| 2957 | Kcnj1 | potassium inwardly-rectifying channel, subfamily J, member 1 | ENCODES a protein that exhibits ATP binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; INVOLVED IN cellular response to magnesium ion; negative regulation of apoptotic process; potassium ion import across plasma membrane; PARTICIPATES IN aldosterone signaling pathway; ASSOCIATED WITH decreased body weight; decreased circulating bicarbonate level; decreased susceptibility to hypertension; ASSOCIATED WITH nephrotic syndrome; Bartter disease (ortholog); Bartter disease type 2 (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); INTERACTS WITH (S)-amphetamine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 8 | 39014822 | 39066716 | Rat | 132 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732016 | KCNJ1 | potassium inwardly rectifying channel subfamily J member 1 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 11 | 128838020 | 128867296 | Human | 218 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736363 | Kcnj1 | potassium inwardly-rectifying channel, subfamily J, member 1 | Predicted to enable several functions, including ATP-activated inward rectifier potassium channel activity; anion binding activity; and potassium ion binding activity. Acts upstream of or within several processes, including regulation of G-protein activated inward rectifier potassium channel activit y; renal sodium ion absorption; and tissue homeostasis. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in heart and metanephros. Used to study Bartter disease type 2. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 32283714 | 32310493 | Mouse | 138 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9041059 | Kcnj1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | NW_004955412 | 29801022 | 29832153 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11878724 | KCNJ1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); membrane (inferred); monoatomic ion channel complex (inferred) | 11 | 123649466 | 123680149 | Bonobo | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12284768 | KCNJ1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | 5 | 5783242 | 5813961 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12478843 | Kcnj1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); membrane (inferred); monoatomic ion channel complex (inferred) | NW_004936572 | 3396329 | 3425848 | Squirrel | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13875195 | KCNJ1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); membrane (inferred); monoatomic ion channel complex (inferred) | | | | Pig | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18789390 | KCNJ1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (inferred); membrane (inferred); monoatomic ion channel complex (inferred) | | | | Green Monkey | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910257 | Kcnj1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 150657632 | KCNJ1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); potassium channel activity (inferred); INVOLVED IN metal ion transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion trans port (inferred); FOUND IN cell surface (inferred); membrane (inferred); monoatomic ion channel complex (inferred) | | | | Dog | 20 | symbol | gene, protein-coding |
| 155243993 | kcnj1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626083765 | Kcnj1 | potassium inwardly rectifying channel subfamily J member 1 | ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cellular response to magnesium ion (ortholog); circulatory system development (ortholog); gene expression (ortholog); ASSOCIATED WITH Bartter disease (ortholog); Bartter disease type 2 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233138 | kcnj1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242365 | kcnj1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 13782352 | Kcnj1em1Kasu | potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu | ASSOCIATED WITH decreased body weight; decreased circulating bicarbonate level; decreased susceptibility to hypertension | | | | Rat | 9 | symbol , description | gene, allele |
| 736667 | Kcnj3 | potassium inwardly-rectifying channel, subfamily J, member 3 | Contributes to G-protein activated inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Part of inward rectifier potassium channel complex. Is active in parallel fiber to Purkinj e cell synapse and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; male reproductive gland or organ; and thymus. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 55301814 | 55488157 | Mouse | 193 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 61822 | Kcnj10 | potassium inwardly-rectifying channel, subfamily J, member 10 | ENCODES a protein that exhibits identical protein binding; signaling receptor binding; inward rectifier potassium channel activity (ortholog); INVOLVED IN L-glutamate import; membrane hyperpolarization; optic nerve development; ASSOCIATED WITH Acute Liver Failure; amyotrophic lateral sclerosis; Brai n Injuries; FOUND IN apical plasma membrane; astrocyte projection; basolateral plasma membrane; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 87334510 | 87367747 | Rat | 185 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62113 | Kcnj10 | potassium inwardly-rectifying channel, subfamily J, member 10 | Enables inward rectifier potassium channel activity. Involved in cellular response to potassium ion and non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; glutamate reuptake; and regulation of resting membrane potential. Located in astrocyte p rojection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; cochlea; genitourinary system; spinal cord; and stomach. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 172168777 | 172201652 | Mouse | 289 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 731912 | KCNJ10 | potassium inwardly rectifying channel subfamily J member 10 | This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the p otassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008] | 1 | 160037467 | 160070160 | Human | 369 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8782144 | Kcnj10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); cellular response to potassium ion (ortholog); central nervous system myelination (ortho log); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | NW_004955468 | 11828525 | 11860365 | Chinchilla | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11765725 | KCNJ10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); cellular response to potassium ion (ortholog); central nervous system myelination (ortho log); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | 1 | 135391321 | 135424100 | Bonobo | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12234066 | KCNJ10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); potassium channel activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); cellular response to potassium ion (ortholog); central nervous system myelination (ortholog); ASSOCIATED WITH EAST syndrome; Acute Liver Failure (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | 38 | 22114718 | 22143625 | Dog | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12730255 | Kcnj10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); central nervous system myelination (ortholog); glutamate reuptake (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic latera l sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | NW_004936740 | 555948 | 589219 | Squirrel | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14165849 | KCNJ10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); central nervous system myelination (ortholog); glutamate reuptake (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic latera l sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | | | | Pig | 105 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18555734 | KCNJ10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); central nervous system myelination (ortholog); glutamate reuptake (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic latera l sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | | | | Green Monkey | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912335 | Kcnj10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); potassium channel activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); cellular response to potassium ion (ortholog); central nervous system myelination (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240273 | kcnj10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626077225 | Kcnj10 | potassium inwardly rectifying channel subfamily J member 10 | ENCODES a protein that exhibits identical protein binding (ortholog); inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); cellular response to potassium ion (ortholog); central nervous system myelination (ortho log); ASSOCIATED WITH Acute Liver Failure (ortholog); amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 69098 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009] | 11 | 17385248 | 17389346 | Human | 1036 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 69099 | Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | Enables ATP binding activity; ATP-activated inward rectifier potassium channel activity; and ankyrin binding activity. Involved in negative regulation of insulin secretion and potassium ion import across plasma membrane. Acts upstream of or within several processes, including CAMKK-AMPK signaling ca scade; determination of adult lifespan; and response to ischemia. Located in T-tubule. Part of inward rectifying potassium channel. Is active in cytoplasm and plasma membrane. Is expressed in several structures, including brain; cardiovascular system; gut; skeletal muscle tissue; and testis. Used to study permanent neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 45746545 | 45750215 | Mouse | 424 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 69247 | Kcnj11 | potassium inwardly-rectifying channel, subfamily J, member 11 | ENCODES a protein that exhibits ankyrin binding; ATP-activated inward rectifier potassium channel activity; ATPase-coupled monoatomic cation transmembrane transporter activity; INVOLVED IN cellular response to glucose stimulus; cellular response to nicotine; cellular response to tumor necrosis facto r; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH epilepsy; Experimental Diabetes Mellitus; hypertension; FOUND IN acrosomal vesicle; axolemma; cell body fiber; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 1 | 105727473 | 105731167 | Rat | 320 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8830632 | Kcnj11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ankyrin binding (ortholog); ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AMPK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmac odynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | NW_004955414 | 32209426 | 32212424 | Chinchilla | 178 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11772177 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AM PK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | 11 | 17440522 | 17444075 | Bonobo | 184 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12137000 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AM PK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | 21 | 39953461 | 39957615 | Dog | 181 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12505084 | Kcnj11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AM PK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | NW_004936528 | 1685015 | 1688220 | Squirrel | 185 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14130684 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AM PK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 180 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18626842 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AM PK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | | | | Green Monkey | 184 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913596 | Kcnj11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ankyrin binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AMPK signalin g cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | | | | Naked Mole-Rat | 187 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285742410 | kcnj11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625925850 | Kcnj11 | potassium inwardly rectifying channel subfamily J member 11 | ENCODES a protein that exhibits ankyrin binding (ortholog); ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AMPK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmac odynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog) | | | | Black Rat | 169 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 621660 | Kcnj12 | potassium inwardly-rectifying channel, subfamily J, member 12 | ENCODES a protein that exhibits PDZ domain binding; inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Pro gression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ortholog); FOUND IN dendrite; neuronal cell body; T-tubule; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil | 10 | 46196110 | 46245008 | Rat | 143 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733298 | KCNJ12 | potassium inwardly rectifying channel subfamily J member 12 | This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chr omosome 17. [provided by RefSeq, Jul 2008] | 17 | 21376357 | 21419870 | Human | 143 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733299 | Kcnj12 | potassium inwardly-rectifying channel, subfamily J, member 12 | Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane; protein homotetramerization; and regulation of monoatomic ion transmembrane transport. Predicted to be located in T-tubule; dendri te; and neuronal cell body. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 60912970 | 60964095 | Mouse | 148 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8984121 | Kcnj12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN potassium ion transport (ortholog); protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ortholog); FOUND IN dendrite (ortholog); membrane (ortholog); neuronal cell body (ortholog) | NW_004955577 | 1348350 | 1359300 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12096879 | KCNJ12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ort holog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); T-tubule (ortholog) | 5 | 42819412 | 42860916 | Dog | 47 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12663383 | Kcnj12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ort holog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); T-tubule (ortholog) | NW_004936741 | 266311 | 303947 | Squirrel | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13912745 | KCNJ12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ort holog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); T-tubule (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 48 | symbol , ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18471395 | KCNJ12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ort holog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); T-tubule (ortholog) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931852 | Kcnj12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ort holog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); T-tubule (ortholog) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 32729247 | KCNJ12 | potassium inwardly rectifying channel subfamily J member 12 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN potassium ion transport (ortholog); protein homotetramerization (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; ASSOCIATED WITH Disease Progression (ortholog); Lymphatic Metastasis (ortholog); urinary bladder cancer (ortholog); FOUND IN dendrite (ortholog); membrane (ortholog); neuronal cell body (ortholog) | 17 | 30190240 | 30233740 | Bonobo | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241346 | kcnj12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 621661 | Kcnj13 | potassium inwardly-rectifying channel, subfamily J, member 13 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); regulation of membrane potential (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH ammonium chloride; bisphenol A; cadmium dichloride | 9 | 95509228 | 95528400 | Rat | 94 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734216 | KCNJ13 | potassium inwardly rectifying channel subfamily J member 13 | This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] | 2 | 232765802 | 232776565 | Human | 181 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 2299525 | Kcnj13 | potassium inwardly-rectifying channel, subfamily J, member 13 | Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is exp ressed in brain; male reproductive gland or organ; metanephros; and respiratory system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 16 and snowflake vitreoretinal degeneration. Orthologous to human KCNJ13 (potassium inwardly rectifying channel subfamily J member 13). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 87312299 | 87322451 | Mouse | 111 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9001603 | Kcnj13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); regulation of membrane potential (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955453 | 3259924 | 3269394 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11753977 | KCNJ13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | 2B | 119997643 | 120009927 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12074939 | KCNJ13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | 25 | 44377848 | 44388537 | Dog | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12537623 | Kcnj13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | NW_004936525 | 4361755 | 4374130 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14106861 | KCNJ13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | | | | Pig | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18459712 | KCNJ13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919230 | Kcnj13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250460 | kcnj13 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625858321 | Kcnj13 | potassium inwardly rectifying channel subfamily J member 13 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); regulation of membrane potential (ortholog); ASSOCIATED WITH Leber congenital amaurosis 16 (ortholog); Marshall syndrome (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 628872 | Kcnj14 | potassium inwardly-rectifying channel, subfamily J, member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity; INVOLVED IN monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); potassium ion transport (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; FOUND IN d endrite; neuronal cell body; INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; acetamide | 1 | 105429607 | 105437258 | Rat | 59 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735432 | KCNJ14 | potassium inwardly rectifying channel subfamily J member 14 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neur ons. [provided by RefSeq, Feb 2013] | 19 | 48455574 | 48466980 | Human | 63 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 735433 | Kcnj14 | potassium inwardly-rectifying channel, subfamily J, member 14 | Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be located in dendrite and neuronal cell body. Predicted to be part of monoatomic ion channe l complex. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; jaw; limb; nervous system; and oral epithelium. Orthologous to human KCNJ14 (potassium inwardly rectifying channel subfamily J member 14). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 45465871 | 45474180 | Mouse | 63 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8930054 | Kcnj14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | NW_004955559 | 2023993 | 2028082 | Chinchilla | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11767823 | KCNJ14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); potassium ion import across plasma membrane (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via t he chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | 19 | 45456082 | 45469017 | Bonobo | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12212078 | KCNJ14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | 1 | 107804400 | 107813888 | Dog | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12583982 | Kcnj14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); potassium ion import across plasma membrane (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via t he chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | NW_004936664 | 2555727 | 2564245 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14100441 | KCNJ14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18373729 | KCNJ14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); potassium ion import across plasma membrane (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via t he chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932398 | Kcnj14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); potassium ion import across plasma membrane (inferred); PARTICIPATES IN neuron-to-neuron signaling pathway via t he chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243926 | kcnj14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625894832 | Kcnj14 | potassium inwardly rectifying channel subfamily J member 14 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 621662 | Kcnj15 | potassium inwardly-rectifying channel, subfamily J, member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity; potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channe l complex (inferred); plasma membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; ammonium chloride | 11 | 48046953 | 48091285 | Rat | 99 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731050 | KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013] | 21 | 38229926 | 38307357 | Human | 104 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731051 | Kcnj15 | potassium inwardly-rectifying channel, subfamily J, member 15 | Enables potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; geni tourinary system; heart; and sensory organ. Orthologous to human KCNJ15 (potassium inwardly rectifying channel subfamily J member 15). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 95058417 | 95101119 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8868980 | Kcnj15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog) | NW_004955407 | 37261892 | 37313484 | Chinchilla | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11841000 | KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | 21 | 24615779 | 24668267 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12167208 | KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred); INTERACTS WITH bisphenol A | 31 | 33314061 | 33388165 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12502978 | Kcnj15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | NW_004936500 | 4685832 | 4690338 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13891485 | KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | | | | Pig | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18485147 | KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932043 | Kcnj15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog); FOUND IN membrane (inferred); monoatomic ion channel complex (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245326 | kcnj15 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626064279 | Kcnj15 | potassium inwardly rectifying channel subfamily J member 15 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH juvenile rheumatoid arthritis (ortholog); Lung Neoplasms (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 61824 | Kcnj16 | potassium inwardly-rectifying channel, subfamily J, member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transport; regulation of pH; response to carbon dioxide; ASSOCIATED WITH decreased body weight; decreased circulating aldosterone level; decreased circulating bicarbonate level; ASSOCIAT ED WITH hypokalemia; metabolic acidosis; Respiratory Underresponsiveness to Hypoxia and Hypercapnia; FOUND IN basolateral plasma membrane; plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; acrolein | 10 | 96489329 | 96520745 | Rat | 137 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62115 | Kcnj16 | potassium inwardly-rectifying channel, subfamily J, member 16 | Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including potassium ion import across plasma membrane; regulation of pH; and response to carbon dioxide. Located in basolateral plasma membrane. Is expressed in cerebral cortex; floor plat e; heart; and metanephros. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 110858859 | 110918794 | Mouse | 121 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343172 | KCNJ16 | potassium inwardly rectifying channel subfamily J member 16 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rath er than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014] | 17 | 70075225 | 70135608 | Human | 130 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8814640 | Kcnj16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog); plasma membrane (ortholog) | NW_004955478 | 2775702 | 2833821 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11946455 | KCNJ16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog) | 17 | 64005085 | 64065153 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12362018 | KCNJ16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog) | 9 | 16369312 | 16441953 | Dog | 30 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12669902 | Kcnj16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog) | NW_004936655 | 3487071 | 3489686 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14282553 | KCNJ16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18673259 | KCNJ16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912846 | Kcnj16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257133 | kcnj16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626111355 | Kcnj16 | potassium inwardly rectifying channel subfamily J member 16 | ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of pH (ortholog); ASSOCIATED WITH Brugada syndrome 1 (ortholog); hypokalemia (ortholog); Hypokalemic Tu bulopathy and Deafness (ortholog); FOUND IN basolateral plasma membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 150523948 | KCNJ17 | inward rectifying K+ channel negative regulator Kir2.2v | ENCODES a protein that exhibits inward rectifier potassium channel activity (inferred); INVOLVED IN monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transport (inferred); monoatomic ion transport (inferred); FOUND IN membrane (inferred); monoatomic ion channel compl ex (inferred) | | | | Human | 11 | symbol , GTEx , COSMIC , Human Proteome Map | gene, protein-coding, PROVISIONAL [RefSeq] |
| 4144939 | KCNJ18 | potassium inwardly rectifying channel subfamily J member 18 | This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic period ic paralysis. [provided by RefSeq, Jan 2013] | 17 | 21692523 | 21704612 | Human | 79 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 155246524 | kcnj10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232933 | kcnj10.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856102 | kcnj11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858677 | kcnj11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863234 | kcnj11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865212 | kcnj11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468493 | kcnj11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857957 | kcnj11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858600 | kcnj11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861105 | kcnj11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861949 | kcnj11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626173233 | kcnj11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236855 | kcnj12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231516 | kcnj12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250459 | kcnj13.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247959 | kcnj13.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253865 | kcnj14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258445 | kcnj14.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252536 | kcnj15.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252225 | kcnj15.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251990 | kcnj16.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155230876 | kcnj16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 728896 | Kcnj15_v1 | potassium inwardly-rectifying channel, subfamily J, member 15, variant 1 | ENCODES an splice that exhibits inward rectifier potassium channel activity; INVOLVED IN potassium ion transport | | | | Rat | 2 | symbol | gene, splice |
| 728897 | Kcnj15_v2 | potassium inwardly-rectifying channel, subfamily J, member 15, variant 2 | ENCODES an splice that exhibits inward rectifier potassium channel activity; INVOLVED IN potassium ion transport | | | | Rat | 2 | symbol | gene, splice |
| 10054406 | Kcnj10em1Mcwi | potassium channel, inwardly rectifying subfamily J, member 10; CRISPR/Cas9 system induced mutant 1, Medical College of Wisconsin | This allele was made by CRISPR/Cas9 system. The resulting mutation is a 1-bp insertion in the Kcnj10 gene | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 10054409 | Kcnj10em3Mcwi | potassium channel, inwardly rectifying subfamily J, member 10; CRISPR/Cas9 system induced mutant 3, Medical College of Wisconsin | This allele was made by CRISPR/Cas9 system. The resulting mutation is a 3-bp deletion in the Kcnj10 gene | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 6893379 | Kcnj11em5Mcwi | potassium inwardly rectifying channel, subfamily J, member 11; zinc finger nuclease induced mutant 5, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting allele is a 8-bp deletion in exon 1 (del 311-318) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 6893381 | Kcnj11em9Mcwi | potassium inwardly rectifying channel, subfamily J, member 11; zinc finger nuclease induced mutant 9, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting allele is a 5-bp deletion in exon 1 (del 310-314) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 13207498 | Kcnj13em1Mcwi | potassium inwardly-rectifying channel, subfamily J, member 13; CRISPR/Cas9 induced mutant1, Mcwi | CRISPR/Cas9 system was used to introduce a mutation in the Kcnj13 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion of exon 2 in the Kcnj13 gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 6893423 | Kcnj16em1Mcwi | potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | ASSOCIATED WITH decreased body weight; decreased circulating aldosterone level; decreased circulating bicarbonate level; ASSOCIATED WITH hypokalemia; metabolic acidosis; Respiratory Underresponsiveness to Hypoxia and Hypercapnia | | | | Rat | 19 | symbol , old_gene_symbol | gene, allele |
| 16562626 | AC124798.1 | antisense to KCNJ11 and overlapping to a novel gene | | | | | Human | | name | gene, lncrna |
| 16563739 | AC069061.1 | potassium inwardly-rectifying channel, subfamily J, member 12 (KCNJ12) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 38613468 | LOC105372430 | uncharacterized LOC105372430 | | 19 | 48465411 | 48469533 | Human | | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
