Usp45 (ubiquitin specific peptidase 45) - Rat Genome Database

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Gene: Usp45 (ubiquitin specific peptidase 45) Heterocephalus glaber
Analyze
Symbol: Usp45
Name: ubiquitin specific peptidase 45
RGD ID: 18921568
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN cell migration (ortholog); DNA repair (ortholog); photoreceptor cell maintenance (ortholog); ASSOCIATED WITH Dwarfism (ortholog); fundus dystrophy (ortholog); Laterality Defects, Autosomal Dominant (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal hydrolase 45
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248105,508,882 - 5,574,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248105,508,912 - 5,574,233 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Naked Mole-RatDwarfism  ISORGD:13221818554872ClinVar Annotator: match by term: Short statureClinVar 
Usp45Naked Mole-Ratfundus dystrophy  ISORGD:13221818554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868|PMID:31345219
Usp45Naked Mole-RatLaterality Defects, Autosomal Dominant  ISORGD:13221818554872ClinVar Annotator: match by term: Laterality defects, autosomal dominantClinVar 
Usp45Naked Mole-RatLeber congenital amaurosis 19  ISORGD:13221818554872ClinVar Annotator: match by term: Leber congenital amaurosis 19ClinVarPMID:25741868|PMID:30573563
Usp45Naked Mole-Ratoptic atrophy  ISORGD:13221818554872ClinVar Annotator: match by term: Optic atrophyClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Naked Mole-RatLeber congenital amaurosis 19  ISORGD:13221817240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Naked Mole-Ratcell migration involved_inISORGD:13221819068941 PMID:30258100UniProtPMID:30258100
Usp45Naked Mole-RatDNA repair acts_upstream_of_or_withinISORGD:13221819068941 PMID:25538220MGIPMID:25538220
Usp45Naked Mole-Ratphotoreceptor cell maintenance involved_inISORGD:15516889068941 PMID:30573563UniProtPMID:30573563
Usp45Naked Mole-Ratprotein deubiquitination acts_upstream_of_or_withinISORGD:13221819068941 PMID:25538220MGIPMID:25538220
Usp45Naked Mole-Ratprotein deubiquitination involved_inIEAInterPro:IPR001394150520179 InterProGO_REF:0000002
Usp45Naked Mole-Ratproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Naked Mole-Ratcytoplasm located_inISORGD:13221819068941 PMID:25538220MGIPMID:25538220
Usp45Naked Mole-Ratcytosol located_inISORGD:13221819068941 HPAGO_REF:0000052
Usp45Naked Mole-Ratnucleoplasm located_inISORGD:13221819068941 HPAGO_REF:0000052
Usp45Naked Mole-Ratnucleus located_inISORGD:13221819068941 PMID:25538220MGIPMID:25538220
Usp45Naked Mole-Ratphotoreceptor inner segment located_inISORGD:13221819068941 PMID:30573563UniProtPMID:30573563

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Naked Mole-Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394|InterPro:IPR018200150520179 InterProGO_REF:0000002
Usp45Naked Mole-Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR000880756150520179 UniProtGO_REF:0000104
Usp45Naked Mole-Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.12150520179 UniProtGO_REF:0000003
Usp45Naked Mole-Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-0788150520179 UniProtGO_REF:0000043
Usp45Naked Mole-Rathydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
Usp45Naked Mole-Ratmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
Usp45Naked Mole-Ratpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
Usp45Naked Mole-Ratprotein binding enablesISOUniProtKB:Q96EA49068941 PMID:30258100UniProtPMID:30258100
Usp45Naked Mole-Ratprotein binding enablesISOPR:P079039068941 PMID:25538220MGIPMID:25538220
Usp45Naked Mole-Ratprotein binding enablesISOUniProtKB:P079929068941 PMID:25538220UniProtPMID:25538220
Usp45Naked Mole-Ratzinc ion binding enablesIEAInterPro:IPR001607150520179 InterProGO_REF:0000002
Usp45Naked Mole-Ratzinc ion binding enablesIEAUniProtKB-KW:KW-0863150520179 UniProtGO_REF:0000043
1 to 12 of 12 rows

