,479,733 - 10,577,918 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,504,358 - 10,589,769 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01210,955,129 - 11,041,174 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,955,164 - 11,051,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,485,701 - 10,567,699 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,569,381 - 10,654,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,663,097 - 10,748,867 (-)NCBIUU_Cfam_GSD_1.0
Usp49
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,957,669 - 46,049,495 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,991,688 - 18,000,794 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,946,875 - 18,002,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,981,383 - 37,052,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,978,291 - 37,054,027 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,393,547 - 42,458,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP49
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,265,322 - 30,373,547 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,356,698 - 30,366,940 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,783,918 - 41,895,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp49
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,266,561 - 17,274,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,226,723 - 17,281,206 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in USP49
40 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1
pathogenic
GRCh38/hg38 6p21.1-12.3(chr6:41638061-46512949)x1 copy number loss See cases [RCV000052182] Chr6:41638061..46512949 [GRCh38]
Chr6:41605799..46480686 [GRCh37]
Chr6:41713777..46588645 [NCBI36]
Chr6:6p21.1-12.3
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_001286554.2(USP49):c.382C>A (p.Leu128Met) single nucleotide variant not provided [RCV000958966] Chr6:41806602 [GRCh38]
Chr6:41774340 [GRCh37]
Chr6:6p21.1
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_001286554.2(USP49):c.703G>C (p.Val235Leu) single nucleotide variant Inborn genetic diseases [RCV003249915] Chr6:41806281 [GRCh38]
Chr6:41774019 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1758C>A (p.Asp586Glu) single nucleotide variant Inborn genetic diseases [RCV003242172] Chr6:41798842 [GRCh38]
Chr6:41766580 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.583C>G (p.Arg195Gly) single nucleotide variant Inborn genetic diseases [RCV003253974] Chr6:41806401 [GRCh38]
Chr6:41774139 [GRCh37]
Chr6:6p21.1
uncertain significance
NC_000006.11:g.(?_41126341)_(43737486_?)dup duplication PRPH2-Related Disorders [RCV003111022] Chr6:41126341..43737486 [GRCh37]
Chr6:6p21.1
uncertain significance
NC_000006.11:g.(?_41126341)_(43752536_?)del deletion Peroxisome biogenesis disorder [RCV003110948] Chr6:41126341..43752536 [GRCh37]
Chr6:6p21.1
pathogenic
NM_001286554.2(USP49):c.1121C>T (p.Ala374Val) single nucleotide variant Inborn genetic diseases [RCV002836905] Chr6:41805863 [GRCh38]
Chr6:41773601 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.103G>A (p.Val35Met) single nucleotide variant Inborn genetic diseases [RCV002864780] Chr6:41806881 [GRCh38]
Chr6:41774619 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.337C>A (p.Arg113Ser) single nucleotide variant Inborn genetic diseases [RCV002997985] Chr6:41806647 [GRCh38]
Chr6:41774385 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.935C>T (p.Ala312Val) single nucleotide variant Inborn genetic diseases [RCV002757617] Chr6:41806049 [GRCh38]
Chr6:41773787 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.544A>G (p.Lys182Glu) single nucleotide variant Inborn genetic diseases [RCV002660383] Chr6:41806440 [GRCh38]
Chr6:41774178 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.986G>T (p.Gly329Val) single nucleotide variant Inborn genetic diseases [RCV002956466] Chr6:41805998 [GRCh38]
Chr6:41773736 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.551A>C (p.Glu184Ala) single nucleotide variant Inborn genetic diseases [RCV002849956] Chr6:41806433 [GRCh38]
Chr6:41774171 [GRCh37]
Chr6:6p21.1
likely benign
NM_001286554.2(USP49):c.322G>A (p.Asp108Asn) single nucleotide variant Inborn genetic diseases [RCV002641321] Chr6:41806662 [GRCh38]
Chr6:41774400 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1286C>G (p.Ser429Cys) single nucleotide variant Inborn genetic diseases [RCV002930803] Chr6:41805698 [GRCh38]
Chr6:41773436 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.557G>C (p.Arg186Pro) single nucleotide variant Inborn genetic diseases [RCV002696842] Chr6:41806427 [GRCh38]
Chr6:41774165 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1530A>C (p.Glu510Asp) single nucleotide variant Inborn genetic diseases [RCV002915298] Chr6:41803837 [GRCh38]
Chr6:41771575 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.154G>A (p.Asp52Asn) single nucleotide variant Inborn genetic diseases [RCV002698308] Chr6:41806830 [GRCh38]
Chr6:41774568 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1576T>C (p.Ser526Pro) single nucleotide variant Inborn genetic diseases [RCV002832697] Chr6:41799924 [GRCh38]
Chr6:41767662 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.683C>A (p.Ala228Asp) single nucleotide variant Inborn genetic diseases [RCV002808341] Chr6:41806301 [GRCh38]
Chr6:41774039 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.957T>G (p.Asn319Lys) single nucleotide variant Inborn genetic diseases [RCV002897780] Chr6:41806027 [GRCh38]
Chr6:41773765 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.422C>A (p.Thr141Lys) single nucleotide variant Inborn genetic diseases [RCV002808425] Chr6:41806562 [GRCh38]
Chr6:41774300 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.160G>A (p.Ala54Thr) single nucleotide variant Inborn genetic diseases [RCV002878390] Chr6:41806824 [GRCh38]
Chr6:41774562 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1012A>G (p.Ile338Val) single nucleotide variant Inborn genetic diseases [RCV002920869] Chr6:41805972 [GRCh38]
Chr6:41773710 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1759A>G (p.Met587Val) single nucleotide variant Inborn genetic diseases [RCV003213532] Chr6:41798841 [GRCh38]
Chr6:41766579 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.662C>T (p.Pro221Leu) single nucleotide variant Inborn genetic diseases [RCV003208081] Chr6:41806322 [GRCh38]
Chr6:41774060 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.461C>T (p.Thr154Met) single nucleotide variant Inborn genetic diseases [RCV003309336] Chr6:41806523 [GRCh38]
Chr6:41774261 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1184A>G (p.Tyr395Cys) single nucleotide variant Inborn genetic diseases [RCV003342567] Chr6:41805800 [GRCh38]
Chr6:41773538 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.1543G>A (p.Ala515Thr) single nucleotide variant Inborn genetic diseases [RCV003343250] Chr6:41803824 [GRCh38]
Chr6:41771562 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_001286554.2(USP49):c.288A>C (p.Arg96Ser) single nucleotide variant Inborn genetic diseases [RCV003379789] Chr6:41806696 [GRCh38]
Chr6:41774434 [GRCh37]
Chr6:6p21.1
uncertain significance
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4300
Count of miRNA genes:1364
Interacting mature miRNAs:1802
Transcripts:ENST00000297229, ENST00000373006, ENST00000373009, ENST00000373010, ENST00000394253, ENST00000423567, ENST00000437061, ENST00000448078
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 8 1 344 3 148 5 166 22 188 24 59 418 1 1
Low 2429 2862 1344 584 1754 424 4188 2105 3532 375 1393 1194 174 1 1204 2786 4 1
Below cutoff 1 126 37 35 49 35 2 70 14 20 6 1 1 1

Sequence


RefSeq Acc Id: ENST00000373006   ⟹   ENSP00000362097
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,797,645 - 41,895,361 (-)Ensembl
RefSeq Acc Id: ENST00000373010   ⟹   ENSP00000362101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,796,498 - 41,887,329 (-)Ensembl
RefSeq Acc Id: ENST00000394253   ⟹   ENSP00000377797
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,789,896 - 41,894,160 (-)Ensembl
RefSeq Acc Id: ENST00000423567   ⟹   ENSP00000411603
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,806,939 - 41,894,455 (-)Ensembl
RefSeq Acc Id: ENST00000448078   ⟹   ENSP00000389842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,796,677 - 41,805,745 (-)Ensembl
RefSeq Acc Id: ENST00000682992   ⟹   ENSP00000507239
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,789,896 - 41,895,375 (-)Ensembl
RefSeq Acc Id: NM_001286554   ⟹   NP_001273483
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,789,896 - 41,895,375 (-)NCBI
HuRef641,476,358 - 41,581,878 (-)NCBI
CHM1_1641,760,993 - 41,842,679 (-)NCBI
T2T-CHM13v2.0641,618,461 - 41,723,935 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001384542   ⟹   NP_001371471
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,789,896 - 41,895,138 (-)NCBI
T2T-CHM13v2.0641,618,461 - 41,723,698 (-)NCBI
Sequence:
RefSeq Acc Id: NM_018561   ⟹   NP_061031
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,797,645 - 41,895,375 (-)NCBI
GRCh37641,757,634 - 41,863,099 (-)NCBI
Build 36641,873,361 - 41,971,077 (-)NCBI Archive
Celera643,318,714 - 43,416,439 (-)RGD
HuRef641,476,358 - 41,581,878 (-)NCBI
CHM1_1641,768,743 - 41,866,405 (-)NCBI
T2T-CHM13v2.0641,626,211 - 41,723,935 (-)NCBI
Sequence:
RefSeq Acc Id: NP_061031   ⟸   NM_018561
- Peptide Label: isoform b
- UniProtKB: Q5T3E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273483   ⟸   NM_001286554
- Peptide Label: isoform a
- UniProtKB: Q5T3E0 (UniProtKB/Swiss-Prot),   Q5T3D9 (UniProtKB/Swiss-Prot),   Q96CK4 (UniProtKB/Swiss-Prot),   Q70CQ1 (UniProtKB/Swiss-Prot),   Q5T3E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000411603   ⟸   ENST00000423567
RefSeq Acc Id: ENSP00000362097   ⟸   ENST00000373006
RefSeq Acc Id: ENSP00000362101   ⟸   ENST00000373010
RefSeq Acc Id: ENSP00000389842   ⟸   ENST00000448078
RefSeq Acc Id: ENSP00000377797   ⟸   ENST00000394253
RefSeq Acc Id: NP_001371471   ⟸   NM_001384542
- Peptide Label: isoform a
- UniProtKB: Q70CQ1 (UniProtKB/Swiss-Prot),   Q5T3E0 (UniProtKB/Swiss-Prot),   Q5T3D9 (UniProtKB/Swiss-Prot),   Q96CK4 (UniProtKB/Swiss-Prot),   Q5T3E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000507239   ⟸   ENST00000682992
Protein Domains
UBP-type   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q70CQ1-F1-model_v2 AlphaFold Q70CQ1 1-688 view protein structure

Promoters
RGD ID:7208031
Promoter ID:EPDNEW_H9760
Type:initiation region
Name:USP49_2
Description:ubiquitin specific peptidase 49
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9761  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,895,375 - 41,895,435EPDNEW
RGD ID:6804986
Promoter ID:HG_KWN:53563
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000394253,   OTTHUMT00000315993
Position:
Human AssemblyChrPosition (strand)Source
Build 36641,970,886 - 41,971,386 (-)MPROMDB
RGD ID:6804983
Promoter ID:HG_KWN:53564
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_018561
Position:
Human AssemblyChrPosition (strand)Source
Build 36641,971,071 - 41,971,862 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20078 AgrOrtholog
COSMIC USP49 COSMIC
Ensembl Genes ENSG00000164663 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000373006 ENTREZGENE
  ENST00000373006.5 UniProtKB/Swiss-Prot
  ENST00000373010.5 UniProtKB/TrEMBL
  ENST00000394253 ENTREZGENE
  ENST00000394253.7 UniProtKB/Swiss-Prot
  ENST00000423567.1 UniProtKB/TrEMBL
  ENST00000448078.1 UniProtKB/TrEMBL
  ENST00000682992 ENTREZGENE
  ENST00000682992.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000164663 GTEx
HGNC ID HGNC:20078 ENTREZGENE
Human Proteome Map USP49 Human Proteome Map
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_UBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:25862 UniProtKB/Swiss-Prot
NCBI Gene 25862 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 49 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-UBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134954570 PharmGKB
PROSITE USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_UBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_UBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6PVU3_HUMAN UniProtKB/TrEMBL
  H7BZI7_HUMAN UniProtKB/TrEMBL
  Q5T3D9 ENTREZGENE
  Q5T3E0 ENTREZGENE
  Q5T3E1 ENTREZGENE, UniProtKB/TrEMBL
  Q70CQ1 ENTREZGENE
  Q96CK4 ENTREZGENE
  UBP49_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q5T3D9 UniProtKB/Swiss-Prot
  Q5T3E0 UniProtKB/Swiss-Prot
  Q96CK4 UniProtKB/Swiss-Prot