Kcnj1<sup>em1Kasu</sup> (potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Kcnj1em1Kasu (potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu) Rattus norvegicus
Symbol: Kcnj1em1Kasu
Name: potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu
RGD ID: 13782352
Description: Zinc Finger Nuclease (ZFN) was utilized to knockout rat Kcnj1 function. ZFN constructs targeting the gene were designed and purchased from Sigma Aldrich (St. Louis, MO, USA).The targeting site sequence is CTCAAGTGACCATAGGTTACGgattcaGGTTTGTGAC (lower case represents the ZFN cleavage site). The resulting mutation is 209 bp deletion from G225 to G433, leading to frameshift and premature termination of Kcnj1 protein in homozygotes.
ASSOCIATED WITH decreased body weight; decreased circulating bicarbonate level; decreased susceptibility to hypertension
Type: allele  of Kcnj1  
Previously known as: Kcnj1^[em1Kasu]
Is Marker For: Strains:   SS-Kcnj1em1Kasu+/-   SS-Kcnj1em1Kasu-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure. Zhou X, etal., Hypertension. 2013 Aug;62(2):288-94. doi: 10.1161/HYPERTENSIONAHA.111.01051. Epub 2013 Jun 10.


Related Rat Strains
The following Strains have been annotated to Kcnj1em1Kasu



Nucleotide Sequences

Additional Information