PMID:22301074  



Usp45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248105,508,882 - 5,574,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248105,508,912 - 5,574,233 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
USP45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38699,432,325 - 99,517,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl699,432,325 - 99,521,728 (-)EnsemblGRCh38hg38GRCh38
GRCh37699,880,201 - 99,963,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36699,986,903 - 100,069,973 (-)NCBINCBI36Build 36hg18NCBI36
Celera6100,524,338 - 100,607,389 (-)NCBICelera
Cytogenetic Map6q16.2NCBI
HuRef697,320,605 - 97,403,620 (-)NCBIHuRef
CHM1_16100,143,216 - 100,226,233 (-)NCBICHM1_1
T2T-CHM13v2.06100,606,672 - 100,692,182 (-)NCBIT2T-CHM13v2.0
Usp45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39421,767,161 - 21,837,872 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl421,767,156 - 21,837,872 (+)EnsemblGRCm39 Ensembl
GRCm38421,767,161 - 21,837,872 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl421,767,156 - 21,837,872 (+)EnsemblGRCm38mm10GRCm38
MGSCv37421,703,417 - 21,765,019 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36421,867,134 - 21,928,707 (+)NCBIMGSCv36mm8
Celera421,521,282 - 21,582,575 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map48.93NCBI
Usp45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,115,394 - 40,188,861 (+)NCBIGRCr8
mRatBN7.2535,318,621 - 35,392,090 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,318,635 - 35,389,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx537,442,950 - 37,516,428 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,035,678 - 39,109,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0538,975,187 - 39,048,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0535,916,763 - 35,984,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl535,916,804 - 35,984,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0540,573,111 - 40,639,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4536,517,213 - 36,590,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1536,502,821 - 36,587,983 (+)NCBI
Celera534,335,326 - 34,403,408 (+)NCBICelera
Cytogenetic Map5q21NCBI
Usp45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541125,316,535 - 25,378,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541125,315,536 - 25,375,283 (-)NCBIChiLan1.0ChiLan1.0
USP45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25119,479,099 - 119,562,643 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16117,357,233 - 117,443,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0697,273,498 - 97,356,749 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16101,155,903 - 101,239,145 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6101,155,903 - 101,238,682 (-)Ensemblpanpan1.1panPan2
USP45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11257,637,890 - 57,706,562 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1257,642,515 - 57,706,511 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1257,396,662 - 57,468,813 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01258,460,557 - 58,533,263 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1258,500,488 - 58,533,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11257,817,618 - 57,889,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01257,662,704 - 57,736,494 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01257,907,902 - 57,981,807 (-)NCBIUU_Cfam_GSD_1.0
Usp45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494692,576,117 - 92,663,981 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366511,037,804 - 1,119,399 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366511,031,328 - 1,119,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl166,387,608 - 66,454,737 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1166,387,616 - 66,454,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2175,067,349 - 75,131,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11374,368,043 - 74,434,884 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1374,362,564 - 74,438,133 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604046,695,092 - 46,768,332 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000000424   ⟹   ENSHGLP00000000388
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248105,508,882 - 5,574,395 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000000425   ⟹   ENSHGLP00000000389
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248105,512,245 - 5,569,666 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000000426   ⟹   ENSHGLP00000000390
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248105,512,245 - 5,569,666 (+)Ensembl
RefSeq Acc Id: XM_004862481   ⟹   XP_004862538
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,509,405 - 5,574,056 (+)NCBI
RefSeq Acc Id: XM_021242691   ⟹   XP_021098350
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,508,912 - 5,574,056 (+)NCBI
RefSeq Acc Id: XM_021242692   ⟹   XP_021098351
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,509,411 - 5,574,056 (+)NCBI
RefSeq Acc Id: XM_021242693   ⟹   XP_021098352
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,512,235 - 5,574,233 (+)NCBI
RefSeq Acc Id: XM_021242694   ⟹   XP_021098353
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,556,294 - 5,574,233 (+)NCBI
RefSeq Acc Id: XM_021242695   ⟹   XP_021098354
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,509,403 - 5,560,287 (+)NCBI
RefSeq Acc Id: XR_002388705
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248105,509,401 - 5,558,416 (+)NCBI
Protein RefSeqs XP_004862538 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098350 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098351 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098352 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098353 (Get FASTA)   NCBI Sequence Viewer  
  XP_021098354 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000389
RefSeq Acc Id: XP_021098350   ⟸   XM_021242691
- Peptide Label: isoform X1
- UniProtKB: A0AAX6RSP0 (UniProtKB/TrEMBL),   G5BJP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098354   ⟸   XM_021242695
- Peptide Label: isoform X4
- UniProtKB: A0AAX6RQS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862538   ⟸   XM_004862481
- Peptide Label: isoform X1
- UniProtKB: A0AAX6RSP0 (UniProtKB/TrEMBL),   G5BJP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098351   ⟸   XM_021242692
- Peptide Label: isoform X1
- UniProtKB: A0AAX6RSP0 (UniProtKB/TrEMBL),   G5BJP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098352   ⟸   XM_021242693
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RKM5 (UniProtKB/TrEMBL)



1 to 28 of 28 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000000362 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000425 ENTREZGENE
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
  Zinc/RING finger domain, C3HC4 (zinc finger) UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/TrEMBL
  Ub_carboxyl-term_hydrolase UniProtKB/TrEMBL
  USP_CS UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_UBP UniProtKB/TrEMBL
NCBI Gene Usp45 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 45 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
  zf-UBP UniProtKB/TrEMBL
PROSITE USP_1 UniProtKB/TrEMBL
  USP_2 UniProtKB/TrEMBL
  USP_3 UniProtKB/TrEMBL
  ZF_UBP UniProtKB/TrEMBL
SMART ZnF_UBP UniProtKB/TrEMBL
Superfamily-SCOP Cysteine proteinases UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt A0AAX6RKM5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RQS0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RRE0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RSP0 ENTREZGENE, UniProtKB/TrEMBL
  G5BJP1 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows